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PDB: 79 件
6Z7Y
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Human insulin in complex with the analytical antibody OXI-005 Fab
分子名称: Insulin, OXI-005 Fab Heavy chain, OXI-005 Fab Light chain
著者Johansson, E.
登録日2020-06-02
公開日2020-12-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Insulin binding to the analytical antibody sandwich pair OXI-005 and HUI-018: Epitope mapping and binding properties.
Protein Sci., 30, 2021
1E5Q
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Ternary complex of saccharopine reductase from Magnaporthe grisea, NADPH and saccharopine
分子名称: N-(5-AMINO-5-CARBOXYPENTYL)GLUTAMIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Saccharopine dehydrogenase [NADP(+), ...
著者Johansson, E, Steffens, J.J, Lindqvist, Y, Schneider, G.
登録日2000-07-28
公開日2000-12-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure of Saccharopine Reductase from Magnaporthe Grisea, an Enzyme of the Alpha-Aminoadipate Pathway of Lysine Biosynthesis
Structure, 8, 2000
1OGH
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Structure of the bifunctional dCTP deaminase-dUTPase from Methanocaldococcus jannaschii
分子名称: BIFUNCTIONAL DEAMINASE/DIPHOSPHATASE
著者Johansson, E, Bjornberg, O, Nyman, P.O, Larsen, S.
登録日2003-05-02
公開日2003-06-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Structure of the Bifunctional Dctp Deaminase-Dutpase from Methanocaldococcus Jannaschii and its Relation to Other Homotrimeric Dutpases
J.Biol.Chem., 278, 2003
1XS6
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dCTP deaminase from Escherichia coli. E138A mutant enzyme in complex with dUTP
分子名称: DEOXYURIDINE-5'-TRIPHOSPHATE, Deoxycytidine triphosphate deaminase, MAGNESIUM ION
著者Johansson, E, Fano, M, Bynck, J.H, Neuhard, J, Larsen, S, Sigurskjold, B.W, Christensen, U, Willemoes, M.
登録日2004-10-18
公開日2004-12-21
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes
J.Biol.Chem., 280, 2005
1XS1
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dCTP deaminase from Escherichia coli in complex with dUTP
分子名称: DEOXYURIDINE-5'-TRIPHOSPHATE, Deoxycytidine triphosphate deaminase, MAGNESIUM ION
著者Johansson, E, Fano, M, Bynck, J.H, Neuhard, J, Larsen, S, Sigurskjold, B.W, Christensen, U, Willemoes, M.
登録日2004-10-18
公開日2004-12-21
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes
J.Biol.Chem., 280, 2005
1XS4
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dCTP deaminase from Escherichia coli- E138A mutant enzyme in complex with dCTP
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxycytidine triphosphate deaminase, MAGNESIUM ION
著者Johansson, E, Fano, M, Bynck, J.H, Neuhard, J, Larsen, S, Sigurskjold, B.W, Christensen, U, Willemoes, M.
登録日2004-10-18
公開日2004-12-21
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes
J.Biol.Chem., 280, 2005
1IDT
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STRUCTURAL STUDIES ON A PRODRUG-ACTIVATING SYSTEM-CB1954 AND FMN-DEPENDENT NITROREDUCTASE
分子名称: 5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE, FLAVIN MONONUCLEOTIDE, MINOR FMN-DEPENDENT NITROREDUCTASE
著者Johansson, E, Parkinson, G.N, Denny, W.A, Neidle, S.
登録日2001-04-05
公開日2003-09-16
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form.
J.Med.Chem., 46, 2003
6QIO
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Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the human growth hormone derivative somapacitan
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-2-microglobulin, CYSTEINE, ...
著者Johansson, E.
登録日2019-01-21
公開日2020-02-05
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Identification of Binding Sites on Human Serum Albumin for Somapacitan, a Long-Acting Growth Hormone Derivative.
Biochemistry, 59, 2020
6QIP
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Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the albumin-biniding side chain of the human growth hormone derivative somapacitan
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BETA-MERCAPTOETHANOL, Beta-2-microglobulin, ...
著者Johansson, E.
登録日2019-01-21
公開日2020-02-05
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Identification of Binding Sites on Human Serum Albumin for Somapacitan, a Long-Acting Growth Hormone Derivative.
Biochemistry, 59, 2020
1JTK
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Crystal structure of cytidine deaminase from Bacillus subtilis in complex with the inhibitor tetrahydrodeoxyuridine
分子名称: TETRAHYDRODEOXYURIDINE, ZINC ION, cytidine deaminase
著者Johansson, E, Mejlhede, N, Neuhard, J, Larsen, S.
登録日2001-08-21
公開日2002-04-10
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Crystal structure of the tetrameric cytidine deaminase from Bacillus subtilis at 2.0 A resolution.
Biochemistry, 41, 2002
1UWZ
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Bacillus subtilis cytidine deaminase with an Arg56 - Ala substitution
分子名称: CYTIDINE DEAMINASE, TETRAHYDRODEOXYURIDINE, ZINC ION
著者Johansson, E, Neuhard, J, Willemoes, M, Larsen, S.
登録日2004-02-18
公開日2004-05-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Structural, Kinetic, and Mutational Studies of the Zinc Ion Environment in Tetrameric Cytidine Deaminase
Biochemistry, 43, 2004
1UX0
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Bacillus subtilis cytidine deaminase with an Arg56 - Gln substitution
分子名称: CYTIDINE DEAMINASE, TETRAHYDRODEOXYURIDINE, ZINC ION
著者Johansson, E, Neuhard, J, Willemoes, M, Larsen, S.
登録日2004-02-18
公開日2004-05-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Structural, Kinetic, and Mutational Studies of the Zinc Ion Environment in Tetrameric Cytidine Deaminase
Biochemistry, 43, 2004
1UX1
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Bacillus subtilis cytidine deaminase with a Cys53His and an Arg56Gln substitution
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CYTIDINE DEAMINASE, TETRAHYDRODEOXYURIDINE, ...
著者Johansson, E, Neuhard, J, Willemoes, M, Larsen, S.
登録日2004-02-18
公開日2004-05-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献Structural, Kinetic, and Mutational Studies of the Zinc Ion Environment in Tetrameric Cytidine Deaminase
Biochemistry, 43, 2004
2J4H
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Crystal structure of a H121A Escherichia coli dCTP deaminase mutant enzyme
分子名称: DEOXYCYTIDINE DIPHOSPHATE, DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE, MAGNESIUM ION
著者Johansson, E, Thymark, M, Bynck, J.H, Fanoe, M, Larsen, S, Willemoes, M.
登録日2006-08-31
公開日2007-08-07
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Regulation of Dctp Deaminase from Escherichia Coli by Nonallosteric Dttp Binding to an Inactive Form of the Enzyme
FEBS J., 274, 2007
2J4Q
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Crystal structure of a E138A Escherichia coli dCTP deaminase mutant enzyme in complex with dTTP
分子名称: DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE, MAGNESIUM ION, THYMIDINE-5'-DIPHOSPHATE, ...
著者Johansson, E, Thymark, M, Bynck, J.H, Fanoe, M, Larsen, S, Willemoes, M.
登録日2006-09-05
公開日2007-08-07
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Regulation of Dctp Deaminase from Escherichia Coli by Nonallosteric Dttp Binding to an Inactive Form of the Enzyme
FEBS J., 274, 2007
5II0
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Crystal structure of the human calcitonin receptor ectodomain in complex with a truncated salmon calcitonin analogue
分子名称: Calcitonin, Calcitonin receptor, SODIUM ION, ...
著者Johansson, E, Reedtz-Runge, S.
登録日2016-03-01
公開日2016-05-11
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.097 Å)
主引用文献Type II Turn of Receptor-bound Salmon Calcitonin Revealed by X-ray Crystallography.
J.Biol.Chem., 291, 2016
1U9Y
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Crystal Structure of Phosphoribosyl Diphosphate Synthase from Methanocaldococcus jannaschii
分子名称: Ribose-phosphate pyrophosphokinase
著者Kadziola, A, Johansson, E, Jepsen, C.H, McGuire, J, Larsen, S, Hove-Jensen, B.
登録日2004-08-11
公開日2005-08-23
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Novel class III phosphoribosyl diphosphate synthase: structure and properties of the tetrameric, phosphate-activated, non-allosterically inhibited enzyme from Methanocaldococcus jannaschii
J.Mol.Biol., 354, 2005
8PJH
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Crystal structure of human insulin desB30 precursor with an Aspartate-Glycine-Lysine C-peptide in dimer (T2) conformation
分子名称: Insulin
著者Schluckebier, G, Johansson, E.
登録日2023-06-23
公開日2023-11-08
最終更新日2024-04-17
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Molecular engineering of insulin for recombinant expression in yeast.
Trends Biotechnol, 42, 2024
8PJC
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Crystal structure of human insulin desB30 precursor with an Alanine-Alanine-Lysine C-peptide in dimer (T2) conformation
分子名称: Insulin
著者Schluckebier, G, Johansson, E.
登録日2023-06-23
公開日2023-11-08
最終更新日2024-04-17
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Molecular engineering of insulin for recombinant expression in yeast.
Trends Biotechnol, 42, 2024
4M8O
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TERNARY COMPLEX OF DNA POLYMERASE EPSILON WITH AN INCOMING dATP
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2-AMINOETHANESULFONIC ACID, CHLORIDE ION, ...
著者Sauer-Eriksson, A.E, Hogg, M, Osterman, P, Johansson, E.
登録日2013-08-13
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for processive DNA synthesis by yeast DNA polymerase epsilon.
Nat.Struct.Mol.Biol., 21, 2014
8CN9
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Factor VII binding Fab of the bispecific antibody HMB-001 in complex with Factor VII
分子名称: CALCIUM ION, CESIUM ION, Coagulation factor VII, ...
著者Schluckebier, G, Johansson, E.
登録日2023-02-22
公開日2023-12-27
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders
Nat Cardiovasc Res, 2023
8RRP
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Insulin Icodec - A14E B16H B25H B29Ne-C20 diacid-LgGlu-2xAdo desB30 human insulin
分子名称: ACETATE ION, Insulin, Insulin B chain
著者Schluckebier, G, Johansson, E.
登録日2024-01-23
公開日2024-07-10
最終更新日2024-07-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Enhanced disulphide bond stability contributes to the once-weekly profile of insulin icodec.
Nat Commun, 15, 2024
6I8A
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BU of 6i8a by Molmil
The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution.
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
著者Parkash, V, Johansson, E.
登録日2018-11-19
公開日2019-01-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.652 Å)
主引用文献Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.
Nat Commun, 10, 2019
6H1V
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The crystal structure of Pol2CORE in complex with DNA and an incoming nucleotide, carrying an Fe-S cluster
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(P*AP*AP*TP*TP*GP*AP*AP*CP*GP*CP*GP*GP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*CP*CP*GP*CP*GP*TP*TP*(DOC))-3'), ...
著者Parkash, V, Johansson, E.
登録日2018-07-12
公開日2019-04-24
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural evidence for an essential Fe-S cluster in the catalytic core domain of DNA polymerase ε.
Nucleic Acids Res., 47, 2019
8B67
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The crystal structure of M644G variant of DNA Pol Epsilon containing CTP in the polymerase active site
分子名称: ACETATE ION, CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, ...
著者Parkash, V, Johansson, E.
登録日2022-09-26
公開日2023-10-25
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A sensor complements the steric gate when DNA polymerase epsilon discriminates ribonucleotides.
Nucleic Acids Res., 2023

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件を2024-08-28に公開中

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