6O7D
 
 | | Crystal structure of Csm1-Csm4 cassette in complex with one ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), Csm4, ... | | Authors: | Jia, N, Patel, D.J. | | Deposit date: | 2019-03-07 | | Release date: | 2019-07-31 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | Second Messenger cA4Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path.
Mol.Cell, 75, 2019
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6O6S
 | | Crystal structure of Apo Csm6 | | Descriptor: | Csm6 | | Authors: | Jia, N, Patel, D.J. | | Deposit date: | 2019-03-07 | | Release date: | 2019-07-31 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4Cleavage with ApA>p Formation Terminating RNase Activity.
Mol.Cell, 75, 2019
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6O7H
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6O7I
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6PPR
 | | Cryo-EM structure of AdnA(D934A)-AdnB(D1014A) in complex with AMPPNP and DNA | | Descriptor: | ATP-dependent DNA helicase (UvrD/REP), DNA (70-MER), IRON/SULFUR CLUSTER, ... | | Authors: | Jia, N, Unciuleac, M, Shuman, S, Patel, D.J. | | Deposit date: | 2019-07-08 | | Release date: | 2019-11-20 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6PPJ
 | | Cryo-EM structure of AdnA(D934A)-AdnB(D1014A) in complex with AMPPNP | | Descriptor: | ATP-dependent DNA helicase (UvrD/REP), IRON/SULFUR CLUSTER, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Jia, N, Unciuleac, M, Shuman, S, Patel, D.J. | | Deposit date: | 2019-07-07 | | Release date: | 2019-11-20 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6MUT
 | | Cryo-EM structure of ternary Csm-crRNA-target RNA with anti-tag sequence complex in type III-A CRISPR-Cas system | | Descriptor: | RNA (5'-R(*GP*UP*GP*GP*AP*AP*AP*GP*GP*CP*GP*GP*GP*CP*AP*GP*AP*GP*GP*C)-3'), RNA (5'-R(P*CP*CP*UP*CP*UP*GP*CP*CP*CP*GP*CP*CP*UP*UP*UP*CP*CP*AP*C)-3'), Uncharacterized protein Csm1, ... | | Authors: | Jia, N, Wang, C, Eng, E.T, Patel, D.J. | | Deposit date: | 2018-10-23 | | Release date: | 2018-12-12 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
Mol. Cell, 73, 2019
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6MUR
 | | Cryo-EM structure of Csm-crRNA-target RNA ternary complex in type III-A CRISPR-Cas system | | Descriptor: | RNA (27-MER), RNA (5'-R(P*GP*CP*AP*AP*AP*CP*CP*GP*CP*CP*UP*CP*UP*GP*CP*CP*CP*GP*C)-3'), Uncharacterized protein, ... | | Authors: | Jia, N, Wang, C, Eng, E.T, Patel, D.J. | | Deposit date: | 2018-10-23 | | Release date: | 2018-12-12 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
Mol. Cell, 73, 2019
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6MUU
 | | Cryo-EM structure of Csm-crRNA binary complex in type III-A CRISPR-Cas system | | Descriptor: | RNA (25-MER), Uncharacterized protein Csm1, Uncharacterized protein Csm2, ... | | Authors: | Jia, N, Wang, C, Eng, E.T, Patel, D.J. | | Deposit date: | 2018-10-23 | | Release date: | 2018-12-19 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
Mol. Cell, 73, 2019
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6MUS
 | | Cryo-EM structure of larger Csm-crRNA-target RNA ternary complex in type III-A CRISPR-Cas system | | Descriptor: | RNA (25-MER), RNA (33-MER), Uncharacterized protein Csm1, ... | | Authors: | Jia, N, Wang, C, Eng, E.T. | | Deposit date: | 2018-10-23 | | Release date: | 2018-12-12 | | Last modified: | 2019-01-30 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
Mol. Cell, 73, 2019
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6MUA
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5Y6K
 | | Human serum trnasferrin bound to a fluorescent probe | | Descriptor: | (2S)-6-[2-(7-azido-4-methyl-2-oxidanylidene-chromen-3-yl)ethanoylamino]-2-[bis(2-hydroxy-2-oxoethyl)amino]hexanoic acid, FE (III) ION, MALONATE ION, ... | | Authors: | Jiang, N, Cheng, T, Wang, M, Chan, G.C.F, Jin, L, Li, H, Sun, H. | | Deposit date: | 2017-08-12 | | Release date: | 2018-01-24 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.86 Å) | | Cite: | Tracking iron-associated proteomes in pathogens by a fluorescence approach.
Metallomics, 10, 2018
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4QLA
 | | Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori | | Descriptor: | Juvenile hormone epoxide hydrolase, PENTAETHYLENE GLYCOL | | Authors: | Zhou, K, Jia, N, Hu, C, Jiang, Y.L, Yang, J.P, Chen, Y, Li, S, Zhou, C.Z. | | Deposit date: | 2014-06-11 | | Release date: | 2014-09-03 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori.
Proteins, 82, 2014
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8WY8
 | | Cryo-EM structure of DSR2 apo complex | | Descriptor: | SIR2 family protein | | Authors: | Zhang, J.T, Jia, N, Liu, X.Y. | | Deposit date: | 2023-10-30 | | Release date: | 2024-04-10 | | Last modified: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system.
Nat Commun, 15, 2024
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8WYD
 | | Cryo-EM structure of DSR2-DSAD1 complex | | Descriptor: | Bacillus phage SPbeta DSAD1 protein, SIR2 family protein | | Authors: | Zhang, J.T, Jia, N, Liu, X.Y. | | Deposit date: | 2023-10-30 | | Release date: | 2024-04-10 | | Last modified: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (2.56 Å) | | Cite: | Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system.
Nat Commun, 15, 2024
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8WY9
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8WYF
 | | Cryo-EM structure of DSR2-DSAD1-NAD+ (partial) complex | | Descriptor: | Bacillus phage SPbeta DSAD1 protein, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SIR2 family protein | | Authors: | Zhang, J.T, Jia, N, Liu, X.Y. | | Deposit date: | 2023-10-30 | | Release date: | 2024-04-10 | | Last modified: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system.
Nat Commun, 15, 2024
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8WYE
 | | Cryo-EM structure of DSR2-DSAD1 (partial) complex | | Descriptor: | Bacillus phage SPbeta DSAD1 protein, SIR2 family protein | | Authors: | Zhang, J.T, Jia, N, Liu, X.Y. | | Deposit date: | 2023-10-30 | | Release date: | 2024-04-10 | | Last modified: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (2.49 Å) | | Cite: | Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system.
Nat Commun, 15, 2024
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8WYC
 | | Cryo-EM structure of DSR2 (H171A)-tube-NAD+ (partial) complex | | Descriptor: | Bacillus phage SPR Tube protein, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SIR2-like domain-containing protein | | Authors: | Zhang, J.T, Jia, N, Liu, X.Y. | | Deposit date: | 2023-10-30 | | Release date: | 2024-04-10 | | Last modified: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system.
Nat Commun, 15, 2024
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8WYB
 | | Cryo-EM structure of DSR2 (H171A)-tube-NAD+ complex | | Descriptor: | Bacillus phage SPR Tube protein, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SIR2-like domain-containing protein | | Authors: | Zhang, J.T, Jia, N, Liu, X.Y. | | Deposit date: | 2023-10-30 | | Release date: | 2024-04-10 | | Last modified: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (3.37 Å) | | Cite: | Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system.
Nat Commun, 15, 2024
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8WYA
 | | Cryo-EM structure of DSR2-tube complex | | Descriptor: | Bacillus phage SPbeta tube protein, SIR2 family protein | | Authors: | Zhang, J.T, Jia, N, Liu, X.Y. | | Deposit date: | 2023-10-30 | | Release date: | 2024-04-10 | | Last modified: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (3.62 Å) | | Cite: | Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system.
Nat Commun, 15, 2024
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8IFM
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8K34
 | | Cryo-EM structure of SPARTA gRNA binary complex | | Descriptor: | MAGNESIUM ION, Piwi domain-containing protein, RNA (5'-R(P*AP*AP*AP*CP*GP*GP*CP*UP*CP*UP*AP*AP*UP*CP*UP*AP*UP*UP*AP*GP*U)-3'), ... | | Authors: | Zhang, J.T, Jia, N. | | Deposit date: | 2023-07-14 | | Release date: | 2024-01-17 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (2.81 Å) | | Cite: | Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system.
Nat.Chem.Biol., 20, 2024
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8IFL
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8IFK
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