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PDB: 2898 件
7AZ0
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Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with TH12161
分子名称: 2-cyclopropyl-~{N}-(4-iodophenyl)quinazolin-4-amine, N-glycosylase/DNA lyase, NICKEL (II) ION
著者Davies, J.R, Masuyer, G, Stenmark, P.
登録日2020-11-13
公開日2022-06-01
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Science, 376, 2022
5WCH
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Crystal structure of the catalytic domain of human USP9X
分子名称: Probable ubiquitin carboxyl-terminal hydrolase FAF-X, UNKNOWN ATOM OR ION, ZINC ION
著者Dong, A, Zhang, Q, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
登録日2017-06-30
公開日2018-07-04
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
5WOF
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1.65 ANGSTROM STRUCTURE OF THE DYNEIN LIGHT CHAIN 1 FROM PLASMODIUM FALCIPARUM
分子名称: Dynein light chain 1, putative
著者Walker, J.R, Lew, J, Amani, M, Alam, Z, Wasney, G, Boulanger, K, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Hui, R, Botchkarev, A, Vedadi, M, Structural Genomics Consortium (SGC)
登録日2017-08-02
公開日2017-08-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Genome-scale Protein Expression and Structural Biology of Plasmodium Falciparum and Related Apicomplexan Organisms.
MOL.BIOCHEM.PARASITOL., 151, 2007
5W9S
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BU of 5w9s by Molmil
Zinc finger of human CXXC5 in complex with CpG DNA
分子名称: CXXC-type zinc finger protein 5, CpG DNA fragment, SULFATE ION, ...
著者Liu, K, Xu, C, Tempel, W, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2017-06-23
公開日2017-10-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 26, 2018
8S99
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Crystal structure of the TYK2 pseudokinase domain in complex with compound 11
分子名称: (8S)-N-[(1R,2S)-2-fluorocyclopropyl]-5-{[(1M,2'M)-3'-fluoro-2-oxo-2H-[1,2'-bipyridin]-3-yl]amino}-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide, 1,2-ETHANEDIOL, ACETATE ION, ...
著者Toms, A.V, Leit, S, Greenwood, J.R, Carriero, S, Mondal, S, Abel, R, Ashwell, M, Blanchette, H, Boyles, N, Cartwright, M, Collis, A, Feng, S, Ghanakota, P, Harriman, G.C, Hosagrahara, V, Kaila, N, Kapeller, R, Rafi, S, Romero, D.L, Tarantino, P, Timaniya, J, Wester, R.T, Westlin, W, Srivastava, B, Miao, W, Tummino, P, McElwee, J.J, Edmondson, S.D, Massee, C.E.
登録日2023-03-27
公開日2023-07-26
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.
J.Med.Chem., 66, 2023
8S9A
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Crystal structure of the TYK2 pseudokinase domain in complex with TAK-279
分子名称: (8S)-N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-{[(1P,2'P)-2-oxo-2H-[1,2'-bipyridin]-3-yl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxamide, 1,2-ETHANEDIOL, ACETATE ION, ...
著者Toms, A.V, Leit, S, Greenwood, J.R, Carriero, S, Mondal, S, Abel, R, Ashwell, M, Blanchette, H, Boyles, N, Cartwright, M, Collis, A, Feng, S, Ghanakota, P, Harriman, G.C, Hosagrahara, V, Kaila, N, Kapeller, R, Rafi, S, Romero, D.L, Tarantino, P, Timaniya, J, Wester, R.T, Westlin, W, Srivastava, B, Miao, W, Tummino, P, McElwee, J.J, Edmondson, S.D, Massee, C.E.
登録日2023-03-27
公開日2023-07-26
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.
J.Med.Chem., 66, 2023
8S98
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Crystal structure of the TYK2 pseudokinase domain in complex with compound 8
分子名称: (8S)-N-cyclopropyl-5-[(2-methoxypyridin-3-yl)amino]-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2
著者Toms, A.V, Leit, S, Greenwood, J.R, Carriero, S, Mondal, S, Abel, R, Ashwell, M, Blanchette, H, Boyles, N, Cartwright, M, Collis, A, Feng, S, Ghanakota, P, Harriman, G.C, Hosagrahara, V, Kaila, N, Kapeller, R, Rafi, S, Romero, D.L, Tarantino, P, Timaniya, J, Wester, R.T, Westlin, W, Srivastava, B, Miao, W, Tummino, P, McElwee, J.J, Edmondson, S.D, Massee, C.E.
登録日2023-03-27
公開日2023-07-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.
J.Med.Chem., 66, 2023
1U7M
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BU of 1u7m by Molmil
Solution structure of a diiron protein model: Due Ferri(II) turn mutant
分子名称: Four-helix bundle model, ZINC ION
著者Maglio, O, Nastri, F, Calhoun, J.R, Lahr, S, Pavone, V, DeGrado, W.F, Lombardi, A.
登録日2004-08-04
公開日2005-03-01
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Analysis and Design of Turns in alpha-Helical Hairpins
J.Mol.Biol., 346, 2005
6MOS
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BU of 6mos by Molmil
Structure of thioredoxin 1 from the thermophilic eubacterium Thermosipho africanus TCF52B
分子名称: TRIS(HYDROXYETHYL)AMINOMETHANE, Thioredoxin
著者Sahtout, N, Kuttiyatveetil, J.R, Sanders, D.A.R.
登録日2018-10-04
公開日2019-08-14
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.80013728 Å)
主引用文献Structure and function of the putative thioredoxin 1 from the thermophilic eubacterium Thermosipho africanus strain TCF52B.
Biochim Biophys Acta Proteins Proteom, 1867, 2019
8K3D
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BU of 8k3d by Molmil
Crystal structure of NRF1 DBD bound to DNA
分子名称: DNA (5'-D(*GP*GP*TP*GP*CP*GP*CP*AP*TP*GP*CP*GP*CP*AP*CP*C)-3'), Nuclear respiratory factor 1
著者Li, W.F, Liu, K, Min, J.R.
登録日2023-07-15
公開日2023-12-06
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Molecular mechanism of specific DNA sequence recognition by NRF1.
Nucleic Acids Res., 52, 2024
8K4L
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Crystal structure of NRF1 homodimer in complex with DNA
分子名称: DNA (14-MER), GLYCEROL, Nuclear respiratory factor 1
著者Liu, K, Li, W.F, Min, J.R.
登録日2023-07-19
公開日2023-12-06
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular mechanism of specific DNA sequence recognition by NRF1.
Nucleic Acids Res., 52, 2024
8K8A
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BU of 8k8a by Molmil
Crystal structure of NFIL3 in complex with TTACGTAA DNA
分子名称: DNA (5'-D(*CP*AP*TP*TP*AP*CP*GP*TP*AP*AP*TP*G)-3'), Nuclear factor interleukin-3-regulated protein
著者Min, J.R, Chen, S.Z, Liu, K.
登録日2023-07-29
公開日2024-03-06
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Structural basis for specific DNA sequence recognition by the transcription factor NFIL3.
J.Biol.Chem., 300, 2024
8K89
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Crystal structure of NFIL3
分子名称: Nuclear factor interleukin-3-regulated protein
著者Min, J.R, Chen, S.Z, Liu, K.
登録日2023-07-29
公開日2024-03-06
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for specific DNA sequence recognition by the transcription factor NFIL3.
J.Biol.Chem., 300, 2024
8K8D
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BU of 8k8d by Molmil
Crystal structure of C/EBPbeta BZIP domain bound to a high affinity DNA
分子名称: CCAAT/enhancer-binding protein beta, DNA (5'-D(*CP*AP*TP*TP*AP*CP*GP*TP*AP*AP*TP*G)-3')
著者Min, J.R, Chen, S.Z, Liu, K.
登録日2023-07-29
公開日2024-03-06
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for specific DNA sequence recognition by the transcription factor NFIL3.
J.Biol.Chem., 300, 2024
8K86
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Crystal structure of NFIL3 in complex with TTATGTAA DNA
分子名称: DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*TP*AP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*TP*AP*CP*AP*TP*AP*AP*TP*G)-3'), Nuclear factor interleukin-3-regulated protein
著者Min, J.R, Chen, S.Z, Liu, K.
登録日2023-07-28
公開日2024-03-06
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Structural basis for specific DNA sequence recognition by the transcription factor NFIL3.
J.Biol.Chem., 300, 2024
8K8C
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BU of 8k8c by Molmil
Crystal structure of C/EBPalpha BZIP domain bound to a high affinity DNA
分子名称: CCAAT/enhancer-binding protein alpha, DNA (5'-D(*CP*AP*TP*TP*AP*CP*GP*TP*AP*AP*TP*GP*A)-3'), DNA (5'-D(*CP*AP*TP*TP*AP*CP*GP*TP*AP*AP*TP*GP*T)-3'), ...
著者Min, J.R, Chen, S.Z, Liu, K.
登録日2023-07-29
公開日2024-03-06
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Structural basis for specific DNA sequence recognition by the transcription factor NFIL3.
J.Biol.Chem., 300, 2024
8J0K
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BU of 8j0k by Molmil
Crystal structure of human TFAP2A in complex with DNA
分子名称: DNA (5'-D(*CP*TP*GP*CP*CP*TP*CP*GP*GP*GP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*CP*CP*CP*GP*AP*GP*GP*CP*AP*G)-3'), GLYCEROL, ...
著者Liu, K, Xiao, Y.Q, Li, W.F, Min, J.R.
登録日2023-04-11
公開日2023-07-05
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors.
Nucleic Acids Res., 51, 2023
8J0Q
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Structure of DNA binding domain of human TFAP2B
分子名称: GLYCEROL, Transcription factor AP-2-beta
著者Liu, K, Xiao, Y.Q, Li, W.F, Min, J.R.
登録日2023-04-11
公開日2023-07-05
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors.
Nucleic Acids Res., 51, 2023
8J0L
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Structure of DNA binding Domain of Human TFAP2A
分子名称: GLYCEROL, Transcription factor AP-2-alpha
著者Liu, K, Xiao, Y.Q, Gan, L.Y, Min, J.R.
登録日2023-04-11
公開日2023-07-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors.
Nucleic Acids Res., 51, 2023
8J0R
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Structure of human TFAP2A in complex with DNA
分子名称: DI(HYDROXYETHYL)ETHER, DNA (5'-D(*CP*TP*GP*CP*CP*TP*CP*AP*GP*GP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*CP*CP*TP*GP*AP*GP*GP*CP*AP*G)-3'), ...
著者Liu, K, Xiao, Y.Q, Li, W.F, Min, J.R.
登録日2023-04-11
公開日2023-07-05
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors.
Nucleic Acids Res., 51, 2023
1ULA
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BU of 1ula by Molmil
APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS
分子名称: PURINE NUCLEOSIDE PHOSPHORYLASE, SULFATE ION
著者Ealick, S.E, Rule, S.A, Carter, D.C, Greenhough, T.J, Babu, Y.S, Cook, W.J, Habash, J, Helliwell, J.R, Stoeckler, J.D, Parksjunior, R.E, Chen, S.-F, Bugg, C.E.
登録日1991-11-05
公開日1993-01-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.
Proc.Natl.Acad.Sci.USA, 88, 1991
1ULB
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APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS
分子名称: GUANINE, PURINE NUCLEOSIDE PHOSPHORYLASE, SULFATE ION
著者Ealick, S.E, Rule, S.A, Carter, D.C, Greenhough, T.J, Babu, Y.S, Cook, W.J, Habash, J, Helliwell, J.R, Stoeckler, J.D, Parksjunior, R.E, Chen, S.-F, Bugg, C.E.
登録日1991-11-05
公開日1993-01-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.
Proc.Natl.Acad.Sci.USA, 88, 1991
7YYK
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Crystal structure of the O-fucosylated form of TSRs1-3 from the human thrombospondin 1
分子名称: 1,2-ETHANEDIOL, Thrombospondin-1, alpha-L-fucopyranose
著者Berardinelli, S.J, Eletsky, A, Valero-Gonzalez, J, Ito, A, Manjunath, R, Hurtado-Guerrero, R, Prestegard, J.R, Woods, R.J, Haltiwanger, R.S.
登録日2022-02-18
公開日2022-05-25
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献O-fucosylation stabilizes the TSR3 motif in thrombospondin-1 by interacting with nearby amino acids and protecting a disulfide bond.
J.Biol.Chem., 298, 2022
6S42
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The double mutant(Ile44Leu+Gln102His) of haloalkane dehalogenase DbeA from Bradyrhizobium elkanii USDA94 with an eliminated halide-binding site
分子名称: CHLORIDE ION, HEXANE-1,6-DIOL, Haloalkane dehalogenase, ...
著者Pudnikova, T, Mesters, J.R, Kuta Smatanova, I.
登録日2019-06-26
公開日2020-02-05
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystallization and Crystallographic Analysis of a Bradyrhizobium Elkanii USDA94 Haloalkane Dehalogenase Variant with an Eliminated Halide-Binding Site
Crystals, 2019
6S06
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Crystal structure of haloalkane dehalogenase LinB D147C+L177C mutant (LinB73) from Sphingobium japonicum UT26
分子名称: CHLORIDE ION, Haloalkane dehalogenase, MAGNESIUM ION
著者Iermak, I, Mesters, J.R, Degtjarik, O, Chaloupkova, R, Kuta Smatanova, I.
登録日2019-06-14
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Description of Transport Tunnel in Haloalkane Dehalogenase Variant LinB D147C+L177C from Sphingobium japonicum
Catalysts, 2021

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