7YYK

Crystal structure of the O-fucosylated form of TSRs1-3 from the human thrombospondin 1

Summary for 7YYK

Entry DOI	10.2210/pdb7yyk/pdb
Descriptor	Thrombospondin-1, alpha-L-fucopyranose, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	o-fucosylation, pofut2, thrombospondin 1, tsrs, cell adhesion
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	18953.95
Authors	Berardinelli, S.J.,Eletsky, A.,Valero-Gonzalez, J.,Ito, A.,Manjunath, R.,Hurtado-Guerrero, R.,Prestegard, J.R.,Woods, R.J.,Haltiwanger, R.S. (deposition date: 2022-02-18, release date: 2022-05-25, Last modification date: 2024-01-31)
Primary citation	Berardinelli, S.J.,Eletsky, A.,Valero-Gonzalez, J.,Ito, A.,Manjunath, R.,Hurtado-Guerrero, R.,Prestegard, J.H.,Woods, R.J.,Haltiwanger, R.S. O-fucosylation stabilizes the TSR3 motif in thrombospondin-1 by interacting with nearby amino acids and protecting a disulfide bond. J.Biol.Chem., 298:102047-102047, 2022 Cited by PubMed: 35597280 DOI: 10.1016/j.jbc.2022.102047 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation