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PDB: 3272 件
4RA0
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BU of 4ra0 by Molmil
An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者Kariolis, M.S, Kapur, S, Mathews, I.I, Cochran, J.R.
登録日2014-09-09
公開日2014-09-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.07 Å)
主引用文献An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis.
Nat.Chem.Biol., 10, 2014
4R0C
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BU of 4r0c by Molmil
Crystal structure of the Alcanivorax borkumensis YdaH transporter reveals an unusual topology
分子名称: AbgT putative transporter family, DODECYL-BETA-D-MALTOSIDE, SODIUM ION, ...
著者Su, C.-C, Bolla, J.R, Yu, E.W.
登録日2014-07-30
公開日2015-04-29
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.963 Å)
主引用文献Crystal structure of the Alcanivorax borkumensis YdaH transporter reveals an unusual topology.
Nat Commun, 6, 2015
6B74
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BU of 6b74 by Molmil
Structures of the two-chain human plasma Factor XIIa co-crystallized with potent inhibitors
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, Coagulation factor XII, ...
著者Dementiev, A.A, Partridge, J.R.
登録日2017-10-03
公開日2018-03-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.323 Å)
主引用文献Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors.
Blood Adv, 2, 2018
4QPP
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BU of 4qpp by Molmil
The Crystal Structure of Human HMT1 hnRNP methyltransferase-like protein 6 in complex with compound DS-421 (2-{4-[3-CHLORO-2-(2-METHOXYPHENYL)-1H-INDOL-5-YL]PIPERIDIN-1-YL}-N-METHYLETHANAMINE
分子名称: 2-{4-[3-chloro-2-(2-methoxyphenyl)-1H-indol-5-yl]piperidin-1-yl}-N-methylethanamine, POLY-UNK, Protein arginine N-methyltransferase 6, ...
著者Dong, A, Zeng, H, Smil, D, Walker, J.R, He, H, Eram, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Vedadi, M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC)
登録日2014-06-24
公開日2014-08-20
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献The Crystal Structure of Human HMT1 hnRNP methyltransferase-like protein 6 in complex with compound DS-421
To be Published
4R6C
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BU of 4r6c by Molmil
X-ray diffraction in temporally and spatially resolved biomolecular science: the X-ray crystal structure of hen egg white lysozyme cocrystallized with Ta6Br12 and then a crystal soaked in K2PtBr6
分子名称: BROMIDE ION, CHLORIDE ION, HEXABROMOPLATINATE(IV), ...
著者Helliwell, J.R.
登録日2014-08-24
公開日2015-02-04
最終更新日2018-03-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献X-ray diffraction in temporally and spatially resolved biomolecular science.
Faraday Discuss, 177, 2015
6BCM
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BU of 6bcm by Molmil
Structure of a Self-inhibited N475A variant of the Venezuelan Equine Encephalitis Virus (VEEV) nsP2 cysteine protease
分子名称: GLYCEROL, Protease nsP2, SODIUM ION
著者Compton, J.R, Legler, P.M.
登録日2017-10-20
公開日2017-11-08
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Mutation of Asn-475 in the Venezuelan Equine Encephalitis Virus nsP2 Cysteine Protease Leads to a Self-Inhibited State.
Biochemistry, 56, 2017
4RE3
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BU of 4re3 by Molmil
Different transition state conformations for the hydrolysis of beta-mannosides and beta-glucosides in the rice Os7BGlu26 family GH1 beta-mannosidase/beta-glucosidase
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-mannosidase/beta-glucosidase, ...
著者Tankrathok, A, Iglesias-Fernandez, J, Williams, R.J, Hakki, Z, Robinson, R.C, Hrmova, M, Rovira, C, Williams, S.J, Ketudat Cairns, J.R.
登録日2014-09-21
公開日2015-09-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献A Single Glycosidase Harnesses Different Pyranoside Ring Transition State Conformations for Hydrolysis of Mannosides and Glucosides
ACS CATALYSIS, 5, 2015
4RE4
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BU of 4re4 by Molmil
Different transition state conformations for the hydrolysis of beta-mannosides and beta-glucosides in the rice Os7BGlu26 family GH1 beta-mannosidase/beta-glucosidase
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, Beta-mannosidase/beta-glucosidase, ...
著者Tankrathok, A, Iglesias-Fernandez, J, Williams, R.J, Hakki, Z, Robinson, R.C, Hrmova, M, Rovira, C, Williams, S.J, Ketudat Cairns, J.R.
登録日2014-09-21
公開日2015-09-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献A Single Glycosidase Harnesses Different Pyranoside Ring Transition State Conformations for Hydrolysis of Mannosides and Glucosides
ACS CATALYSIS, 5, 2015
6B2N
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BU of 6b2n by Molmil
Crystal structure of TEM-1 beta-lactamase mutant M182N
分子名称: Beta-lactamase TEM, SULFATE ION
著者Jimah, J.R, Tolia, N.H.
登録日2017-09-20
公開日2018-01-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models.
ACS Cent Sci, 3, 2017
4R9F
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BU of 4r9f by Molmil
CpMnBP1 with Mannobiose Bound
分子名称: MBP1, beta-D-mannopyranose-(1-4)-beta-D-mannopyranose
著者Chekan, J.R, Agarwal, V, Nair, S.K.
登録日2014-09-04
公開日2014-10-29
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural and Biochemical Basis for Mannan Utilization by Caldanaerobius polysaccharolyticus Strain ATCC BAA-17.
J.Biol.Chem., 289, 2014
6BKW
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BU of 6bkw by Molmil
BTK complex with compound 12
分子名称: GLYCEROL, N-(3-{5-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-2,6-difluorophenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide, SULFATE ION, ...
著者Kiefer, J.R, Eigenbrot, C, Yu, C.L.
登録日2017-11-09
公開日2018-11-07
最終更新日2019-03-27
実験手法X-RAY DIFFRACTION (1.499 Å)
主引用文献Water molecules in protein-ligand interfaces. Evaluation of software tools and SAR comparison.
J. Comput. Aided Mol. Des., 33, 2019
6BLN
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BU of 6bln by Molmil
BTK complex with compound 13
分子名称: GLYCEROL, N-(3-{5-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}-2,6-difluorophenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide, SULFATE ION, ...
著者Kiefer, J.R, Eigenbrot, C, Yu, C.L.
登録日2017-11-10
公開日2018-11-07
最終更新日2019-03-27
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Water molecules in protein-ligand interfaces. Evaluation of software tools and SAR comparison.
J. Comput. Aided Mol. Des., 33, 2019
4R9G
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BU of 4r9g by Molmil
CpMnBP1 with Mannotriose Bound
分子名称: MBP1, ZINC ION, beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-4)-alpha-D-mannopyranose
著者Chekan, J.R, Agarwal, V, Nair, S.K.
登録日2014-09-04
公開日2014-10-29
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural and Biochemical Basis for Mannan Utilization by Caldanaerobius polysaccharolyticus Strain ATCC BAA-17.
J.Biol.Chem., 289, 2014
4REV
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BU of 4rev by Molmil
Structure of the dirigent protein DRR206
分子名称: 2,3-DIMETHYLIMIDAZOLIUM ION, CHLORIDE ION, Disease resistance response protein 206, ...
著者Kim, K.-Y, Smith, C.A, Merkley, E.D, Cort, J.R, Davin, L.B, Lewis, N.G.
登録日2014-09-24
公開日2014-11-26
最終更新日2015-02-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Trimeric Structure of (+)-Pinoresinol-forming Dirigent Protein at 1.95 angstrom Resolution with Three Isolated Active Sites.
J.Biol.Chem., 290, 2015
4RG1
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BU of 4rg1 by Molmil
Methyltransferase domain of C9orf114
分子名称: C9orf114, POLYETHYLENE GLYCOL (N=34), S-1,2-PROPANEDIOL, ...
著者Dong, A, Zeng, H, Walker, J.R, Li, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC)
登録日2014-09-29
公開日2014-10-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献The Crystal Structure of Human C9orf114 in complex with S-adenosyl-homocysteine
To be Published
4RGJ
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BU of 4rgj by Molmil
Apo crystal structure of CDPK4 from Plasmodium falciparum, PF3D7_0717500
分子名称: Calcium-dependent protein kinase 4
著者Wernimont, A.K, Walker, J.R, Hutchinson, A, Seitova, A, He, H, Loppnau, P, Neculai, M, Amani, M, Lin, Y.H, Ravichandran, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Lovato, D.V, Structural Genomics Consortium (SGC)
登録日2014-09-30
公開日2014-10-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.303 Å)
主引用文献Apo crystal structure of CDPK4 from Plasmodium falciparum, PF3D7_0717500
To be Published
4R1I
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BU of 4r1i by Molmil
Structure and Function of Neisseria gonorrhoeae MtrF Illuminates a Class of Antimetabolite Efflux Pumps
分子名称: Aminobenzoyl-glutamate transporter
著者Su, C.-C, Bolla, J.R, Yu, E.W.
登録日2014-08-06
公開日2015-04-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.959 Å)
主引用文献Structure and Function of Neisseria gonorrhoeae MtrF Illuminates a Class of Antimetabolite Efflux Pumps.
Cell Rep, 11, 2015
6C6Y
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BU of 6c6y by Molmil
Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque in complex with MERS Receptor Binding Domain
分子名称: JC57-14 Heavy chain, JC57-14 Light chain, SULFATE ION, ...
著者Joyce, M.G, Mascola, J.R, Graham, B.S, Kwong, P.D.
登録日2018-01-19
公開日2018-03-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.32 Å)
主引用文献Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape.
J. Virol., 92, 2018
4PLW
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BU of 4plw by Molmil
Crystal structure of ancestral apicomplexan malate dehydrogenase with lactate.
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, PHOSPHATE ION, malate dehydrogenase
著者Boucher, J.I, Jacobowitz, J.R, Beckett, B.C, Classen, S, Theobald, D.L.
登録日2014-05-19
公開日2014-07-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases.
Elife, 3, 2014
4PLC
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BU of 4plc by Molmil
Crystal structure of ancestral apicomplexan lactate dehydrogenase with malate.
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PYRUVIC ACID, ...
著者Boucher, J.I, Jacobowitz, J.R, Beckett, B.C, Classen, S, Theobald, D.L.
登録日2014-05-16
公開日2014-07-02
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases.
Elife, 3, 2014
4PAR
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BU of 4par by Molmil
The 5-Hydroxymethylcytosine-Specific Restriction Enzyme AbaSI in a Complex with Product-like DNA
分子名称: 1,2-ETHANEDIOL, DNA 14-MER, DNA 18-MER, ...
著者Horton, J.R, Cheng, X.
登録日2014-04-09
公開日2014-06-25
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Structure of 5-hydroxymethylcytosine-specific restriction enzyme, AbaSI, in complex with DNA.
Nucleic Acids Res., 42, 2014
4P16
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BU of 4p16 by Molmil
Crystal structure of the papain-like protease of Middle-East Respiratory Syndrome coronavirus
分子名称: ORF1a, ZINC ION
著者Lei, J, Mesters, J.R, Ma, Q, Hilgenfeld, R.
登録日2014-02-25
公開日2014-05-07
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features.
Antiviral Res., 109C, 2014
4PBB
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BU of 4pbb by Molmil
The 5-Hydroxymethylcytosine-Specific Restriction Enzyme AbaSI
分子名称: SULFATE ION, Uncharacterized protein AbaSI
著者Horton, J.R, Cheng, X.
登録日2014-04-11
公開日2014-06-25
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (3.46 Å)
主引用文献Structure of 5-hydroxymethylcytosine-specific restriction enzyme, AbaSI, in complex with DNA.
Nucleic Acids Res., 42, 2014
6C6X
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BU of 6c6x by Molmil
Crystal structure of Middle-East Respiratory Syndrome (MERS) coronavirus neutralizing antibody JC57-14 isolated from a vaccinated rhesus macaque.
分子名称: JC57-14 Heavy chain, JC57-14 Light chain
著者Joyce, M.G, Mascola, J.R, Graham, B.S, Kwong, P.D.
登録日2018-01-19
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape.
J. Virol., 92, 2018
6BLW
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BU of 6blw by Molmil
Zinc finger Domain of WT1(+KTS form) with M342R Mutation and 17+1mer Oligonucleotide with Triplet GGT
分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*TP*AP*AP*CP*CP*CP*TP*CP*CP*CP*AP*TP*TP*TP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*AP*AP*AP*TP*GP*GP*GP*AP*GP*GP*GP*TP*T)-3'), ...
著者Horton, J.R, Cheng, X.
登録日2017-11-11
公開日2018-01-03
最終更新日2018-05-16
実験手法X-RAY DIFFRACTION (1.835 Å)
主引用文献Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites.
Nucleic Acids Res., 46, 2018

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