6BLW
Zinc finger Domain of WT1(+KTS form) with M342R Mutation and 17+1mer Oligonucleotide with Triplet GGT
Summary for 6BLW
Entry DOI | 10.2210/pdb6blw/pdb |
Descriptor | Wilms tumor protein, DNA (5'-D(P*GP*CP*GP*AP*AP*AP*TP*GP*GP*GP*AP*GP*GP*GP*TP*T)-3'), DNA (5'-D(*TP*AP*AP*CP*CP*CP*TP*CP*CP*CP*AP*TP*TP*TP*CP*GP*C)-3'), ... (7 entities in total) |
Functional Keywords | protein-dna complex wilms tumor suppressor protein zinc-fingers, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus . Isoform 1: Nucleus speckle . Isoform 4: Nucleus, nucleoplasm : P19544 |
Total number of polymer chains | 3 |
Total formula weight | 26862.75 |
Authors | Horton, J.R.,Cheng, X. (deposition date: 2017-11-11, release date: 2018-01-03, Last modification date: 2018-05-16) |
Primary citation | Wang, D.,Horton, J.R.,Zheng, Y.,Blumenthal, R.M.,Zhang, X.,Cheng, X. Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites. Nucleic Acids Res., 46:3864-3877, 2018 Cited by PubMed: 29294058DOI: 10.1093/nar/gkx1274 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.835 Å) |
Structure validation
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