8FB4
| Structure of an alternating AT 16-mer bound by diamidine DB1476: 5'-GCTGGATATATCCAGC-3 | 分子名称: | 4,4'-(1H-benzimidazole-2,6-diyl)di(benzene-1-carboximidamide), CALCIUM ION, DNA (5'-D(*GP*CP*TP*GP*GP*AP*TP*AP*TP*AP*TP*CP*CP*AP*GP*C)-3') | 著者 | Terrell, J.R, Ogbonna, E.N, Wilson, W.D. | 登録日 | 2022-11-29 | 公開日 | 2023-02-22 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | X-ray Structure Characterization of the Selective Recognition of AT Base Pair Sequences. Acs Bio Med Chem Au, 3, 2023
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6HCX
| Influenza Virus N9 Neuraminidase A complex with Zanamivir molecule (Tern). | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | 著者 | Salinger, M.T, Hobbs, J.R, Murray, J.W, Laver, W.G, Kuhn, P, Garman, E.F. | 登録日 | 2018-08-16 | 公開日 | 2018-08-29 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | High Resolution Structures of Viral Neuraminidase with Drugs Bound in the Active Site. (In preparation) To Be Published
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6HGB
| Influenza A virus N6 neuraminidase native structure (Duck/England/56). | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Salinger, M.T, Hobbs, J.R, Murray, J.W, Laver, W.G, Kuhn, P, Garman, E.F. | 登録日 | 2018-08-23 | 公開日 | 2018-09-05 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | High Resolution Structures of Viral Neuraminidase with Drugs Bound in the Active Site. (In preparation) To Be Published
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8FS1
| CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor 11a (YD905) | 分子名称: | 1,2-ETHANEDIOL, 5'-S-{2-[N'-(cyclohexylmethyl)carbamimidamido]ethyl}-N-(3-phenylpropyl)-5'-thioadenosine, DNA (5'-D(*AP*TP*GP*GP*GP*AP*CP*TP*TP*TP*TP*TP*GP*A)-3'), ... | 著者 | Zhou, J, Horton, J.R, Cheng, X. | 登録日 | 2023-01-09 | 公開日 | 2023-05-10 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile- Specific DNA Adenine Methyltransferase. Acs Chem.Biol., 18, 2023
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6HG0
| Influenza A Virus N9 Neuraminidase complex with NANA (Tern/Australia). | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | 著者 | Salinger, M.T, Hobbs, J.R, Murray, J.W, Laver, W.G, Kuhn, P, Garman, E.F. | 登録日 | 2018-08-22 | 公開日 | 2018-08-29 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | High Resolution Structures of Viral Neuraminidase with Drugs Bound in the Active Site. (In preparation) To Be Published
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8FTG
| Biophysical and Structural Characterization of an Anti-Caffeine VHH Antibody | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Anti-Caffeine VHH Antibody, CAFFEINE, ... | 著者 | Horn, J.R, Smith, C.A, Sonneson, G.J, Walter, R. | 登録日 | 2023-01-12 | 公開日 | 2023-06-07 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | 主引用文献 | Molecular recognition requires dimerization of a VHH antibody. Mabs, 15, 2023
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8FS2
| CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor 11b (YD907) | 分子名称: | 1,2-ETHANEDIOL, 5'-S-{3-[N'-(cyclohexylmethyl)carbamimidamido]propyl}-N-(3-phenylpropyl)-5'-thioadenosine, DNA (5'-D(*TP*TP*CP*AP*AP*AP*AP*AP*GP*TP*CP*CP*CP*A)-3'), ... | 著者 | Zhou, J, Horton, J.R, Cheng, X. | 登録日 | 2023-01-09 | 公開日 | 2023-05-10 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile- Specific DNA Adenine Methyltransferase. Acs Chem.Biol., 18, 2023
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6H9W
| Unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens | 分子名称: | CITRIC ACID, ISOPROPYL ALCOHOL, Outer capsid protein VP4, ... | 著者 | Ciges-Tomas, J.R, Gozalbo-Rovira, R, Vila-Vicent, S, Buesa, J, Santiso-Bellon, C, Monedero, V, Yebra, M.J, Rodriguez-Diaz, J, Marina, A. | 登録日 | 2018-08-06 | 公開日 | 2019-06-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens. Plos Pathog., 15, 2019
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6HA0
| Unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens | 分子名称: | Outer capsid protein VP4, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Ciges-Tomas, J.R, Gozalbo-Rovira, R, Vila-Vicent, S, Buesa, J, Santiso-Bellon, C, Monedero, V, Yebra, M.J, Rodriguez-Diaz, J, Marina, A. | 登録日 | 2018-08-06 | 公開日 | 2019-06-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens. Plos Pathog., 15, 2019
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6HEB
| Influenza A Virus N9 Neuraminidase complex with Oseltamivir (Tern). | 分子名称: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Salinger, M.T, Hobbs, J.R, Murray, J.W, Laver, W.G, Kuhn, P, Garman, E.F. | 登録日 | 2018-08-20 | 公開日 | 2018-08-29 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | High Resolution Structures of Viral Neuraminidase with Drugs Bound in the Active Site. To Be Published
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6HFC
| Influenza A Virus N9 Neuraminidase Native (Tern). | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CARBON DIOXIDE, ... | 著者 | Salinger, M.T, Hobbs, J.R, Murray, J.W, Laver, W.G, Kuhn, P, Garman, E.F. | 登録日 | 2018-08-21 | 公開日 | 2018-08-29 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | 主引用文献 | High Resolution Structures of Viral Neuraminidase with Drugs Bound in the Active Site. (In preparation) To Be Published
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6HG5
| Influenza A virus N6 neuraminidase complex with Oseltamivir (Duck/England/56). | 分子名称: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Salinger, M.T, Hobbs, J.R, Murray, J.W, Laver, W.G, Kuhn, P, Garman, E.F. | 登録日 | 2018-08-22 | 公開日 | 2018-08-29 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | High Resolution Structures of Viral Neuraminidase with Drugs Bound in the Active Site. To Be Published
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6HFY
| Influenza A virus N6 neuraminidase complex with DANA (Duck/England/56). | 分子名称: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Salinger, M.T, Hobbs, J.R, Murray, J.W, Laver, W.G, Kuhn, P, Garman, E.F. | 登録日 | 2018-08-22 | 公開日 | 2018-08-29 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | High Resolution Structures of Viral Neuraminidase with Drugs Bound in the Active Site. (In preparation) To Be Published
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6H9Y
| Unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Outer capsid protein VP4, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Ciges-Tomas, J.R, Gozalbo-Rovira, R, Vila-Vicent, S, Buesa, J, Santiso-Bellon, C, Monedero, V, Yebra, M.J, Rodriguez-Diaz, J, Marina, A. | 登録日 | 2018-08-06 | 公開日 | 2019-06-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | Unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens. Plos Pathog., 15, 2019
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6HUL
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8GUB
| Cryo-EM structure of cancer-specific PI3Kalpha mutant H1047R in complex with BYL-719 | 分子名称: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Liu, X, Zhou, Q, Hart, J.R, Xu, Y, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. | 登録日 | 2022-09-11 | 公開日 | 2022-11-23 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | 主引用文献 | Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha. Proc.Natl.Acad.Sci.USA, 119, 2022
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8GUD
| Cryo-EM structure of cancer-specific PI3Kalpha mutant E545K in complex with BYL-719 | 分子名称: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Liu, X, Zhou, Q, Hart, J.R, Xu, Y, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. | 登録日 | 2022-09-11 | 公開日 | 2022-11-23 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | 主引用文献 | Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha. Proc.Natl.Acad.Sci.USA, 119, 2022
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8GUA
| Cryo-EM structure of cancer-specific PI3Kalpha mutant E542K in complex with BYL-719 | 分子名称: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Liu, X, Zhou, Q, Hart, J.R, Xu, Y, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. | 登録日 | 2022-09-11 | 公開日 | 2022-12-07 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha. Proc.Natl.Acad.Sci.USA, 119, 2022
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6IAH
| Phosphatase Tt82 from Thermococcus thioreducens | 分子名称: | CHLORIDE ION, Hydrolase, MAGNESIUM ION | 著者 | Havlickova, P, Brinsa, V, Brynda, J, Pachl, P, Prudnikova, T, Mesters, J.R, Kascakova, B, Kuty, M, Pusey, M.L, Ng, J.D, Rezacova, P, Smatanova, I.K. | 登録日 | 2018-11-26 | 公開日 | 2019-08-14 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | A novel structurally characterized haloacid dehalogenase superfamily phosphatase from Thermococcus thioreducens with diverse substrate specificity. Acta Crystallogr D Struct Biol, 75, 2019
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8G7X
| Human fatty acid synthase dehydratase domain | 分子名称: | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, ACETATE ION, DIMETHYL SULFOXIDE, ... | 著者 | Akey, D.L, Konwerski, J.R, McCullough, T.M, Smith, J.L. | 登録日 | 2023-02-17 | 公開日 | 2023-06-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.815 Å) | 主引用文献 | Structure of a modular polyketide synthase reducing region. Structure, 31, 2023
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8G7M
| ATP-bound mtHsp60 V72I focus | 分子名称: | 60 kDa heat shock protein, mitochondrial, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Braxton, J.R, Shao, H, Tse, E, Gestwicki, J.E, Southworth, D.R. | 登録日 | 2023-02-16 | 公開日 | 2023-07-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly. Biorxiv, 2023
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8G7L
| ATP-bound mtHsp60 V72I | 分子名称: | 60 kDa heat shock protein, mitochondrial, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Braxton, J.R, Shao, H, Tse, E, Gestwicki, J.E, Southworth, D.R. | 登録日 | 2023-02-16 | 公開日 | 2023-07-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly. Biorxiv, 2023
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8G7O
| ATP- and mtHsp10-bound mtHsp60 V72I focus | 分子名称: | 10 kDa heat shock protein, mitochondrial, 60 kDa heat shock protein, ... | 著者 | Braxton, J.R, Shao, H, Tse, E, Gestwicki, J.E, Southworth, D.R. | 登録日 | 2023-02-16 | 公開日 | 2023-07-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly. Biorxiv, 2023
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8G7N
| ATP- and mtHsp10-bound mtHsp60 V72I | 分子名称: | 10 kDa heat shock protein, mitochondrial, 60 kDa heat shock protein, ... | 著者 | Braxton, J.R, Shao, H, Tse, E, Gestwicki, J.E, Southworth, D.R. | 登録日 | 2023-02-16 | 公開日 | 2023-07-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly. Biorxiv, 2023
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8G7J
| mtHsp60 V72I apo | 分子名称: | 60 kDa heat shock protein, mitochondrial | 著者 | Braxton, J.R, Shao, H, Tse, E, Gestwicki, J.E, Southworth, D.R. | 登録日 | 2023-02-16 | 公開日 | 2023-07-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly. Biorxiv, 2023
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