7JYP
| |
6TN6
| X-ray structure of the endo-beta-1,4-mannanase from Thermotoga petrophila | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | 著者 | da Silva, V.M, Squina, F.M, Sperenca, M, Martin, L, Muniz, J.R.C, Garcia, W, Nicolet, Y. | 登録日 | 2019-12-06 | 公開日 | 2020-04-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | High-resolution structure of a modular hyperthermostable endo-beta-1,4-mannanase from Thermotoga petrophila: The ancillary immunoglobulin-like module is a thermostabilizing domain. Biochim Biophys Acta Proteins Proteom, 1868, 2020
|
|
6Z5U
| |
5MLN
| |
7ANM
| Nudaurelia capensis omega virus capsid: virus-like particles expressed in Nicotiana benthamiana | 分子名称: | p70 | 著者 | Castells-Graells, R, Ribeiro, J.R.S, Domitrovic, T, Hesketh, E.L, Scarff, C.A, Johnson, J.E, Ranson, N.A, Lawson, D.M, Lomonossoff, G.P. | 登録日 | 2020-10-12 | 公開日 | 2021-08-25 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | 主引用文献 | Plant-expressed virus-like particles reveal the intricate maturation process of a eukaryotic virus. Commun Biol, 4, 2021
|
|
7ATA
| Nudaurelia capensis omega virus procapsid: virus-like particles expressed in Nicotiana benthamiana | 分子名称: | p70 | 著者 | Castells-Graells, R, Ribeiro, J.R.S, Domitrovic, T, Hesketh, E.L, Scarff, C.A, Johnson, J.E, Ranson, N.A, Lawson, D.M, Lomonossoff, G.P. | 登録日 | 2020-10-29 | 公開日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (6.63 Å) | 主引用文献 | Plant-expressed virus-like particles reveal the intricate maturation process of a eukaryotic virus. Commun Biol, 4, 2021
|
|
5N9S
| TTK kinase domain in complex with BAY 1161909 | 分子名称: | (2~{R})-2-(4-fluorophenyl)-~{N}-[4-[2-[(2-methoxy-4-methylsulfonyl-phenyl)amino]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]propanamide, Dual specificity protein kinase TTK | 著者 | Uitdehaag, J, Willemsen-Seegers, N, de Man, J, Buijsman, R.C, Zaman, G.J.R. | 登録日 | 2017-02-27 | 公開日 | 2017-05-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity. J. Mol. Biol., 429, 2017
|
|
5NBT
| Apo structure of p60N/p80C katanin | 分子名称: | Katanin p60 ATPase-containing subunit A1, Katanin p80 WD40 repeat-containing subunit B1 | 著者 | Jiang, K, Rezabkova, L, Hua, S, Liu, Q, Capitani, G, Altelaar, A.F.M, Heck, A.J.R, Kammerer, R.A, Steinmetz, M.O, Akhmanova, A. | 登録日 | 2017-03-02 | 公開日 | 2017-04-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex. Nat. Cell Biol., 19, 2017
|
|
7VUT
| Crystal structure of AlleyCat10 | 分子名称: | AlleyCat10, CALCIUM ION | 著者 | Tame, J.R.H, Korendovych, I.V, Margheritis, E, Takahashi, K. | 登録日 | 2021-11-04 | 公開日 | 2022-07-27 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | NMR-guided directed evolution. Nature, 610, 2022
|
|
5NA0
| TTK kinase domain in complex with a PEG-linked pyrimido-indolizine | 分子名称: | Dual specificity protein kinase TTK, ~{N}-[3,5-diethyl-1-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]pyrazol-4-yl]-2-[[2-methoxy-4-[4-(2-methoxyethanoyl)piperazin-1-yl]phenyl]amino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide | 著者 | Uitdehaag, J, Willemsen-Seegers, N, de Man, J, Buijsman, R.C, Zaman, G.J.R. | 登録日 | 2017-02-27 | 公開日 | 2017-05-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity. J. Mol. Biol., 429, 2017
|
|
5N87
| TTK kinase domain in complex with NTRC 0066-0 | 分子名称: | 2,5,8,11-TETRAOXATRIDECANE, Dual specificity protein kinase TTK, SODIUM ION, ... | 著者 | Uitdehaag, J, Willemsen-Seegers, N, Sterrenburg, J.G, de Man, J, Buijsman, R.C, Zaman, G.J.R. | 登録日 | 2017-02-23 | 公開日 | 2017-05-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity. J. Mol. Biol., 429, 2017
|
|
5NMR
| Monomeric mouse Sortilin extracellular domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Leloup, N.O.L, Loessl, P, Meijer, D.H.M, Heck, A.J.R, Thies-Weesie, D.M.E, Janssen, B.J.C. | 登録日 | 2017-04-07 | 公開日 | 2017-12-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release. Nat Commun, 8, 2017
|
|
5M0W
| N-terminal domain of mouse Shisa 3 | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | 著者 | Lohkamp, B, Ojala, J.R.M. | 登録日 | 2016-10-06 | 公開日 | 2017-04-05 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | 主引用文献 | Ab initio solution of macromolecular crystal structures without direct methods. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
5NAD
| TTK kinase domain in complex with BAY 1217389 | 分子名称: | BAY 1217389, Dual specificity protein kinase TTK | 著者 | Uitdehaag, J.C.M, Willemsen-Seegers, N, Sterrenburg, J.G, de Man, J, Buijsman, R.C, Zaman, G.J.R. | 登録日 | 2017-02-27 | 公開日 | 2017-05-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity. J. Mol. Biol., 429, 2017
|
|
5N93
| TTK kinase domain in complex with TC-Mps1-12 | 分子名称: | 4-[[4-azanyl-6-(~{tert}-butylamino)-5-cyano-pyridin-2-yl]amino]benzamide, Dual specificity protein kinase TTK | 著者 | Uitdehaag, J, Willemsen-Seegers, N, de Man, J, Buijsman, R.C, Zaman, G.J.R. | 登録日 | 2017-02-24 | 公開日 | 2017-05-31 | 最終更新日 | 2017-08-23 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity. J. Mol. Biol., 429, 2017
|
|
7VUS
| Crystal structure of AlleyCat9 with 5-nitro-benzotriazole | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5-nitro-1H-benzotriazole, AlleyCat, ... | 著者 | Tame, J.R.H, Korendovych, I.V, Margheritis, E, Takahashi, K. | 登録日 | 2021-11-04 | 公開日 | 2022-07-27 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | NMR-guided directed evolution. Nature, 610, 2022
|
|
7VUR
| Crystal structure of AlleyCat9 with calcium but no inhibitor | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, AlleyCat, CALCIUM ION | 著者 | Margheritis, E, Takahashi, K, Korendovych, I.V, Tame, J.R.H. | 登録日 | 2021-11-04 | 公開日 | 2022-07-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | NMR-guided directed evolution. Nature, 610, 2022
|
|
7VUC
| |
7VUU
| Crystal structure of AlleyCat10 with inhibitor | 分子名称: | 5-nitro-1H-benzotriazole, AlleyCat, CALCIUM ION | 著者 | Tame, J.R.H, Korendovych, I.V, Margheritis, E, Takahashi, K. | 登録日 | 2021-11-04 | 公開日 | 2022-07-27 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | NMR-guided directed evolution. Nature, 610, 2022
|
|
5XG5
| Crystal structure of Mitsuba-1 with bound NAcGal | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, MITSUBA-1 | 著者 | Terada, D, Voet, A.R.D, Kamata, K, Zhang, K.Y.J, Tame, J.R.H. | 登録日 | 2017-04-12 | 公開日 | 2017-07-12 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Computational design of a symmetrical beta-trefoil lectin with cancer cell binding activity. Sci Rep, 7, 2017
|
|
4OGU
| The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates | 分子名称: | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... | 著者 | Tsoumpra, M.K, Barnett, B.L, Muniz, J.R.C, Walter, R.L, Ebetino, F.H, von Delft, F, Russell, R.G.G, Oppermann, U, Dunford, J.E. | 登録日 | 2014-01-16 | 公開日 | 2015-01-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates To be Published
|
|
8TOV
| HIV-CA Disulfide linked Hexamer bound to Quinazolin-4-one Scaffold inhibitor | 分子名称: | 2-[4-(4-aminobenzene-1-sulfonyl)-2-oxopiperazin-1-yl]-N-[(1R)-2-(3,5-difluorophenyl)-1-{3-[4-(morpholine-4-sulfonyl)phenyl]-4-oxo-3,4-dihydroquinazolin-2-yl}ethyl]acetamide, Matrix protein p17 | 著者 | Goldstone, D.C, Barnett, M.J, Taka, J.R.H. | 登録日 | 2023-08-04 | 公開日 | 2023-12-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators. J.Med.Chem., 66, 2023
|
|
7YYO
| Cryo-EM structure of an a-carboxysome RuBisCO enzyme at 2.9 A resolution | 分子名称: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, Ribulose bisphosphate carboxylase large chain, ... | 著者 | Mann, D, Evans, S.L, Bergeron, J.R.C. | 登録日 | 2022-02-18 | 公開日 | 2023-01-25 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | 主引用文献 | Single-particle cryo-EM analysis of the shell architecture and internal organization of an intact alpha-carboxysome. Structure, 31, 2023
|
|
7ZCJ
| Crystal structure of Pizza6-TNH-TSH with Silicotungstic Acid (STA) polyoxometalate | 分子名称: | Keggin (STA), Pizza6-TNH-TSH | 著者 | Wouters, S.M.L, Kamata, K, Takahashi, K, Vandebroek, L, Parac-Vogt, T.N, Tame, J.R.H, Voet, A.R.D. | 登録日 | 2022-03-28 | 公開日 | 2023-04-19 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Mutational study of a symmetry matched protein-polyoxometalate interface To be published
|
|
8TQP
| HIV-CA Disulfide linked Hexamer bound to Quinazolin-4-one Scaffold inhibitor | 分子名称: | 2-[4-(4-aminobenzene-1-sulfonyl)-2-oxopiperazin-1-yl]-N-{(1R)-2-(3,5-difluorophenyl)-1-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}acetamide, Gag polyprotein | 著者 | Goldstone, D.C, Barnett, M.J, Taka, J.R.H. | 登録日 | 2023-08-08 | 公開日 | 2023-12-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators. J.Med.Chem., 66, 2023
|
|