2ZJ0
 
 | | Crystal structure of Mycobacterium tuberculosis S-Adenosyl-L-homocysteine hydrolase in ternary complex with NAD and 2-fluoroadenosine | | 分子名称: | 2-(6-AMINO-2-FLUORO-PURIN-9-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Reddy, M.C.M, Gokulan, K, Shetty, N.D, Owen, J.L, Ioerger, T.R, Sacchettini, J.C. | | 登録日 | 2008-02-29 | | 公開日 | 2008-09-16 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | | 主引用文献 | Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Protein Sci., 17, 2008
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2C2M
 | | Crystal structures of caspase-3 in complex with aza-peptide Michael acceptor inhibitors. | | 分子名称: | AZA-PEPTIDE INHIBITOR (5S, 8R, 11S)-14-[4-(BENZYLOXY)-4-OXOBUTANOYL]-8-(2-CARBOXYETHYL)-5-(CARBOXYMETHYL)-11-(1-METHYLETHYL)-3,6,9,12-TETRAOXO-1-PHENYL-2-OXA-4,7,10,13,14 -PENTAAZAHEXADECAN-16-OIC ACID, ... | | 著者 | Ganesan, R, Jelakovic, S, Ekici, O.D, Li, Z.Z, James, K.E, Asgian, J.L, Campbell, A, Mikolajczyk, J, Salvesen, G.S, Gruetter, M.G, Powers, J.C. | | 登録日 | 2005-09-29 | | 公開日 | 2006-09-20 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10.
J.Med.Chem., 49, 2006
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2C2O
 | | Crystal structures of caspase-3 in complex with aza-peptide Michael acceptor inhibitors. | | 分子名称: | AZA-PEPTIDE INHIBITOR (5S, 8R, 11S)-14-{4-[BENZYL(METHYL) AMINO]-4-OXOBUTANOYL}-8-(2-CARBOXYETHYL)-5-(CARBOXYMETHYL)-11-(1-METHYLETHYL)-3,6,9,12-TETRAOXO-1-PHENYL-2-OXA-4,7,10,13,14-PENTAAZAHEXADECAN-16-OIC ACID, ... | | 著者 | Ganesan, R, Jelakovic, S, Ekici, O.D, Li, Z.Z, James, K.E, Asgian, J.L, Campbell, A, Mikolajczyk, J, Salvesen, G.S, Gruetter, M.G, Powers, J.C. | | 登録日 | 2005-09-29 | | 公開日 | 2006-09-20 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10.
J.Med.Chem., 49, 2006
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2C2K
 | | Crystal structures of caspase-3 in complex with aza-peptide Michael acceptor inhibitors. | | 分子名称: | AZA-PEPTIDE INHIBITOR (5S, 8R, 11S)-8-(2-CARBOXYETHYL)-5-(CARBOXYMETHYL)-14-(4-ETHOXY-4-OXOBUTANOYL)-11-(1-METHYLETHYL)-3,6,9,12-TETRAOXO-1-PHENYL-2-OXA-4,7,10,13,14-PENTAAZAHEXADECAN -16-OIC ACID, ... | | 著者 | Ganesan, R, Jelakovic, S, Ekici, O.D, Li, Z.Z, James, K.E, Asgian, J.L, Campbell, A.J, Mikolajczyk, J, Salvesen, G.S, Gruetter, M.G, Powers, J.C. | | 登録日 | 2005-09-29 | | 公開日 | 2006-09-20 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10.
J.Med.Chem., 49, 2006
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2C5R
 | | The structure of phage phi29 replication organizer protein p16.7 in complex with double stranded DNA | | 分子名称: | 5'-D(*CP*CP*GP*GP*TP*GP*GP*AP)-3', 5'-D(*TP*CP*CP*AP*CP*CP*GP*GP)-3', EARLY PROTEIN P16.7 | | 著者 | Albert, A, Jimenez, M, Munoz-Espin, D, Asensio, J.L, Hermoso, J.A, Salas, M, Meijer, W.J.J. | | 登録日 | 2005-10-31 | | 公開日 | 2005-11-08 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural Basis for Membrane Anchorage of Viral Phi 29 DNA During Replication.
J.Biol.Chem., 280, 2005
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6RVS
 | | Atomic structure of the Epstein-Barr portal, structure II | | 分子名称: | Portal protein | | 著者 | Machon, C, Fabrega-Ferrer, M, Zhou, D, Cuervo, A, Carrascosa, J.L, Stuart, D.I, Coll, M. | | 登録日 | 2019-05-31 | | 公開日 | 2019-09-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | | 主引用文献 | Atomic structure of the Epstein-Barr virus portal.
Nat Commun, 10, 2019
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6S5Z
 | | Structure of Rib R28N from Streptococcus pyogenes | | 分子名称: | SODIUM ION, Surface protein R28 | | 著者 | Whelan, F, Griffiths, S.C, Whittingham, J.L, Bateman, A, Potts, J.R. | | 登録日 | 2019-07-02 | | 公開日 | 2019-12-11 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection.
Proc.Natl.Acad.Sci.USA, 116, 2019
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1OLU
 | | Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase | | 分子名称: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, GLYCEROL, ... | | 著者 | Wynn, R.M, Machius, M, Chuang, J.L, Li, J, Tomchick, D.R, Chuang, D.T. | | 登録日 | 2003-08-15 | | 公開日 | 2003-08-28 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Roles of His291-Alpha and His146-Beta' in the Reductive Acylation Reaction Catalyzed by Human Branched-Chain Alpha-Ketoacid Dehydrogenase: Refined Phosphorylation Loop Structure in the Active Site.
J.Biol.Chem., 278, 2003
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2XYS
 | | Crystal structure of Aplysia californica AChBP in complex with strychnine | | 分子名称: | SOLUBLE ACETYLCHOLINE RECEPTOR, STRYCHNINE | | 著者 | Brams, M, Pandya, A, Kuzmin, D, van Elk, R, Krijnen, L, Yakel, J.L, Tsetlin, V, Smit, A.B, Ulens, C. | | 登録日 | 2010-11-19 | | 公開日 | 2011-03-23 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.909 Å) | | 主引用文献 | A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and D-Tubocurarine by Different Cys-Loop Receptors.
Plos Biol., 9, 2011
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8B8E
 | | Wild-type GH11 from Blastobotrys mokoenaii | | 分子名称: | 1,2-ETHANEDIOL, BmGH11, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Coleman, T, Ravn, J.L, Larsbrink, J. | | 登録日 | 2022-10-04 | | 公開日 | 2023-05-17 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Yeasts Have Evolved Divergent Enzyme Strategies To Deconstruct and Metabolize Xylan.
Microbiol Spectr, 11, 2023
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2XYT
 | | Crystal structure of Aplysia californica AChBP in complex with d- tubocurarine | | 分子名称: | D-TUBOCURARINE, SOLUBLE ACETYLCHOLINE RECEPTOR | | 著者 | Brams, M, Pandya, A, Kuzmin, D, van Elk, R, Krijnen, L, Yakel, J.L, Tsetlin, V, Smit, A.B, Ulens, C. | | 登録日 | 2010-11-19 | | 公開日 | 2011-03-23 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and D-Tubocurarine by Different Cys-Loop Receptors.
Plos Biol., 9, 2011
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6ROH
 | | Cryo-EM structure of the autoinhibited Drs2p-Cdc50p | | 分子名称: | 1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Timcenko, M, Lyons, J.A, Januliene, D, Ulstrup, J.J, Dieudonne, T, Montigny, C, Ash, M.R, Karlsen, J.L, Boesen, T, Kuhlbrandt, W, Lenoir, G, Moeller, A, Nissen, P. | | 登録日 | 2019-05-13 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structure and autoregulation of a P4-ATPase lipid flippase.
Nature, 571, 2019
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2X0U
 | | STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO A 2-amino substituted benzothiazole scaffold | | 分子名称: | 6,7-DIHYDRO[1,4]DIOXINO[2,3-F][1,3]BENZOTHIAZOL-2-AMINE, CELLULAR TUMOR ANTIGEN P53, ZINC ION | | 著者 | Joerger, A.C, Kaar, J.L, Basse, N, Fersht, A.R. | | 登録日 | 2009-12-17 | | 公開日 | 2010-01-26 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Toward the Rational Design of P53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant.
Chem.Biol., 17, 2010
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1OLX
 | | Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase | | 分子名称: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, GLYCEROL, ... | | 著者 | Wynn, R.M, Machius, M, Chuang, J.L, Li, J, Tomchick, D.R, Chuang, D.T. | | 登録日 | 2003-08-18 | | 公開日 | 2003-08-28 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Roles of His291-Alpha and His146-Beta' in the Reductive Acylation Reaction Catalyzed by Human Branched-Chain Alpha-Ketoacid Dehydrogenase: Refined Phosphorylation Loop Structure in the Active Site.
J.Biol.Chem., 278, 2003
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2WWF
 | | Plasmodium falciparum thymidylate kinase in complex with TMP and ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, SODIUM ION, ... | | 著者 | Whittingham, J.L, Carrero-Lerida, J, Brannigan, J.A, Ruiz-Perez, L.M, Silva, A.P.G, Fogg, M.J, Wilkinson, A.J, Gilbert, I.H, Wilson, K.S, Gonzalez-Pacanowska, D. | | 登録日 | 2009-10-23 | | 公開日 | 2010-04-21 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Structural Basis for the Efficient Phosphorylation of Aztmp and Dgmp by Plasmodium Falciparum Type I Thymidylate Kinase.
Biochem.J., 428, 2010
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6RPU
 | | Structure of the ternary complex of the IMPDH enzyme from Ashbya gossypii bound to the dinucleoside polyphosphate Ap5G and GDP | | 分子名称: | ACETATE ION, GUANOSINE-5'-DIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase, ... | | 著者 | Buey, R.M, Fernandez-Justel, D, Revuelta, J.L. | | 登録日 | 2019-05-14 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | The Bateman domain of IMP dehydrogenase is a binding target for dinucleoside polyphosphates.
J.Biol.Chem., 294, 2019
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2WWI
 | | Plasmodium falciparum thymidylate kinase in complex with AZTMP and ADP | | 分子名称: | 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, THYMIDILATE KINASE, ... | | 著者 | Whittingham, J.L, Carrero-Lerida, J, Brannigan, J.A, Ruiz-Perez, L.M, Silva, A.P.G, Fogg, M.J, Wilkinson, A.J, Gilbert, I.H, Wilson, K.S, Gonzalez-Pacanowska, D. | | 登録日 | 2009-10-23 | | 公開日 | 2010-04-21 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | | 主引用文献 | Structural Basis for the Efficient Phosphorylation of Aztmp and Dgmp by Plasmodium Falciparum Type I Thymidylate Kinase.
Biochem.J., 428, 2010
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8BVS
 | | Cryo-EM structure of rat SLC22A6 bound to tenofovir | | 分子名称: | CHLORIDE ION, Solute carrier family 22 member 6, Synthetic nanobody (Sybody), ... | | 著者 | Parker, J.L, Kato, T, Newstead, S. | | 登録日 | 2022-12-05 | | 公開日 | 2023-07-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | | 主引用文献 | Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Nat.Struct.Mol.Biol., 30, 2023
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8BVR
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8BVT
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8BW7
 | | Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid | | 分子名称: | 2-OXOGLUTARIC ACID, CHLORIDE ION, Solute carrier family 22 member 6, ... | | 著者 | Parker, J.L, Kato, T, Newstead, S. | | 登録日 | 2022-12-06 | | 公開日 | 2023-07-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | | 主引用文献 | Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Nat.Struct.Mol.Biol., 30, 2023
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4ZL7
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2BMZ
 | | Banana Lectin bound to Xyl-b1,3 Man-a-O-Methyl (XM) | | 分子名称: | CADMIUM ION, RIPENING-ASSOCIATED PROTEIN, SULFATE ION, ... | | 著者 | Meagher, J.L, Winter, H.C, Ezell, P, Goldstein, I.J, Stuckey, J.A. | | 登録日 | 2005-03-17 | | 公開日 | 2005-06-16 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal Structure of Banana Lectin Reveals a Novel Second Sugar Binding Site.
Glycobiology, 15, 2005
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2BMY
 | | Banana Lectin | | 分子名称: | CADMIUM ION, RIPENING-ASSOCIATED PROTEIN, SULFATE ION | | 著者 | Meagher, J.L, Winter, H.C, Ezell, P, Goldstein, I.J, Stuckey, J.A. | | 登録日 | 2005-03-17 | | 公開日 | 2005-06-16 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of Banana Lectin Reveals a Novel Second Sugar Binding Site.
Glycobiology, 15, 2005
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3PUK
 | | Re-refinement of the crystal structure of Munc18-3 and Syntaxin4 N-peptide complex | | 分子名称: | Syntaxin-4 N-terminal peptide, Syntaxin-binding protein 3 | | 著者 | Hu, S.-H, Christie, M.P, Saez, N.J, Latham, C.F, Jarrott, R, Lua, L.H.L, Collins, B.M, Martin, J.L. | | 登録日 | 2010-12-05 | | 公開日 | 2011-01-19 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.054 Å) | | 主引用文献 | Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation
Proc.Natl.Acad.Sci.USA, 108, 2011
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