5W5V
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![BU of 5w5v by Molmil](/molmil-images/mine/5w5v) | TBK1 co-crystal structure with amlexanox | Descriptor: | 2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid, Serine/threonine-protein kinase TBK1 | Authors: | Beyett, T.S, Tesmer, J.J.G. | Deposit date: | 2017-06-15 | Release date: | 2018-06-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.645 Å) | Cite: | Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition. Mol. Pharmacol., 94, 2018
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2Q1Y
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2ONX
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![BU of 2onx by Molmil](/molmil-images/mine/2onx) | NNQQ peptide corresponding to residues 8-11 of yeast prion sup35 (alternate crystal form) | Descriptor: | peptide corresponding to residues 8-11 of yeast prion sup35 | Authors: | Sawaya, M.R, Sambashivan, S, Nelson, R, Ivanova, M, Sievers, S.A, Apostol, M.I, Thompson, M.J, Balbirnie, M, Wiltzius, J.J, McFarlane, H, Madsen, A.O, Riekel, C, Eisenberg, D. | Deposit date: | 2007-01-24 | Release date: | 2007-02-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Atomic structures of amyloid cross-beta spines reveal varied steric zippers. Nature, 447, 2007
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2OP8
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2OLQ
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![BU of 2olq by Molmil](/molmil-images/mine/2olq) | How Does an Enzyme Recognize CO2? | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CARBON DIOXIDE, MAGNESIUM ION, ... | Authors: | Puttick, J, Goldie, H, Cotelesage, J.J, Rajabi, B, Novakovski, B, Delbaere, L.T. | Deposit date: | 2007-01-19 | Release date: | 2007-06-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | How does an enzyme recognize CO2? Int.J.Biochem.Cell Biol., 39, 2007
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2N70
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![BU of 2n70 by Molmil](/molmil-images/mine/2n70) | Two-fold symmetric structure of the 18-60 construct of S31N M2 from Influenza A in lipid bilayers | Descriptor: | Matrix protein 2 | Authors: | Andreas, L.B, Reese, M, Eddy, M.T, Gelev, V, Ni, Q, Miller, E.A, Emsley, L, Pintacuda, G, Chou, J.J, Griffin, R.G. | Deposit date: | 2015-09-01 | Release date: | 2015-09-23 | Last modified: | 2024-05-15 | Method: | SOLID-STATE NMR | Cite: | Structure and Mechanism of the Influenza A M218-60 Dimer of Dimers. J.Am.Chem.Soc., 137, 2015
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2NA6
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![BU of 2na6 by Molmil](/molmil-images/mine/2na6) | Transmembrane domain of mouse Fas/CD95 death receptor | Descriptor: | Tumor necrosis factor receptor superfamily member 6 | Authors: | Fu, Q, Chou, J.J, Wu, H, Fu, T, Membrane Protein Structures by Solution NMR (MPSbyNMR) | Deposit date: | 2015-12-21 | Release date: | 2016-01-27 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor. Mol.Cell, 61, 2016
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2NPR
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![BU of 2npr by Molmil](/molmil-images/mine/2npr) | Structural Studies on Plasmodium vivax Merozoite Surface Protein-1 | Descriptor: | Merozoite surface protein 1 | Authors: | Babon, J.J, Morgan, W.D, Kelly, G, Eccleston, J.F, Feeney, J, Holder, A.A. | Deposit date: | 2006-10-29 | Release date: | 2007-03-20 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Structural studies on Plasmodium vivax merozoite surface protein-1 Mol.Biochem.Parasitol., 153, 2007
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2Q1X
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2NQO
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![BU of 2nqo by Molmil](/molmil-images/mine/2nqo) | Crystal Structure of Helicobacter pylori gamma-Glutamyltranspeptidase | Descriptor: | Gamma-glutamyltranspeptidase | Authors: | Boanca, G, Sand, A, Okada, T, Suzuki, H, Kumagai, H, Fukuyama, K, Barycki, J.J. | Deposit date: | 2006-10-31 | Release date: | 2006-11-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Autoprocessing of Helicobacter pylori gamma-glutamyltranspeptidase leads to the formation of a threonine-threonine catalytic dyad. J.Biol.Chem., 282, 2007
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2NA7
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4CYW
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![BU of 4cyw by Molmil](/molmil-images/mine/4cyw) | Structure of the A_mallard_Sweden_51_2002 H10 Avian Haemmaglutinin in complex with human receptor analog 6-SLN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HEMAGGLUTININ, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Vachieri, S.G, Xiong, X, Collins, P.J, Walker, P.A, Martin, S.R, Haire, L.F, McCauley, J.W, Gamblin, S.J, Skehel, J.J. | Deposit date: | 2014-04-15 | Release date: | 2014-06-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Receptor Binding by H10 Influenza Viruses. Nature, 511, 2014
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2FZ3
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4CQS
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![BU of 4cqs by Molmil](/molmil-images/mine/4cqs) | H5 (VN1194) Asn186Lys Mutant Haemagglutinin in Complex with Avian Receptor Analogue 3'SLN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ... | Authors: | Xiong, X, Xiao, H, Martin, S.R, Coombs, P.J, Liu, J, Collins, P.J, Vachieri, S.G, Walker, P.A, Lin, Y.P, McCauley, J.W, Gamblin, S.J, Skehel, J.J. | Deposit date: | 2014-02-21 | Release date: | 2014-05-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Enhanced Human Receptor Binding by H5 Haemagglutinins. Virology, 456, 2014
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4CPO
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![BU of 4cpo by Molmil](/molmil-images/mine/4cpo) | Structure of the Neuraminidase from the B/Lyon/CHU/15.216/2011 virus | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Vachieri, S.G, Collins, P.J, Escuret, V, Casalegno, J.S, Cattle, N, Ferraris, O, Sabatier, M, Frobert, E, Caro, V, Skehel, J.J, Gamblin, S.J, Valla, F, Valette, M, Ottmann, M, McCauley, J.W, Daniels, R.S, Lina, B. | Deposit date: | 2014-02-08 | Release date: | 2014-05-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A Novel I221 L Substitution in Neuraminidase Confers High Level Resistance to Oseltamivir in Influenza B Viruses. J.Infect.Dis., 210, 2014
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4CPY
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![BU of 4cpy by Molmil](/molmil-images/mine/4cpy) | Structure of the Neuraminidase from the B/Lyon/CHU/15.216/2011 virus in complex with Oseltamivir | Descriptor: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Vachieri, S.G, Collins, P.J, Escuret, V, Casalegno, J.S, Cattle, N, Ferraris, O, Sabatier, M, Frobert, E, Caro, V, Skehel, J.J, Gamblin, S.J, Valla, F, Valette, M, Ottmann, M, McCauley, J.W, Daniels, R.S, Lina, B. | Deposit date: | 2014-02-09 | Release date: | 2014-05-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A Novel I221 L Substitution in Neuraminidase Confers High Level Resistance to Oseltamivir in Influenza B Viruses. J.Infect.Dis., 210, 2014
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4CYV
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![BU of 4cyv by Molmil](/molmil-images/mine/4cyv) | Structure of the A_mallard_Sweden_51_2002 H10 Avian Haemmaglutinin | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Vachieri, S.G, Xiong, X, Collins, P.J, Walker, P.A, Martin, S.R, Haire, L.F, McCauley, J.W, Gamblin, S.J, Skehel, J.J. | Deposit date: | 2014-04-15 | Release date: | 2014-06-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Receptor Binding by H10 Influenza Viruses. Nature, 511, 2014
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4D00
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![BU of 4d00 by Molmil](/molmil-images/mine/4d00) | Haemagglutinin of H10N8 Influenza Virus Isolated from Humans in Complex with Human Receptor Analogue 6'SLN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HAEMAGGLUTININ HA1, ... | Authors: | Xiong, X, Haire, L.F, Vachieri, S.G, Collins, P.J, Walker, P.A, Martin, S.R, Zhang, Y, McCauley, J.W, Gamblin, S.J, Skehel, J.J. | Deposit date: | 2014-04-23 | Release date: | 2014-06-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Receptor Binding by H10 Influenza Viruses. Nature, 511, 2014
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4CQR
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![BU of 4cqr by Molmil](/molmil-images/mine/4cqr) | H5 (VN1194) Ser227Asn/Gln196Arg Mutant Haemagglutinin in Complex with Human Receptor Analogue 6'SLN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ... | Authors: | Xiong, X, Xiao, H, Martin, S.R, Coombs, P.J, Liu, J, Collins, P.J, Vachieri, S.G, Walker, P.A, Lin, Y.P, McCauley, J.W, Gamblin, S.J, Skehel, J.J. | Deposit date: | 2014-02-21 | Release date: | 2014-05-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Enhanced Human Receptor Binding by H5 Haemagglutinins. Virology, 456, 2014
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2G82
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4CQU
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![BU of 4cqu by Molmil](/molmil-images/mine/4cqu) | H5 (VN1194) Asn186Lys Mutant Haemagglutinin in Complex with Human Receptor Analogue 6'SLN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ... | Authors: | Xiong, X, Xiao, H, Martin, S.R, Coombs, P.J, Liu, J, Collins, P.J, Vachieri, S.G, Walker, P.A, Lin, Y.P, McCauley, J.W, Gamblin, S.J, Skehel, J.J. | Deposit date: | 2014-02-21 | Release date: | 2014-05-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Enhanced Human Receptor Binding by H5 Haemagglutinins. Virology, 456, 2014
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4CQP
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![BU of 4cqp by Molmil](/molmil-images/mine/4cqp) | Crystal Structure of H5 (VN1194) Ser227Asn/Gln196Arg Mutant Haemagglutinin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ... | Authors: | Xiong, X, Xiao, H, Martin, S.R, Coombs, P.J, Liu, J, Collins, P.J, Vachieri, S.G, Walker, P.A, Lin, Y.P, McCauley, J.W, Gamblin, S.J, Skehel, J.J. | Deposit date: | 2014-02-21 | Release date: | 2014-05-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Enhanced Human Receptor Binding by H5 Haemagglutinins. Virology, 456, 2014
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2G37
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![BU of 2g37 by Molmil](/molmil-images/mine/2g37) | Structure of Thermus thermophilus L-proline dehydrogenase | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase | Authors: | Tanner, J.J, White, T.A. | Deposit date: | 2006-02-17 | Release date: | 2007-02-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and Kinetics of Monofunctional Proline Dehydrogenase from Thermus thermophilus. J.Biol.Chem., 282, 2007
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6I3H
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![BU of 6i3h by Molmil](/molmil-images/mine/6i3h) | Crystal structure of influenza A virus M1 N-terminal domain (G18A mutation) | Descriptor: | Matrix protein 1, PHOSPHATE ION | Authors: | Miyake, Y, Keusch, J.J, Decamps, L, Ho-Xuan, H, Iketani, S, Gut, H, Kutay, U, Helenius, A, Yamauchi, Y. | Deposit date: | 2018-11-06 | Release date: | 2019-09-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Influenza virus uses transportin 1 for vRNP debundling during cell entry. Nat Microbiol, 4, 2019
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2I9K
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![BU of 2i9k by Molmil](/molmil-images/mine/2i9k) | Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI | Descriptor: | 5'-D(*T*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', Modification methylase HhaI, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Youngblood, B, Shieh, F.K, De Los Rios, S, Perona, J.J, Reich, N.O. | Deposit date: | 2006-09-05 | Release date: | 2006-10-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI J.Mol.Biol., 362, 2006
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