4CPO

Structure of the Neuraminidase from the B/Lyon/CHU/15.216/2011 virus

Summary for 4CPO

Entry DOI	10.2210/pdb4cpo/pdb
Related	4CPL 4CPM 4CPN 4CPY 4CPZ
Descriptor	NEURAMINIDASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	hydrolase, influenza, neuraminidase
Biological source	INFLUENZA B VIRUS
Total number of polymer chains	2
Total formula weight	105081.18
Authors	Vachieri, S.G.,Collins, P.J.,Escuret, V.,Casalegno, J.S.,Cattle, N.,Ferraris, O.,Sabatier, M.,Frobert, E.,Caro, V.,Skehel, J.J.,Gamblin, S.J.,Valla, F.,Valette, M.,Ottmann, M.,McCauley, J.W.,Daniels, R.S.,Lina, B. (deposition date: 2014-02-08, release date: 2014-05-14, Last modification date: 2023-12-20)
Primary citation	Escuret, V.,Collins, P.J.,Casalegno, J.,Vachieri, S.G.,Cattle, N.,Ferraris, O.,Sabatier, M.,Frobert, E.,Caro, V.,Skehel, J.J.,Gamblin, S.,Valla, F.,Valette, M.,Ottmann, M.,Mccauley, J.W.,Daniels, R.S.,Lina, B. A Novel I221 L Substitution in Neuraminidase Confers High Level Resistance to Oseltamivir in Influenza B Viruses. J.Infect.Dis., 210:1260-, 2014 Cited by PubMed: 24795482 DOI: 10.1093/INFDIS/JIU244 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation