4CPM

Structure of the Neuraminidase from the B/Brisbane/60/2008 virus in complex with Oseltamivir

Summary for 4CPM

• Entry DOI: 10.2210/pdb4cpm/pdb
• Related: 4CPL 4CPN 4CPO 4CPY 4CPZ
• Descriptor: NEURAMINIDASE, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: hydrolase, viral protein, oseltamivir
• Biological source: INFLUENZA B VIRUS (B/BRISBANE/60/2008)
• Cellular location: Virion membrane : C0LT34
• Total number of polymer chains: 2
• Total formula weight: 105670.91

Authors

Vachieri, S.G.,Collins, P.J.,Escuret, V.,Casalegno, J.S.,Cattle, N.,Ferraris, O.,Sabatier, M.,Frobert, E.,Caro, V.,Skehel, J.J.,Gamblin, S.J.,Valla, F.,Valette, M.,Ottmann, M.,McCauley, J.W.,Daniels, R.S.,Lina, B. (deposition date: 2014-02-07, release date: 2014-05-14, Last modification date: 2024-10-09)

Primary citation

Escuret, V.,Collins, P.J.,Casalegno, J.,Vachieri, S.G.,Cattle, N.,Ferraris, O.,Sabatier, M.,Frobert, E.,Caro, V.,Skehel, J.J.,Gamblin, S.,Valla, F.,Valette, M.,Ottmann, M.,Mccauley, J.W.,Daniels, R.S.,Lina, B.
A Novel I221 L Substitution in Neuraminidase Confers High Level Resistance to Oseltamivir in Influenza B Viruses.
J.Infect.Dis., 210:1260-, 2014

PubMed Abstract: Influenza B viruses with a novel I221L substitution in neuraminidase (NA) conferring high-level resistance to oseltamivir were isolated from an immunocompromised patient after prolonged oseltamivir treatment.

PubMed: 24795482
DOI: 10.1093/INFDIS/JIU244

Experimental method

X-RAY DIFFRACTION (2.75 Å)