5I9S
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![BU of 5i9s by Molmil](/molmil-images/mine/5i9s) | MicroED structure of proteinase K at 1.75 A resolution | Descriptor: | Proteinase K, SULFATE ION | Authors: | Hattne, J, Shi, D, de la Cruz, M.J, Reyes, F.E, Gonen, T. | Deposit date: | 2016-02-20 | Release date: | 2016-06-08 | Last modified: | 2023-08-30 | Method: | ELECTRON CRYSTALLOGRAPHY (1.75 Å) | Cite: | Modeling truncated pixel values of faint reflections in MicroED images. J.Appl.Crystallogr., 49, 2016
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5OVI
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![BU of 5ovi by Molmil](/molmil-images/mine/5ovi) | Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor BAY-293 (compound 23) | Descriptor: | 1,2-ETHANEDIOL, 6,7-dimethoxy-2-methyl-~{N}-[(1~{R})-1-[4-[2-(methylaminomethyl)phenyl]thiophen-2-yl]ethyl]quinazolin-4-amine, Son of sevenless homolog 1 | Authors: | Hillig, R.C, Sautier, B, Schroeder, J, Moosmayer, D, Hilpmann, A, Stegmann, C.M, Briem, H, Boemer, U, Weiske, J, Badock, V, Petersen, K, Kahmann, J, Wegener, D, Bohnke, N, Eis, K, Graham, K, Wortmann, L, von Nussbaum, F, Bader, B. | Deposit date: | 2017-08-28 | Release date: | 2019-02-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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7KHP
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![BU of 7khp by Molmil](/molmil-images/mine/7khp) | Acyl-enzyme intermediate structure of SARS-CoV-2 Mpro in complex with its C-terminal autoprocessing sequence. | Descriptor: | 3C-like proteinase, DIMETHYL SULFOXIDE | Authors: | Lee, J, Worrall, L.J, Paetzel, M, Strynadka, N.C.J. | Deposit date: | 2020-10-21 | Release date: | 2020-10-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site. Nat Commun, 11, 2020
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5CQA
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![BU of 5cqa by Molmil](/molmil-images/mine/5cqa) | Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with N-methyl-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxamide (SGC - Diamond I04-1 fragment screening) | Descriptor: | 1,2-ETHANEDIOL, Bromodomain adjacent to zinc finger domain protein 2B, N-methyl-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxamide | Authors: | Bradley, A, Pearce, N, Krojer, T, Ng, J, Talon, R, Vollmar, M, Jose, B, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2015-07-21 | Release date: | 2015-09-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with N-methyl-2,3-dihydrothieno[3,4-b][1,4]dioxine-5-carboxamide (SGC - Diamond I04-1 fragment screening) To be published
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2ZOT
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5I1C
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![BU of 5i1c by Molmil](/molmil-images/mine/5i1c) | CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3-23/IGKV3-20 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, FAB HEAVY CHAIN, ... | Authors: | Teplyakov, A, Obmolova, G, Malia, T, Luo, J, Gilliland, G. | Deposit date: | 2016-02-05 | Release date: | 2016-06-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural diversity in a human antibody germline library. Mabs, 8, 2016
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5I1M
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![BU of 5i1m by Molmil](/molmil-images/mine/5i1m) | Yeast V-ATPase average of densities, a subunit segment | Descriptor: | V-type proton ATPase subunit a, vacuolar isoform | Authors: | Schep, D.G, Zhao, J, Rubinstein, J.L. | Deposit date: | 2016-02-05 | Release date: | 2016-03-09 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Models for the a subunits of the Thermus thermophilus V/A-ATPase and Saccharomyces cerevisiae V-ATPase enzymes by cryo-EM and evolutionary covariance. Proc.Natl.Acad.Sci.USA, 113, 2016
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2ZR1
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![BU of 2zr1 by Molmil](/molmil-images/mine/2zr1) | Agglutinin from Abrus Precatorius | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Agglutinin-1 chain A, Agglutinin-1 chain B | Authors: | Cheng, J, Lu, T.H, Liu, C.L, Lin, J.Y. | Deposit date: | 2008-08-22 | Release date: | 2009-08-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A biophysical elucidation for less toxicity of Agglutinin than Abrin-a from the Seeds of Abrus Precatorius in consequence of crystal structure J.Biomed.Sci., 17, 2010
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2ZPK
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![BU of 2zpk by Molmil](/molmil-images/mine/2zpk) | Crystal structure of P20.1 Fab fragment in complex with its antigen peptide | Descriptor: | GLYCEROL, IgG1-lambda P20.1 Fab (heavy chain), IgG1-lambda P20.1 Fab (light chain), ... | Authors: | Nogi, T, Sanagawa, T, Takagi, J. | Deposit date: | 2008-07-16 | Release date: | 2008-12-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Novel affinity tag system using structurally defined antibody-tag interaction: application to single-step protein purification Protein Sci., 17, 2008
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8B9Z
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![BU of 8b9z by Molmil](/molmil-images/mine/8b9z) | Drosophila melanogaster complex I in the Active state (Dm1) | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Agip, A.A, Chung, I, Sanchez-Martinez, A, Whitworth, A.J, Hirst, J. | Deposit date: | 2022-10-10 | Release date: | 2023-01-18 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster. Elife, 12, 2023
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8BG0
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![BU of 8bg0 by Molmil](/molmil-images/mine/8bg0) | Amyloid-beta tetrameric filaments with the Arctic mutation (E22G) from Alzheimer's disease brains | ABeta40 | Descriptor: | Amyloid-beta precursor protein | Authors: | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W. | Deposit date: | 2022-10-27 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (1.99 Å) | Cite: | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
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2ZV8
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![BU of 2zv8 by Molmil](/molmil-images/mine/2zv8) | Lyn Tyrosine Kinase Domain-AMP-PNP complex | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tyrosine-protein kinase Lyn | Authors: | Williams, N.K, Rossjohn, J. | Deposit date: | 2008-11-04 | Release date: | 2008-11-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal Structures of the Lyn Protein Tyrosine Kinase Domain in Its Apo- and Inhibitor-bound State J.Biol.Chem., 284, 2009
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5CQ8
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![BU of 5cq8 by Molmil](/molmil-images/mine/5cq8) | Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with 4'-Hydroxyacetophenone (SGC - Diamond I04-1 fragment screening) | Descriptor: | 1,2-ETHANEDIOL, Bromodomain adjacent to zinc finger domain protein 2B, P-HYDROXYACETOPHENONE | Authors: | Bradley, A, Pearce, N, Krojer, T, Ng, J, Talon, R, Vollmar, M, Jose, B, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2015-07-21 | Release date: | 2015-09-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.651 Å) | Cite: | Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with 4'-Hydroxyacetophenone (SGC - Diamond I04-1 fragment screening) To be published
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2ZVA
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![BU of 2zva by Molmil](/molmil-images/mine/2zva) | Lyn Tyrosine Kinase Domain-Dasatinib complex | Descriptor: | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, Tyrosine-protein kinase Lyn | Authors: | Williams, N.K, Rossjohn, J. | Deposit date: | 2008-11-04 | Release date: | 2008-11-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structures of the Lyn Protein Tyrosine Kinase Domain in Its Apo- and Inhibitor-bound State J.Biol.Chem., 284, 2009
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7KJP
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![BU of 7kjp by Molmil](/molmil-images/mine/7kjp) | Disulfide Stabilized Norovirus GI.1 VLP Shell Region | Descriptor: | Capsid protein VP1 | Authors: | Gorman, J, Kwong, P.D. | Deposit date: | 2020-10-26 | Release date: | 2020-12-02 | Last modified: | 2020-12-30 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes. NPJ Vaccines, 5, 2020
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8KAB
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8BFZ
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![BU of 8bfz by Molmil](/molmil-images/mine/8bfz) | Amyloid-beta 42 filaments extracted from the human brain with Arctic mutation (E22G) of Alzheimer's disease | ABeta42 | Descriptor: | Amyloid-beta precursor protein | Authors: | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordberg, A, Goedert, M, Scheres, S.H.W. | Deposit date: | 2022-10-27 | Release date: | 2023-01-18 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
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8K8M
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5I1A
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![BU of 5i1a by Molmil](/molmil-images/mine/5i1a) | CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3-23/IGKV3-11 | Descriptor: | ACETATE ION, CNTO388 HEAVY CHAIN, CNTO388 LIGHT CHAIN, ... | Authors: | Teplyakov, A, Obmolova, G, Malia, T, Luo, J, Gilliland, G. | Deposit date: | 2016-02-05 | Release date: | 2016-06-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural diversity in a human antibody germline library. Mabs, 8, 2016
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8K60
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![BU of 8k60 by Molmil](/molmil-images/mine/8k60) | |
1HJZ
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![BU of 1hjz by Molmil](/molmil-images/mine/1hjz) | Crystal structure of AF1521 protein containing a macroH2A domain | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, HYPOTHETICAL PROTEIN AF1521 | Authors: | Allen, M.D, Buckle, A.M, Cordell, S.C, Lowe, J, Bycroft, M. | Deposit date: | 2003-03-05 | Release date: | 2003-07-10 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Crystal Structure of Af1521 a Protein from Archaeoglobus Fulgidus with Homology to the Non-Histone Domain of Macroh2A J.Mol.Biol., 330, 2003
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8KB8
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![BU of 8kb8 by Molmil](/molmil-images/mine/8kb8) | Structure of the WDR91 WD40 domain complexed with Rab7 | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-7a, ... | Authors: | Li, J, Ma, X.L, Banerjee, S, Dong, Z.G. | Deposit date: | 2023-08-04 | Release date: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structure of the WDR91 WD40 domain complexed with Rab7 To Be Published
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5CQ7
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![BU of 5cq7 by Molmil](/molmil-images/mine/5cq7) | Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with N,N-dimethylquinoxaline-6-carboxamide (SGC - Diamond I04-1 fragment screening) | Descriptor: | 1,2-ETHANEDIOL, Bromodomain adjacent to zinc finger domain protein 2B, N,N-dimethylquinoxaline-6-carboxamide | Authors: | Bradley, A, Pearce, N, Krojer, T, Ng, J, Talon, R, Vollmar, M, Jose, B, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2015-07-21 | Release date: | 2015-09-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with N,N-dimethylquinoxaline-6-carboxamide (SGC - Diamond I04-1 fragment screening) To be published
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1USQ
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![BU of 1usq by Molmil](/molmil-images/mine/1usq) | Complex of E. Coli DraE adhesin with Chloramphenicol | Descriptor: | 1,2-ETHANEDIOL, CHLORAMPHENICOL, DR HEMAGGLUTININ STRUCTURAL SUBUNIT, ... | Authors: | Anderson, K.L, Billington, J, Pettigrew, D, Cota, E, Roversi, P, Simpson, P, Chen, H.A, Urvil, P, Dumerle, L, Barlow, P, Medof, E, Smith, R.A.G, Nowicki, B, Le Bouguenec, C, Lea, S.M, Matthews, S. | Deposit date: | 2003-11-27 | Release date: | 2004-08-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | High Resolution Studies of the Afa/Dr Adhesin Drae and its Interaction with Chloramphenicol J.Biol.Chem., 279, 2004
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5I68
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![BU of 5i68 by Molmil](/molmil-images/mine/5i68) | Alcohol oxidase from Pichia pastoris | Descriptor: | Alcohol oxidase 1, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION | Authors: | Vonck, J, Mills, D.J, Parcej, D.N. | Deposit date: | 2016-02-16 | Release date: | 2016-08-03 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Structure of Alcohol Oxidase from Pichia pastoris by Cryo-Electron Microscopy. Plos One, 11, 2016
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