2X2L
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![BU of 2x2l by Molmil](/molmil-images/mine/2x2l) | Crystal Structure of phosphorylated RET tyrosine kinase domain with inhibitor | 分子名称: | (3Z)-5-AMINO-3-[(4-METHOXYPHENYL)METHYLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE, FORMIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET | 著者 | Knowles, P.P, Murray-Rust, J, Kjaer, S, McDonald, N.Q. | 登録日 | 2010-01-13 | 公開日 | 2010-02-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors. Bioorg. Med. Chem., 18, 2010
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2P26
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![BU of 2p26 by Molmil](/molmil-images/mine/2p26) | Structure of the PHE2 and PHE3 fragments of the integrin beta2 subunit | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin beta-2 | 著者 | Shi, M, Foo, S.Y, Tan, S.M, Mitchell, E.P, Law, S.K.A, Lescar, J. | 登録日 | 2007-03-06 | 公開日 | 2007-08-14 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | A structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrins J.Biol.Chem., 282, 2007
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6K4N
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![BU of 6k4n by Molmil](/molmil-images/mine/6k4n) | Cryo-EM structure of p300 | 分子名称: | Histone acetyltransferase p300 | 著者 | Ghosh, R, Roy, S, Sengupta, J. | 登録日 | 2019-05-24 | 公開日 | 2019-06-19 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (9.8 Å) | 主引用文献 | Tumor Suppressor p53-Mediated Structural Reorganization of the Transcriptional Coactivator p300. Biochemistry, 58, 2019
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6K4S
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![BU of 6k4s by Molmil](/molmil-images/mine/6k4s) | Crystal structure of xCas9 in complex with sgRNA and DNA (TGC PAM) | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, non-targeted DNA, sgRNA, ... | 著者 | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | 登録日 | 2019-05-26 | 公開日 | 2019-09-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease. Plos Biol., 17, 2019
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2X9E
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![BU of 2x9e by Molmil](/molmil-images/mine/2x9e) | HUMAN MPS1 IN COMPLEX WITH NMS-P715 | 分子名称: | DUAL SPECIFICITY PROTEIN KINASE TTK, N-(2,6-DIETHYLPHENYL)-1-METHYL-8-({4-[(1-METHYLPIPERIDIN-4-YL)CARBAMOYL]-2-(TRIFLUOROMETHOXY)PHENYL}AMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE | 著者 | Colombo, R, Caldarelli, M, Mennecozzi, M, Giorgini, M.L, Sola, F, Cappella, P, Perrera, C, DePaolini, S.R, Rusconi, L, Cucchi, U, Avanzi, N, Bertrand, J.A, Bossi, R.T, Pesenti, E, Galvani, A, Isacchi, A, Colotta, F, Donati, D, Moll, J. | 登録日 | 2010-03-17 | 公開日 | 2010-12-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Targeting the Mitotic Checkpoint for Cancer Therapy with Nms-P715, an Inhibitor of Mps1 Kinase. Cancer Res., 70, 2010
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6KG7
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![BU of 6kg7 by Molmil](/molmil-images/mine/6kg7) | Cryo-EM Structure of the Mammalian Tactile Channel Piezo2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Piezo-type mechanosensitive ion channel component 2 | 著者 | Wang, L, Zhou, H, Zhang, M, Liu, W, Deng, T, Zhao, Q, Li, Y, Lei, J, Li, X, Xiao, B. | 登録日 | 2019-07-11 | 公開日 | 2019-09-04 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure and mechanogating of the mammalian tactile channel PIEZO2. Nature, 573, 2019
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1HQE
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2OX0
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![BU of 2ox0 by Molmil](/molmil-images/mine/2ox0) | Crystal structure of JMJD2A complexed with histone H3 peptide dimethylated at Lys9 | 分子名称: | CHLORIDE ION, JmjC domain-containing histone demethylation protein 3A, N-OXALYLGLYCINE, ... | 著者 | Pilka, E.S, Ng, S.S, Kavanagh, K.L, McDonough, M.A, Savitsky, P, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Sundstrom, M, Schofield, C.J, Oppermann, U, Structural Genomics Consortium (SGC) | 登録日 | 2007-02-19 | 公開日 | 2007-03-13 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature, 448, 2007
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2WV5
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![BU of 2wv5 by Molmil](/molmil-images/mine/2wv5) | Crystal structure of foot-and-mouth disease virus 3C protease in complex with a decameric peptide corresponding to the VP1-2A cleavage junction with a GLN to Glu substitution at P1 | 分子名称: | FOOT AND MOUTH DISEASE VIRUS (SEROTYPE A) VARIANT VP1 CAPSID PROTEIN, PICORNAIN 3C | 著者 | Zunszain, P.A, Knox, S.R, Sweeney, T.R, Yang, J, Roque-Rosell, N, Belsham, G.J, Leatherbarrow, R.J, Curry, S. | 登録日 | 2009-10-13 | 公開日 | 2009-10-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Insights Into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate. J.Mol.Biol., 395, 2010
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2WW4
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![BU of 2ww4 by Molmil](/molmil-images/mine/2ww4) | a triclinic crystal form of E. coli 4-diphosphocytidyl-2C-methyl-D- erythritol kinase | 分子名称: | 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL KINASE, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL | 著者 | Kalinowska-Tluscik, J, Miallau, L, Gabrielsen, M, Leonard, G.A, McSweeney, S.M, Hunter, W.N. | 登録日 | 2009-10-21 | 公開日 | 2010-03-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A Triclinic Crystal Form of Escherichia Coli 4-Diphosphocytidyl-2C-Methyl-D-Erythritol Kinase and Reassessment of the Quaternary Structure. Acta Crystallogr.,Sect.F, 66, 2010
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2WWE
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![BU of 2wwe by Molmil](/molmil-images/mine/2wwe) | Crystal structure of the phox homology domain of human phosphoinositide-3-kinase-C2-gamma | 分子名称: | PHOSPHOINOSITIDE-3-KINASE, CLASS 2, GAMMA POLYPEPTIDE | 著者 | Roos, A.K, Tresaugues, L, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Karlberg, T, Kotyenova, T, Kotzch, A, Kraulis, P, Markova, N, Moche, M, Nielsen, T.K, Nyman, T, Persson, C, Schuler, H, Schutz, P, Siponen, M.I, Svensson, L, Thorsell, A.G, Van Der Berg, S, Wahlberg, E, Weigelt, J, Welin, M, Wisniewska, M, Nordlund, P, Structural Genomics Consortium (SGC) | 登録日 | 2009-10-22 | 公開日 | 2009-11-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Crystal Structure of the Phox Homology Domain of Human Phosphoinositide-3-Kinase-C2-Gamma To be Published
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2WWY
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![BU of 2wwy by Molmil](/molmil-images/mine/2wwy) | Structure of human RECQ-like helicase in complex with a DNA substrate | 分子名称: | 1,2-ETHANEDIOL, 5'-D(*DA DG DC DG DT DC DG DA DG DA DT DC DCP)-3', ATP-DEPENDENT DNA HELICASE Q1, ... | 著者 | Pike, A.C.W, Zhang, Y, Schnecke, C, Chaikuad, A, Krojer, T, Cooper, C.D.O, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, Gileadi, O. | 登録日 | 2009-10-30 | 公開日 | 2009-12-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Recq1 Helicase-Driven DNA Unwinding, Annealing, and Branch Migration: Insights from DNA Complex Structures Proc.Natl.Acad.Sci.USA, 112, 2015
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2WWN
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![BU of 2wwn by Molmil](/molmil-images/mine/2wwn) | Yersinia pseudotuberculosis Superoxide Dismutase C with bound Azide | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, AZIDE ION, SUPEROXIDE DISMUTASE [CU-ZN], ... | 著者 | Basak, A.K, Duffield, M.L, Naylor, C.E, Huyet, J, Titball, R.W. | 登録日 | 2009-10-26 | 公開日 | 2010-11-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structure of the Yersinia Pseudotuberculosis Superoxide Dismutase (Sodc) To be Published
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2X9P
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![BU of 2x9p by Molmil](/molmil-images/mine/2x9p) | X-ray structure of the substrate-free cytochrome P450 PimD - a polyene macrolide antibiotic pimaricin epoxidase | 分子名称: | PIMD PROTEIN, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | 著者 | Kells, P.M, Ouellet, H, Santos-Aberturas, J, Aparicio, J.F, Podust, L.M. | 登録日 | 2010-03-23 | 公開日 | 2010-08-04 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of Cytochrome P450 Pimd Suggests Epoxidation of the Polyene Macrolide Pimaricin Occurs Via a Hydroperoxoferric Intermediate. Chem.Biol., 17, 2010
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5UNN
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![BU of 5unn by Molmil](/molmil-images/mine/5unn) | Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase SMc02828 (SmGhrA) from Sinorhizobium meliloti in apo form | 分子名称: | CHLORIDE ION, GLYCEROL, NADPH-dependent glyoxylate/hydroxypyruvate reductase | 著者 | Shabalin, I.G, LaRowe, C, Kutner, J, Gasiorowska, O.A, Handing, K.B, Bonanno, J, Almo, S.C, Minor, W, New York Structural Genomics Research Consortium (NYSGRC) | 登録日 | 2017-01-31 | 公開日 | 2017-02-22 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural, Biochemical, and Evolutionary Characterizations of Glyoxylate/Hydroxypyruvate Reductases Show Their Division into Two Distinct Subfamilies. Biochemistry, 57, 2018
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2XAK
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6JX2
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![BU of 6jx2 by Molmil](/molmil-images/mine/6jx2) | Crystal structure of Ketol-acid reductoisomerase from Corynebacterium glutamicum | 分子名称: | 1,2-ETHANEDIOL, Ketol-acid reductoisomerase (NADP(+)), MAGNESIUM ION, ... | 著者 | Lee, D, Hong, J, Kim, K.-J. | 登録日 | 2019-04-22 | 公開日 | 2019-08-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structure and Biochemical Characterization of Ketol-Acid Reductoisomerase fromCorynebacterium glutamicum. J.Agric.Food Chem., 67, 2019
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6K17
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![BU of 6k17 by Molmil](/molmil-images/mine/6k17) | Crystal structure of EXD2 exonuclease domain | 分子名称: | Exonuclease 3'-5' domain-containing protein 2, SODIUM ION | 著者 | Park, J, Lee, C. | 登録日 | 2019-05-10 | 公開日 | 2019-05-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.602 Å) | 主引用文献 | The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination. Nucleic Acids Res., 47, 2019
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6K1E
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2WS4
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![BU of 2ws4 by Molmil](/molmil-images/mine/2ws4) | Semi-synthetic analogue of human insulin ProB26-DTI in monomer form | 分子名称: | INSULIN A CHAIN, INSULIN B CHAIN | 著者 | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | 登録日 | 2009-09-03 | 公開日 | 2010-02-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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6K3O
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6K21
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![BU of 6k21 by Molmil](/molmil-images/mine/6k21) | Pyrophosphatase from Acinetobacter baumannii | 分子名称: | Inorganic pyrophosphatase, MAGNESIUM ION, SODIUM ION | 著者 | Su, J. | 登録日 | 2019-05-13 | 公開日 | 2019-10-02 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structures of Pyrophosphatase from Acinetobacter baumannii: Snapshots of Pyrophosphate Binding and Identification of a Phosphorylated Enzyme Intermediate. Int J Mol Sci, 20, 2019
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6K27
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![BU of 6k27 by Molmil](/molmil-images/mine/6k27) | Pyrophosphatase with PPi from Acinetobacter baumannii | 分子名称: | DIPHOSPHATE, Inorganic pyrophosphatase, MAGNESIUM ION | 著者 | Su, J. | 登録日 | 2019-05-13 | 公開日 | 2019-10-02 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Crystal Structures of Pyrophosphatase from Acinetobacter baumannii: Snapshots of Pyrophosphate Binding and Identification of a Phosphorylated Enzyme Intermediate. Int J Mol Sci, 20, 2019
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6K3E
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![BU of 6k3e by Molmil](/molmil-images/mine/6k3e) | LSD1/Co-Rest structure with an inhibitor | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-PCPA derivative, ... | 著者 | Wang, J. | 登録日 | 2019-05-17 | 公開日 | 2020-05-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | LSD1/Co-Rest structure with an inhibitor To Be Published
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2X15
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![BU of 2x15 by Molmil](/molmil-images/mine/2x15) | The catalytically active fully closed conformation of human phosphoglycerate kinase in complex with ADP and 1,3- bisphosphoglycerate | 分子名称: | 1,3-BISPHOSPHOGLYCERIC ACID, 3-PHOSPHOGLYCERIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Bowler, M.W, Cliff, M.J, Marston, J.P.M, Baxter, N.J, Hounslow, A.M.H, Varga, A.V, Szabo, J, Vas, M, Blackburn, G.M, Waltho, J.P. | 登録日 | 2009-12-21 | 公開日 | 2011-02-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The Structure of Human Phosphoglycerate Kinase in its Fully Active Conformation in Complex with Ground State Analoges To be Published
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