2CKP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ckp by Molmil](/molmil-images/mine/2ckp) | |
2CKQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ckq by Molmil](/molmil-images/mine/2ckq) | |
2YPV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ypv by Molmil](/molmil-images/mine/2ypv) | Crystal structure of the Meningococcal vaccine antigen factor H binding protein in complex with a bactericidal antibody | Descriptor: | 1,2-ETHANEDIOL, FAB 12C1, LIPOPROTEIN | Authors: | Malito, E, Veggi, D, Bottomley, M.J. | Deposit date: | 2012-11-01 | Release date: | 2013-02-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Defining a Protective Epitope on Factor H Binding Protein, a Key Meningococcal Virulence Factor and Vaccine Antigen. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
2Y7S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2y7s by Molmil](/molmil-images/mine/2y7s) | |
4BIG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4big by Molmil](/molmil-images/mine/4big) | Crystal structure of the conserved staphylococcal antigen 1B, Csa1B | Descriptor: | UNCHARACTERIZED LIPOPROTEIN SAOUHSC_00053 | Authors: | Malito, E, Bottomley, M.J, Schluepen, C, Liberatori, S. | Deposit date: | 2013-04-10 | Release date: | 2013-08-07 | Last modified: | 2013-10-30 | Method: | X-RAY DIFFRACTION (2.274 Å) | Cite: | Mining the Bacterial Unknown Proteome: Identification and Characterization of a Novel Family of Highly Conserved Protective Antigens in Staphylococcus Aureus Biochem.J., 455, 2013
|
|
4AE0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ae0 by Molmil](/molmil-images/mine/4ae0) | |
4AE1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ae1 by Molmil](/molmil-images/mine/4ae1) | |
4BIH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4bih by Molmil](/molmil-images/mine/4bih) | Crystal structure of the conserved staphylococcal antigen 1A, Csa1A | Descriptor: | CALCIUM ION, UNCHARACTERIZED LIPOPROTEIN SAOUHSC_00053 | Authors: | Malito, E, Bottomley, M.J, Spraggon, G, Schluepen, C, Liberatori, S. | Deposit date: | 2013-04-10 | Release date: | 2013-08-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.459 Å) | Cite: | Mining the Bacterial Unknown Proteome: Identification and Characterization of a Novel Family of Highly Conserved Protective Antigens in Staphylococcus Aureus Biochem.J., 455, 2013
|
|
4CJD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4cjd by Molmil](/molmil-images/mine/4cjd) | Crystal structure of Neisseria meningitidis trimeric autotransporter and vaccine antigen NadA | Descriptor: | IODIDE ION, NADA | Authors: | Malito, E, Biancucci, M, Spraggon, G, Bottomley, M.J. | Deposit date: | 2013-12-19 | Release date: | 2014-11-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.056 Å) | Cite: | Structure of the Meningococcal Vaccine Antigen Nada and Epitope Mapping of a Bactericidal Antibody. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4B8Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4b8y by Molmil](/molmil-images/mine/4b8y) | Ferrichrome-bound FhuD2 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, FE (III) ION, ... | Authors: | Malito, E, Bottomley, M.J, Spraggon, G. | Deposit date: | 2012-08-31 | Release date: | 2012-11-21 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and Functional Characterization of the Staphylococcus Aureus Virulence Factor and Vaccine Candidate Fhud2. Biochem.J., 449, 2013
|
|
3O0P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3o0p by Molmil](/molmil-images/mine/3o0p) | Pilus-related Sortase C of Group B Streptococcus | Descriptor: | Sortase family protein | Authors: | Malito, E, Spraggon, G. | Deposit date: | 2010-07-19 | Release date: | 2011-03-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structure analysis and site-directed mutagenesis of defined key residues and motives for pilus-related sortase C1 in group B Streptococcus. Faseb J., 25, 2011
|
|
2WBY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wby by Molmil](/molmil-images/mine/2wby) | Crystal structure of human insulin-degrading enzyme in complex with insulin | Descriptor: | INSULIN A CHAIN, INSULIN B CHAIN, INSULIN-DEGRADING ENZYME, ... | Authors: | Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J. | Deposit date: | 2009-03-06 | Release date: | 2009-03-24 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme. J.Biol.Chem., 284, 2009
|
|
2VQB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vqb by Molmil](/molmil-images/mine/2vqb) | Bacterial flavin-containing monooxygenase in complex with NADP: soaking in aerated solution | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Alfieri, A, Malito, E, Orru, R, Fraaije, M.W, Mattevi, A. | Deposit date: | 2008-03-12 | Release date: | 2008-04-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Revealing the Moonlighting Role of Nadp in the Structure of a Flavin-Containing Monooxygenase. Proc.Natl.Acad.Sci.USA, 105, 2008
|
|
2EFC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2efc by Molmil](/molmil-images/mine/2efc) | Ara7-GDP/AtVps9a | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Similarity to vacuolar protein sorting-associated protein VPS9, Small GTP-binding protein-like | Authors: | Uejima, T, Ihara, K, Goh, T, Ito, E, Sunada, M, Ueda, T, Nakano, A, Wakatsuki, S. | Deposit date: | 2007-02-22 | Release date: | 2008-02-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | GDP-bound and nucleotide-free intermediates of the guanine nucleotide exchange in the Rab5/Vps9 system J.Biol.Chem., 285, 2010
|
|
7NRU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7nru by Molmil](/molmil-images/mine/7nru) | |
5N4G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5n4g by Molmil](/molmil-images/mine/5n4g) | |
5M63
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5m63 by Molmil](/molmil-images/mine/5m63) | Crystal structure of group B Streptococcus type III DP2 oligosaccharide bound to Fab NVS-1-19-5 | Descriptor: | (2~{R},3~{R},4~{S},5~{S})-2-[bis(oxidanyl)methyl]-5-(hydroxymethyl)oxolane-3,4-diol, 1,2-ETHANEDIOL, H chain of Fab NVS-1-19-5, ... | Authors: | Carboni, F, Adamo, R, Veggi, D, Rappuoli, R, Malito, E, Margarit, I.R, Berti, F. | Deposit date: | 2016-10-24 | Release date: | 2017-05-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Structure of a protective epitope of group B Streptococcus type III capsular polysaccharide. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
5N4J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5n4j by Molmil](/molmil-images/mine/5n4j) | |
7SBZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sbz by Molmil](/molmil-images/mine/7sbz) | |
5AIQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5aiq by Molmil](/molmil-images/mine/5aiq) | Crystal structure of ligand-free NadR | Descriptor: | TRANSCRIPTIONAL REGULATOR, MARR FAMILY | Authors: | Liguori, A, Malito, E, Bottomley, M.J. | Deposit date: | 2015-02-16 | Release date: | 2016-03-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.716 Å) | Cite: | Molecular Basis of Ligand-Dependent Regulation of Nadr, the Transcriptional Repressor of Meningococcal Virulence Factor Nada. Plos Pathog., 12, 2016
|
|
5AIP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5aip by Molmil](/molmil-images/mine/5aip) | Crystal structure of NadR in complex with 4-hydroxyphenylacetate | Descriptor: | 4-HYDROXYPHENYLACETATE, TRANSCRIPTIONAL REGULATOR, MARR FAMILY | Authors: | Liguori, A, Malito, E, Bottomley, M.J. | Deposit date: | 2015-02-16 | Release date: | 2016-03-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular Basis of Ligand-Dependent Regulation of Nadr, the Transcriptional Repressor of Meningococcal Virulence Factor Nada. Plos Pathog., 12, 2016
|
|
7SA6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sa6 by Molmil](/molmil-images/mine/7sa6) | fHbp mutant 2416 bound to Fab JAR5 | Descriptor: | Factor H-binding protein 2416, JAR5 Heavy Chain, JAR5 Light Chain | Authors: | Chesterman, C, Malito, E, Bottomley, M.J. | Deposit date: | 2021-09-22 | Release date: | 2022-10-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Active Learning for Rapid Design: An iterative AI approach for accelerated vaccine design that combines active machine learning and high-throughput experimental evaluation To Be Published
|
|
6EUP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6eup by Molmil](/molmil-images/mine/6eup) | Crystal structure of Neisseria meningitidis NadA variant 3 double mutant A33I-I38L | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, Adhesin A, ... | Authors: | Dello Iacono, L, Liguori, A, Malito, E, Bottomley, M.J. | Deposit date: | 2017-10-31 | Release date: | 2018-10-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | NadA3 Structures Reveal Undecad Coiled Coils and LOX1 Binding Regions Competed by Meningococcus B Vaccine-Elicited Human Antibodies. MBio, 9, 2018
|
|
6H2Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6h2y by Molmil](/molmil-images/mine/6h2y) | human Fab 1E6 bound to fHbp variant 3 from Neisseria meningitidis serogroup B | Descriptor: | 1,2-ETHANEDIOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, DI(HYDROXYETHYL)ETHER, ... | Authors: | Veggi, D, Bianchi, F, Cozzi, R, Malito, E, Bottomley, M.J. | Deposit date: | 2018-07-17 | Release date: | 2019-08-14 | Last modified: | 2020-02-26 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Cocrystal structure of meningococcal factor H binding protein variant 3 reveals a new crossprotective epitope recognized by human mAb 1E6. Faseb J., 33, 2019
|
|
6EUN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6eun by Molmil](/molmil-images/mine/6eun) | Crystal structure of Neisseria meningitidis vaccine antigen NadA variant 3 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ... | Authors: | Dello Iacono, L, Liguori, A, Malito, E, Bottomley, M.J. | Deposit date: | 2017-10-30 | Release date: | 2018-10-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | NadA3 Structures Reveal Undecad Coiled Coils and LOX1 Binding Regions Competed by Meningococcus B Vaccine-Elicited Human Antibodies. MBio, 9, 2018
|
|