4D08
| PDE2a catalytic domain in complex with a brain penetrant inhibitor | Descriptor: | 1-(5-butoxypyridin-3-yl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo[4,3-a]quinoxaline, CGMP-DEPENDENT 3', 5'-CYCLIC PHOSPHODIESTERASE, ... | Authors: | Buijnsters, P, Andres, J.I, DeAngelis, M, Langlois, X, Rombouts, F, Sanderson, W, Tresadern, G, Trabanco, A, VanHoof, G, VanRoosbroeck, Y. | Deposit date: | 2014-04-24 | Release date: | 2014-08-06 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-Based Design of a Potent, Selective, and Brain Penetrating Pde2 Inhibitor with Demonstrated Target Engagement. Acs Med.Chem.Lett., 5, 2014
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2JQH
| VPS4B MIT | Descriptor: | Vacuolar protein sorting-associating protein 4B | Authors: | Stuchell-Brereton, M.D, Skalicky, J.J, Kieffer, C, Ghaffarian, S, Sundquist, W.I. | Deposit date: | 2007-06-01 | Release date: | 2007-10-16 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | ESCRT-III recognition by VPS4 ATPases. Nature, 449, 2007
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1Q6B
| Solution Structure of the C-terminal Domain of Thermosynechococcus elongatus KaiA (ThKaiA180C); Ensemble of 25 Structures | Descriptor: | Circadian clock protein KaiA homolog | Authors: | Vakonakis, I, Sun, J, Golden, S.S, Holzenburg, A, LiWang, A.C. | Deposit date: | 2003-08-13 | Release date: | 2003-08-19 | Last modified: | 2011-07-13 | Method: | SOLUTION NMR | Cite: | NMR structure of the KaiC-interacting C-terminal domain of KaiA, a circadian clock protein: implications for KaiA-KaiC interaction Proc.Natl.Acad.Sci.USA, 101, 2004
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2JQR
| Solution model of crosslinked complex of cytochrome c and adrenodoxin | Descriptor: | Adrenodoxin, mitochondrial, Cytochrome c iso-1, ... | Authors: | Xu, X, Reinle, W, Hannemann, F, Konarev, P.V, Svergun, D.I, Bernhardt, R, Ubbink, M. | Deposit date: | 2007-06-07 | Release date: | 2008-04-22 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | Dynamics in a pure encounter complex of two proteins studied by solution scattering and paramagnetic NMR spectroscopy J.Am.Chem.Soc., 130, 2008
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1H2L
| Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide | Descriptor: | 2-OXOGLUTARIC ACID, FACTOR INHIBITING HIF1, FE (II) ION, ... | Authors: | Elkins, J.M, Hewitson, K.S, McNeill, L.A, Schlemminger, I, Seibel, J.F, Schofield, C.J. | Deposit date: | 2002-08-12 | Release date: | 2002-11-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha J.Biol.Chem., 278, 2003
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1H9E
| LEM-LIKE DOMAIN OF HUMAN INNER NUCLEAR MEMBRANE PROTEIN LAP2 | Descriptor: | LAMINA-ASSOCIATED POLYPEPTIDE 2 | Authors: | Laguri, C, Gilquin, B, Wolff, N, Romi-Lebrun, R, Courchay, K, Callebaut, I, Worman, H.J, Zinn-Justin, S. | Deposit date: | 2001-03-08 | Release date: | 2001-06-17 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Characterization of the Lem Motif Common to Three Human Inner Nuclear Membrane Proteins Structure, 9, 2001
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1QIX
| Porcine pancreatic elastase complexed with human beta-casomorphin-7 | Descriptor: | BETA-CASOMORPHIN-7, CALCIUM ION, ELASTASE, ... | Authors: | Wilmouth, R.C, Clifton, I.J, Hajdu, J, Schofield, C.J. | Deposit date: | 1999-06-18 | Release date: | 1999-12-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of a Specific Acyl-Enzyme Complex Formed between Beta-Casomorphin-7 and Porcine Pancreatic Elastase Nat.Struct.Biol., 4, 1997
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1Q6Q
| Structure of 3-keto-L-gulonate 6-phosphate decarboxylase with bound xylitol 5-phosphate | Descriptor: | 3-keto-L-gulonate 6-phosphate decarboxylase, L-XYLITOL 5-PHOSPHATE, MAGNESIUM ION | Authors: | Wise, E.L, Yew, W.S, Gerlt, J.A, Rayment, I. | Deposit date: | 2003-08-13 | Release date: | 2003-10-28 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (1.695 Å) | Cite: | Structural Evidence for a 1,2-Enediolate Intermediate in the Reaction Catalyzed by 3-Keto-l-Gulonate 6-Phosphate Decarboxylase, a Member of the Orotidine 5'-Monophosphate Decarboxylase Suprafamily Biochemistry, 42, 2003
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1GSP
| RIBONUCLEASE T1 COMPLEXED WITH 2',3'-CGPS, 1 DAY | Descriptor: | CALCIUM ION, GUANOSINE-2',3'-CYCLOPHOSPHOROTHIOATE, RIBONUCLEASE T1 | Authors: | Zegers, I, Wyns, L. | Deposit date: | 1997-11-28 | Release date: | 1998-02-25 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Hydrolysis of a slow cyclic thiophosphate substrate of RNase T1 analyzed by time-resolved crystallography. Nat.Struct.Biol., 5, 1998
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1QB3
| CRYSTAL STRUCTURE OF THE CELL CYCLE REGULATORY PROTEIN CKS1 | Descriptor: | CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT | Authors: | Bourne, Y, Watson, M.H, Arvai, A.S, Bernstein, S.L, Reed, S.I, Tainer, J.A. | Deposit date: | 1999-04-30 | Release date: | 2000-08-31 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure and mutational analysis of the Saccharomyces cerevisiae cell cycle regulatory protein Cks1: implications for domain swapping, anion binding and protein interactions. Structure Fold.Des., 8, 2000
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1E9K
| The structure of the RACK1 interaction sites located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5. | Descriptor: | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Authors: | Bolger, G.B, Smith, K.J, McCahill, A, Hyde, E.I, Steele, M.R, Houslay, M.D. | Deposit date: | 2000-10-20 | Release date: | 2001-10-18 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | 1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1. Cell. Signal., 19, 2007
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1QRW
| CRYSTAL STRUCTURE OF AN ALPHA-LYTIC PROTEASE MUTANT WITH ACCELERATED FOLDING KINETICS, R102H/G134S, PH 8 | Descriptor: | ALHPA-LYTIC PROTEASE, GLYCEROL, SULFATE ION | Authors: | Derman, A.I, Mau, T, Agard, D.A. | Deposit date: | 1999-06-16 | Release date: | 1999-06-18 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | A Genetic Screen That Targets Specifically the Folding Transition State of Alpha-Lytic Protease To be Published, 1999
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2G3Q
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1F0R
| CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR208815 | Descriptor: | CALCIUM ION, COAGULATION FACTOR XA, THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE | Authors: | Maignan, S, Guilloteau, J.P, Pouzieux, S, Choi-Sledeski, Y.M, Becker, M.R, Klein, S.I, Ewing, W.R, Pauls, H.W, Spada, A.P, Mikol, V. | Deposit date: | 2000-05-17 | Release date: | 2000-09-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of human factor Xa complexed with potent inhibitors. J.Med.Chem., 43, 2000
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1F0I
| THE FIRST CRYSTAL STRUCTURE OF A PHOSPHOLIPASE D | Descriptor: | PHOSPHATE ION, PHOSPHOLIPASE D | Authors: | Leiros, I, Secundo, F, Zambonelli, C, Servi, S, Hough, E. | Deposit date: | 2000-05-16 | Release date: | 2001-05-16 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The first crystal structure of a phospholipase D. Structure Fold.Des., 8, 2000
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1F0T
| BOVINE TRYPSIN COMPLEXED WITH RPR131247 | Descriptor: | 4-HYDROXY-3-[2-OXO-3-(THIENO[3,2-B]PYRIDINE-2-SULFONYLAMINO)-PYRROLIDIN-1-YLMETHYL]-BENZAMIDINE, CALCIUM ION, SULFATE ION, ... | Authors: | Maignan, S, Guilloteau, J.P, Pouzieux, S, Choi-Sledeski, Y.M, Becker, M.R, Klein, S.I, Ewing, W.R, Pauls, H.W, Spada, A.P, Mikol, V. | Deposit date: | 2000-05-17 | Release date: | 2000-09-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of human factor Xa complexed with potent inhibitors. J.Med.Chem., 43, 2000
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1QYK
| GCATGCT + Barium | Descriptor: | 5'-D(*GP*CP*AP*TP*GP*CP*T)-3', BARIUM ION | Authors: | Cardin, C.J, Gan, Y, Thorpe, J.H, Teixeira, S.C.M, Gale, B.C, Moraes, M.I.A. | Deposit date: | 2003-09-11 | Release date: | 2003-10-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Metal Ion Distribution and Stabilization of the DNA Quadruplex Structure Formed by d(GCATGCT) To be published
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1Q6O
| Structure of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-gulonaet 6-phosphate | Descriptor: | 3-keto-L-gulonate 6-phosphate decarboxylase, L-GULURONIC ACID 6-PHOSPHATE, MAGNESIUM ION | Authors: | Wise, E.L, Yew, W.S, Gerlt, J.A, Rayment, I. | Deposit date: | 2003-08-13 | Release date: | 2003-10-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.202 Å) | Cite: | Structural Evidence for a 1,2-Enediolate Intermediate in the Reaction Catalyzed by 3-Keto-l-Gulonate 6-Phosphate Decarboxylase, a Member of the Orotidine 5'-Monophosphate Decarboxylase Suprafamily Biochemistry, 42, 2003
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2JNZ
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1F2V
| CRYSTAL STRUCTURE ANALYSIS OF PRECORRIN-8X METHYLMUTASE OF AEROBIC VITAMIN B12 SYNTHESIS | Descriptor: | PRECORRIN-8X METHYLMUTASE | Authors: | Shipman, L.W, Li, D, Roessner, C.A, Scott, A.I, Sacchettini, J.C. | Deposit date: | 2000-05-29 | Release date: | 2001-07-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of precorrin-8x methyl mutase. Structure, 9, 2001
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1Q6R
| Structure of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-xylulose 5-phosphate | Descriptor: | 3-keto-L-gulonate 6-phosphate decarboxylase, L-XYLULOSE 5-PHOSPHATE, MAGNESIUM ION | Authors: | Wise, E.L, Yew, W.S, Gerlt, J.A, Rayment, I. | Deposit date: | 2003-08-13 | Release date: | 2003-10-28 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Structural Evidence for a 1,2-Enediolate Intermediate in the Reaction Catalyzed by 3-Keto-l-Gulonate 6-Phosphate Decarboxylase, a Member of the Orotidine 5'-Monophosphate Decarboxylase Suprafamily Biochemistry, 42, 2003
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2JPP
| Structural basis of RsmA/CsrA RNA recognition: Structure of RsmE bound to the Shine-Dalgarno sequence of hcnA mRNA | Descriptor: | RNA (5'-R(*GP*GP*GP*CP*UP*UP*CP*AP*CP*GP*GP*AP*UP*GP*AP*AP*GP*CP*CP*C)-3'), Translational repressor | Authors: | Schubert, M, Lapouge, K, Duss, O, Oberstrass, F.C, Jelesarov, I, Haas, D, Allain, F.H.-T. | Deposit date: | 2007-05-21 | Release date: | 2007-08-21 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | Molecular basis of messenger RNA recognition by the specific bacterial repressing clamp RsmA/CsrA Nat.Struct.Mol.Biol., 14, 2007
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1F4K
| CRYSTAL STRUCTURE OF THE REPLICATION TERMINATOR PROTEIN/B-SITE DNA COMPLEX | Descriptor: | 5'-D(*CP*TP*AP*TP*GP*AP*AP*CP*AP*TP*AP*AP*TP*GP*TP*TP*CP*AP*TP*AP*G)-3', 5'-D(*CP*TP*AP*TP*GP*AP*AP*CP*AP*TP*TP*AP*TP*GP*TP*TP*CP*AP*TP*AP*G)-3', REPLICATION TERMINATION PROTEIN | Authors: | Wilce, J.A, Vivian, J.P, Hastings, A.F, Otting, G, Folmer, R.H.A, Duggin, I.G, Wake, R.G, Wilce, M.C.J. | Deposit date: | 2000-06-08 | Release date: | 2001-06-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the RTP-DNA complex and the mechanism of polar replication fork arrest Nat.Struct.Biol., 8, 2001
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2JNP
| Solution structure of matrix metalloproteinase 3 (MMP-3) in the presence of N-isobutyl-N-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid (NNGH) | Descriptor: | CALCIUM ION, Matrix metalloproteinase-3, N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID, ... | Authors: | Alcaraz, L.A, Banci, L, Bertini, I, Cantini, F, Donaire, A, Gonnelli, L. | Deposit date: | 2007-01-30 | Release date: | 2007-12-11 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Matrix metalloproteinase-inhibitor interaction: the solution structure of the catalytic domain of human matrix metalloproteinase-3 with different inhibitors J.Biol.Inorg.Chem., 12, 2007
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1EZQ
| CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR128515 | Descriptor: | 3-[(3'-AMINOMETHYL-BIPHENYL-4-CARBONYL)-AMINO]-2-(3-CARBAMIMIDOYL-BENZYL)-BUTYRIC ACID METHYL ESTER, CALCIUM ION, COAGULATION FACTOR XA | Authors: | Maignan, S, Guilloteau, J.P, Pouzieux, S, Choi-Sledeski, Y.M, Becker, M.R, Klein, S.I, Ewing, W.R, Pauls, H.W, Spada, A.P, Mikol, V. | Deposit date: | 2000-05-11 | Release date: | 2000-09-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of human factor Xa complexed with potent inhibitors. J.Med.Chem., 43, 2000
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