4U3M
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![BU of 4u3m by Molmil](/molmil-images/mine/4u3m) | Crystal structure of Anisomycin bound to the yeast 80S ribosome | Descriptor: | 18S rRNA, 25s rRNA, 40S ribosomal protein S0-A, ... | Authors: | Garreau de Loubresse, N, Prokhorova, I, Yusupova, G, Yusupov, M. | Deposit date: | 2014-07-22 | Release date: | 2014-10-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for the inhibition of the eukaryotic ribosome. Nature, 513, 2014
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8GF2
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![BU of 8gf2 by Molmil](/molmil-images/mine/8gf2) | Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies eCR3022.20 and CC12.3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.3 Fab heavy chain, ... | Authors: | Yuan, M, Zhu, X, Wilson, I.A. | Deposit date: | 2023-03-07 | Release date: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.851 Å) | Cite: | Broadening a SARS-CoV-1-neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution. Sci.Signal., 16, 2023
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5O9P
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![BU of 5o9p by Molmil](/molmil-images/mine/5o9p) | Crystal structure of Gas2 in complex with compound 10 | Descriptor: | (2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{R},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{R},3~{R},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-3,5-bis(oxidanyl)-6-[4-(pyridin-2-ylmethoxymethyl)-1,2,3-triazol-1-yl]oxan-4-yl]oxy-3,5-bis(oxidanyl)oxan-4-yl]oxy-oxane-3,4,5-triol, 1,2-ETHANEDIOL, 1,3-beta-glucanosyltransferase GAS2 | Authors: | Delso, I, Valero-Gonzalez, J, Gomollon-Bel, F, Castro-Lopez, J, Fang, W, Navratilova, I, Van Aalten, D, Tejero, T, Merino, P, Hurtado-Guerrero, R. | Deposit date: | 2017-06-19 | Release date: | 2018-05-02 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Inhibitors against Fungal Cell Wall Remodeling Enzymes. ChemMedChem, 13, 2018
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1AEC
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![BU of 1aec by Molmil](/molmil-images/mine/1aec) | CRYSTAL STRUCTURE OF ACTINIDIN-E-64 COMPLEX+ | Descriptor: | ACTINIDIN, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE | Authors: | Varughese, K.I. | Deposit date: | 1992-02-05 | Release date: | 1993-10-31 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Crystal structure of an actinidin-E-64 complex. Biochemistry, 31, 1992
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6BPT
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![BU of 6bpt by Molmil](/molmil-images/mine/6bpt) | Crystal structure of ferrous form of the uncrosslinked F2-Tyr157 human cysteine dioxygenase | Descriptor: | Cysteine dioxygenase type 1, FE (II) ION, GLYCEROL, ... | Authors: | Liu, A, Li, J, Shin, I. | Deposit date: | 2017-11-26 | Release date: | 2018-07-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.402 Å) | Cite: | Cleavage of a carbon-fluorine bond by an engineered cysteine dioxygenase. Nat. Chem. Biol., 14, 2018
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6BPW
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![BU of 6bpw by Molmil](/molmil-images/mine/6bpw) | Crystal structure of ferrous form of the Cl2-Tyr157 human cysteine dioxygenase with both uncrosslinked and crosslinked cofactor | Descriptor: | Cysteine dioxygenase type 1, FE (II) ION, GLYCEROL, ... | Authors: | Liu, A, Li, J, Shin, I. | Deposit date: | 2017-11-26 | Release date: | 2018-07-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Cleavage of a carbon-fluorine bond by an engineered cysteine dioxygenase. Nat. Chem. Biol., 14, 2018
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1BH9
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![BU of 1bh9 by Molmil](/molmil-images/mine/1bh9) | HTAFII18/HTAFII28 HETERODIMER CRYSTAL STRUCTURE WITH BOUND PCMBS | Descriptor: | PARA-MERCURY-BENZENESULFONIC ACID, TAFII18, TAFII28 | Authors: | Birck, C, Poch, O, Romier, C, Ruff, M, Mengus, G, Lavigne, A.-C, Davidson, I, Moras, D. | Deposit date: | 1998-06-16 | Release date: | 1999-06-22 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family. Cell(Cambridge,Mass.), 94, 1998
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3DZF
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![BU of 3dzf by Molmil](/molmil-images/mine/3dzf) | Crystal structure of human CD38 extracellular domain complexed with a covalent intermediate, ara-F-ribose-5'-phosphate | Descriptor: | 2-deoxy-2-fluoro-5-O-phosphono-alpha-D-arabinofuranose, ADP-ribosyl cyclase 1 | Authors: | Liu, Q, Kriksunov, I.A, Jiang, H, Graeff, R, Lin, H, Lee, H.C, Hao, Q. | Deposit date: | 2008-07-29 | Release date: | 2008-11-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38. Chem.Biol., 15, 2008
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4TUO
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![BU of 4tuo by Molmil](/molmil-images/mine/4tuo) | Crystal structure of monoclonal antibody against neuroblastoma associated antigen. | Descriptor: | Heavy chain of monoclonal antibody against neuroblastoma associated antigen, Light chain of monoclonal antibody against neuroblastoma associated antigen, N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-alpha-neuraminic acid-(2-3)-[2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)]beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose, ... | Authors: | Golik, P, Grudnik, P, Horwacik, I, Zdzalik, M, Rokita, H, Dubin, G. | Deposit date: | 2014-06-24 | Release date: | 2015-07-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural Basis of GD2 Ganglioside and Mimetic Peptide Recognition by 14G2a Antibody. Mol.Cell Proteomics, 14, 2015
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3DKX
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![BU of 3dkx by Molmil](/molmil-images/mine/3dkx) | Crystal Structure of the replication initiator protein encoded on plasmid pMV158 (RepB), trigonal form, to 2.7 Ang resolution | Descriptor: | CHLORIDE ION, MAGNESIUM ION, MANGANESE (II) ION, ... | Authors: | Boer, D.R, Ruiz-Maso, J.A, Blanco, A.G, Vives-Llacer, M, Uson, I, Gomis-Ruth, F.X, Espinosa, M, Del Solar, G, Coll, M. | Deposit date: | 2008-06-26 | Release date: | 2009-06-30 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Plasmid replication initiator RepB forms a hexamer reminiscent of ring helicases and has mobile nuclease domains Embo J., 28, 2009
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3DLQ
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![BU of 3dlq by Molmil](/molmil-images/mine/3dlq) | Crystal structure of the IL-22/IL-22R1 complex | Descriptor: | Interleukin-22, Interleukin-22 receptor subunit alpha-1 | Authors: | Bleicher, L, de Moura, P.R, Watanabe, L, Colau, D, Dumoutier, L, Renauld, J.-C, Polikarpov, I. | Deposit date: | 2008-06-28 | Release date: | 2008-08-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism Febs Lett., 582, 2008
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8DQN
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6ZXG
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![BU of 6zxg by Molmil](/molmil-images/mine/6zxg) | Cryo-EM structure of a late human pre-40S ribosomal subunit - State H1 | Descriptor: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | Authors: | Ameismeier, M, Zemp, I, van den Heuvel, J, Thoms, M, Berninghausen, O, Kutay, U, Beckmann, R. | Deposit date: | 2020-07-29 | Release date: | 2020-12-02 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural basis for the final steps of human 40S ribosome maturation. Nature, 587, 2020
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8DQM
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3DKY
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![BU of 3dky by Molmil](/molmil-images/mine/3dky) | Crystal Structure of the replication initiator protein encoded on plasmid pMV158 (RepB), tetragonal form, to 3.6 Ang resolution | Descriptor: | MANGANESE (II) ION, Replication protein repB | Authors: | Boer, D.R, Ruiz-Maso, J.A, Blanco, A.G, Vives-Llacer, M, Uson, I, Gomis-Ruth, F.X, Espinosa, M, Del Solar, G, Coll, M. | Deposit date: | 2008-06-26 | Release date: | 2009-06-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Plasmid replication initiator RepB forms a hexamer reminiscent of ring helicases and has mobile nuclease domains Embo J., 28, 2009
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2BM8
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![BU of 2bm8 by Molmil](/molmil-images/mine/2bm8) | CmcI-N160 apo-structure | Descriptor: | CEPHALOSPORIN HYDROXYLASE CMCI | Authors: | Oster, L.M, Lester, D.R, Terwisscha van Scheltinga, A, Svenda, M, Genereux, C, Andersson, I. | Deposit date: | 2005-03-10 | Release date: | 2006-03-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Insights Into Cephamycin Biosynthesis: The Crystal Structure of Cmci from Streptomyces Clavuligerus J.Mol.Biol., 358, 2006
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7AE8
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![BU of 7ae8 by Molmil](/molmil-images/mine/7ae8) | Crystal structure of HEPN(R102A) toxin | Descriptor: | ACETATE ION, HEPN toxin | Authors: | Tamulaitiene, G, Sasnauskas, G, Songailiene, I, Juozapaitis, J, Siksnys, V. | Deposit date: | 2020-09-17 | Release date: | 2020-12-30 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | HEPN-MNT Toxin-Antitoxin System: The HEPN Ribonuclease Is Neutralized by OligoAMPylation. Mol.Cell, 80, 2020
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4UEK
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![BU of 4uek by Molmil](/molmil-images/mine/4uek) | Galactitol-1-phosphate 5-dehydrogenase from E. coli with Tris within the active site. | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GALACTITOL-1-PHOSPHATE 5-DEHYDROGENASE, ZINC ION | Authors: | Benavente, R, Esteban-Torres, M, Kohring, G.W, Cortes-Cabrera, A, Gago, F, Acebron, I, de las Rivas, B, Munoz, R, Mancheno, J.M. | Deposit date: | 2014-12-18 | Release date: | 2015-07-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Enantioselective Oxidation of Galactitol 1-Phosphate by Galactitol-1-Phosphate 5-Dehydrogenase from Escherichia Coli Acta Crystallogr.,Sect.D, 71, 2015
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1BGO
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![BU of 1bgo by Molmil](/molmil-images/mine/1bgo) | CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PEPTIDOMIMETIC INHIBITOR | Descriptor: | 1-[2-(3-BIPHENYL)-4-METHYLVALERYL)]AMINO-3-(2-PYRIDYLSULFONYL)AMINO-2-PROPANONE, CATHEPSIN K | Authors: | Desjarlais, R.L, Yamashita, D.S, Oh, H.-J, Bondinell, W.E, Uzinskas, I.N, Erhard, K.F, Allen, A.C, Haltiwanger, R.C, Zhao, B, Smith, W.W, Abdel-Meguid, S.S, D'Alessio, K, Janson, C.A, Mcqueney, M.S, Tomaszek, T.A, Levy, M.A, Veber, D.F. | Deposit date: | 1998-05-29 | Release date: | 1999-06-08 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Use of X-Ray Co-Crystal Structures and Molecular Modeling to Design Potent and Selective Non-Peptide Inhibitors of Cathepsin K J.Am.Chem.Soc., 120, 1998
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1BIT
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![BU of 1bit by Molmil](/molmil-images/mine/1bit) | |
3DWR
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![BU of 3dwr by Molmil](/molmil-images/mine/3dwr) | |
5ME1
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![BU of 5me1 by Molmil](/molmil-images/mine/5me1) | Structure of the 30S Pre-Initiation Complex 2 (30S IC-2) Stalled by GE81112 | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Lopez-Alonso, J.P, Fabbretti, A, Kaminishi, T, Iturrioz, I, Brandi, L, Gil Carton, D, Gualerzi, C, Fucini, P, Connell, S. | Deposit date: | 2016-11-14 | Release date: | 2017-01-11 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (13.5 Å) | Cite: | Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways. Nucleic Acids Res., 45, 2017
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6TKB
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![BU of 6tkb by Molmil](/molmil-images/mine/6tkb) | ChiLob 7/4 H2 HC-C224S F(ab')2 | Descriptor: | Chilob 7/4 H2 heavy chain C224S, Chilob 7/4 H2 kappa chain | Authors: | Orr, C.M, Fisher, H, Tews, I. | Deposit date: | 2019-11-28 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility. Sci Immunol, 7, 2022
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6TKD
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![BU of 6tkd by Molmil](/molmil-images/mine/6tkd) | ChiLob 7/4 H2 HC-C228S F(ab')2 | Descriptor: | Chilob 7/4 H2 heavy chain C228S, Chilob 7/4 H2 kappa chain | Authors: | Orr, C.M, Fisher, H, Tews, I. | Deposit date: | 2019-11-28 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility. Sci Immunol, 7, 2022
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6TKE
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![BU of 6tke by Molmil](/molmil-images/mine/6tke) | ChiLob 7/4 H2 HC-C224S Kappa LC-C214S F(ab')2 | Descriptor: | ChiLob 7/4 H2 heavy chain C224S, ChiLob 7/4 H2 kappa chain C214S | Authors: | Orr, C.M, Fisher, H, Tews, I. | Deposit date: | 2019-11-28 | Release date: | 2021-06-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility. Sci Immunol, 7, 2022
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