3DZF

Crystal structure of human CD38 extracellular domain complexed with a covalent intermediate, ara-F-ribose-5'-phosphate

Summary for 3DZF

Related3DZG 3DZH 3DZI 3DZJ 3DZK
DescriptorADP-ribosyl cyclase 1, 2-deoxy-2-fluoro-5-O-phosphono-alpha-D-arabinofuranose (3 entities in total)
Functional Keywordscovalent intermediate, beta sheets, alpha bundle, diabetes mellitus, glycoprotein, hydrolase, membrane, nad, receptor, signal-anchor, transmembrane
Biological sourceHomo sapiens
Cellular locationMembrane; Single-pass type II membrane protein P28907
Total number of polymer chains6
Total molecular weight183674.96
Authors
Liu, Q.,Kriksunov, I.A.,Jiang, H.,Graeff, R.,Lin, H.,Lee, H.C.,Hao, Q. (deposition date: 2008-07-29, release date: 2008-11-04, Last modification date: 2016-06-08)
Primary citation
Liu, Q.,Kriksunov, I.A.,Jiang, H.,Graeff, R.,Lin, H.,Lee, H.C.,Hao, Q.
Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15:1068-1078, 2008
PubMed: 18940667 (PDB entries with the same primary citation)
DOI: 10.1016/j.chembiol.2008.08.007
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.01 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.274201.5%6.9%15.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution