3DZF
Crystal structure of human CD38 extracellular domain complexed with a covalent intermediate, ara-F-ribose-5'-phosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | ADP-ribosyl cyclase 1 | polymer | 262 | 30380.4 | 6 | UniProt (P28907) Pfam (PF02267) | Homo sapiens | Cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, T10, CD38 antigen |
| 2 | G, H, I, J, K... (A, B, C, D, E...) | 2-deoxy-2-fluoro-5-O-phosphono-alpha-D-arabinofuranose | non-polymer | 232.1 | 6 | Chemie (RF5) | |||
| 3 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 609 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 45 - 300 (UniProt: P28907)
| PDB | External Database | Details |
|---|---|---|
| Lys 39 | - | expression tag |
| Arg 40 | - | expression tag |
| Glu 41 | - | expression tag |
| Ala 42 | - | expression tag |
| Glu 43 | - | expression tag |
| Ala 44 | - | expression tag |
| Thr 49 | Gln 49 | engineered mutation |
| Asp 100 | Asn 100 | engineered mutation |
| Asp 164 | Asn 164 | engineered mutation |
| Asp 209 | Asn 209 | engineered mutation |
| Asp 219 | Asn 219 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 182282.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1392.6 | |
| All* | Total formula weight | 183675.0 |
