8CR2
| Homo sapiens Get1/Get2 heterotetramer (a3' deletion variant) in complex with a Get3 dimer | 分子名称: | ATPase ASNA1, Guided entry of tail-anchored proteins factor CAMLG,Guided entry of tail-anchored proteins factor 1, ZINC ION | 著者 | McDowell, M.A, Heimes, M, Wild, K, Sinning, I. | 登録日 | 2023-03-07 | 公開日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | The GET insertase exhibits conformational plasticity and induces membrane thinning. Nat Commun, 14, 2023
|
|
8CQZ
| Homo sapiens Get3 in complex with the Get1 cytoplasmic domain | 分子名称: | ATPase ASNA1, Guided entry of tail-anchored proteins factor 1 | 著者 | McDowell, M.A, Heimes, M, Wild, K, Saar, D, Sinning, I. | 登録日 | 2023-03-07 | 公開日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The GET insertase exhibits conformational plasticity and induces membrane thinning. Nat Commun, 14, 2023
|
|
2B1I
| crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase | 分子名称: | Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, [3,4-DIHYDROXY-5R-(2,2,4-TRIOXO-1,2R,3S,4R-TETRAHYDRO-2L6-IMIDAZO[4,5-C][1,2,6]THIADIAZIN-7-YL)TETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN PHOSPHATE | 著者 | Xu, L, Chong, Y, Hwang, I, D'Onofrio, A, Amore, K, Beardsley, G.P, Li, C, Olson, A.J, Boger, D.L, Wilson, I.A. | 登録日 | 2005-09-15 | 公開日 | 2006-11-21 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase. J.Biol.Chem., 282, 2007
|
|
8EUA
| Structure of SARS-CoV2 PLpro bound to a covalent inhibitor | 分子名称: | Papain-like protease nsp3, SULFATE ION, ZINC ION, ... | 著者 | Mathews, I.I, Pokhrel, S, Wakatsuki, S. | 登録日 | 2022-10-18 | 公開日 | 2023-04-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2. Nat Commun, 14, 2023
|
|
5G5J
| |
8ELQ
| |
4QXU
| Novel Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational antibody | 分子名称: | Matrix metalloproteinase-14, SULFATE ION, anti_MT1-MMP Heavy chain, ... | 著者 | Udi, Y, Grossman, M, Solomonov, I, Dym, O, Rozenberg, H, Moreno, v, Cuiniasse, P, Dive, V, Arroyo, A.G, Sagi, I, Israel Structural Proteomics Center (ISPC) | 登録日 | 2014-07-22 | 公開日 | 2014-12-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Inhibition mechanism of membrane metalloprotease by an exosite-swiveling conformational antibody. Structure, 23, 2015
|
|
6X1N
| |
1J1B
| Binary complex structure of human tau protein kinase I with AMPPNP | 分子名称: | Glycogen synthase kinase-3 beta, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Aoki, M, Yokota, T, Sugiura, I, Sasaki, C, Hasegawa, T, Okumura, C, Kohno, T, Sugio, S, Matsuzaki, T. | 登録日 | 2002-12-03 | 公開日 | 2003-12-03 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta. Acta Crystallogr.,Sect.D, 60, 2004
|
|
1LH2
| X-RAY STRUCTURAL INVESTIGATION OF LEGHEMOGLOBIN. VI. STRUCTURE OF ACETATE-FERRILEGHEMOGLOBIN AT A RESOLUTION OF 2.0 ANGSTROMS (RUSSIAN) | 分子名称: | LEGHEMOGLOBIN (AQUO MET), PROTOPORPHYRIN IX CONTAINING FE | 著者 | Vainshtein, B.K, Harutyunyan, E.H, Kuranova, I.P, Borisov, V.V, Sosfenov, N.I, Pavlovsky, A.G, Grebenko, A.I, Konareva, N.V. | 登録日 | 1982-04-23 | 公開日 | 1983-01-20 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | X-Ray Structural Investigation of Leghemoglobin. Vi. Structure of Acetate-Ferrileghemoglobin at a Resolution of 2.0 Angstroms (Russian) Kristallografiya, 25, 1980
|
|
3CMQ
| Crystal structure of human mitochondrial phenylalanine tRNA synthetase | 分子名称: | ADENOSINE-5'-[PHENYLALANINYL-PHOSPHATE], MAGNESIUM ION, Phenylalanyl-tRNA synthetase, ... | 著者 | Klipcan, L, Levin, I.L, Kessler, N, Moor, N, Finarov, I, Safro, M. | 登録日 | 2008-03-24 | 公開日 | 2008-07-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The tRNA-Induced Conformational Activation of Human Mitochondrial Phenylalanyl-tRNA Synthetase. Structure, 16, 2008
|
|
6FSP
| Crystal structure of APRT from Thermus thermophilus | 分子名称: | PRPP-binding protein, adenine/guanine phosphoribosyltransferase | 著者 | Timofeev, V.I, Sinitsyna, E.V, Kostromina, M.A, Muravieva, T.I, Makarov, D.A, Mikheeva, O.O, Kuranova, I.P, Esipov, R.S. | 登録日 | 2018-02-20 | 公開日 | 2019-03-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of APRT from Thermus thermophilus To Be Published
|
|
7QNY
| The receptor binding domain of SARS-CoV-2 spike glycoprotein in complex with COVOX-58 and COVOX-158 Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-158 heavy chain, COVOX-158 light chain, ... | 著者 | Zhou, D, Ren, J, Stuart, D.I. | 登録日 | 2021-12-23 | 公開日 | 2022-01-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. Cell, 185, 2022
|
|
6WCR
| |
7Q87
| Carboxypeptidase T with (S)-3-phenyllactic acid | 分子名称: | ALPHA-HYDROXY-BETA-PHENYL-PROPIONIC ACID, CALCIUM ION, Carboxypeptidase T, ... | 著者 | Timofeev, V.I, Akparov, V.K, Shevtsov, M.B, Kuranova, I.P. | 登録日 | 2021-11-10 | 公開日 | 2022-01-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Carboxypeptidase T with (S)-3-phenyllactic acid To Be Published
|
|
5N7Q
| CRYSTAL STRUCTURE OF MATURE CATHEPSIN D FROM THE TICK IXODES RICINUS (IRCD1) IN COMPLEX WITH THE INHIBITOR PEPSTATIN A | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, PEPSTATIN A, ... | 著者 | Brynda, J, Hanova, I, Hobizalova, R, Mares, M. | 登録日 | 2017-02-21 | 公開日 | 2017-12-27 | 最終更新日 | 2018-06-13 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Novel Structural Mechanism of Allosteric Regulation of Aspartic Peptidases via an Evolutionarily Conserved Exosite. Cell Chem Biol, 25, 2018
|
|
6WVT
| Structural basis of alphaE-catenin - F-actin catch bond behavior | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Xu, X.P, Pokutta, S, Torres, M, Swift, M.F, Hanein, D, Volkmann, N, Weis, W.I. | 登録日 | 2020-05-06 | 公開日 | 2020-10-07 | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | 主引用文献 | Structural basis of alpha E-catenin-F-actin catch bond behavior. Elife, 9, 2020
|
|
8F71
| |
1TL3
| Crystal structure of hiv-1 reverse transcriptase in complex with gw450557 | 分子名称: | 6-CHLORO-4-(CYCLOHEXYLOXY)-3-ISOPROPYLQUINOLIN-2(1H)-ONE, PHOSPHATE ION, Pol polyprotein, ... | 著者 | Hopkins, A.L, Ren, J, Stuart, D.I, Stammers, D.K. | 登録日 | 2004-06-09 | 公開日 | 2004-12-07 | 最終更新日 | 2022-12-21 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1. J.Med.Chem., 47, 2004
|
|
1J1C
| Binary complex structure of human tau protein kinase I with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Glycogen synthase kinase-3 beta, MAGNESIUM ION | 著者 | Aoki, M, Yokota, T, Sugiura, I, Sasaki, C, Hasegawa, T, Okumura, C, Kohno, T, Sugio, S, Matsuzaki, T. | 登録日 | 2002-12-03 | 公開日 | 2003-12-03 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta. Acta Crystallogr.,Sect.D, 60, 2004
|
|
6WFZ
| |
6WGF
| Atomic model of mutant Mcm2-7 hexamer with Mcm6 WHD truncation | 分子名称: | DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ... | 著者 | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | 登録日 | 2020-04-05 | 公開日 | 2020-07-15 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (7.7 Å) | 主引用文献 | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6GNV
| Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and a isopropyl methyl indole aryl sulphonamide ligand | 分子名称: | GLYCEROL, Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, ... | 著者 | Robinson, D.A, Harrison, J.R, Brand, S, Smith, V.C, Thompson, S, Smith, A, Davies, K, Mok, N.Y, Torrie, L.S, Collie, I, Hallyburton, I, Norval, S, Simeons, F.R.C, Stojanovski, L, Frearson, J.A, Brenk, R, Wyatt, P.G, Gilbert, I.H, Read, K.D. | 登録日 | 2018-05-31 | 公開日 | 2018-10-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors. J. Med. Chem., 61, 2018
|
|
4R10
| A conserved phosphorylation switch controls the interaction between cadherin and beta-catenin in vitro and in vivo | 分子名称: | 1,2-ETHANEDIOL, Cadherin-related hmr-1, Protein humpback-2, ... | 著者 | Choi, H.-J, Loveless, T, Lynch, A, Bang, I, Hardin, J, Weis, W.I. | 登録日 | 2014-08-03 | 公開日 | 2015-04-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A Conserved Phosphorylation Switch Controls the Interaction between Cadherin and beta-Catenin In Vitro and In Vivo Dev.Cell, 33, 2015
|
|
6GNH
| Crystal Structure of Leishmania major N-Myristoyltransferase (NMT) With Bound Myristoyl-CoA and an Azepanyl Phenyl Benzylsulphonamide Ligand | 分子名称: | Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, methyl 4-(azepan-1-yl)-3-[(4-methoxyphenyl)sulfonylamino]benzoate | 著者 | Robinson, D.A, Harrison, J.R, Brand, S, Smith, V.C, Thompson, S, Smith, A, Davies, K, Mok, N.Y, Torrie, L.S, Collie, I, Hallyburton, I, Norval, S, Simeons, F.R.C, Stojanovski, L, Frearson, J.A, Brenk, R, Wyatt, P.G, Gilbert, I.H, Read, K.D. | 登録日 | 2018-05-30 | 公開日 | 2018-09-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors. J. Med. Chem., 61, 2018
|
|