Crystal structure of hiv-1 reverse transcriptase in complex with gw450557

Summary for 1TL3
DescriptorPol polyprotein, Reverse transcriptase, Chain A, Pol polyprotein, Reverse transcriptase, Chain B, PHOSPHATE ION, ... (4 entities in total)
Functional Keywordshiv-1 reverse transcriptase, aids, nnrti, gw450557, drug design, transferase
Biological sourceHuman immunodeficiency virus 1
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
Total number of polymer chains2
Total formula weight116598.74
Hopkins, A.L.,Ren, J.,Stuart, D.I.,Stammers, D.K. (deposition date: 2004-06-09, release date: 2004-12-07, Last modification date: 2018-01-31)
Primary citationChan, J.H.,Hazen, R.J.,Hopkins, A.L.,Milton, J.,Ren, J.,Stammers, D.K.,Stuart, D.I.
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
J.Med.Chem., 47:5912-5922, 2004
PubMed: 15537346
DOI: 110.1021/jm040071z
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-09