6WCR

Crystal structure of the A/Puerto Rico/8/1934 (H1N1) influenza virus hemagglutinin in complex with small molecule F0045(S)

Summary for 6WCR

Entry DOI	10.2210/pdb6wcr/pdb
Descriptor	Hemagglutinin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	hemagglutinin, fusion inhibitors, small molecules, antiviral protein
Biological source	Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) More
Total number of polymer chains	2
Total formula weight	58578.26
Authors	kadam, R.U.,Wilson, I.A. (deposition date: 2020-03-31, release date: 2020-08-05, Last modification date: 2023-10-18)
Primary citation	Yao, Y.,Kadam, R.U.,Lee, C.D.,Woehl, J.L.,Wu, N.C.,Zhu, X.,Kitamura, S.,Wilson, I.A.,Wolan, D.W. An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen. Proc.Natl.Acad.Sci.USA, 117:18431-18438, 2020 Cited by PubMed: 32690700 DOI: 10.1073/pnas.2006893117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.68 Å)

Structure validation