1BRL
 
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2JCN
 | | The crystal structure of BAK1 - a mitochondrial apoptosis regulator | | 分子名称: | BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, SULFATE ION | | 著者 | Moche, M, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ericsson, U.B, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg Schiavone, L, Johansson, I, Karlberg, T, Kosinska, U, Kotenyova, T, Lundgren, S, Nilsson, M.E, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Upsten, M, Thorsell, A.G, van den Berg, S, Weigelt, J, Nordlund, P, Structural Genomics Consortium (SGC) | | 登録日 | 2006-12-27 | | 公開日 | 2007-01-04 | | 最終更新日 | 2018-06-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The Crystal Structure of Bak1 - an Apoptosis Trigger in the Mitochondrial Outer Membrane
To be Published
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2J9Z
 | | Tryptophan Synthase T110 mutant complex | | 分子名称: | PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, TRYPTOPHAN SYNTHASE ALPHA CHAIN, ... | | 著者 | Blumenstein, L, Domratcheva, T, Niks, D, Ngo, H, Seidel, R, Dunn, M.F, Schlichting, I. | | 登録日 | 2006-11-16 | | 公開日 | 2007-12-04 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Betaq114N and Betat110V Mutations Reveal a Critically Important Role of the Substrate Alpha-Carboxylate Site in the Reaction Specificity of Tryptophan Synthase.
Biochemistry, 46, 2007
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5C7B
 | | Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 5 | | 分子名称: | (2R)-2-methyl-4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]piperazin-1-ium, E3 ubiquitin-protein ligase XIAP, ZINC ION | | 著者 | Chessari, G, Buck, I.M, Day, J.E.H, Day, P.J, Iqbal, A, Johnson, C.N, Lewis, E.J, Martins, V, Miller, D, Reader, M, Rees, D.C, Rich, S.J, Tamanini, E, Vitorino, M, Ward, G.A, Williams, P.A, Williams, G, Wilsher, N.E, Woolford, A.J.-A. | | 登録日 | 2015-06-24 | | 公開日 | 2015-08-12 | | 最終更新日 | 2015-09-09 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
J.Med.Chem., 58, 2015
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2JB8
 | | Deacetoxycephalosporin C synthase complexed with 5-hydroxy-4-keto valeric acid | | 分子名称: | 4,5-DIOXOPENTANOIC ACID, DEACETOXYCEPHALOSPORIN C SYNTHETASE, FE (III) ION | | 著者 | Cicero, G, Carbonera, C, Valegard, K, Hajdu, J, Andersson, I, Ranghino, G. | | 登録日 | 2006-12-05 | | 公開日 | 2008-02-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Study of the Oxidative Half-Reaction Catalysed by a Non-Heme Ferrous Catalytic Centre by Means of Structural and Computational Methodologies
Int.J.Quantum Chem., 107, 2007
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5C91
 | | NEDD4 HECT with covalently bound indole-based inhibitor | | 分子名称: | E3 ubiquitin-protein ligase NEDD4, methyl (2E)-4-{[(5-methoxy-1,2-dimethyl-1H-indol-3-yl)carbonyl]amino}but-2-enoate | | 著者 | Span, I, Smith, A.T, Kathman, S, Statsyuk, A.V, Rosenzweig, A.C. | | 登録日 | 2015-06-26 | | 公開日 | 2015-09-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism.
J. Am. Chem. Soc., 137, 2015
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1BNC
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2JQ9
 | | VPS4A MIT-CHMP1A complex | | 分子名称: | Chromatin-modifying protein 1a, Vacuolar protein sorting-associating protein 4A | | 著者 | Stuchell-Brereton, M.D, Skalicky, J.J, Kieffer, C, Ghaffarian, S, Sundquist, W.I. | | 登録日 | 2007-05-30 | | 公開日 | 2007-10-16 | | 最終更新日 | 2023-12-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | ESCRT-III recognition by VPS4 ATPases.
Nature, 449, 2007
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5CEB
 | | Bd3459 Predatory Endopeptidase from Bdellovibrio bacteriovorus, K38M form | | 分子名称: | Bd3459 | | 著者 | Lovering, A.L, Cadby, I.T, Lambert, C, Sockett, R.E. | | 登録日 | 2015-07-06 | | 公開日 | 2015-12-09 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus.
Nat Commun, 6, 2015
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3NPO
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2EKS
 | | Crystal structure of humanized HyHEL-10 FV-HEN lysozyme complex | | 分子名称: | ANTI-LYSOZYME ANTIBODY FV REGION, Lysozyme C | | 著者 | Nakanishi, T, Tsumoto, K, Yokota, A, Kondo, H, Kumagai, I. | | 登録日 | 2007-03-24 | | 公開日 | 2008-03-25 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Critical contribution of VH-VL interaction to reshaping of an antibody: the case of humanization of anti-lysozyme antibody, HyHEL-10
Protein Sci., 17, 2008
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2K0C
 | | Zinc-finger 2 of Nup153 | | 分子名称: | Nuclear pore complex protein Nup153, ZINC ION | | 著者 | Bangert, J.A, Schrader, N, Vetter, I.R, Stoll, R. | | 登録日 | 2008-01-31 | | 公開日 | 2008-07-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Crystal Structure of the Ran-Nup153ZnF2 Complex: a General Ran Docking Site at the Nuclear Pore Complex.
Structure, 16, 2008
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8KDK
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5CG5
 | | Neutron crystal structure of human farnesyl pyrophosphate synthase in complex with risedronate | | 分子名称: | 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, Farnesyl pyrophosphate synthase, MAGNESIUM ION | | 著者 | Yokoyama, T, Mizuguchi, M, Ostermann, A, Kusaka, K, Niimura, N, Schrader, T.E, Tanaka, I. | | 登録日 | 2015-07-09 | | 公開日 | 2015-10-14 | | 最終更新日 | 2024-04-03 | | 実験手法 | NEUTRON DIFFRACTION (1.402 Å), X-RAY DIFFRACTION | | 主引用文献 | Protonation State and Hydration of Bisphosphonate Bound to Farnesyl Pyrophosphate Synthase
J.Med.Chem., 58, 2015
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5C0K
 | | Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 3 | | 分子名称: | (2S)-1-{[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino}-1-oxopropan-2-aminium, 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase XIAP, ... | | 著者 | Chessari, G, Buck, I.M, Day, J.E.H, Day, P.J, Iqbal, A, Johnson, C.N, Lewis, E.J, Martins, V, Miller, D, Reader, M, Rees, D.C, Rich, S.J, Tamanini, E, Vitorino, M, Ward, G.A, Williams, P.A, Williams, G, Wilsher, N.E, Woolford, A.J.-A. | | 登録日 | 2015-06-12 | | 公開日 | 2015-08-12 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
J.Med.Chem., 58, 2015
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2JJ4
 | | The complex of PII and acetylglutamate kinase from Synechococcus elongatus PCC7942 | | 分子名称: | ACETYLGLUTAMATE KINASE, N-ACETYL-L-GLUTAMATE, NITROGEN REGULATORY PROTEIN P-II | | 著者 | Llacer, J.L, Marco-Marin, C, Gil-Ortiz, F, Fita, I, Rubio, V. | | 登録日 | 2007-07-04 | | 公開日 | 2007-10-16 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (3.46 Å) | | 主引用文献 | The Crystal Structure of the Complex of Pii and Acetylglutamate Kinase Reveals How Pii Controls the Storage of Nitrogen as Arginine
Proc.Natl.Acad.Sci.USA, 104, 2007
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2JRW
 | | Solution structure of Cyclic extended Pep1(Cyc.ext.Pep.1) for autoimmune myasthenia gravis | | 分子名称: | Cyclic extended Pep.1 | | 著者 | Jung, H.H, Yi, H.J, Lee, S.K, Lee, J.Y, Jung, H.J, Yang, S.T, Eu, Y.-J, Im, S.-H, Kim, J.I. | | 登録日 | 2007-06-29 | | 公開日 | 2008-07-01 | | 最終更新日 | 2022-03-09 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural analysis of immunotherapeutic peptides for autoimmune Myasthenia gravis
Biochemistry, 46, 2007
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2JV2
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2JYO
 | | NMR Solution structure of Human MIP-3alpha/CCL20 | | 分子名称: | C-C motif chemokine 20 (Small-inducible cytokine A20) (Macrophage inflammatory protein 3 alpha) (MIP-3-alpha) (Liver and activation-regulated chemokine) (CC chemokine LARC) (Beta chemokine exodus-1) | | 著者 | Chan, D.I, Hunter, H.N, Tack, B.F, Vogel, H.J. | | 登録日 | 2007-12-14 | | 公開日 | 2008-01-01 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Human macrophage inflammatory protein 3alpha: protein and peptide nuclear magnetic resonance solution structures, dimerization, dynamics, and anti-infective properties.
Antimicrob.Agents Chemother., 52, 2008
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8PW3
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2JQQ
 | | Solution structure of Saccharomyces cerevisiae conserved oligomeric Golgi subunit 2 protein (Cog2p) | | 分子名称: | Conserved oligomeric Golgi complex subunit 2 | | 著者 | Cavanaugh, L.F, Chen, X, Pelczer, I, Rizo, J, Hughson, F.M. | | 登録日 | 2007-06-06 | | 公開日 | 2007-06-19 | | 最終更新日 | 2024-05-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural analysis of conserved oligomeric Golgi complex subunit 2
J.Biol.Chem., 282, 2007
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2BX8
 | | Human serum albumin complexed with azapropazone | | 分子名称: | AZAPROPAZONE, SERUM ALBUMIN | | 著者 | Ghuman, J, Zunszain, P.A, Petitpas, I, Bhattacharya, A.A, Curry, S. | | 登録日 | 2005-07-25 | | 公開日 | 2005-09-22 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural Basis of the Drug-Binding Specificity of Human Serum Albumin.
J.Mol.Biol., 353, 2005
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2JP8
 | | Angiotensin 1-7 | | 分子名称: | Angiotensin-(1-7) | | 著者 | Lula, I, Denadai, A.L, Resende, J.M, de Souza, F.B, de Lima, G.F, Pilo-Veloso, D, Heine, T, Duarte, H.A, Santos, R.A.S, Sinesterra, R.D. | | 登録日 | 2007-04-27 | | 公開日 | 2007-10-30 | | 最終更新日 | 2023-12-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Study of angiotensin-(1-7) vasoactive peptide and its beta-cyclodextrin inclusion complexes: complete sequence-specific NMR assignments and structural studies
Peptides, 28, 2007
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8QQW
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3O2A
 | | Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator | | 分子名称: | GLUTAMIC ACID, GLYCEROL, Glutamate receptor 2, ... | | 著者 | Maclean, J.K.F, Basten, S, Campbell, R.A, Cumming, I.A, Gillen, K.J, Gillespie, J, Jamieson, C, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Papakosta, M, Rankovic, Z, Smith, L. | | 登録日 | 2010-07-22 | | 公開日 | 2010-09-15 | | 最終更新日 | 2017-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies.
Bioorg.Med.Chem.Lett., 20, 2010
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