7A2G
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![BU of 7a2g by Molmil](/molmil-images/mine/7a2g) | Full-length structure of the substrate-free tyrosine hydroxylase (apo-TH). | 分子名称: | FE (III) ION, Tyrosine 3-monooxygenase | 著者 | Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Flydal, M.I, Martinez, A, Valpuesta, J.M. | 登録日 | 2020-08-17 | 公開日 | 2021-12-01 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13, 2022
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6ZN2
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![BU of 6zn2 by Molmil](/molmil-images/mine/6zn2) | Partial structure of tyrosine hydroxylase in complex with dopamine showing the catalytic domain and an alpha-helix from the regulatory domain involved in dopamine binding. | 分子名称: | FE (III) ION, L-DOPAMINE, SER-LEU-ILE-GLU-ASP-ALA-ARG-LYS-GLU-ARG-GLU-ALA-ALA-VAL-ALA-ALA-ALA-ALA, ... | 著者 | Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Valpuesta, J.M, Martinez, A, Flydal, M.I. | 登録日 | 2020-07-06 | 公開日 | 2021-12-08 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13, 2022
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1CF9
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![BU of 1cf9 by Molmil](/molmil-images/mine/1cf9) | |
8OLS
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5EL6
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![BU of 5el6 by Molmil](/molmil-images/mine/5el6) | Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Rozov, A, Demeshkina, N, Khusainov, I, Yusupov, M, Yusupova, G. | 登録日 | 2015-11-04 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Novel base-pairing interactions at the tRNA wobble position crucial for accurate reading of the genetic code. Nat Commun, 7, 2016
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5T0D
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![BU of 5t0d by Molmil](/molmil-images/mine/5t0d) | Crystal structure of H6 hemagglutinin G225D mutant from Taiwan (2013) H6N1 influenza virus in complex with 3'-SLN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, Hemagglutinin HA2 chain, ... | 著者 | Wilson, I.A, Tzarum, N, Zhu, X. | 登録日 | 2016-08-15 | 公開日 | 2017-06-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.864 Å) | 主引用文献 | A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors. EMBO Mol Med, 9, 2017
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2WCF
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![BU of 2wcf by Molmil](/molmil-images/mine/2wcf) | calcium-free (apo) S100A12 | 分子名称: | PROTEIN S100-A12, SODIUM ION | 著者 | Moroz, O.V, Blagova, E.V, Wilkinson, A.J, Wilson, K.S, Bronstein, I.B. | 登録日 | 2009-03-11 | 公開日 | 2009-06-23 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | The Crystal Structures of Human S100A12 in Apo Form and in Complex with Zinc: New Insights Into S100A12 Oligomerisation. J.Mol.Biol., 391, 2009
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8OLY
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8OM0
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![BU of 8om0 by Molmil](/molmil-images/mine/8om0) | Structure of Oceanobacillus iheyensis group II intron in the presence of Na+, Mg2+ and intronistat B | 分子名称: | 3,4,5-trihydroxybenzoic acid, Domains 1-5, MAGNESIUM ION, ... | 著者 | Silvestri, I, Marcia, M. | 登録日 | 2023-03-31 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (3.61 Å) | 主引用文献 | Targeting the conserved active site of splicing machines with specific and selective small molecule modulators. Nat Commun, 15, 2024
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8OLZ
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![BU of 8olz by Molmil](/molmil-images/mine/8olz) | Structure of Oceanobacillus iheyensis group II intron in the presence of K+, Mg2+, 5'-exon, and intronistat B after 2h30 soaking | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-exon, DOMAINS 1-5, ... | 著者 | Silvestri, I, Marcia, M. | 登録日 | 2023-03-30 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | 主引用文献 | Targeting the conserved active site of splicing machines with specific and selective small molecule modulators. Nat Commun, 15, 2024
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7SJS
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5ADP
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![BU of 5adp by Molmil](/molmil-images/mine/5adp) | Crystal structure of the A.17 antibody FAB fragment - Light chain S35R mutant | 分子名称: | FAB A.17 | 著者 | Chatziefthimiou, S.D, Smirnov, I.V, Golovin, A.V, Stepanova, A.V, Peng, Y, Zolotareva, O.I, Belogurov, A.A, Ponomarenko, N.A, Blackburn, G.M, Gabibov, A.A, Lerner, R, Wilmanns, M. | 登録日 | 2015-08-21 | 公開日 | 2016-11-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Robotic Qm/Mm-Driven Maturation of Antibody Combining Sites. Sci.Adv., 2, 2016
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1K5G
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![BU of 1k5g by Molmil](/molmil-images/mine/1k5g) | Crystal structure of Ran-GDP-AlFx-RanBP1-RanGAP complex | 分子名称: | ALUMINUM FLUORIDE, GTP-binding nuclear protein RAN, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Seewald, M.J, Koerner, C, Wittinghofer, A, Vetter, I.R. | 登録日 | 2001-10-10 | 公開日 | 2002-02-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | RanGAP mediates GTP hydrolysis without an arginine finger. Nature, 415, 2002
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3LIO
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![BU of 3lio by Molmil](/molmil-images/mine/3lio) | X-ray structure of the iron superoxide dismutase from pseudoalteromonas haloplanktis (crystal form I) | 分子名称: | FE (III) ION, alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose, iron superoxide dismutase | 著者 | Merlino, A, Russo Krauss, I, Rossi, B, Conte, M, Vergara, A, Sica, F. | 登録日 | 2010-01-25 | 公開日 | 2010-09-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure and flexibility in cold-adapted iron superoxide dismutases: the case of the enzyme isolated from Pseudoalteromonas haloplanktis. J.Struct.Biol., 172, 2010
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7SEA
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![BU of 7sea by Molmil](/molmil-images/mine/7sea) | Crystal structure of human Fibrillarin in complex with compound 2 from cocktail soak | 分子名称: | 6-(trifluoromethyl)pyrimidin-4-amine, DIMETHYL SULFOXIDE, FORMIC ACID, ... | 著者 | Shi, Y, El-Deeb, I.M, Masic, V, Hartley-Tassell, L, Maggioni, A, von Itzstein, M, Ve, T. | 登録日 | 2021-09-30 | 公開日 | 2022-02-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin. Pharmaceuticals, 15, 2021
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7SEC
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![BU of 7sec by Molmil](/molmil-images/mine/7sec) | Crystal structure of human Fibrillarin in complex with compound 1a | 分子名称: | 2-[(8S)-4-oxo-2-(trifluoromethyl)-4,5-dihydropyrazolo[1,5-a]pyrazin-6-yl]acetamide, DIMETHYL SULFOXIDE, FORMIC ACID, ... | 著者 | Shi, Y, El-Deeb, I.M, Masic, V, Hartley-Tassell, L, Maggioni, A, von Itzstein, M, Ve, T. | 登録日 | 2021-09-30 | 公開日 | 2022-02-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin. Pharmaceuticals, 15, 2021
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7SE8
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![BU of 7se8 by Molmil](/molmil-images/mine/7se8) | Crystal structure of human Fibrillarin in complex with fragment 1 from cocktail soak | 分子名称: | (5S)-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one, DIMETHYL SULFOXIDE, FORMIC ACID, ... | 著者 | Shi, Y, El-Deeb, I.M, Masic, V, Hartley-Tassell, L, Maggioni, A, von Itzstein, M, Ve, T. | 登録日 | 2021-09-30 | 公開日 | 2022-02-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin. Pharmaceuticals, 15, 2021
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7SE9
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![BU of 7se9 by Molmil](/molmil-images/mine/7se9) | Crystal structure of human Fibrillarin in complex with compound 1 from single soak | 分子名称: | (5S)-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one, DIMETHYL SULFOXIDE, FORMIC ACID, ... | 著者 | Shi, Y, El-Deeb, I.M, Masic, V, Hartley-Tassell, L, Maggioni, A, von Itzstein, M, Ve, T. | 登録日 | 2021-09-30 | 公開日 | 2022-02-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin. Pharmaceuticals, 15, 2021
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5OW6
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![BU of 5ow6 by Molmil](/molmil-images/mine/5ow6) | CryoEM structure of recombinant CMV particles with Tetanus-epitope | 分子名称: | Capsid protein, VP2, VP3, ... | 著者 | Kotecha, A, Stuart, D.I, Backmann, M. | 登録日 | 2017-08-30 | 公開日 | 2017-09-13 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Incorporation of tetanus-epitope into virus-like particles achieves vaccine responses even in older recipients in models of psoriasis, Alzheimer's and cat allergy. NPJ Vaccines, 2, 2017
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7B0A
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![BU of 7b0a by Molmil](/molmil-images/mine/7b0a) | Puumala virus-like particle glycoprotein spike and lattice contacts model. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope polyprotein, ... | 著者 | Rissanen, I, Stass, R, Huiskonen, J.T, Bowden, T.A. | 登録日 | 2020-11-19 | 公開日 | 2020-12-16 | 最終更新日 | 2021-01-13 | 実験手法 | ELECTRON MICROSCOPY (13.9 Å) | 主引用文献 | Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein. Elife, 9, 2020
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2YM7
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![BU of 2ym7 by Molmil](/molmil-images/mine/2ym7) | Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors | 分子名称: | 1,2-ETHANEDIOL, 5-({6-[(piperidin-4-ylmethyl)amino]pyrimidin-4-yl}amino)pyrazine-2-carbonitrile, SERINE/THREONINE-PROTEIN KINASE CHK1 | 著者 | Reader, J.C, Matthews, T.P, Klair, S, Cheung, K.M.J, Scanlon, J, Proisy, N, Addison, G, Ellard, J, Piton, N, Taylor, S, Cherry, M, Fisher, M, Boxall, K, Burns, S, Walton, M.I, Westwood, I.M, Hayes, A, Eve, P, Valenti, M, Brandon, A.H, Box, G, vanMontfort, R.L.M, Williams, D.H, Aherne, G.W, Raynaud, F.I, Eccles, S.A, Garrett, M.D, Collins, I. | 登録日 | 2011-06-06 | 公開日 | 2012-01-11 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Structure-Guided Evolution of Potent and Selective Chk1 Inhibitors Through Scaffold Morphing. J.Med.Chem., 54, 2011
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2Y7C
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![BU of 2y7c by Molmil](/molmil-images/mine/2y7c) | Atomic model of the Ocr-bound methylase complex from the Type I restriction-modification enzyme EcoKI (M2S1). Based on fitting into EM map 1534. | 分子名称: | GENE 0.3 PROTEIN, TYPE I RESTRICTION ENZYME ECOKI M PROTEIN, TYPE-1 RESTRICTION ENZYME ECOKI SPECIFICITY PROTEIN | 著者 | Kennaway, C.K, Obarska-Kosinska, A, White, J.H, Tuszynska, I, Cooper, L.P, Bujnicki, J.M, Trinick, J, Dryden, D.T.F. | 登録日 | 2011-01-31 | 公開日 | 2011-02-09 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (18 Å) | 主引用文献 | The Structure of M.Ecoki Type I DNA Methyltransferase with a DNA Mimic Antirestriction Protein. Nucleic Acids Res., 37, 2009
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5OYI
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![BU of 5oyi by Molmil](/molmil-images/mine/5oyi) | FMDV A10 dissociated pentamer | 分子名称: | Genome polyprotein | 著者 | Kotecha, A, Malik, N, Stuart, D.I. | 登録日 | 2017-09-09 | 公開日 | 2017-09-20 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (8.2 Å) | 主引用文献 | Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation. PLoS Pathog., 13, 2017
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3MXA
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![BU of 3mxa by Molmil](/molmil-images/mine/3mxa) | Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus | 分子名称: | DNA (5'-D(*TP*CP*TP*GP*GP*CP*TP*GP*AP*GP*GP*TP*AP*C)-3'), DNA (5'-D(*TP*TP*GP*TP*TP*CP*TP*CP*AP*GP*GP*TP*AP*C)-3'), DNA (5'-D(P*CP*TP*CP*AP*GP*CP*CP*AP*GP*A)-3'), ... | 著者 | Munoz, I.G, Prieto, J, Subramanian, S, Coloma, J, Montoya, G. | 登録日 | 2010-05-07 | 公開日 | 2010-10-06 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus. Nucleic Acids Res., 39, 2011
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5I67
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![BU of 5i67 by Molmil](/molmil-images/mine/5i67) | Crystal Structure Analysis of MTB PEPCK mutant C273S | 分子名称: | DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... | 著者 | Dostal, J, Pachl, P, Machova, I, Pichova, I, Snasel, J. | 登録日 | 2016-02-16 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | 主引用文献 | Crystal Structure Analysis of MTB PEPCK mutant C273S To Be Published
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