5KYK
| Covalent GTP-competitive inhibitors of KRAS G12C: Guanosine bisphosphonate Analogs | 分子名称: | 5'-O-[(R)-[({2-[(chloroacetyl)amino]ethyl}sulfamoyl)methyl](hydroxy)phosphoryl]guanosine, GTPase KRas | 著者 | Xiong, Y, Lu, J, Hunter, J, Li, L, Scott, D, Manandhar, A, Gondi, S, Westover, K.D, Gray, N.S. | 登録日 | 2016-07-21 | 公開日 | 2017-04-12 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.702 Å) | 主引用文献 | Covalent Guanosine Mimetic Inhibitors of G12C KRAS. ACS Med Chem Lett, 8, 2017
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4O91
| Crystal Structure of type II inhibitor NG25 bound to TAK1-TAB1 | 分子名称: | Mitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera, N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide | 著者 | Gurbani, D, Hunter, J.C, Tan, L, Westover, K.D. | 登録日 | 2013-12-31 | 公開日 | 2014-07-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.393 Å) | 主引用文献 | Discovery of Type II Inhibitors of TGF beta-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2). J.Med.Chem., 58, 2015
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1T1F
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2BEH
| Crystal structure of antithrombin variant S137A/V317C/T401C with plasma latent antithrombin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III, ... | 著者 | Johnson, D.J, Luis, S.A, Huntington, J.A. | 登録日 | 2005-10-24 | 公開日 | 2005-11-01 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation. J.Biol.Chem., 281, 2006
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1JVQ
| Crystal structure at 2.6A of the ternary complex between antithrombin, a P14-P8 reactive loop peptide, and an exogenous tetrapeptide | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ... | 著者 | Zhou, A, Huntington, J.A, Lomas, D.A, Carrell, R.W, Stein, P.E. | 登録日 | 2001-08-31 | 公開日 | 2003-06-03 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | How small peptides block and reverse serpin polymerisation J.Mol.Biol., 342, 2004
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4EB1
| Hyperstable in-frame insertion variant of antithrombin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III | 著者 | Martinez-Martinez, I, Johnson, D.J.D, Yamasaki, M, Corral, J, Huntington, J.A. | 登録日 | 2012-03-23 | 公開日 | 2012-07-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Type II antithrombin deficiency caused by a large in-frame insertion: structural, functional and pathological relevance. J.Thromb.Haemost., 10, 2012
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2B5T
| 2.1 Angstrom structure of a nonproductive complex between antithrombin, synthetic heparin mimetic SR123781 and two S195A thrombin molecules | 分子名称: | 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfonato-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-alpha-L-idopyranuronic acid-(1-4)-methyl 3-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Johnson, D.J, Li, W, Luis, S.A, Carrell, R.W, Huntington, J.A. | 登録日 | 2005-09-29 | 公開日 | 2006-09-19 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation. J.Biol.Chem., 281, 2006
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1RD3
| 2.5A Structure of Anticoagulant Thrombin Variant E217K | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, PHOSPHATE ION, ... | 著者 | Carter, W.J, Myles, T, Leung, L.L, Huntington, J.A. | 登録日 | 2003-11-05 | 公開日 | 2004-05-04 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of Anticoagulant Thrombin Variant E217K Provides Insights into Thrombin Allostery J.Biol.Chem., 279, 2004
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1LK6
| Structure of dimeric antithrombin complexed with a P14-P9 reactive loop peptide and an exogenous tripeptide | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | 著者 | Zhou, A, Huntington, J.A, Lomas, D.A, Carrell, R.W, Stein, P.E. | 登録日 | 2002-04-24 | 公開日 | 2003-06-03 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Serpin Polymerization Is Prevented by a Hydrogen Bond Network That Is Centered on His-334 and Stabilized by Glycerol J.Biol.Chem., 278, 2003
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1SV0
| Crystal Structure Of Yan-SAM/Mae-SAM Complex | 分子名称: | Ets DNA-binding protein pokkuri, modulator of the activity of Ets CG15085-PA | 著者 | Qiao, F, Song, H, Kim, C.A, Sawaya, M.R, Hunter, J.B, Gingery, M, Rebay, I, Courey, A.J, Bowie, J.U. | 登録日 | 2004-03-26 | 公開日 | 2004-07-27 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Derepression by depolymerization; structural insights into the regulation of yan by mae. Cell(Cambridge,Mass.), 118, 2004
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1SV4
| Crystal Structure of Yan-SAM | 分子名称: | Ets DNA-binding protein pokkuri | 著者 | Qiao, F, Song, H, Kim, C.A, Sawaya, M.R, Hunter, J.B, Gingery, M, Rebay, I, Courey, A.J, Bowie, J.U. | 登録日 | 2004-03-27 | 公開日 | 2004-07-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Derepression by depolymerization; structural insights into the regulation of yan by mae. Cell(Cambridge,Mass.), 118, 2004
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1OYH
| Crystal Structure of P13 Alanine Variant of Antithrombin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III, ... | 著者 | Johnson, D.J.D, Huntington, J.A. | 登録日 | 2003-04-04 | 公開日 | 2004-04-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | The influence of hinge region residue Glu-381 on antithrombin allostery and metastability J.Biol.Chem., 279, 2004
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2B4X
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1XMN
| Crystal structure of thrombin bound to heparin | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ... | 著者 | Carter, W.J, Cama, E, Huntington, J.A. | 登録日 | 2004-10-04 | 公開日 | 2004-11-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structure of thrombin bound to heparin J.Biol.Chem., 280, 2005
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1TB6
| 2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfonato-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-alpha-L-idopyranuronic acid-(1-4)-methyl 3-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Li, W, Johnson, D.J, Esmon, C.T, Huntington, J.A. | 登録日 | 2004-05-19 | 公開日 | 2004-08-17 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat.Struct.Mol.Biol., 11, 2004
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3B9F
| 1.6 A structure of the PCI-thrombin-heparin complex | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, GLYCEROL, Plasma serine protease inhibitor, ... | 著者 | Li, W, Adams, T.E, Huntington, J.A. | 登録日 | 2007-11-05 | 公開日 | 2008-04-22 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex. Proc.Natl.Acad.Sci.Usa, 105, 2008
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2ZNH
| Crystal Structure of a Domain-Swapped Serpin Dimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III, ... | 著者 | Yamasaki, M, Huntington, J.A. | 登録日 | 2008-04-25 | 公開日 | 2008-10-21 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization Nature, 455, 2008
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1DZG
| N135Q-S380C-ANTITHROMBIN-III | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ... | 著者 | McCoy, A.J, Huntington, J.A, Carrell, R.W. | 登録日 | 2000-02-28 | 公開日 | 2000-05-26 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The Conformational Activation of Antithrombin. A 2. 85-A Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge and Heparin Binding Regions. J.Biol.Chem., 275, 2000
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1DZH
| P14-FLUORESCEIN-N135Q-S380C-ANTITHROMBIN-III | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ... | 著者 | Mccoy, A.J, Huntington, J.A, Carrell, R.W. | 登録日 | 2000-02-28 | 公開日 | 2000-05-26 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | The Conformational Activation of Antithrombin. A 2. 85-A Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge and Heparin Binding Regions. J.Biol.Chem., 275, 2000
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4BXS
| Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Lechtenberg, B.C, Murray-Rust, T.A, Johnson, D.J.D, Adams, T.E, Krishnaswamy, S, Camire, R.M, Huntington, J.A. | 登録日 | 2013-07-15 | 公開日 | 2013-07-31 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.32 Å) | 主引用文献 | Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis. Blood, 122, 2013
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4BXW
| Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis | 分子名称: | COAGULATION FACTOR V, FACTOR XA, GLYCEROL, ... | 著者 | Lechtenberg, B.C, Murray-Rust, T.A, Johnson, D.J.D, Adams, T.E, Krishnaswamy, S, Camire, R.M, Huntington, J.A. | 登録日 | 2013-07-16 | 公開日 | 2013-07-31 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis. Blood, 122, 2013
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4QVR
| 2.3 Angstrom Crystal Structure of Hypothetical Protein FTT1539c from Francisella tularensis. | 分子名称: | Uncharacterized hypothetical protein FTT_1539c | 著者 | Minasov, G, Shuvalova, L, Dubrovska, I, Flores, K, Ren, G, Huntley, J.F, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2014-07-15 | 公開日 | 2014-07-30 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | 2.3 Angstrom Crystal Structure of Hypothetical Protein FTT1539c from Francisella tularensis. TO BE PUBLISHED
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2OL2
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1JMO
| Crystal Structure of the Heparin Cofactor II-S195A Thrombin Complex | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Baglin, T.P, Carrell, R.W, Esmon, C.T, Huntington, J.A. | 登録日 | 2001-07-19 | 公開日 | 2002-08-30 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism. Proc.Natl.Acad.Sci.USA, 99, 2002
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2GD4
| Crystal Structure of the Antithrombin-S195A Factor Xa-Pentasaccharide Complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside, ... | 著者 | Johnson, D.J, Li, W, Adams, T.E, Huntington, J.A. | 登録日 | 2006-03-15 | 公開日 | 2006-05-09 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Antithrombin-S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation. Embo J., 25, 2006
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