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PDB: 43 件
6QFY
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CRYSTAL STRUCTURE OF PORCINE HEMAGGLUTINATING ENCEPHALOMYELITIS VIRUS SPIKE PROTEIN LECTIN DOMAIN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者Huizinga, E.G, Bakkers, M, Lang, Y.
登録日2019-01-10
公開日2019-02-06
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
1MAF
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The Active Site Structure of Methylamine Dehydrogenase: Hydrazines Identify C6 as the Reactive Site of the Tryptophan Derived Quinone Cofactor
分子名称: METHYLAMINE DEHYDROGENASE (HEAVY SUBUNIT), METHYLAMINE DEHYDROGENASE (LIGHT SUBUNIT), NITROGEN MOLECULE
著者Huizinga, E.G, Vellieux, F.M.D, Hol, W.G.J.
登録日1992-05-20
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Active site structure of methylamine dehydrogenase: hydrazines identify C6 as the reactive site of the tryptophan-derived quinone cofactor.
Biochemistry, 31, 1992
1MAE
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The Active Site Structure of Methylamine Dehydrogenase: Hydrazines Identify C6 as the Reactive Site of the Tryptophan Derived Quinone Cofactor
分子名称: METHYLAMINE DEHYDROGENASE (HEAVY SUBUNIT), METHYLAMINE DEHYDROGENASE (LIGHT SUBUNIT), NITROGEN MOLECULE
著者Huizinga, E.G, Vellieux, F.M.D, Hol, W.G.J.
登録日1992-05-20
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Active site structure of methylamine dehydrogenase: hydrazines identify C6 as the reactive site of the tryptophan-derived quinone cofactor.
Biochemistry, 31, 1992
1ATZ
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HUMAN VON WILLEBRAND FACTOR A3 DOMAIN
分子名称: VON WILLEBRAND FACTOR
著者Huizinga, E.G, Gros, P.
登録日1997-08-15
公開日1998-02-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of the A3 domain of human von Willebrand factor: implications for collagen binding.
Structure, 5, 1997
2MAD
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BU of 2mad by Molmil
THE ACTIVE SITE STRUCTURE OF METHYLAMINE DEHYDROGENASE: HYDRAZINES IDENTIFY C6 AS THE REACTIVE SITE OF THE TRYPTOPHAN DERIVED QUINONE COFACTOR
分子名称: METHYLAMINE DEHYDROGENASE (HEAVY SUBUNIT), METHYLAMINE DEHYDROGENASE (LIGHT SUBUNIT)
著者Huizinga, E.G, Vellieux, F.M.D, Hol, W.G.J.
登録日1992-05-20
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Active site structure of methylamine dehydrogenase: hydrazines identify C6 as the reactive site of the tryptophan-derived quinone cofactor.
Biochemistry, 31, 1992
1I8N
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CRYSTAL STRUCTURE OF LEECH ANTI-PLATELET PROTEIN
分子名称: ANTI-PLATELET PROTEIN, PROPIONAMIDE
著者Huizinga, E.G, Schouten, A, Connolly, T.M, Kroon, J, Sixma, J.J, Gros, P.
登録日2001-03-15
公開日2001-08-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The structure of leech anti-platelet protein, an inhibitor of haemostasis.
Acta Crystallogr.,Sect.D, 57, 2001
1M10
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Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor A1 Domain
分子名称: Glycoprotein Ib alpha, von Willebrand Factor
著者Huizinga, E.G, Tsuji, S, Romijn, R.A.P, Schiphorst, M.E, de Groot, P.G, Sixma, J.J, Gros, P.
登録日2002-06-16
公開日2002-08-28
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain.
Science, 297, 2002
1M0Z
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Crystal Structure of the von Willebrand Factor Binding Domain of Glycoprotein Ib alpha
分子名称: Glycoprotein Ib alpha
著者Huizinga, E.G, Tsuji, S, Romijn, R.A.P, Schiphorst, M.E, de Groot, P.G, Sixma, J.J, Gros, P.
登録日2002-06-16
公開日2002-08-28
最終更新日2021-11-10
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain.
Science, 297, 2002
1FE8
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CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR A3 DOMAIN IN COMPLEX WITH A FAB FRAGMENT OF IGG RU5 THAT INHIBITS COLLAGEN BINDING
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, IMMUNOGLOBULIN IGG RU5, ...
著者Bouma, B, Huizinga, E.G, Schiphorst, M.E, Sixma, J.J, Kroon, J, Gros, P.
登録日2000-07-21
公開日2001-04-04
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Identification of the collagen-binding site of the von Willebrand factor A3-domain.
J.Biol.Chem., 276, 2001
4ZXN
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Crystal structure of rat coronavirus strain New-Jersey Hemagglutinin-Esterase
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HE protein, SODIUM ION, ...
著者Bakkers, M.J.G, Feitsma, L.J, Huizinga, E.G, de Groot, R.J.
登録日2015-05-20
公開日2016-05-11
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structures of murine coronavirus hemagglutinin-esterases reveal structural basis for esterase substrate specificity
To Be Published
5N11
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BU of 5n11 by Molmil
Crystal structure of Human beta1-coronavirus OC43 NL/A/2005 Hemagglutinin-Esterase
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, ...
著者Bakkers, M.J.G, Feitsma, L.J, de Groot, R.J, Huizinga, E.G.
登録日2017-02-04
公開日2017-03-22
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity.
Cell Host Microbe, 21, 2017
2ADF
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Crystal Structure and Paratope Determination of 82D6A3, an Antithrombotic Antibody Directed Against the von Willebrand factor A3-Domain
分子名称: 82D6A3 IgG, ACETIC ACID, GLYCEROL, ...
著者Staelens, S, Hadders, M.A, Vauterin, S, Platteau, C, Vanhoorelbeke, K, Huizinga, E.G, Deckmyn, H.
登録日2005-07-20
公開日2005-12-06
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Paratope determination of the antithrombotic antibody 82D6A3 based on the crystal structure of its complex with the von Willebrand factor A3-domain
J.Biol.Chem., 281, 2006
3ZQK
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Von Willebrand Factor A2 domain with calcium
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ...
著者Jakobi, A.J, Huizinga, E.G.
登録日2011-06-09
公開日2011-07-27
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Calcium Modulates Force Sensing by the Von Willebrand Factor A2 Domain.
Nat.Commun., 2, 2011
4C7L
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BU of 4c7l by Molmil
Crystal structure of Mouse Hepatitis virus strain S Hemagglutinin- esterase
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
著者Zeng, Q.H, Huizinga, E.G.
登録日2013-09-23
公開日2013-10-09
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Murine Coronavirus Hemagglutinin-Esterase Receptor-Binding Site: A Major Shift in Ligand Specificity Through Modest Changes in Architecture.
Plos Pathog., 8, 2012
2I6S
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BU of 2i6s by Molmil
Complement component C2a
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C2a fragment, ...
著者Milder, F.J, Raaijmakers, H.C.A, Vandeputte, D.A.A, Schouten, A, Huizinga, E.G, Romijn, R.A, Hemrika, W, Roos, A, Daha, M.R, Gros, P.
登録日2006-08-29
公開日2006-10-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of complement component c2a: implications for convertase formation and substrate binding.
Structure, 14, 2006
2I6Q
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Complement component C2a
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C2a fragment, ...
著者Milder, F.J, Raaijmakers, H.C.A, Vandeputte, D.A.A, Schouten, A, Huizinga, E.G, Romijn, R.A, Hemrika, W, Roos, A, Daha, M.R, Gros, P.
登録日2006-08-29
公開日2006-10-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of complement component c2a: implications for convertase formation and substrate binding.
Structure, 14, 2006
5JIF
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Crystal structure of mouse hepatitis virus strain DVIM Hemagglutinin-Esterase
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
著者Zeng, Q.H, Bakkers, M.J.G, Feitsma, L.J, de Groot, R.J, Huizinga, E.G.
登録日2016-04-22
公開日2016-05-11
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Coronavirus receptor switch explained from the stereochemistry of protein-carbohydrate interactions and a single mutation.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JIL
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Crystal structure of rat coronavirus strain New-Jersey Hemagglutinin-Esterase in complex with 4N-acetyl sialic acid
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin-esterase, ...
著者Bakkers, M.J.G, Feitsma, L.J, de Groot, R.J, Huizinga, E.G.
登録日2016-04-22
公開日2016-05-11
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Coronavirus receptor switch explained from the stereochemistry of protein-carbohydrate interactions and a single mutation.
Proc.Natl.Acad.Sci.USA, 113, 2016
3D68
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Crystal structure of a T325I/T329I/H333Y/H335Q mutant of Thrombin-Activatable Fibrinolysis Inhibitor (TAFI-IIYQ)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ARGININE, Carboxypeptidase B2, ...
著者Brondijk, T.H.C, Huizinga, E.G.
登録日2008-05-19
公開日2008-07-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structures of TAFI elucidate the inactivation mechanism of activated TAFI: a novel mechanism for enzyme autoregulation
Blood, 112, 2008
3CL5
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Structure of coronavirus hemagglutinin-esterase in complex with 4,9-O-diacetyl sialic acid
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, ...
著者Zeng, Q.H, Langereis, M.A, van Vliet, A.L.W, Huizinga, E.G, de Groot, R.J.
登録日2008-03-18
公開日2008-06-03
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of coronavirus hemagglutinin-esterase offers insight into corona and influenza virus evolution.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3D66
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Crystal structure of Thrombin-Activatable Fibrinolysis Inhibitor (TAFI)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Carboxypeptidase B2, ZINC ION
著者Brondijk, T.H.C, Huizinga, E.G.
登録日2008-05-19
公開日2008-07-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystal structures of TAFI elucidate the inactivation mechanism of activated TAFI: a novel mechanism for enzyme autoregulation
Blood, 112, 2008
3D67
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Crystal structure of Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) in complex with 2-guanidino-ethyl-mercaptosuccinic acid (GEMSA)
分子名称: (2-GUANIDINOETHYLMERCAPTO)SUCCINIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Carboxypeptidase B2, ...
著者Brondijk, T.H.C, Huizinga, E.G.
登録日2008-05-19
公開日2008-07-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Crystal structures of TAFI elucidate the inactivation mechanism of activated TAFI: a novel mechanism for enzyme autoregulation
Blood, 112, 2008
3CL4
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Crystal structure of bovine coronavirus hemagglutinin-esterase
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin-esterase, ...
著者Zeng, Q.H, Langereis, M.A, van Vliet, A.L.W, Huizinga, E.G, de Groot, R.J.
登録日2008-03-18
公開日2008-06-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of coronavirus hemagglutinin-esterase offers insight into corona and influenza virus evolution.
Proc.Natl.Acad.Sci.Usa, 105, 2008
4DMT
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Crystal structure of a VWF binding collagen III derived triple helical peptide
分子名称: Collagen III derived peptide, GLYCEROL
著者Brondijk, T.H.C, Huizinga, E.G.
登録日2012-02-08
公開日2012-03-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献Implications for collagen I chain registry from the structure of the collagen von Willebrand factor A3 domain complex.
Proc.Natl.Acad.Sci.USA, 109, 2012
4C7W
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Crystal structure of Mouse Hepatitis virus strain S Hemagglutinin- esterase in complex with 4-O-acetylated sialic acid
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
著者Zeng, Q.H, Huizinga, E.G.
登録日2013-09-26
公開日2013-10-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The Murine Coronavirus Hemagglutinin-Esterase Receptor-Binding Site: A Major Shift in Ligand Specificity Through Modest Changes in Architecture.
Plos Pathog., 8, 2012

 

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