3D67

Crystal structure of Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) in complex with 2-guanidino-ethyl-mercaptosuccinic acid (GEMSA)

Summary for 3D67

• Entry DOI: 10.2210/pdb3d67/pdb
• Related: 3D66 3D68
• Descriptor: Carboxypeptidase B2, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (4 entities in total)
• Functional Keywords: protein-inhibitor complex, alpha/beta hydrolase fold, carboxypeptidase, glycoprotein, metal-binding, metalloprotease, protease, secreted, zymogen, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 149341.35

Authors

Brondijk, T.H.C.,Huizinga, E.G. (deposition date: 2008-05-19, release date: 2008-07-01, Last modification date: 2023-11-01)

• Primary citation: Marx, P.F.,Brondijk, T.H.,Plug, T.,Romijn, R.A.,Hemrika, W.,Meijers, J.C.M.,Huizinga, E.G.; Crystal structures of TAFI elucidate the inactivation mechanism of activated TAFI: a novel mechanism for enzyme autoregulation; Blood, 112:2803-2809, 2008; PubMed: 18559974; DOI: 10.1182/blood-2008-03-146001

Experimental method

X-RAY DIFFRACTION (3.4 Å)