6N8X
 
 | | Hsp90-alpha bound to PU-11-trans | | 分子名称: | 9-[(2E)-but-2-en-1-yl]-8-[(3,4,5-trimethoxyphenyl)methyl]-9H-purin-6-amine, Heat shock protein HSP 90-alpha | | 著者 | Huck, J.D, Que, N.L.S, Gewirth, D.T. | | 登録日 | 2018-11-30 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.49484479 Å) | | 主引用文献 | Structures of Hsp90 alpha and Hsp90 beta bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity.
Proteins, 87, 2019
|
|
6N8W
 | |
6N8Y
 | | Hsp90-beta bound to PU-11-trans | | 分子名称: | 9-[(2E)-but-2-en-1-yl]-8-[(3,4,5-trimethoxyphenyl)methyl]-9H-purin-6-amine, Heat shock protein HSP 90-beta | | 著者 | Huck, J.D, Que, N.L.S, Gewirth, D.T. | | 登録日 | 2018-11-30 | | 公開日 | 2019-07-03 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.553908 Å) | | 主引用文献 | Structures of Hsp90 alpha and Hsp90 beta bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity.
Proteins, 87, 2019
|
|
5ULS
 | | Structure of GRP94 in the active conformation | | 分子名称: | Endoplasmin, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | Huck, J.D, Que, N.L.S, Gewirth, D.T. | | 登録日 | 2017-01-25 | | 公開日 | 2017-09-27 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.622 Å) | | 主引用文献 | Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site.
Cell Rep, 20, 2017
|
|
6B9A
 | |
6B99
 | |
6CYG
 | | Hsp90-alpha N-domain bound to NEOCA | | 分子名称: | 5'-N-(2-HYDROXYL)ETHYL CARBOXYAMIDO ADENOSINE, Heat shock protein HSP 90-alpha, MAGNESIUM ION | | 著者 | Huck, J.D, Campomizzi, C, Gewirth, D.T. | | 登録日 | 2018-04-05 | | 公開日 | 2019-04-10 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.503922 Å) | | 主引用文献 | NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90.
J.Biol.Chem., 294, 2019
|
|
6CYH
 | | Hsp90-alpha N-domain bound to NEACA | | 分子名称: | 5'-N-[(2-AMINO)ETHYL CARBOXAMIDO] ADENOSINE, Heat shock protein HSP 90-alpha, MAGNESIUM ION | | 著者 | Huck, J.D, Campomizzi, C, Gewirth, D.T. | | 登録日 | 2018-04-05 | | 公開日 | 2019-04-10 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90.
J.Biol.Chem., 294, 2019
|
|
6CYI
 | | Grp94 N-domain bound to NEOCA | | 分子名称: | 5'-N-(2-HYDROXYL)ETHYL CARBOXYAMIDO ADENOSINE, Endoplasmin, TETRAETHYLENE GLYCOL, ... | | 著者 | Huck, J.D, Aw, W.J, Gewirth, D.T. | | 登録日 | 2018-04-05 | | 公開日 | 2019-04-10 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.7565825 Å) | | 主引用文献 | NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90.
J.Biol.Chem., 294, 2019
|
|
6OLX
 | | Hsp90-alpha S52A bound to PU-11-trans | | 分子名称: | 9-[(2E)-but-2-en-1-yl]-8-[(3,4,5-trimethoxyphenyl)methyl]-9H-purin-6-amine, Heat shock protein HSP 90-alpha | | 著者 | Gewirth, D.T, Huck, J.D. | | 登録日 | 2019-04-17 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.43760586 Å) | | 主引用文献 | Structures of Hsp90 alpha and Hsp90 beta bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity.
Proteins, 87, 2019
|
|
