Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 276 results

6UZA
DownloadVisualize
BU of 6uza by Molmil
Cryo-EM structure of human TRPC6 in complex with antagonist AM-1473
Descriptor: 2-[[(2~{S})-2-decanoyloxypropoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, 4-({(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile, CHOLESTEROL HEMISUCCINATE, ...
Authors:Bai, Y, Yu, X, Huang, X, Chen, H.
Deposit date:2019-11-14
Release date:2020-03-18
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Structural basis for pharmacological modulation of the TRPC6 channel.
Elife, 9, 2020
6UZ8
DownloadVisualize
BU of 6uz8 by Molmil
Cryo-EM structure of human TRPC6 in complex with agonist AM-0883
Descriptor: (5-chloro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)[(2R)-2,3-dihydro-1,4-benzodioxin-2-yl]methanone, 2-[[(2~{S})-2-decanoyloxy-3-dodecanoyloxy-propoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, CHOLESTEROL HEMISUCCINATE, ...
Authors:Bai, Y, Yu, X, Huang, X, Chen, H.
Deposit date:2019-11-14
Release date:2020-03-18
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Structural basis for pharmacological modulation of the TRPC6 channel.
Elife, 9, 2020
4OGV
DownloadVisualize
BU of 4ogv by Molmil
Co-Crystal Structure of MDM2 with Inhibitor Compound 49
Descriptor: E3 ubiquitin-protein ligase Mdm2, [(2S,5R,6R)-4-[(2S)-1-(tert-butylsulfonyl)butan-2-yl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid
Authors:Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M.
Deposit date:2014-01-16
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.197 Å)
Cite:Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.
J.Med.Chem., 57, 2014
4OGN
DownloadVisualize
BU of 4ogn by Molmil
Co-Crystal Structure of MDM2 with Inhbitor Compound 3
Descriptor: 6-{[(3R,5R,6S)-1-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl}pyridine-3-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
Authors:Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M.
Deposit date:2014-01-16
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.377 Å)
Cite:Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.
J.Med.Chem., 57, 2014
4OGT
DownloadVisualize
BU of 4ogt by Molmil
Co-Crystal Structure of MDM2 with Inhbitor Compound 46
Descriptor: 6-{[(2R,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl]methyl}pyridine-3-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
Authors:Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M.
Deposit date:2014-01-16
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5361 Å)
Cite:Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.
J.Med.Chem., 57, 2014
4OBA
DownloadVisualize
BU of 4oba by Molmil
Co-crystal structure of MDM2 with Inhibitor Compound 4
Descriptor: E3 ubiquitin-protein ligase Mdm2, [(2R,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid
Authors:Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M.
Deposit date:2014-01-07
Release date:2014-03-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.602 Å)
Cite:Selective and Potent Morpholinone Inhibitors of the MDM2-p53 Protein-Protein Interaction.
J.Med.Chem., 57, 2014
4ODF
DownloadVisualize
BU of 4odf by Molmil
Co-Crystal Structure of MDM2 with Inhibitor Compound 47
Descriptor: 6-{[(2S,5R,6R)-4-[(1S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl]methyl}pyridine-3-carboxylic acid, E3 ubiquitin-protein ligase Mdm2
Authors:Shaffer, P.L, Huang, X, Yakowec, P, Long, A.M.
Deposit date:2014-01-10
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2006 Å)
Cite:Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.
J.Med.Chem., 57, 2014
1T36
DownloadVisualize
BU of 1t36 by Molmil
Crystal structure of E. coli carbamoyl phosphate synthetase small subunit mutant C248D complexed with uridine 5'-monophosphate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Carbamoyl-phosphate synthase large chain, ...
Authors:Thoden, J.B, Huang, X, Raushel, F.M, Holden, H.M.
Deposit date:2004-04-24
Release date:2004-09-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Long-range allosteric transitions in carbamoyl phosphate synthetase.
Protein Sci., 13, 2004
4IAQ
DownloadVisualize
BU of 4iaq by Molmil
Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with dihydroergotamine (PSI Community Target)
Descriptor: Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Dihydroergotamine
Authors:Wang, C, Jiang, Y, Ma, J, Wu, H, Wacker, D, Katritch, V, Han, G.W, Liu, W, Huang, X, Vardy, E, McCorvy, J.D, Gao, X, Zhou, E.X, Melcher, K, Zhang, C, Bai, F, Yang, H, Yang, L, Jiang, H, Roth, B.L, Cherezov, V, Stevens, R.C, Xu, H.E, GPCR Network (GPCR)
Deposit date:2012-12-07
Release date:2013-03-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for molecular recognition at serotonin receptors.
Science, 340, 2013
1XC9
DownloadVisualize
BU of 1xc9 by Molmil
Structure of a high-fidelity polymerase bound to a benzo[a]pyrene adduct that blocks replication
Descriptor: 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE, DNA polymerase I, DNA primer strand, ...
Authors:Hsu, G.W, Huang, X, Luneva, N.P, Geacintov, N.E, Beese, L.S.
Deposit date:2004-09-01
Release date:2004-12-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a High Fidelity DNA Polymerase Bound to a Benzo[a]pyrene Adduct That Blocks Replication
J.Biol.Chem., 280, 2005
1Y9H
DownloadVisualize
BU of 1y9h by Molmil
Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement
Descriptor: 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE, 5'-D(*CP*CP*AP*TP*(5CM)P*(BPG)P*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3'
Authors:Zhang, N, Lin, C, Huang, X, Kolbanovskiy, A, Hingerty, B.E, Amin, S, Broyde, S, Geacintov, N.E, Patel, D.J.
Deposit date:2004-12-15
Release date:2005-03-22
Last modified:2024-04-24
Method:SOLUTION NMR
Cite:Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement.
J.Mol.Biol., 346, 2005
4IAR
DownloadVisualize
BU of 4iar by Molmil
Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with ergotamine (PSI Community Target)
Descriptor: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Ergotamine
Authors:Wang, C, Jiang, Y, Ma, J, Wu, H, Wacker, D, Katritch, V, Han, G.W, Liu, W, Huang, X, Vardy, E, McCorvy, J.D, Gao, X, Zhou, E.X, Melcher, K, Zhang, C, Bai, F, Yang, H, Yang, L, Jiang, H, Roth, B.L, Cherezov, V, Stevens, R.C, Xu, H.E, GPCR Network (GPCR)
Deposit date:2012-12-07
Release date:2013-03-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for molecular recognition at serotonin receptors.
Science, 340, 2013
5GNS
DownloadVisualize
BU of 5gns by Molmil
Structures of human Mitofusin 1 provide insight into mitochondrial tethering
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Mitofusin-1
Authors:Qi, Y, Yan, L, Yu, C, Guo, X, Zhou, X, Hu, X, Huang, X, Rao, Z, Lou, Z, Hu, J.
Deposit date:2016-07-24
Release date:2016-12-07
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.702 Å)
Cite:Structures of human Mitofusin 1 provide insight into mitochondrial tethering
To Be Published
3GTL
DownloadVisualize
BU of 3gtl by Molmil
Backtracked RNA polymerase II complex with 13mer with G<>U mismatch
Descriptor: DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ...
Authors:Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D.
Deposit date:2009-03-27
Release date:2009-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.38 Å)
Cite:Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
3GTJ
DownloadVisualize
BU of 3gtj by Molmil
Backtracked RNA polymerase II complex with 13mer RNA
Descriptor: DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ...
Authors:Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D.
Deposit date:2009-03-27
Release date:2009-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
6AGF
DownloadVisualize
BU of 6agf by Molmil
Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Pan, X.J, li, Z.Q, Zhou, Q, Shen, H.Z, Wu, K, Huang, X.S, Chen, J.F, Zhang, J.R, Zhu, X.C, Lei, J.L, Xiong, W, Gong, H.P, Xiao, B.L, Yan, N.
Deposit date:2018-08-11
Release date:2018-10-10
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta 1.
Science, 362, 2018
6J8E
DownloadVisualize
BU of 6j8e by Molmil
Human Nav1.2-beta2-KIIIA ternary complex
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Pan, X, Li, Z, Huang, X, Huang, G, Yan, N.
Deposit date:2019-01-18
Release date:2019-02-27
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular basis for pore blockade of human Na+channel Nav1.2 by the mu-conotoxin KIIIA.
Science, 363, 2019
9AXH
DownloadVisualize
BU of 9axh by Molmil
Crystal structure of KSR1/MEK1 complex heterotetramer with NST-628
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, ...
Authors:Quade, B, Huang, X.
Deposit date:2024-03-06
Release date:2024-04-17
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers.
Cancer Discov, 14, 2024
9AXY
DownloadVisualize
BU of 9axy by Molmil
Crystal structure of BRAF/MEK complex with NST-628 and inactive RAF
Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide, ...
Authors:Quade, B, Huang, X.
Deposit date:2024-03-06
Release date:2024-04-17
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers.
Cancer Discov, 14, 2024
9AY7
DownloadVisualize
BU of 9ay7 by Molmil
Crystal structure of CRAF/MEK1 complex with NST-628 and inactive RAF
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Dual specificity mitogen-activated protein kinase kinase 1, ...
Authors:Quade, B, Huang, X.
Deposit date:2024-03-07
Release date:2024-04-17
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers.
Cancer Discov, 14, 2024
9AXM
DownloadVisualize
BU of 9axm by Molmil
Crystal structure of ARAF/MEK1 complex with NST-628 and a RAF dimer
Descriptor: 1,2-ETHANEDIOL, Dual specificity mitogen-activated protein kinase kinase 1, GLYCEROL, ...
Authors:Quade, B, Huang, X.
Deposit date:2024-03-06
Release date:2024-04-17
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers.
Cancer Discov, 14, 2024
9AXC
DownloadVisualize
BU of 9axc by Molmil
Activated CRAF/MEK heterotetramer from focused refinement of CRAF/MEK/14-3-3 complex
Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, GST26/CRAF chimera, N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide
Authors:Quade, B, Cohen, S.E, Huang, X.
Deposit date:2024-03-06
Release date:2024-04-17
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.16 Å)
Cite:The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers.
Cancer Discov, 14, 2024
3GTK
DownloadVisualize
BU of 3gtk by Molmil
Backtracked RNA polymerase II complex with 18mer RNA
Descriptor: DNA (29-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ...
Authors:Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D.
Deposit date:2009-03-27
Release date:2009-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
9AXX
DownloadVisualize
BU of 9axx by Molmil
Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dual specificity mitogen-activated protein kinase kinase 1, ...
Authors:Quade, B, Huang, X.
Deposit date:2024-03-06
Release date:2024-04-17
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers.
Cancer Discov, 14, 2024
8WIK
DownloadVisualize
BU of 8wik by Molmil
Crystal structure of human FSP1
Descriptor: 6-HYDROXY-FLAVIN-ADENINE DINUCLEOTIDE, Ferroptosis suppressor protein 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Feng, S, Huang, X, Tang, D, Qi, S.
Deposit date:2023-09-24
Release date:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of human ferroptosis suppressive protein 1 in complex with flavin adenine dinucleotide and nicotinamide adenine nucleotide.
MedComm (2020), 5, 2024

224004

数据于2024-08-21公开中

PDB statisticsPDBj update infoContact PDBjnumon