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PDB: 263 件
6YNJ
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Crystal structure of YTHDC1 with compound DHU_DC1_046
分子名称: (2~{R})-2-(2-chlorophenyl)-5,5-dimethyl-morpholine, SULFATE ION, YTHDC1
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-13
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
6YNM
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Crystal structure of YTHDC1 with compound DHU_DC1_096
分子名称: 1-[(2~{R},5~{S})-2-(3-chlorophenyl)-5-methyl-morpholin-4-yl]-3-methoxy-propan-2-ol, SULFATE ION, YTHDC1
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-14
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
6YKJ
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Crystal structure of YTHDC1 with compound DHU_DC1_125
分子名称: SULFATE ION, YTHDC1, ~{N}-methyl-4-(methylamino)pyridine-2-carboxamide
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-06
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
6Y22
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RING-DTC domains of Deltex 2, Form 1
分子名称: Probable E3 ubiquitin-protein ligase DTX2, ZINC ION
著者Gabrielssen, M, Buetow, L, Huang, D.T.
登録日2020-02-14
公開日2020-09-02
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.069 Å)
主引用文献DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.
Sci Adv, 6, 2020
6YNI
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Crystal structure of YTHDC1 with compound DHU_DC1_036
分子名称: (2~{R},3~{R})-2-(3-chlorophenyl)-3,5,5-trimethyl-morpholine, SULFATE ION, YTHDC1
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-13
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
6YNL
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Crystal structure of YTHDC1 with compound DHU_DC1_078
分子名称: 3-[(2~{R})-5,5-dimethyl-2-phenyl-morpholin-4-yl]-~{N}-(methylcarbamoyl)propanamide, SULFATE ION, YTHDC1
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-14
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
6YNP
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Crystal structure of YTHDC1 with compound T96C1
分子名称: CHLORIDE ION, SULFATE ION, YTHDC1, ...
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-14
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
6YL8
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Crystal structure of YTHDC1 with compound DHU_DC1_011
分子名称: (2~{R},5~{S})-2-(2-chlorophenyl)-5-methyl-morpholine, SULFATE ION, YTHDC1
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-06
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
6YNO
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Crystal structure of YTHDC1 with compound DHU_DC1_139
分子名称: 6-[[methyl-[(1-phenylpyrazol-3-yl)methyl]amino]methyl]-1~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-14
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1.
J Chem Theory Comput, 17, 2021
6ZCN
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Crystal structure of YTHDC1 with m6A
分子名称: N6-METHYLADENOSINE-5'-MONOPHOSPHATE, SULFATE ION, YTHDC1
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-06-11
公開日2020-07-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1.
J Chem Theory Comput, 17, 2021
6ZCM
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Crystal structure of YTHDC1 with compound DHU_DC1_180
分子名称: 6-[[cyclopropyl-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]amino]methyl]-1~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-06-11
公開日2020-07-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.24 Å)
主引用文献Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1.
J Chem Theory Comput, 17, 2021
1HCZ
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BU of 1hcz by Molmil
LUMEN-SIDE DOMAIN OF REDUCED CYTOCHROME F AT-35 DEGREES CELSIUS
分子名称: CYTOCHROME F, PROTOPORPHYRIN IX CONTAINING FE
著者Martinez, S.E, Huang, D, Szczepaniak, A, Cramer, W.A, Smith, J.L.
登録日1996-09-18
公開日1997-03-12
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献The heme redox center of chloroplast cytochrome f is linked to a buried five-water chain.
Protein Sci., 5, 1996
7AI0
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BU of 7ai0 by Molmil
Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 1)
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ...
著者Magnussen, H.M, Huang, D.T.
登録日2020-09-25
公開日2021-01-20
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.559 Å)
主引用文献Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
J.Mol.Biol., 433, 2021
7AI1
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Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 2)
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ...
著者Magnussen, H.M, Huang, D.T.
登録日2020-09-25
公開日2021-01-20
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
J.Mol.Biol., 433, 2021
7AH2
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Crystal structure of Zebrafish MDM2 RING domain homodimer
分子名称: E3 ubiquitin-protein ligase Mdm2, ZINC ION
著者Magnussen, H.M, Huang, D.T.
登録日2020-09-24
公開日2021-01-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.872 Å)
主引用文献Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
J.Mol.Biol., 433, 2021
1LVE
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BU of 1lve by Molmil
STRUCTURE OF THE VARIABLE DOMAIN OF HUMAN IMMUNOGLOBULIN K-4 LIGHT CHAIN LEN
分子名称: LEN, A VARIABLE DOMAIN FROM KAPPA-4 TYPE
著者Schiffer, M, Huang, D.-B, Chang, C.-H.
登録日1996-07-17
公開日1998-01-21
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Variable domain structure of kappaIV human light chain Len: high homology to the murine light chain McPC603.
Mol.Immunol., 34, 1997
5LVE
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BU of 5lve by Molmil
STRUCTURE OF THE VARIABLE DOMAIN OF HUMAN IMMUNOGLOBULIN K-4 LIGHT CHAIN LEN
分子名称: BENCE-JONES PROTEIN LEN, ZINC ION
著者Schiffer, M, Huang, D.-B, Chang, C.-H.
登録日1999-02-24
公開日2000-02-18
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Change in dimerization mode by removal of a single unsatisfied polar residue located at the interface.
Protein Sci., 9, 2000
1LE5
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BU of 1le5 by Molmil
Crystal structure of a NF-kB heterodimer bound to an IFNb-kB
分子名称: 5'-D(*AP*AP*GP*GP*AP*AP*TP*TP*TP*CP*CP*C)-3', 5'-D(*TP*GP*GP*GP*AP*AP*AP*TP*TP*CP*CP*T)-3', Nuclear factor NF-kappa-B p50 subunit, ...
著者Berkowitz, B, Huang, D.B, Chen-Park, F.E, Sigler, P.B, Ghosh, G.
登録日2002-04-09
公開日2003-04-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献The X-ray crystal structure of the NF-kB p50/p65 heterodimer bound to the Interferon beta-kB site
J.Biol.Chem., 277, 2002
1LEI
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BU of 1lei by Molmil
The kB DNA sequence from the HLV-LTR functions as an allosteric regulator of HIV transcription
分子名称: 5'-D(*CP*TP*CP*AP*GP*GP*GP*AP*AP*AP*GP*TP*AP*CP*AP*GP*A)-3', 5'-D(*TP*CP*TP*GP*5ITP*AP*CP*5ITP*5ITP*5ITP*CP*CP*CP*TP*GP*AP*G)-3', NUCLEAR FACTOR NF-KAPPA-B P50 SUBUNIT, ...
著者Chen-Park, F, Huang, D.B, Ghosh, G.
登録日2002-04-09
公開日2003-04-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The kB DNA sequence from the HIV Long Terminal Repeat functions as an allosteric regulator of HIV transcription
J.Biol.Chem., 277, 2002
5EBZ
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Crystal structure of human IKK1
分子名称: 2,3-di-O-sulfo-alpha-D-glucopyranose-(1-6)-alpha-D-glucopyranose-(1-6)-2,4-di-O-sulfo-alpha-D-glucopyranose, 2-azanyl-5-phenyl-3-(4-sulfamoylphenyl)benzamide, Inhibitor of nuclear factor kappa-B kinase subunit alpha, ...
著者Polley, S, Passos, D, Huang, D, Biswas, T, Verma, I, Lyumkis, D, Ghosh, G.
登録日2015-10-20
公開日2016-11-02
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (4.5 Å)
主引用文献Structural Basis for the Activation of IKK1/ alpha.
Cell Rep, 17, 2016
2VTY
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Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain swapped dimer
分子名称: PROTEIN F1
著者Kvansakul, M, Yang, H, Fairlie, W.D, Czabotar, P.E, Fischer, S.F, Perugini, M.A, Huang, D.C.S, Colman, P.M.
登録日2008-05-19
公開日2008-06-24
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Vaccinia Virus Anti-Apoptotic F1L is a Novel Bcl-2-Like Domain-Swapped Dimer that Binds a Highly Selective Subset of Bh3-Containing Death Ligands.
Cell Death Differ., 15, 2008
4OT9
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BU of 4ot9 by Molmil
crystal structure of the C-terminal domain of p100/NF-kB2
分子名称: Nuclear factor NF-kappa-B p100 subunit, SULFATE ION
著者Tao, Z.H, Huang, D.B, Fusco, A, Gupta, K, Ware, C.F, Duynne, G.V.
登録日2014-02-13
公開日2015-01-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献p100/I kappa B delta sequesters and inhibits NF-kappa B through kappaBsome formation.
Proc.Natl.Acad.Sci.USA, 111, 2014
1MY5
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NF-kappaB p65 subunit dimerization domain homodimer
分子名称: NF-kappaB p65 (RelA) subunit
著者Huxford, T, Mishler, D, Phelps, C.B, Huang, D.-B, Sengchanthalangsy, L.L, Reeves, R, Hughes, C.A, Komives, E.A, Ghosh, G.
登録日2002-10-03
公開日2002-12-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/I kappaB alpha complex formation
J.Mol.Biol., 324, 2002
1CTM
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BU of 1ctm by Molmil
CRYSTAL STRUCTURE OF CHLOROPLAST CYTOCHROME F REVEALS A NOVEL CYTOCHROME FOLD AND UNEXPECTED HEME LIGATION
分子名称: CYTOCHROME F, HEME C
著者Martinez, S.E, Huang, D, Szczepaniak, A, Cramer, W.A, Smith, J.L.
登録日1994-01-02
公開日1994-05-31
最終更新日2021-03-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of chloroplast cytochrome f reveals a novel cytochrome fold and unexpected heme ligation.
Structure, 2, 1994
1K3Z
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X-ray crystal structure of the IkBb/NF-kB p65 homodimer complex
分子名称: Transcription factor p65, transcription factor inhibitor I-kappa-B-beta
著者Shiva, M, Huang, D.B, Chen, Y, Huxford, T, Ghosh, S, Ghosh, G.
登録日2001-10-04
公開日2002-10-04
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex.
J.Biol.Chem., 278, 2003

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