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PDB: 263 件
6QK9
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BU of 6qk9 by Molmil
A dimeric ubiquitin formed by a single amino acid substitution
分子名称: Polyubiquitin-B
著者Gabrielsen, M, Kowalczyk, D, Buetow, L, Huang, D.T.
登録日2019-01-28
公開日2019-07-24
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.231 Å)
主引用文献Identification and Characterization of Mutations in Ubiquitin Required for Non-covalent Dimer Formation.
Structure, 27, 2019
5O6S
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BU of 5o6s by Molmil
UbV.B4R, a dimeric ubiquitin variant binding to BIRC4 RING
分子名称: Polyubiquitin-B
著者Gabrielsen, M, Buetow, L, Huang, D.T.
登録日2017-06-07
公開日2017-11-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
6SQO
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BU of 6sqo by Molmil
Crystal structure of human MDM2 RING domain homodimer bound to UbcH5B-Ub
分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, NITRATE ION, ...
著者Magnussen, H.M, Ahmed, S.F, Huang, D.T.
登録日2019-09-04
公開日2020-05-06
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain.
Nat Commun, 11, 2020
6Y5N
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BU of 6y5n by Molmil
RING-DTC domain of Deltex1
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase DTX1, ...
著者Gabrielsen, M, Buetow, L, Huang, D.T.
登録日2020-02-25
公開日2020-09-30
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases.
Sci Adv, 6, 2020
6YKI
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BU of 6yki by Molmil
Crystal structure of YTHDC1 with compound DHU_DC1_092
分子名称: SULFATE ION, YTHDC1, ~{N}-ethyl-2-[(2~{S},5~{R})-5-methyl-2-phenyl-morpholin-4-yl]ethanamine
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-06
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
6Y2X
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BU of 6y2x by Molmil
RING-DTC domains of Deltex 2, Form 2
分子名称: Probable E3 ubiquitin-protein ligase DTX2, ZINC ION
著者Gabrielsen, M, Buetow, L, Huang, D.T.
登録日2020-02-17
公開日2020-09-02
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.
Sci Adv, 6, 2020
5O75
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BU of 5o75 by Molmil
Ube4B U-box domain
分子名称: SULFATE ION, Ubiquitin conjugation factor E4 B
著者Gabrielsen, M, Buetow, L, Nakasone, M.A, Huang, D.T.
登録日2017-06-08
公開日2017-11-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.483 Å)
主引用文献A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
6Y3J
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BU of 6y3j by Molmil
RING-DTC domains of Deltex 2, bound to ADP-ribose
分子名称: ADENOSINE-5-DIPHOSPHORIBOSE, Probable E3 ubiquitin-protein ligase DTX2, ZINC ION
著者Gabrielssen, M, Buetow, L, Huang, D.T.
登録日2020-02-18
公開日2020-09-02
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.
Sci Adv, 6, 2020
7ACD
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BU of 7acd by Molmil
Crystal structure of the human METTL3-METTL14 complex with compound T30 (UZH1a)
分子名称: 4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-oxidanyl-~{N}-[[(3~{R})-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide, ACETATE ION, MAGNESIUM ION, ...
著者Bedi, R.K, Huang, D, Caflisch, A.
登録日2020-09-10
公開日2020-10-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes.
Chemmedchem, 16, 2021
4BHM
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BU of 4bhm by Molmil
The crystal structure of MoSub1-DNA complex reveals a novel DNA binding mode
分子名称: 5'-D(*TP*TP*TP*TP*TP*TP*TP*TP)-3', MOSUB1 TRANSCRIPTION COFACTOR, SULFATE ION
著者Huang, J, Liu, H, Zhao, Y, Huang, D, liu, J, Peng, Y.
登録日2013-04-04
公開日2014-04-23
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Substitution of Tryptophan 89 with Tyrosine Switches the DNA Binding Mode of Pc4.
Sci.Rep., 5, 2015
4AGH
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BU of 4agh by Molmil
Structural features of ssDNA binding protein MoSub1 from Magnaporthe oryzae
分子名称: MOSUB1, TRANSCRIPTION COFACTOR
著者Huang, J, Zhao, Y, Huang, D, liu, J, Peng, Y.
登録日2012-01-27
公開日2012-08-29
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.787 Å)
主引用文献Structural Features of the Single-Stranded DNA-Binding Protein Mosub1 from Magnaporthe Oryzae.
Acta Crystallogr.,Sect.D, 68, 2012
3DO7
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BU of 3do7 by Molmil
X-ray structure of a NF-kB p52/RelB/DNA complex
分子名称: 5'-D(*DCP*DGP*DGP*DGP*DAP*DAP*DTP*DTP*DCP*DCP*DC)-3', Avian reticuloendotheliosis viral (V-rel) oncogene related B, Nuclear factor NF-kappa-B p100 subunit
著者Fusco, A, Huang, D.B, Miller, D, Vu, D, Ghosh, G.
登録日2008-07-03
公開日2009-07-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献NF-kapppaB p52:RelB heterodimer uses different binding modes to recognize different kappaB DNA
TO BE PUBLISHED
2V6Q
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BU of 2v6q by Molmil
Crystal Structure of a BHRF-1 : Bim BH3 complex
分子名称: BCL-2-LIKE PROTEIN 11, BHRF1 PROTEIN, BROMIDE ION
著者Kvansakul, M, Huang, D.C.S, Colman, P.M.
登録日2007-07-20
公開日2008-08-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus Bhrf1.
Plos Pathog., 6, 2010
1IKN
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BU of 1ikn by Molmil
IKAPPABALPHA/NF-KAPPAB COMPLEX
分子名称: PROTEIN (I-KAPPA-B-ALPHA), PROTEIN (NF-KAPPA-B P50D SUBUNIT), PROTEIN (NF-KAPPA-B P65 SUBUNIT)
著者Huxford, T, Huang, D.-B, Malek, S, Ghosh, G.
登録日1998-11-13
公開日1999-04-12
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation.
Cell(Cambridge,Mass.), 95, 1998
2WH6
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BU of 2wh6 by Molmil
Crystal structure of anti-apoptotic BHRF1 in complex with the Bim BH3 domain
分子名称: BCL-2-LIKE PROTEIN 11, BROMIDE ION, EARLY ANTIGEN PROTEIN R, ...
著者Kvansakul, M, Huang, D.C.S, Colman, P.M.
登録日2009-05-01
公開日2010-05-26
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.
PLoS Pathog., 6, 2010
6Y5P
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BU of 6y5p by Molmil
RING-DTC domain of Deltex1 bound to NAD
分子名称: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase DTX1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Gabrielsen, M, Buetow, L, Huang, D.T.
登録日2020-02-25
公開日2020-09-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases.
Sci Adv, 6, 2020
2V2T
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BU of 2v2t by Molmil
X-ray structure of a NF-kB p50-RelB-DNA complex
分子名称: 5'-D(*CP*GP*GP*GP*AP*AP*TP*TP*CP*CP*CP)-3', NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT, TRANSCRIPTION FACTOR RELB
著者Moorthy, A.K, Huang, D.B, Wang, V.Y, Vu, D, Ghosh, G.
登録日2007-06-07
公開日2007-07-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献X-Ray Structure of a NF-kappaB p50/Relb/DNA Complex Reveals Assembly of Multiple Dimers on Tandem kappaB Sites.
J.Mol.Biol., 373, 2007
7AHZ
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BU of 7ahz by Molmil
Crystal structure of Western clawed frog MDM2 RING domain homodimer bound to UbcH5B-Ub
分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, Polyubiquitin-B, ...
著者Magnussen, H.M, Huang, D.T.
登録日2020-09-25
公開日2021-01-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant.
J.Mol.Biol., 433, 2021
6YKE
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BU of 6yke by Molmil
Crystal structure of YTHDC1 with compound DHU_DC1_038
分子名称: (2~{R})-2-(3-fluorophenyl)-5,5-dimethyl-morpholine, SULFATE ION, YTHDC1
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-06
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
6YKZ
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BU of 6ykz by Molmil
Crystal structure of YTHDC1 with compound DHU_DC1_234
分子名称: SULFATE ION, YTHDC1, ~{N}-methyl-1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxamide
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-06
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
6YL0
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BU of 6yl0 by Molmil
Crystal structure of YTHDC1 with compound T_96
分子名称: DI(HYDROXYETHYL)ETHER, SULFATE ION, YTHDC1, ...
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-06
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal structure of YTHDC1 with compound T_96
To Be Published
6YL9
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BU of 6yl9 by Molmil
Crystal structure of YTHDC1 with compound DHU_DC1_085
分子名称: 3-[(2~{R},5~{S})-2-(2,5-dimethylphenyl)-5-methyl-morpholin-4-yl]propane-1-sulfonamide, SULFATE ION, YTHDC1
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-06
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
5KBD
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BU of 5kbd by Molmil
Structural Studies of Transcription Factor p73 DNA Binding Domain Bound to PA26 20-mer Response Element
分子名称: DNA (5'-D(P*AP*GP*AP*CP*TP*TP*GP*TP*CP*C)-3'), DNA (5'-D(P*GP*GP*AP*CP*AP*AP*GP*TP*CP*T)-3'), Tumor protein p73, ...
著者Nguyen, H.T, Huang, D.
登録日2016-06-03
公開日2016-08-31
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Studies of Transcription Factor p73 DNA Binding Domain Bound to PA26 20-mer Response Element
To Be Published
6YNK
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BU of 6ynk by Molmil
Crystal structure of YTHDC1 with compound DHU_DC1_068
分子名称: 6-[[furan-2-ylmethyl(methyl)amino]methyl]-5~{H}-pyrimidine-2,4-dione, DI(HYDROXYETHYL)ETHER, SULFATE ION, ...
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-13
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Structure-based design of ligands of the m6A-RNA reader YTHDC1
Eur J Med Chem Rep, 5, 2022
6YNN
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BU of 6ynn by Molmil
Crystal structure of YTHDC1 with compound DHU_DC1_135
分子名称: 6-[[(2-chloranyl-6-fluoranyl-phenyl)methyl-methyl-amino]methyl]-1~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-14
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1.
J Chem Theory Comput, 17, 2021

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件を2024-08-07に公開中

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