7ACD

Crystal structure of the human METTL3-METTL14 complex with compound T30 (UZH1a)

Summary for 7ACD

Entry DOI	10.2210/pdb7acd/pdb
Descriptor	N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, 4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-oxidanyl-~{N}-[[(3~{R})-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide, ... (6 entities in total)
Functional Keywords	inhibitor, complex, mettl3, sinefungin, mettl14, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	62407.39
Authors	Bedi, R.K.,Huang, D.,Caflisch, A. (deposition date: 2020-09-10, release date: 2020-10-28, Last modification date: 2024-01-31)
Primary citation	Moroz-Omori, E.V.,Huang, D.,Kumar Bedi, R.,Cheriyamkunnel, S.J.,Bochenkova, E.,Dolbois, A.,Rzeczkowski, M.D.,Li, Y.,Wiedmer, L.,Caflisch, A. METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes. Chemmedchem, 16:3035-3043, 2021 Cited by PubMed: 34237194 DOI: 10.1002/cmdc.202100291 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation