6X3W
| Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus phenobarbital | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione, ... | 著者 | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | 登録日 | 2020-05-21 | 公開日 | 2020-09-09 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature, 585, 2020
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6X3U
| Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus flumazenil | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | 登録日 | 2020-05-21 | 公開日 | 2020-09-09 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature, 585, 2020
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6X3S
| Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with bicuculline methbromide | 分子名称: | (5S)-6,6-dimethyl-5-[(6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | 登録日 | 2020-05-21 | 公開日 | 2020-09-09 | 最終更新日 | 2020-09-23 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature, 585, 2020
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6X40
| Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus picrotoxin | 分子名称: | (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | 登録日 | 2020-05-21 | 公開日 | 2020-09-09 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature, 585, 2020
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8KCI
| ATP-bound hMRP5 outward-open | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 5, MAGNESIUM ION | 著者 | Liu, Z.M, Huang, Y. | 登録日 | 2023-08-07 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.94 Å) | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
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6IRC
| C-terminal domain of Drosophila phospholipase b NORPA, methylated | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | 著者 | Ye, F, Li, J, Huang, Y, Liu, W, Zhang, M. | 登録日 | 2018-11-12 | 公開日 | 2019-01-02 | 最終更新日 | 2020-10-28 | 実験手法 | X-RAY DIFFRACTION (3.538 Å) | 主引用文献 | An unexpected INAD PDZ tandem-mediated plc beta binding in Drosophila photo receptors. Elife, 7, 2018
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6IRB
| C-terminal coiled coil domain of Drosophila phospholipase C beta NORPA, selenomethionine | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | 著者 | Ye, F, Li, J, Huang, Y, Liu, W, Zhang, M. | 登録日 | 2018-11-12 | 公開日 | 2019-01-02 | 最終更新日 | 2020-10-28 | 実験手法 | X-RAY DIFFRACTION (2.661 Å) | 主引用文献 | An unexpected INAD PDZ tandem-mediated plc beta binding in Drosophila photo receptors. Elife, 7, 2018
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8FXF
| Crystal structure of the coiled-coil domain of TRIM56 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E3 ubiquitin-protein ligase TRIM56 | 著者 | Lou, X.H, Ma, B.B, Zhuang, Y, Li, X.C. | 登録日 | 2023-01-24 | 公開日 | 2023-05-24 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | TRIM56 coiled-coil domain structure provides insights into its E3 ligase functions. Comput Struct Biotechnol J, 21, 2023
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5YVX
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5XVW
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5Y21
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5Y53
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8I0L
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5YTX
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5YTT
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5YTS
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5YTV
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8I0M
| Structure of CDK6 in complex with inhibitor | 分子名称: | 2-[(4-azanylcyclohexyl)amino]-7-cyclopentyl-~{N},~{N}-dimethyl-pyrrolo[2,3-d]pyrimidine-6-carboxamide, Cyclin-dependent kinase 6 | 著者 | Jiang, C, Ye, Y, Huang, Y. | 登録日 | 2023-01-11 | 公開日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.7772 Å) | 主引用文献 | Structure of CDK6 in complex with inhibitor To Be Published
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5ZNL
| Crystal structure of PDE10A catalytic domain complexed with LHB-6 | 分子名称: | MAGNESIUM ION, N-[2-(7-methoxy-4-morpholin-4-yl-quinazolin-6-yl)oxyethyl]-1,3-benzothiazol-2-amine, ZINC ION, ... | 著者 | Li, Z, Huang, Y, Zhan, C.G, Luo, H.B. | 登録日 | 2018-04-09 | 公開日 | 2019-02-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Absolute Binding Free Energy Calculation and Design of a Subnanomolar Inhibitor of Phosphodiesterase-10. J. Med. Chem., 62, 2019
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5XVJ
| Crystal structure of AL7 PAL domain | 分子名称: | PHD finger protein ALFIN-LIKE 7, SULFATE ION | 著者 | Peng, L, Wang, L.L, Huang, Y. | 登録日 | 2017-06-28 | 公開日 | 2018-07-04 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch J. Mol. Biol., 430, 2018
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5XVL
| Crystal structure of AL2 PAL domain | 分子名称: | PHD finger protein ALFIN-LIKE 2, SULFATE ION | 著者 | Peng, L, Wang, L.L, Huang, Y. | 登録日 | 2017-06-28 | 公開日 | 2018-07-04 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.629 Å) | 主引用文献 | Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch J. Mol. Biol., 430, 2018
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6A6J
| Crystal structure of Zebra fish Y-box protein1 (YB-1) Cold-shock domain in complex with 6mer m5C RNA | 分子名称: | RNA (5'-R(P*CP*AP*UP*(5MC)P*U)-3'), ZINC ION, Zebra fish Y-box protein1 (YB-1) | 著者 | Zhang, M.M, Wu, B.X, Huang, Y, Ma, J.B. | 登録日 | 2018-06-28 | 公開日 | 2019-06-19 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.255 Å) | 主引用文献 | RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Mol.Cell, 75, 2019
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7WZ6
| Crystal structure of MyoD-E47 | 分子名称: | Isoform E47 of Transcription factor E2-alpha, Myoblast determination protein 1 | 著者 | Zhong, J, Huang, Y, Ma, J. | 登録日 | 2022-02-17 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural basis of the bHLH domains of MyoD-E47 heterodimer. Biochem.Biophys.Res.Commun., 621, 2022
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7F9Y
| ghrelin-bound ghrelin receptor in complex with Gq | 分子名称: | CHOLESTEROL, Engineered G-alpha-q subunit, Ghrelin-28, ... | 著者 | Wang, Y, Zhuang, Y, Xu, P, Xu, H.E, Jiang, Y. | 登録日 | 2021-07-05 | 公開日 | 2021-08-18 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor. Nat Commun, 12, 2021
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7F9Z
| GHRP-6-bound ghrelin receptor in complex with Gq | 分子名称: | 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, Engineered G-alpha-q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wang, Y, Zhuang, Y, Xu, P, Xu, H.E, Jiang, Y. | 登録日 | 2021-07-05 | 公開日 | 2021-08-18 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor. Nat Commun, 12, 2021
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