4WUA
 
 | | Crystal structure of human SRPK1 complexed to an inhibitor SRPIN340 | | 分子名称: | CITRIC ACID, N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide, SRSF protein kinase 1, ... | | 著者 | Hoshina, M, Ikura, T, Hosoya, T, Hagiwara, M, Ito, N. | | 登録日 | 2014-10-31 | | 公開日 | 2015-09-16 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice
Mol.Pharmacol., 88, 2015
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3U2J
 | | Neutron crystal structure of human Transthyretin | | 分子名称: | Transthyretin | | 著者 | Yokoyama, T, Mizuguchi, M, Nabeshima, Y, Kusaka, K, Yamada, T, Hosoya, T, Ohhara, T, Kurihara, K, Tomoyori, K, Tanaka, I, Niimura, N. | | 登録日 | 2011-10-03 | | 公開日 | 2012-02-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | NEUTRON DIFFRACTION (2 Å) | | 主引用文献 | Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin
J.Struct.Biol., 177, 2012
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3U2I
 | | X-ray crystal structure of human Transthyretin at room temperature | | 分子名称: | Transthyretin | | 著者 | Yokoyama, T, Mizuguchi, M, Nabeshima, Y, Kusaka, K, Yamada, T, Hosoya, T, Ohhara, T, Kurihara, K, Tomoyori, K, Tanaka, I, Niimura, N. | | 登録日 | 2011-10-03 | | 公開日 | 2012-02-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin
J.Struct.Biol., 177, 2012
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3ANR
 | | human DYRK1A/harmine complex | | 分子名称: | 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE, Dual specificity tyrosine-phosphorylation-regulated kinase 1A | | 著者 | Nonaka, Y, Hosoya, T, Hagiwara, M, Ito, N. | | 登録日 | 2010-09-06 | | 公開日 | 2010-11-10 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A
Nat Commun, 1, 2010
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3ANQ
 | | human DYRK1A/inhibitor complex | | 分子名称: | (1Z)-1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2(3H)-ylidene)propan-2-one, Dual specificity tyrosine-phosphorylation-regulated kinase 1A | | 著者 | Nonaka, Y, Hosoya, T, Hagiwara, M, Ito, N. | | 登録日 | 2010-09-06 | | 公開日 | 2010-11-10 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A
Nat Commun, 1, 2010
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7FHS
 | | Crystal structure of DYRK1A in complex with RD0392 | | 分子名称: | (5~{Z})-5-[(3-ethoxy-4-oxidanyl-phenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, GLYCEROL | | 著者 | Kikuchi, M, Sumida, T, Hosoya, T, Kii, I, Umehara, T. | | 登録日 | 2021-07-30 | | 公開日 | 2022-03-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | | 主引用文献 | Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A.
Eur.J.Med.Chem., 227, 2022
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7FHT
 | | Crystal structure of DYRK1A in complex with RD0448 | | 分子名称: | (5~{Z})-5-[(3-ethynyl-4-methoxy-phenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, Dual specificity tyrosine-phosphorylation-regulated kinase 1A | | 著者 | Kikuchi, M, Sumida, Y, Hosoya, T, Kii, I, Umehara, T. | | 登録日 | 2021-07-30 | | 公開日 | 2022-03-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A.
Eur.J.Med.Chem., 227, 2022
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5ZAB
 | | Crystal structure of cf3-aequorin | | 分子名称: | (2S)-8-benzyl-2-hydroperoxy-6-(4-hydroxyphenyl)-2-{[4-(trifluoromethyl)phenyl]methyl}imidazo[1,2-a]pyrazin-3(2H)-one, Aequorin-2 | | 著者 | Inouye, S, Tomabechi, Y, Sekine, S.I, Shirouzu, M, Hosoya, T. | | 登録日 | 2018-02-07 | | 公開日 | 2018-06-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.147 Å) | | 主引用文献 | Slow luminescence kinetics of semi-synthetic aequorin: expression, purification and structure determination of cf3-aequorin.
J. Biochem., 164, 2018
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