7FHT

Crystal structure of DYRK1A in complex with RD0448

Summary for 7FHT

Entry DOI	10.2210/pdb7fht/pdb
Descriptor	Dual specificity tyrosine-phosphorylation-regulated kinase 1A, (5~{Z})-5-[(3-ethynyl-4-methoxy-phenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one (3 entities in total)
Functional Keywords	dyrk1a, kinase, inhibitor, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	169130.95
Authors	Kikuchi, M.,Sumida, Y.,Hosoya, T.,Kii, I.,Umehara, T. (deposition date: 2021-07-30, release date: 2022-03-23, Last modification date: 2023-11-29)
Primary citation	Miyazaki, Y.,Kikuchi, M.,Umezawa, K.,Descamps, A.,Nakamura, D.,Furuie, G.,Sumida, T.,Saito, K.,Kimura, N.,Niwa, T.,Sumida, Y.,Umehara, T.,Hosoya, T.,Kii, I. Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A. Eur.J.Med.Chem., 227:113948-113948, 2022 Cited by PubMed: 34742017 DOI: 10.1016/j.ejmech.2021.113948 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.68 Å)

Structure validation