3E40
 
 | | Q138F HincII bound to GTTAAC and cocrystallized with 5 mM Ca2+ | | 分子名称: | 5'-D(*DGP*DCP*DCP*DGP*DGP*DTP*DP*DAP*DAP*DCP*DCP*DGP*DGP*DC)-3'), CALCIUM ION, SODIUM ION, ... | | 著者 | Horton, N.C, Babic, A.C, Little, E.J, Manohar, V.M. | | 登録日 | 2008-08-08 | | 公開日 | 2008-08-26 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | DNA distortion and specificity in a sequence-specific endonuclease.
J.Mol.Biol., 383, 2008
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3E3Y
 | | Q138F HincII bound to GTTAAC and cocrystallized with 5 mM Ca2+ | | 分子名称: | 5'-D(*DGP*DCP*DCP*DGP*DGP*DTP*DTP*DAP*DAP*DCP*DCP*DGP*DGP*DC)-3', CALCIUM ION, SODIUM ION, ... | | 著者 | Horton, N.C, Babic, A.C, Little, E.J, Manohar, V.M. | | 登録日 | 2008-08-08 | | 公開日 | 2008-08-26 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | DNA distortion and specificity in a sequence-specific endonuclease.
J.Mol.Biol., 383, 2008
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3E43
 | | Q138F HincII bound to GTTAAC and cocrystallized with 2.5 mM MgCl2 | | 分子名称: | 5'-D(*DGP*DCP*DCP*DGP*DGP*DTP*DTP*DAP*DAP*DCP*DCP*DGP*DGP*DC)-3', Type-2 restriction enzyme HindII, UNKNOWN ATOM OR ION | | 著者 | Horton, N.C, Babic, A.C, Little, E.J, Manohar, V.M. | | 登録日 | 2008-08-08 | | 公開日 | 2008-08-26 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | | 主引用文献 | DNA distortion and specificity in a sequence-specific endonuclease.
J.Mol.Biol., 383, 2008
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2AUD
 | | Unliganded HincII | | 分子名称: | Type II restriction enzyme HincII | | 著者 | Horton, N.C, Little, E.J. | | 登録日 | 2005-08-27 | | 公開日 | 2005-10-04 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | DNA-induced conformational changes in Type II restriction endonucleases: The structure of unliganded HincII
J.Mol.Biol., 351, 2005
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7SZY
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7SZX
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7S8D
 | | Structure of DNA-free SgrAI | | 分子名称: | CALCIUM ION, SgraIR restriction enzyme | | 著者 | Horton, N.C. | | 登録日 | 2021-09-17 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Pretransition state and apo structures of the filament-forming enzyme SgrAI elucidate mechanisms of activation and substrate specificity.
J.Biol.Chem., 298, 2022
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7S3P
 | | BD2 domain of human BRD3 bound to Physachenolide C | | 分子名称: | Bromodomain-containing protein 3, CHLORIDE ION, Physachenolide C | | 著者 | Horton, N.C, Chapman, E, Sivinski, J, Zerio, C, Ghadirian, N. | | 登録日 | 2021-09-07 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Physachenolide C is a Potent, Selective BET Inhibitor.
J.Med.Chem., 66, 2023
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4WA8
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4C3G
 | | cryo-EM structure of activated and oligomeric restriction endonuclease SgrAI | | 分子名称: | 5'-D(*CP*CP*GP*GP*TP*GP*TP*GP*AP*AP*GP*AP*CP*CP *CP*AP*CP*GP*CP*AP*TP*CP)-3', 5'-D(*GP*AP*TP*GP*CP*GP*TP*GP*GP*GP*TP*CP*TP*TP *CP*AP*CP*AP)-3', SGRAIR RESTRICTION ENZYME | | 著者 | Lyumkis, D, Talley, H, Stewart, A, Shah, S, Park, C.K, Tama, F, Potter, C.S, Carragher, B, Horton, N.C. | | 登録日 | 2013-08-23 | | 公開日 | 2013-09-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (8.6 Å) | | 主引用文献 | Allosteric Regulation of DNA Cleavage and Sequence-Specificity Through Run-on Oligomerization.
Structure, 21, 2013
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1TW8
 | | HincII bound to Ca2+ and cognate DNA GTCGAC | | 分子名称: | 5'-D(*GP*CP*CP*GP*GP*TP*CP*GP*AP*CP*CP*GP*G)-3', CALCIUM ION, Hinc II endonuclease, ... | | 著者 | Etzkorn, C, Horton, N.C. | | 登録日 | 2004-06-30 | | 公開日 | 2004-08-10 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Ca2+ binding in the active site of HincII: implications for the catalytic mechanism
Biochemistry, 43, 2004
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1BGB
 | | ECORV ENDONUCLEASE COMPLEX WITH 5'-CGGGATATCCC DNA | | 分子名称: | DNA (5'-D(*CP*GP*GP*GP*AP*TP*AP*TP*CP*CP*C)-3'), ECORV ENDONUCLEASE | | 著者 | Perona, J, Horton, N.C. | | 登録日 | 1998-05-28 | | 公開日 | 1998-10-28 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Recognition of flanking DNA sequences by EcoRV endonuclease involves alternative patterns of water-mediated contacts.
J.Biol.Chem., 273, 1998
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1BSS
 | | ECORV-T93A/DNA/CA2+ | | 分子名称: | 5'-D(*AP*AP*AP*GP*AP*TP*AP*TP*CP*TP*T)-3', CALCIUM ION, ECORV ENDONUCLEASE | | 著者 | Perona, J.J, Horton, N.C. | | 登録日 | 1998-08-30 | | 公開日 | 1998-09-02 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Metal ion-mediated substrate-assisted catalysis in type II restriction endonucleases
Proc.Natl.Acad.Sci.USA, 95, 1998
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1LBG
 | | LACTOSE OPERON REPRESSOR BOUND TO 21-BASE PAIR SYMMETRIC OPERATOR DNA, ALPHA CARBONS ONLY | | 分子名称: | DNA (5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), PROTEIN (LACTOSE OPERON REPRESSOR) | | 著者 | Lewis, M, Chang, G, Horton, N.C, Kercher, M.A, Pace, H.C, Lu, P. | | 登録日 | 1996-01-03 | | 公開日 | 1996-02-17 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (4.8 Å) | | 主引用文献 | Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
Science, 271, 1996
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1LBH
 | | INTACT LACTOSE OPERON REPRESSOR WITH GRATUITOUS INDUCER IPTG | | 分子名称: | 1-methylethyl 1-thio-beta-D-galactopyranoside, INTACT LACTOSE OPERON REPRESSOR WITH GRATUITOUS INDUCER IPTG | | 著者 | Lewis, M, Chang, G, Horton, N.C, Kercher, M.A, Pace, H.C, Lu, P. | | 登録日 | 1996-02-17 | | 公開日 | 1996-07-11 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
Science, 271, 1996
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1LBI
 | | LAC REPRESSOR | | 分子名称: | LAC REPRESSOR | | 著者 | Lewis, M, Chang, G, Horton, N.C, Kercher, M.A, Pace, H.C, Lu, P. | | 登録日 | 1996-02-17 | | 公開日 | 1996-07-11 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.
Science, 271, 1996
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3MQY
 | | SgrAI with cleaved DNA and Magnesium bound | | 分子名称: | DNA (5'-D(*GP*AP*GP*TP*CP*CP*A)-3'), DNA (5'-D(P*CP*CP*GP*GP*TP*GP*GP*AP*CP*TP*C)-3'), MAGNESIUM ION, ... | | 著者 | Dunten, P.W, Horton, N.C, Little, E.J. | | 登録日 | 2010-04-28 | | 公開日 | 2010-11-24 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | New clues in the allosteric activation of DNA cleavage by SgrAI: structures of SgrAI bound to cleaved primary-site DNA and uncleaved secondary-site DNA.
Acta Crystallogr.,Sect.D, 67, 2011
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3MQ6
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3DPG
 | | SgrAI with noncognate DNA bound | | 分子名称: | CALCIUM ION, DNA (5'-D(*DAP*DAP*DGP*DTP*DCP*DGP*DAP*DCP*DCP*DGP*DGP*DTP*DGP*DGP*DAP*DCP*DT)-3'), SgraIR restriction enzyme | | 著者 | Dunten, P.W, Horton, N.C, Little, E.J. | | 登録日 | 2008-07-08 | | 公開日 | 2008-08-19 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | The structure of SgrAI bound to DNA; recognition of an 8 base pair target.
Nucleic Acids Res., 36, 2008
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3DVO
 | | SgrAI with cognate DNA and calcium bound | | 分子名称: | CALCIUM ION, DNA (5'-D(*DGP*DAP*DGP*DTP*DCP*DCP*DAP*DCP*DCP*DGP*DGP*DTP*DGP*DGP*DAP*DCP*DTP*DC)-3'), SgraIR restriction enzyme | | 著者 | Dunten, P.W, Horton, N.C, Little, E.J. | | 登録日 | 2008-07-18 | | 公開日 | 2008-08-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.892 Å) | | 主引用文献 | The structure of SgrAI bound to DNA; recognition of an 8 base pair target.
Nucleic Acids Res., 36, 2008
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3DW9
 | | SgrAI with cognate DNA and manganese bound | | 分子名称: | DNA (5'-D(*DGP*DAP*DGP*DTP*DCP*DCP*DAP*DCP*DCP*DGP*DGP*DTP*DGP*DGP*DAP*DCP*DTP*DC)-3'), MANGANESE (II) ION, SgraIR restriction enzyme | | 著者 | Dunten, P.W, Horton, N.C, Little, E.J. | | 登録日 | 2008-07-21 | | 公開日 | 2008-08-19 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The structure of SgrAI bound to DNA; recognition of an 8 base pair target.
Nucleic Acids Res., 36, 2008
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3EBC
 | | Structure of N141A HincII with Cognate DNA | | 分子名称: | 5'-D(*DGP*DCP*DCP*DCP*DGP*DTP*DCP*DGP*DAP*DCP*DCP*DGP*DGP*DC)-3', 5'-D(*DGP*DCP*DCP*DGP*DGP*DTP*DCP*DGP*DAP*DCP*DGP*DGP*DGP*DC)-3', MANGANESE (II) ION, ... | | 著者 | Little, E.J, Babic, A.C, Horton, N.C. | | 登録日 | 2008-08-27 | | 公開日 | 2008-12-23 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Early Interrogation and Recognition of DNA Sequence by Indirect Readout
Structure, 16, 2008
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1XHU
 | | HincII bound to cleaved, cognate DNA containing GTCGAC | | 分子名称: | 5'-D(*GP*CP*CP*GP*GP*TP*C)-3', 5'-D(P*GP*AP*CP*CP*GP*G)-3', Type II restriction enzyme HincII | | 著者 | Etzkorn, C, Horton, N.C. | | 登録日 | 2004-09-20 | | 公開日 | 2004-09-28 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Mechanistic Insights from the Structures of HincII Bound to Cognate DNA Cleaved from Addition of Mg(2+) and Mn(2+)
J.Mol.Biol., 343, 2004
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1XHV
 | | HincII bound to cleaved cognate DNA GTCGAC and Mn2+ | | 分子名称: | 5'-D(*GP*CP*CP*GP*GP*TP*C)-3', 5'-D(P*GP*AP*CP*CP*GP*G)-3', MANGANESE (II) ION, ... | | 著者 | Etzkorn, C, Horton, N.C. | | 登録日 | 2004-09-20 | | 公開日 | 2004-09-28 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mechanistic Insights from the Structures of HincII Bound to Cognate DNA Cleaved from Addition of Mg(2+) and Mn(2+)
J.Mol.Biol., 343, 2004
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6OBJ
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