7YZP
 
 | | Hairpin-bound state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and a DNA hairpin | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA hairpin (59-MER), MAGNESIUM ION, ... | | Authors: | Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P. | | Deposit date: | 2022-02-21 | | Release date: | 2022-08-17 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Mol.Cell, 82, 2022
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7YZO
 | | Endonuclease state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and dsDNA | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (31-MER), MAGNESIUM ION, ... | | Authors: | Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P. | | Deposit date: | 2022-02-21 | | Release date: | 2022-08-17 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Mol.Cell, 82, 2022
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7Z03
 | | Endonuclease state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ADP and extended dsDNA | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (39-MER), MAGNESIUM ION, ... | | Authors: | Gut, F, Kaeshammer, L, Lammens, K, Bartho, J, van de Logt, E, Kessler, B, Hopfner, K.P. | | Deposit date: | 2022-02-21 | | Release date: | 2022-08-17 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50.
Mol.Cell, 82, 2022
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4WZS
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8A5A
 | | Structure of Arp4-Ies4-N-actin-Arp8-Ino80HSA subcomplex (A-module) of INO80 | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, Actin-like protein ARP8, ... | | Authors: | Kunert, F, Metzner, F.J, Eustermann, S, Jung, J, Woike, S, Schall, K, Kostrewa, D, Hopfner, K.P. | | Deposit date: | 2022-06-14 | | Release date: | 2022-12-14 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural mechanism of extranucleosomal DNA readout by the INO80 complex.
Sci Adv, 8, 2022
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8A5O
 | | Structure of Arp4-Ies4-N-actin-Arp8-Ino80HSA subcomplex (A-module) of S. cerevisiae INO80 | | Descriptor: | Actin, Actin-like protein ARP8, Actin-related protein 4, ... | | Authors: | Kunert, F, Metzner, F.J, Eustermann, S, Jung, J, Woike, S, Schall, K, Kostrewa, D, Hopfner, K.P. | | Deposit date: | 2022-06-15 | | Release date: | 2022-12-14 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural mechanism of extranucleosomal DNA readout by the INO80 complex.
Sci Adv, 8, 2022
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8A5D
 | | Structure of Arp4-Ies4-N-actin-Arp8-Ino80HSA subcomplex (A-module) of Chaetomium thermophilum INO80 | | Descriptor: | Actin, Actin related protein 4 (Arp4), Actin-related protein 8, ... | | Authors: | Kunert, F, Metzner, F.J, Eustermann, S, Jung, J, Woike, S, Schall, K, Kostrewa, D, Hopfner, K.P. | | Deposit date: | 2022-06-14 | | Release date: | 2022-12-28 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural mechanism of extranucleosomal DNA readout by the INO80 complex.
Sci Adv, 8, 2022
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4WK1
 | | Crystal structure of Staphylococcus aureus PstA in complex with c-di-AMP | | Descriptor: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, CALCIUM ION, PstA | | Authors: | Mueller, M, Hopfner, K.-P, Witte, G. | | Deposit date: | 2014-10-01 | | Release date: | 2014-11-26 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | c-di-AMP recognition by Staphylococcus aureus PstA.
Febs Lett., 589, 2015
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4WK3
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4YVZ
 | | Structure of Thermotoga maritima DisA in complex with 3'-dATP/Mn2+ | | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, DNA integrity scanning protein DisA, MANGANESE (II) ION | | Authors: | Mueller, M, Deimling, T, Hopfner, K.-P, Witte, G. | | Deposit date: | 2015-03-20 | | Release date: | 2015-06-03 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.495 Å) | | Cite: | Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.
Biochem.J., 469, 2015
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4YXM
 | | Structure of Thermotoga maritima DisA D75N mutant with reaction product c-di-AMP | | Descriptor: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, (4S)-2-METHYL-2,4-PENTANEDIOL, DNA integrity scanning protein DisA | | Authors: | Mueller, M, Deimling, T, Hopfner, K.-P, Witte, G. | | Deposit date: | 2015-03-23 | | Release date: | 2015-06-03 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.
Biochem.J., 469, 2015
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4YXJ
 | | Structure of Thermotoga maritima DisA in complex with ApCpp | | Descriptor: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA integrity scanning protein DisA | | Authors: | Mueller, M, Deimling, T, Hopfner, K.-P, Witte, G. | | Deposit date: | 2015-03-23 | | Release date: | 2015-06-03 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.
Biochem.J., 469, 2015
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4JC5
 | | Immune activator bound to receptor | | Descriptor: | (9-oxoacridin-10(9H)-yl)acetic acid, Transmembrane protein 173 | | Authors: | Deimling, T, Hopfner, K.P. | | Deposit date: | 2013-02-21 | | Release date: | 2013-05-08 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Species-specific detection of the antiviral small-molecule compound CMA by STING.
Embo J., 32, 2013
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4JLX
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4JLZ
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1Z63
 | | Sulfolobus solfataricus SWI2/SNF2 ATPase core in complex with dsDNA | | Descriptor: | 5'-D(*AP*AP*AP*AP*AP*A*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*GP*AP*AP*AP*AP*AP*A)-3', 5'-D(*TP*TP*TP*TP*TP*TP*TP*CP*GP*TP*CP*TP*TP*CP*GP*GP*CP*AP*AP*TP*TP*TP*TP*TP*T)-3', Helicase of the snf2/rad54 family | | Authors: | Duerr, H, Koerner, C, Mueller, M, Hickmann, V, Hopfner, K.P. | | Deposit date: | 2005-03-21 | | Release date: | 2005-05-17 | | Last modified: | 2017-08-23 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | X-ray structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase core and its complex with DNA.
Cell(Cambridge,Mass.), 121, 2005
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4IMK
 | | Uncrossed Fab binding to human Angiopoietin 2 | | Descriptor: | GLYCEROL, Heavy Chain, Light Chain, ... | | Authors: | Fenn, S, Schiller, C, Griese, J.J, Hopfner, K.-P, Kettenberger, H. | | Deposit date: | 2013-01-03 | | Release date: | 2013-04-17 | | Last modified: | 2013-05-22 | | Method: | X-RAY DIFFRACTION (2.202 Å) | | Cite: | Crystal Structure of an Anti-Ang2 CrossFab Demonstrates Complete Structural and Functional Integrity of the Variable Domain.
Plos One, 8, 2013
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3OC3
 | | Crystal structure of the Mot1 N-terminal domain in complex with TBP | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, HELICASE MOT1, TRANSCRIPTION INITIATION FACTOR TFIID (TFIID-1) | | Authors: | Wollmann, P, Cui, S, Viswanathan, R, Berninghausen, O, Wells, M.N, Moldt, M, Witte, G, Butryn, A, Wendler, P, Beckmann, R, Auble, D.T, Hopfner, K.-P. | | Deposit date: | 2010-08-09 | | Release date: | 2011-07-13 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP.
Nature, 475, 2011
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3OCI
 | | Crystal structure of TBP (TATA box binding protein) | | Descriptor: | 1,2-ETHANEDIOL, TRANSCRIPTION INITIATION FACTOR TFIID (TFIID-1) | | Authors: | Cui, S, Wollmann, P, Moldt, M, Hopfner, K.-P. | | Deposit date: | 2010-08-10 | | Release date: | 2011-07-13 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.899 Å) | | Cite: | Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP.
Nature, 475, 2011
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3K1K
 | | Green fluorescent protein bound to enhancer nanobody | | Descriptor: | Enhancer, Green Fluorescent Protein | | Authors: | Kirchhofer, A, Helma, J, Schmidthals, K, Frauer, C, Cui, S, Karcher, A, Pellis, M, Muyldermans, S, Delucci, C.C, Cardoso, M.C, Leonhardt, H, Hopfner, K.-P, Rothbauer, U. | | Deposit date: | 2009-09-28 | | Release date: | 2009-12-08 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Modulation of protein properties in living cells using nanobodies
Nat.Struct.Mol.Biol., 17, 2010
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1XBS
 | | Crystal structure of human dim2: a dim1-like protein | | Descriptor: | Dim1-like protein | | Authors: | Simeoni, F, Arvai, A, Hopfner, K.-P, Bello, P, Gondeau, C, Heitz, F, Tainer, J, Divita, G. | | Deposit date: | 2004-08-31 | | Release date: | 2005-08-30 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Biochemical Characterization and Crystal Structure of a Dim1 Family Associated Protein: Dim2
Biochemistry, 44, 2005
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1XEX
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1XEW
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1US8
 | | The Rad50 signature motif: essential to ATP binding and biological function | | Descriptor: | DNA DOUBLE-STRAND BREAK REPAIR RAD50 ATPASE | | Authors: | Moncalian, G, Lengsfeld, B, Bhaskara, V, Hopfner, K.P, Karcher, A, Alden, E, Tainer, J.A, Paull, T.T. | | Deposit date: | 2003-11-20 | | Release date: | 2003-11-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The Rad50 Signature Motif: Essential to ATP Binding and Biological Function
J.Mol.Biol., 335, 2004
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1Z5Z
 | | Sulfolobus solfataricus SWI2/SNF2 ATPase C-terminal domain | | Descriptor: | Helicase of the snf2/rad54 family | | Authors: | Duerr, H, Koerner, C, Mueller, M, Hickmann, V, Hopfner, K.P. | | Deposit date: | 2005-03-21 | | Release date: | 2005-05-03 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | X-ray structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase core and its complex with DNA
Cell(Cambridge,Mass.), 121, 2005
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