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PDB: 300 件
1RHD
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STRUCTURE OF BOVINE LIVER RHODANESE. I. STRUCTURE DETERMINATION AT 2.5 ANGSTROMS RESOLUTION AND A COMPARISON OF THE CONFORMATION AND SEQUENCE OF ITS TWO DOMAINS
分子名称: RHODANESE
著者Hol, W.G.J, Ploegman, J.H, Kalk, K.H, Drent, G.
登録日1977-11-23
公開日1978-01-16
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of bovine liver rhodanese. I. Structure determination at 2.5 A resolution and a comparison of the conformation and sequence of its two domains.
J.Mol.Biol., 123, 1978
4KSS
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Crystal Structure of Vibrio cholerae ATPase GspsE Hexamer
分子名称: Type II secretion system protein E, hemolysin-coregulated protein
著者Hol, W.G, Turley, S, Lu, C.Y, Park, Y.J.
登録日2013-05-17
公開日2013-09-04
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (7.58 Å)
主引用文献Hexamers of the Type II Secretion ATPase GspE from Vibrio cholerae with Increased ATPase Activity.
Structure, 21, 2013
4KSR
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Crystal Structure of the Vibrio cholerae ATPase GspE Hexamer
分子名称: Type II secretion system protein E, Hemolysin-coregulated protein
著者Hol, W.G, Turley, S, Lu, C.Y, Park, Y.J, Marionni, S.T, Lee, K, Patrick, M, Sandkvist, M, Bush, M, Shah, R.
登録日2013-05-17
公開日2013-09-04
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献Hexamers of the Type II Secretion ATPase GspE from Vibrio cholerae with Increased ATPase Activity.
Structure, 21, 2013
1SVV
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Initial Stuctural Analysis of Leishmania major Threonine Aldolase
分子名称: THREONINE ALDOLASE, UNKNOWN LIGAND
著者Hol, W.G.J, Robien, M.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2004-03-30
公開日2004-08-17
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Initial Structural Analysis of Leishmania major Threonine Aldolase
To be Published
6TIM
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BU of 6tim by Molmil
THE ADAPTABILITY OF THE ACTIVE SITE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE AS OBSERVED IN THE CRYSTAL STRUCTURES OF THREE DIFFERENT COMPLEXES
分子名称: SN-GLYCEROL-3-PHOSPHATE, TRIOSEPHOSPHATE ISOMERASE
著者Noble, M.E.M, Wierenga, R.K, Hol, W.G.J.
登録日1991-04-23
公開日1992-10-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes.
Proteins, 10, 1991
1MAF
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The Active Site Structure of Methylamine Dehydrogenase: Hydrazines Identify C6 as the Reactive Site of the Tryptophan Derived Quinone Cofactor
分子名称: METHYLAMINE DEHYDROGENASE (HEAVY SUBUNIT), METHYLAMINE DEHYDROGENASE (LIGHT SUBUNIT), NITROGEN MOLECULE
著者Huizinga, E.G, Vellieux, F.M.D, Hol, W.G.J.
登録日1992-05-20
公開日1994-01-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Active site structure of methylamine dehydrogenase: hydrazines identify C6 as the reactive site of the tryptophan-derived quinone cofactor.
Biochemistry, 31, 1992
3CHB
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BU of 3chb by Molmil
CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHOLERA TOXIN, UNKNOWN ATOM OR ION, ...
著者Merritt, E.A, Hol, W.G.J.
登録日1998-03-24
公開日1998-08-12
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site.
J.Mol.Biol., 282, 1998
4TIM
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CRYSTALLOGRAPHIC AND MOLECULAR MODELING STUDIES ON TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE: A CRITICAL ASSESSMENT OF THE PREDICTED AND OBSERVED STRUCTURES OF THE COMPLEX WITH 2-PHOSPHOGLYCERATE
分子名称: 2-PHOSPHOGLYCERIC ACID, TRIOSEPHOSPHATE ISOMERASE
著者Nobel, M.E.M, Wierenga, R.K, Hol, W.G.J.
登録日1991-04-11
公開日1992-10-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate.
J.Med.Chem., 34, 1991
3CVL
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Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to T. brucei Phosphofructokinase (PFK) PTS1 peptide
分子名称: Peroxisome targeting signal 1 receptor PEX5, T. brucei PFK PTS1 peptide Ac-HEELAKL
著者Sampathkumar, P, Roach, C, Michels, P.A.M, Hol, W.G.J.
登録日2008-04-18
公開日2008-06-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural Insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.
J.Mol.Biol., 381, 2008
3CVQ
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Structure of Peroxisomal Targeting Signal 1 (PTS1) binding domain of Trypanosoma brucei Peroxin 5 (TbPEX5)complexed to PTS1 peptide (7-SKL)
分子名称: GLYCEROL, PTS1 peptide 7-SKL (Ac-SNRWSKL), Peroxisome targeting signal 1 receptor PEX5
著者Sampathkumar, P, Roach, C, Michels, P.A.M, Hol, W.G.J.
登録日2008-04-18
公開日2008-06-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Structural Insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5.
J.Mol.Biol., 381, 2008
3BWB
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BU of 3bwb by Molmil
Crystal structure of the apo form of spermidine synthase from Trypanosoma cruzi at 2.5 A resolution
分子名称: Spermidine synthase
著者Bosch, J, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
登録日2008-01-08
公開日2008-04-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of spermidine synthase from Trypanosoma cruzi.
To be Published
1M66
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Crystal Structure of Leishmania mexicana GPDH Complexed with Inhibitor 2-bromo-6-chloro-purine
分子名称: 2-BROMO-6-CHLORO-PURINE, Glycerol-3-phosphate dehydrogenase, PALMITIC ACID
著者Choe, J, Suresh, S, Wisedchaisri, G, Kennedy, K.J, Gelb, M.H, Hol, W.G.J.
登録日2002-07-12
公開日2002-12-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase
Chem.Biol., 9, 2002
1M67
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Crystal Structure of Leishmania mexicana GPDH Complexed with Inhibitor 2-bromo-6-hydroxy-purine
分子名称: 2-BROMO-6-HYDROXY-PURINE, Glycerol-3-phosphate dehydrogenase, PALMITIC ACID
著者Choe, J, Suresh, S, Wisedchaisri, G, Kennedy, K.J, Gelb, M.H, Hol, W.G.J.
登録日2002-07-12
公開日2002-12-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase
Chem.Biol., 9, 2002
4PHC
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Crystal Structure of a human cytosolic histidyl-tRNA synthetase, histidine-bound
分子名称: GLYCEROL, HISTIDINE, Histidine--tRNA ligase, ...
著者Koh, C.Y, Wetzel, A.B, de van der Schueren, W.J, Hol, W.G.J.
登録日2014-05-06
公開日2014-08-27
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.844 Å)
主引用文献Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases.
Biochimie, 106, 2014
2ISZ
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Crystal structure of a two-domain IdeR-DNA complex crystal form I
分子名称: Iron-dependent repressor ideR, NICKEL (II) ION, SODIUM ION, ...
著者Wisedchaisri, G, Chou, C.J, Wu, M, Roach, C, Rice, A.E, Holmes, R.K, Beeson, C, Hol, W.G.
登録日2006-10-18
公開日2007-02-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.403 Å)
主引用文献Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis
Biochemistry, 46, 2007
2ISY
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Crystal structure of the nickel-activated two-domain iron-dependent regulator (IdeR)
分子名称: Iron-dependent repressor ideR, NICKEL (II) ION, PHOSPHATE ION
著者Wisedchaisri, G, Chou, C.J, Wu, M, Roach, C, Rice, A.E, Holmes, R.K, Beeson, C, Hol, W.G.
登録日2006-10-18
公開日2007-02-13
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.955 Å)
主引用文献Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis
Biochemistry, 46, 2007
2IT0
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Crystal structure of a two-domain IdeR-DNA complex crystal form II
分子名称: ACETATE ION, Iron-dependent repressor ideR, NICKEL (II) ION, ...
著者Wisedchaisri, G, Chou, C.J, Wu, M, Roach, C, Rice, A.E, Holmes, R.K, Beeson, C, Hol, W.G.
登録日2006-10-18
公開日2007-02-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis
Biochemistry, 46, 2007
2I4S
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PDZ domain of EpsC from Vibrio cholerae, residues 204-305
分子名称: General secretion pathway protein C
著者Korotkov, K.V, Krumm, B, Bagdasarian, M, Hol, W.G.J.
登録日2006-08-22
公開日2006-10-17
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Structural and Functional Studies of EpsC, a Crucial Component of the Type 2 Secretion System from Vibrio cholerae.
J.Mol.Biol., 363, 2006
2I6V
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PDZ domain of EpsC from Vibrio cholerae, residues 219-305
分子名称: General secretion pathway protein C
著者Korotkov, K.V, Krumm, B, Bagdasarian, M, Hol, W.G.J.
登録日2006-08-29
公開日2006-10-17
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Structural and Functional Studies of EpsC, a Crucial Component of the Type 2 Secretion System from Vibrio cholerae.
J.Mol.Biol., 363, 2006
2GQ2
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Mycobacterium tuberculosis ThyX-NADP complex
分子名称: GLYCEROL, IODIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Sampathkumar, P, Turley, S, Sibley, C.H, Hol, W.G.
登録日2006-04-19
公開日2006-06-27
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献NADP+ expels both the co-factor and a substrate analog from the Mycobacterium tuberculosis ThyX active site: opportunities for anti-bacterial drug design.
J.Mol.Biol., 360, 2006
4YRL
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BU of 4yrl by Molmil
Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 4-(methylsulfanyl)aniline (Chem 262)
分子名称: 1,2-ETHANEDIOL, 4-(methylsulfanyl)aniline, DIMETHYL SULFOXIDE, ...
著者Koh, C.-Y, Hol, W.G.J.
登録日2015-03-15
公開日2015-08-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
4YP0
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BU of 4yp0 by Molmil
Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 5-aminoisoquinoline (Chem 79)
分子名称: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, HISTIDINE, ...
著者Koh, C.-Y, Hol, W.G.J.
登録日2015-03-12
公開日2015-08-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
4YRE
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BU of 4yre by Molmil
Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with (2-bromophenyl)methanol (Chem 145)
分子名称: (2-bromophenyl)methanol, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ...
著者Koh, C.-Y, Hol, W.G.J.
登録日2015-03-15
公開日2015-08-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
4YRJ
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Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 4-chlorobenzene-1,2-diamine (Chem 256)
分子名称: 1,2-ETHANEDIOL, 4-chlorobenzene-1,2-diamine, DIMETHYL SULFOXIDE, ...
著者Koh, C.-Y, Hol, W.G.J.
登録日2015-03-15
公開日2015-08-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
4YRS
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BU of 4yrs by Molmil
Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with N-(quinolin-3-yl)propanamide (Chem 1698)
分子名称: HISTIDINE, Histidyl-tRNA synthetase, N-(quinolin-3-yl)propanamide
著者Koh, C.-Y, Hol, W.G.J.
登録日2015-03-15
公開日2015-08-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015

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