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PDB: 164 件
5OCT
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Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method.
分子名称: DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, GTPase KRas, ...
著者Cruz-Migoni, A, Ehebauer, M.T, Phillips, S.E.V, Quevedo, C.E, Rabbitts, T.H.
登録日2017-07-03
公開日2018-08-22
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
Nat Commun, 9, 2018
3S4G
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Low Resolution Structure of STNV complexed with RNA
分子名称: Capsid protein, RNA (5'-R(P*AP*AP*A)-3'), RNA (5'-R(P*UP*UP*UP*U)-3')
著者Lane, S.W, Dennis, C.A, Lane, C.L, Trinh, C.H, Rizkallah, P.J, Stockley, P.G, Phillips, S.E.V.
登録日2011-05-19
公開日2011-08-03
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (6 Å)
主引用文献Construction and crystal structure of recombinant STNV capsids.
J.Mol.Biol., 413, 2011
1QY2
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Thermodynamics of Binding of 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the Major Urinary Protein
分子名称: 2-ISOPROPYL-3-METHOXYPYRAZINE, CADMIUM ION, Major Urinary Protein, ...
著者Bingham, R.J, Findlay, J.B.C, Hsieh, S.-Y, Kalverda, A.P, Kjellberg, A, Perazzolo, C, Phillips, S.E.V, Seshadri, K, Trinh, C.H, Turnbull, W.B, Bodenhausen, G, Homans, S.W.
登録日2003-09-09
公開日2004-02-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Thermodynamics of Binding of 2-Methoxy-3-isopropylpyrazine and 2-Methoxy-3-isobutylpyrazine to the Major Urinary Protein.
J.Am.Chem.Soc., 126, 2004
1QY1
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Thermodynamics of Binding of 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the Major Urinary Protein
分子名称: 2-ISOBUTYL-3-METHOXYPYRAZINE, CADMIUM ION, Major Urinary Protein, ...
著者Bingham, R.J, Findlay, J.B.C, Hsieh, S.-Y, Kalverda, A.P, Kjellberg, A, Perazzolo, C, Phillips, S.E.V, Seshadri, K, Trinh, C.H, Turnbull, W.B, Bodenhausen, G, Homans, S.W.
登録日2003-09-09
公開日2004-02-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Thermodynamics of Binding of 2-Methoxy-3-isopropylpyrazine and 2-Methoxy-3-isobutylpyrazine to the Major Urinary Protein.
J.Am.Chem.Soc., 126, 2004
5OYM
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HIV Integrase Binding Domain of Lens Epithelium-Derived Growth Factor
分子名称: PC4 and SFRS1-interacting protein
著者Rabbitts, T.H, Phillips, S.E.V, Cruz-Migoni, A, Carr, S.B, Hannon, C.
登録日2017-09-11
公開日2018-03-07
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Cloning, purification and structure determination of the HIV integrase-binding domain of lens epithelium-derived growth factor.
Acta Crystallogr F Struct Biol Commun, 74, 2018
5N88
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Crystal structure of antibody bound to viral protein
分子名称: PC4 and SFRS1-interacting protein, VH59 antibody
著者Bao, L, Hannon, C, Cruz-Migoni, A, Ptchelkine, D, Sun, M.-y, Derveni, M, Bunjobpol, W, Chambers, J.S, Simmons, A, Phillips, S.E.V, Rabbitts, T.H.
登録日2017-02-23
公開日2017-12-20
最終更新日2019-10-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein.
Sci Rep, 7, 2017
1OAC
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CRYSTAL STRUCTURE OF A QUINOENZYME: COPPER AMINE OXIDASE OF ESCHERICHIA COLI AT 2 ANGSTROEMS RESOLUTION
分子名称: CALCIUM ION, COPPER (II) ION, COPPER AMINE OXIDASE
著者Parsons, M.R, Convery, M.A, Wilmot, C.M, Phillips, S.E.V.
登録日1995-09-27
公開日1996-04-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of a quinoenzyme: copper amine oxidase of Escherichia coli at 2 A resolution.
Structure, 3, 1995
5OXE
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Structure of major capsid protein VP1 of Aeropyrum pernix bacilliform virus 1 APBV1
分子名称: Major virion protein
著者Huiskonen, J.T, Ptchelkine, D, Phillpps, S.E.V.
登録日2017-09-06
公開日2017-11-22
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Unique architecture of thermophilic archaeal virus APBV1 and its genome packaging.
Nat Commun, 8, 2017
1MJL
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METHIONINE REPRESSOR MUTANT (Q44K) COMPLEX WITH THE COREPRESSOR SAM (S-ADENOSYL METHIONINE) FROM ESCHERICHIA COLI
分子名称: METHIONINE REPRESSOR PROTEIN METJ, S-ADENOSYLMETHIONINE
著者Garvie, C.W, Phillips, S.E.V.
登録日1998-01-26
公開日1998-04-29
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystallographic studies of the methionine repressor-operator complex and the oc31 42kDa repressor
Thesis, University of Leeds, 1997
1QY0
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Thermodynamics of Binding of 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the Major Urinary Protein
分子名称: CADMIUM ION, GLYCEROL, Major urinary protein, ...
著者Bingham, R.J, Findlay, J.B.C, Hsieh, S.-Y, Kalverda, A.P, Kjellberg, A, Perazzolo, C, Phillips, S.E.V, Seshadri, K, Trinh, C.H, Turnbull, W.B, Bodenhausen, G, Homans, S.W.
登録日2003-09-09
公開日2004-02-24
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Thermodynamics of Binding of 2-Methoxy-3-isopropylpyrazine and 2-Methoxy-3-isobutylpyrazine to the Major Urinary Protein.
J.Am.Chem.Soc., 126, 2004
5OCO
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BU of 5oco by Molmil
Discovery of small molecules binding to KRAS via high affinity antibody fragment competition method.
分子名称: CITRIC ACID, DI(HYDROXYETHYL)ETHER, GTPase KRas, ...
著者Cruz-Migoni, A, Ehebauer, M.T, Phillips, S.E.V, Quevedo, C.E, Rabbitts, T.H.
登録日2017-07-03
公開日2018-08-22
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
Nat Commun, 9, 2018
1PKL
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THE STRUCTURE OF LEISHMANIA PYRUVATE KINASE
分子名称: PROTEIN (PYRUVATE KINASE), SULFATE ION
著者Rigden, D.J, Phillips, S.E.V, Michels, P.A.M, Fothergill-Gilmore, L.A.
登録日1998-09-15
公開日1998-09-23
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献The structure of pyruvate kinase from Leishmania mexicana reveals details of the allosteric transition and unusual effector specificity.
J.Mol.Biol., 291, 1999
5PGM
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SACCHAROMYCES CEREVISIAE PHOSPHOGLYCERATE MUTASE
分子名称: ALANINE, PHOSPHOGLYCERATE MUTASE 1, SULFATE ION
著者Rigden, D.J, Phillips, S.E.V, Fothergill-Gilmore, L.A.
登録日1998-08-19
公開日1999-02-16
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Sulphate ions observed in the 2.12 A structure of a new crystal form of S. cerevisiae phosphoglycerate mutase provide insights into understanding the catalytic mechanism.
J.Mol.Biol., 286, 1999
1MJK
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METHIONINE REPRESSOR MUTANT APOREPRESSOR (Q44K) FROM ESCHERICHIA COLI
分子名称: METHIONINE REPRESSOR, PHOSPHATE ION
著者Garvie, C.W, Phillips, S.E.V.
登録日1998-01-16
公開日1998-05-27
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystallographic studies of the methionine repressor-operator complex and the oc31 42kDa repressor
Thesis, University of Leeds, 1997
1SPU
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STRUCTURE OF OXIDOREDUCTASE
分子名称: CALCIUM ION, COPPER (II) ION, COPPER AMINE OXIDASE
著者Wilmot, C.M, Phillips, S.E.V.
登録日1996-11-13
公開日1997-03-12
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Catalytic mechanism of the quinoenzyme amine oxidase from Escherichia coli: exploring the reductive half-reaction.
Biochemistry, 36, 1997
4PGM
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SACCHAROMYCES CEREVISIAE PHOSPHOGLYCERATE MUTASE
分子名称: PHOSPHOGLYCERATE MUTASE 1
著者Rigden, D.J, Alexeev, D, Phillips, S.E.V, Fothergill-Gilmore, L.A.
登録日1997-04-25
公開日1997-10-29
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The 2.3 A X-ray crystal structure of S. cerevisiae phosphoglycerate mutase.
J.Mol.Biol., 276, 1998
1YP7
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Van der Waals Interactions Dominate Hydrophobic Association in a Protein Binding Site Occluded From Solvent Water
分子名称: CADMIUM ION, MAJOR URINARY PROTEIN 1
著者Barratt, E, Bingham, R.J, Warner, D.J, Laughton, C.A, Phillips, S.E.V, Homans, S.W.
登録日2005-01-30
公開日2005-08-30
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Van der Waals Interactions Dominate Ligand-Protein Association in a Protein Binding Site Occluded from Solvent Water
J.Am.Chem.Soc., 127, 2005
1BFV
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MONOCLONAL ANTIBODY FRAGMENT FV4155 FROM E. COLI
分子名称: ESTRIOL 3-(B-D-GLUCURONIDE), FV4155, ZINC ION
著者Trinh, C.H, Phillips, S.E.V.
登録日1997-05-27
公開日1997-12-03
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Antibody fragment Fv4155 bound to two closely related steroid hormones: the structural basis of fine specificity.
Structure, 5, 1997
1BQ4
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SACCHAROMYCES CEREVISIAE PHOSPHOGLYCERATE MUTASE IN COMPLEX WITH BENZENE HEXACARBOXYLATE
分子名称: BENZENE HEXACARBOXYLIC ACID, PROTEIN (PHOSPHOGLYCERATE MUTASE 1), SULFATE ION
著者Rigden, D.J, Phillips, S.E.V, Fothergill-Gilmore, L.A.
登録日1998-08-20
公開日1998-08-26
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Polyanionic inhibitors of phosphoglycerate mutase: combined structural and biochemical analysis.
J.Mol.Biol., 289, 1999
1YP6
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Van der Waals Interactions Dominate Hydrophobic Association in a Protein Binding Site Occluded From Solvent Water
分子名称: 2-ISOBUTYL-3-METHOXYPYRAZINE, CADMIUM ION, CHLORIDE ION, ...
著者Barratt, E, Bingham, R.J, Warner, D.J, Laughton, C.A, Phillips, S.E.V, Homans, S.W.
登録日2005-01-30
公開日2005-08-30
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Van der Waals Interactions Dominate Ligand-Protein Association in a Protein Binding Site Occluded from Solvent Water
J.Am.Chem.Soc., 127, 2005
1ZSE
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RNA stemloop from bacteriophage Qbeta complexed with an N87S mutant MS2 Capsid
分子名称: Coat protein, RNA HAIRPIN
著者Horn, W.T, Tars, K, Grahn, E, Helgstrand, C, Baron, A.J, Lago, H, Adams, C.J, Peabody, D.S, Phillips, S.E.V, Stonehouse, N.J, Liljas, L, Stockley, P.G.
登録日2005-05-24
公開日2006-05-09
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural Basis of RNA Binding Discrimination between Bacteriophages Qbeta and MS2
Structure, 14, 2006
1D6Z
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CRYSTAL STRUCTURE OF THE AEROBICALLY FREEZE TRAPPED RATE-DETERMINING CATALYTIC INTERMEDIATE OF E. COLI COPPER-CONTAINING AMINE OXIDASE.
分子名称: 2-PHENYLETHYLAMINE, CALCIUM ION, COPPER (II) ION, ...
著者Wilmot, C.M, Hajdu, J, McPherson, M.J, Knowles, P.F, Phillips, S.E.V.
登録日1999-10-16
公開日2000-02-02
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Visualization of dioxygen bound to copper during enzyme catalysis.
Science, 286, 1999
1CMC
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BU of 1cmc by Molmil
THREE DIMENSIONAL CRYSTAL STRUCTURES OF E. COLI MET REPRESSOR WITH AND WITHOUT COREPRESSOR
分子名称: MAGNESIUM ION, MET REPRESSOR, S-ADENOSYLMETHIONINE
著者Somers, W.S, Phillips, S.E.V.
登録日1992-08-28
公開日1993-10-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Three-dimensional crystal structures of Escherichia coli met repressor with and without corepressor.
Nature, 341, 1989
1D6Y
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CRYSTAL STRUCTURE OF E. COLI COPPER-CONTAINING AMINE OXIDASE ANAEROBICALLY REDUCED WITH BETA-PHENYLETHYLAMINE AND COMPLEXED WITH NITRIC OXIDE.
分子名称: 2-PHENYLETHYLAMINE, CALCIUM ION, COPPER (II) ION, ...
著者Wilmot, C.M, Hajdu, J, McPherson, M.J, Knowles, P.F, Phillips, S.E.V.
登録日1999-10-16
公開日2000-02-02
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Visualization of dioxygen bound to copper during enzyme catalysis.
Science, 286, 1999
1CFV
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MONOCLONAL ANTIBODY FRAGMENT FV4155 FROM E. COLI
分子名称: ESTRONE BETA-D-GLUCURONIDE, MONOCLONAL ANTIBODY FV4155, ZINC ION
著者Trinh, C.H, Phillips, S.E.V.
登録日1997-04-11
公開日1997-10-15
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Antibody fragment Fv4155 bound to two closely related steroid hormones: the structural basis of fine specificity.
Structure, 5, 1997

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