1EYO
 
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1N3K
 | | Solution structure of phosphoprotein enriched in astrocytes 15 kDa (PEA-15) | | Descriptor: | Astrocytic phosphoprotein PEA-15 | | Authors: | Hill, J.M, Vaidyanathan, H, Ramos, J.W, Ginsberg, M.H, Werner, M.H. | | Deposit date: | 2002-10-28 | | Release date: | 2003-01-14 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Recognition of ERK MAP Kinase by PEA-15 Reveals a Common Docking Site Within the Death Domain and Death Effector Domain
Embo J., 21, 2002
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1JPH
 | | Ile260Thr mutant of Human UroD, human uroporphyrinogen III decarboxylase | | Descriptor: | UROPORPHYRINOGEN DECARBOXYLASE | | Authors: | Phillips, J.D, Parker, T.L, Schubert, H.L, Whitby, F.G, Hill, C.P, Kushner, J.P. | | Deposit date: | 2001-08-02 | | Release date: | 2001-12-19 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Functional consequences of naturally occurring mutations in human uroporphyrinogen decarboxylase.
Blood, 98, 2001
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1JPK
 | | Gly156Asp mutant of Human UroD, human uroporphyrinogen III decarboxylase | | Descriptor: | UROPORPHYRINOGEN DECARBOXYLASE | | Authors: | Phillips, J.D, Parker, T.L, Schubert, H.L, Whitby, F.G, Hill, C.P, Kushner, J.P. | | Deposit date: | 2001-08-02 | | Release date: | 2001-12-19 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Functional consequences of naturally occurring mutations in human uroporphyrinogen decarboxylase.
Blood, 98, 2001
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1JPI
 | | Phe232Leu mutant of human UROD, human uroporphyrinogen III decarboxylase | | Descriptor: | UROPORPHYRINOGEN DECARBOXYLASE | | Authors: | Phillips, J.D, Parker, T.L, Schubert, H.L, Whitby, F.G, Hill, C.P, Kushner, J.P. | | Deposit date: | 2001-08-02 | | Release date: | 2001-12-19 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Functional consequences of naturally occurring mutations in human uroporphyrinogen decarboxylase.
Blood, 98, 2001
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5MHF
 | | Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin. | | Descriptor: | 2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mannosyl-oligosaccharide glucosidase, ... | | Authors: | Hill, J.C, Caputo, A.T, Roversi, P, Zitzmann, N. | | Deposit date: | 2016-11-24 | | Release date: | 2017-12-20 | | Last modified: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Targeting Endoplasmic Reticulum alpha-Glucosidase I with a Single-Dose Iminosugar Treatment Protects against Lethal Influenza and Dengue Virus Infections.
J.Med.Chem., 2020
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1TLB
 | | Yeast coproporphyrinogen oxidase | | Descriptor: | Coproporphyrinogen III oxidase, SULFATE ION | | Authors: | Phillip, J.D, Whitby, F.G, Warby, C.A, Labbe, P, Yang, C, Pflugrath, J.W, Ferrara, J.D, Robinson, H, Kushner, J.P, Hill, C.P. | | Deposit date: | 2004-06-09 | | Release date: | 2004-07-20 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the oxygen-dependent coproporphyrinogen oxidase (Hem13p) of Saccharomyces cerevisiae
J.Biol.Chem., 279, 2004
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1TK1
 | | YEAST OXYGEN-DEPENDENT COPROPORPHYRINOGEN OXIDASE | | Descriptor: | Coproporphyrinogen III oxidase | | Authors: | Phillips, J.D, Whitby, F.G, Warby, C.A, Labbe, P, Yang, C, Pflugrath, J.W, Ferrara, J.D, Robinson, H, Kushner, J.P, Hill, C.P. | | Deposit date: | 2004-06-08 | | Release date: | 2004-07-20 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal Structure of the Oxygen-dependant Coproporphyrinogen Oxidase (Hem13p) of Saccharomyces cerevisiae
J.Biol.Chem., 279, 2004
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1TKL
 | | Yeast Oxygen-Dependent Coproporphyrinogen Oxidase | | Descriptor: | Coproporphyrinogen III oxidase | | Authors: | Phillips, J.D, Whitby, F.G, Warby, C.A, Labbe, P, Yang, C, Pflugrath, J.W, Ferrara, J.D, Robinson, H, Kushner, J.P, Hill, C.P. | | Deposit date: | 2004-06-08 | | Release date: | 2004-07-20 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of the Oxygen-dependant Coproporphyrinogen Oxidase (Hem13p) of Saccharomyces cerevisiae
J.Biol.Chem., 279, 2004
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1R3V
 | | Uroporphyrinogen Decarboxylase single mutant D86E in complex with coproporphyrinogen-I | | Descriptor: | BETA-MERCAPTOETHANOL, COPROPORPHYRINOGEN I, Uroporphyrinogen Decarboxylase | | Authors: | Phillips, J.D, Whitby, F.G, Kushner, J.P, Hill, C.P. | | Deposit date: | 2003-10-03 | | Release date: | 2003-12-09 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase
Embo J., 22, 2003
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1R3W
 | | Uroporphyrinogen Decarboxylase Y164F mutant in complex with coproporphyrinogen-III | | Descriptor: | COPROPORPHYRINOGEN III, Uroporphyrinogen Decarboxylase | | Authors: | Phillips, J.D, Whitby, F.G, Kushner, J.P, Hill, C.P. | | Deposit date: | 2003-10-03 | | Release date: | 2003-12-09 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase
Embo J., 22, 2003
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1R3S
 | | Uroporphyrinogen Decarboxylase single mutant D86G in complex with coproporphyrinogen-I | | Descriptor: | COPROPORPHYRINOGEN I, Uroporphyrinogen Decarboxylase | | Authors: | Phillips, J.D, Whitby, F.G, Kushner, J.P, Hill, C.P. | | Deposit date: | 2003-10-03 | | Release date: | 2003-12-09 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase
Embo J., 22, 2003
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1R3Q
 | | Uroporphyrinogen Decarboxylase in complex with coproporphyrinogen-I | | Descriptor: | CARBON DIOXIDE, COPROPORPHYRINOGEN I, Uroporphyrinogen Decarboxylase | | Authors: | Phillips, J.D, Whitby, F.G, Kushner, J.P, Hill, C.P. | | Deposit date: | 2003-10-03 | | Release date: | 2003-12-09 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase
Embo J., 22, 2003
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1R3R
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1R3T
 | | Uroporphyrinogen Decarboxylase single mutant D86G in complex with coproporphyrinogen-III | | Descriptor: | COPROPORPHYRINOGEN III, Uroporphyrinogen Decarboxylase | | Authors: | Phillips, J.D, Whitby, F.G, Kushner, J.P, Hill, C.P. | | Deposit date: | 2003-10-03 | | Release date: | 2003-12-09 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase
Embo J., 22, 2003
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1GIB
 | | MU-CONOTOXIN GIIIB, NMR | | Descriptor: | MU-CONOTOXIN GIIIB | | Authors: | Hill, J.M, Alewood, P.F, Craik, D.J. | | Deposit date: | 1996-04-17 | | Release date: | 1996-11-08 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels.
Biochemistry, 35, 1996
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1R3Y
 | | Uroporphyrinogen Decarboxylase in complex with coproporphyrinogen-III | | Descriptor: | COPROPORPHYRINOGEN III, Uroporphyrinogen Decarboxylase | | Authors: | Phillips, J.D, Whitby, F.G, Kushner, J.P, Hill, C.P. | | Deposit date: | 2003-10-03 | | Release date: | 2003-12-09 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.755 Å) | | Cite: | Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase
Embo J., 22, 2003
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2Q71
 | | Uroporphyrinogen Decarboxylase G168R single mutant enzyme in complex with coproporphyrinogen-III | | Descriptor: | COPROPORPHYRINOGEN III, Uroporphyrinogen decarboxylase | | Authors: | Phillips, J.D, Whitby, F.G, Stadtmueller, B.M, Edwards, C.Q, Hill, C.P, Kushner, J.P. | | Deposit date: | 2007-06-05 | | Release date: | 2007-06-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Two Novel Uropophyrinogen Decarboxylase (URO-D) Mutations Causing Hepatoerythropoietic Porphyria (HEP)
Transl.Res., 149, 2007
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2Q6Z
 | | Uroporphyrinogen Decarboxylase G168R single mutant apo-enzyme | | Descriptor: | Uroporphyrinogen decarboxylase | | Authors: | Phillips, J.D, Whitby, F.G, Stadtmueller, B.M, Edwards, C.Q, Hill, C.P, Kushner, J.P. | | Deposit date: | 2007-06-05 | | Release date: | 2007-06-26 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Two novel uroporphyrinogen decarboxylase (URO-D) mutations causing hepatoerythropoietic porphyria (HEP).
Transl.Res., 149, 2007
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4WMJ
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1MII
 | | SOLUTION STRUCTURE OF ALPHA-CONOTOXIN MII | | Descriptor: | PROTEIN (ALPHA CONOTOXIN MII) | | Authors: | Hill, J.M, Oomen, C.J, Miranda, L.P, Bingham, J.P, Alewood, P.F, Craik, D.J. | | Deposit date: | 1998-10-05 | | Release date: | 1998-10-21 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Three-dimensional solution structure of alpha-conotoxin MII by NMR spectroscopy: effects of solution environment on helicity.
Biochemistry, 37, 1998
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1AG7
 | | CONOTOXIN GS, NMR, 20 STRUCTURES | | Descriptor: | CONOTOXIN GS | | Authors: | Hill, J.M, Alewood, P.F, Craik, D.J. | | Deposit date: | 1997-04-03 | | Release date: | 1998-04-08 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the sodium channel antagonist conotoxin GS: a new molecular caliper for probing sodium channel geometry.
Structure, 5, 1997
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6YV4
 | | STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A PYRROLE-3-CARBOXYLIC ACID FRAGMENT 686 | | Descriptor: | 1,2-ETHANEDIOL, 1-cyclopropyl-2,5-dimethyl-pyrrole-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Hillier, J, Ruza, R.R, Jones, E.Y. | | Deposit date: | 2020-04-27 | | Release date: | 2020-05-06 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.
J.Med.Chem., 63, 2020
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6YUY
 | | STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A PYRROLE-3-CARBOXYLIC ACID FRAGMENT 471 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-methyl-5-(trifluoromethyl)-1~{H}-pyrrole-3-carboxylic acid, DIMETHYL SULFOXIDE, ... | | Authors: | Hillier, J, Ruza, R.R, Jones, E.Y. | | Deposit date: | 2020-04-27 | | Release date: | 2020-05-06 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.
J.Med.Chem., 63, 2020
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7ZKP
 | | Late assembly intermediate of the proximal proton pumping module of complex I with assembly factors NDUFAF1 and CIA84 | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CARDIOLIPIN, ... | | Authors: | Schiller, J, Laube, E, Vonck, J, Zickermann, V. | | Deposit date: | 2022-04-13 | | Release date: | 2022-11-23 | | Last modified: | 2022-11-30 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Insights into complex I assembly: Function of NDUFAF1 and a link with cardiolipin remodeling.
Sci Adv, 8, 2022
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