7PHW
 
 | | PfCyRPA bound to monoclonal antibody Cy.004 Fab fragment | | Descriptor: | CALCIUM ION, Cysteine-rich protective antigen, Monoclonal antibody Cy.004 heavy chain, ... | | Authors: | Ragotte, R.J, Higgins, M.K. | | Deposit date: | 2021-08-18 | | Release date: | 2022-02-09 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.793 Å) | | Cite: | Heterotypic interactions drive antibody synergy against a malaria vaccine candidate.
Nat Commun, 13, 2022
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7PI2
 | | PfCyRPA bound to monoclonal antibody Cy.003 Fab fragment | | Descriptor: | Cysteine-rich protective antigen, Monoclonal antibody Cy.003 heavy chain, Monoclonal antibody Cy.003 light chain | | Authors: | Ragotte, R.J, Higgins, M.K. | | Deposit date: | 2021-08-19 | | Release date: | 2022-02-09 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.14 Å) | | Cite: | Heterotypic interactions drive antibody synergy against a malaria vaccine candidate.
Nat Commun, 13, 2022
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2J44
 | | Alpha-glucan binding by a streptococcal virulence factor | | Descriptor: | ALKALINE AMYLOPULLULANASE, ZINC ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... | | Authors: | Lammerts van Bueren, A, Higgins, M, Wang, D, Burke, R.D, Boraston, A.B. | | Deposit date: | 2006-08-24 | | Release date: | 2006-12-11 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Identification and Structural Basis of Binding to Host Lung Glycogen by Streptococcal Virulence Factors.
Nat.Struct.Mol.Biol., 14, 2007
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2J43
 | | Alpha-glucan recognition by family 41 carbohydrate-binding modules from streptococcal virulence factors | | Descriptor: | SPYDX | | Authors: | Lammerts van Bueren, A, Higgins, M, Wang, D, Burke, R.D, Boraston, A.B. | | Deposit date: | 2006-08-24 | | Release date: | 2006-12-11 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Identification and Structural Basis of Binding to Host Lung Glycogen by Streptococcal Virulence Factors.
Nat.Struct.Mol.Biol., 14, 2007
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5AC5
 | | GH20C, Beta-hexosaminidase from Streptococcus pneumoniae in complex with GlcNAc | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | | Authors: | Cid, M, Robb, C.S, Higgins, M.A, Boraston, A.B. | | Deposit date: | 2015-08-11 | | Release date: | 2015-09-23 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | A Second beta-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans.
J. Biol. Chem., 290, 2015
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5AC4
 | | GH20C, Beta-hexosaminidase from Streptococcus pneumoniae in complex with GalNAc | | Descriptor: | 2-acetamido-2-deoxy-beta-D-galactopyranose, N-ACETYL-BETA-D-GLUCOSAMINIDASE | | Authors: | Cid, M, Robb, C.S, Higgins, M.A, Boraston, A.B. | | Deposit date: | 2015-08-11 | | Release date: | 2015-09-23 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | A Second beta-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans.
J. Biol. Chem., 290, 2015
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5A6B
 | | GH20C, Beta-hexosaminidase from Streptococcus pneumoniae in complex with PUGNAc | | Descriptor: | MAGNESIUM ION, N-ACETYL-BETA-D-GLUCOSAMINIDASE, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE | | Authors: | Cid, M, Robb, C.S, Higgins, M.A, Boraston, A.B. | | Deposit date: | 2015-06-24 | | Release date: | 2015-09-23 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | A Second beta-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans.
J. Biol. Chem., 290, 2015
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5A69
 | | GH20C, Beta-hexosaminidase from Streptococcus pneumoniae in complex with Gal-PUGNAc | | Descriptor: | N-ACETYL-BETA-D-GLUCOSAMINIDASE, [(Z)-[(3R,4R,5R,6R)-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-ylidene]amino] N-phenylcarbamate | | Authors: | Cid, M, Robb, C.S, Higgins, M.A, Boraston, A.B. | | Deposit date: | 2015-06-24 | | Release date: | 2015-09-23 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | A Second beta-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans.
J. Biol. Chem., 290, 2015
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5A6J
 | | GH20C, Beta-hexosaminidase from Streptococcus pneumoniae | | Descriptor: | 1,2-ETHANEDIOL, N-ACETYL-BETA-D-GLUCOSAMINIDASE | | Authors: | Cid, M, Robb, C.S, Higgins, M.A, Boraston, A.B. | | Deposit date: | 2015-06-26 | | Release date: | 2015-09-23 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | A Second beta-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans.
J. Biol. Chem., 290, 2015
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5A6K
 | | GH20C, Beta-hexosaminidase from Streptococcus pneumoniae in complex with Gal-NGT | | Descriptor: | (2S,3aR,5R,6R,7R,7aR)-5-(hydroxymethyl)-2-methyl-2,3a,5,6,7,7a-hexahydro-1H-pyrano[3,2-d][1,3]thiazole-6,7-diol, GH20C | | Authors: | Cid, M, Robb, C.S, Higgins, M.A, Boraston, A.B. | | Deposit date: | 2015-06-26 | | Release date: | 2015-09-23 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | A Second Beta-Hexosaminidase Encoded in the Streptococcus Pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans
J.Biol.Chem., 290, 2015
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5A6A
 | | GH20C, Beta-hexosaminidase from Streptococcus pneumoniae in complex with NGT | | Descriptor: | 1,2-ETHANEDIOL, 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL, N-ACETYL-BETA-D-GLUCOSAMINIDASE | | Authors: | Cid, M, Robb, C.S, Higgins, M.A, Boraston, A.B. | | Deposit date: | 2015-06-24 | | Release date: | 2015-09-23 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.69 Å) | | Cite: | A Second beta-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans.
J. Biol. Chem., 290, 2015
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2WAU
 | | Structure of DBL6 epsilon domain from VAR2CSA | | Descriptor: | ERYTHROCYTE MEMBRANE PROTEIN 1 (PFEMP1) | | Authors: | Khunrae, P, Higgins, M.K. | | Deposit date: | 2009-02-16 | | Release date: | 2009-08-18 | | Last modified: | 2014-12-03 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural Comparison of Two Cspg-Binding Dbl Domains from the Var2Csa Protein Important in Malaria During Pregnancy.
J.Mol.Biol., 393, 2009
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2YL8
 | | Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose, BETA-N-ACETYLHEXOSAMINIDASE, ... | | Authors: | Pluvinage, B, Higgins, M.A, Abbott, D.W, Robb, C, Dalia, A.B, Deng, L, Weiser, J.N, Parsons, T.B, Fairbanks, A.J, Vocadlo, D.J, Boraston, A.B. | | Deposit date: | 2011-05-31 | | Release date: | 2011-09-07 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Inhibition of the Pneumococcal Virulence Factor Strh and Molecular Insights Into N-Glycan Recognition and Hydrolysis.
Structure, 19, 2011
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2YL9
 | | INHIBITION OF THE PNEUMOCOCCAL VIRULENCE FACTOR STRH AND MOLECULAR INSIGHTS INTO N-GLYCAN RECOGNITION AND HYDROLYSIS | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BETA-N-ACETYLHEXOSAMINIDASE | | Authors: | Pluvinage, B, Higgins, M.A, Abbott, D.W, Robb, C, Dalia, A.B, Deng, L, Weiser, J.N, Parsons, T.B, Fairbanks, A.J, Vocadlo, D.J, Boraston, A.B. | | Deposit date: | 2011-06-01 | | Release date: | 2011-09-21 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Inhibition of the Pneumococcal Virulence Factor Strh and Molecular Insights Into N-Glycan Recognition and Hydrolysis.
Structure, 19, 2011
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2YL5
 | | Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis | | Descriptor: | 1,2-ETHANEDIOL, BETA-N-ACETYLHEXOSAMINIDASE, MAGNESIUM ION | | Authors: | Pluvinage, B, Higgins, M.A, Abbott, D.W, Robb, C, Dalia, A.B, Deng, L, Weiser, J.N, Parsons, T.B, Fairbanks, A.J, Vocadlo, D.J, Boraston, A.B. | | Deposit date: | 2011-05-31 | | Release date: | 2011-09-14 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Inhibition of the Pneumococcal Virulence Factor Strh and Molecular Insights Into N-Glycan Recognition and Hydrolysis.
Structure, 19, 2011
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2YLL
 | | Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis | | Descriptor: | 1,2-ETHANEDIOL, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, BETA-N-ACETYLHEXOSAMINIDASE, ... | | Authors: | Pluvinage, B, Higgins, M.A, Abbott, D.W, Robb, C, Dalia, A.B, Deng, L, Weiser, J.N, Parsons, T.B, Fairbanks, A.J, Vocadlo, D.J, Boraston, A.B. | | Deposit date: | 2011-06-02 | | Release date: | 2011-09-21 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Inhibition of the Pneumococcal Virulence Factor Strh and Molecular Insights Into N-Glycan Recognition and Hydrolysis.
Structure, 19, 2011
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2YA2
 | | Catalytic Module of the Multi-modular glycogen-degrading pneumococcal virulence factor SpuA in complex with an inhibitor. | | Descriptor: | CALCIUM ION, PUTATIVE ALKALINE AMYLOPULLULANASE, SODIUM ION, ... | | Authors: | Lammerts van Bueren, A, Ficko-Blean, E, Pluvinage, B, Hehemann, J.H, Higgins, M.A, Deng, L, Ogunniyi, A.D, Stroeher, U.H, Warry, N.E, Burke, R.D, Czjzek, M, Paton, J.C, Vocadlo, D.J, Boraston, A.B. | | Deposit date: | 2011-02-17 | | Release date: | 2011-04-20 | | Last modified: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | The Conformation and Function of a Multimodular Glycogen-Degrading Pneumococcal Virulence Factor.
Structure, 19, 2011
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2YA0
 | | Catalytic Module of the Multi-modular glycogen-degrading pneumococcal virulence factor SpuA | | Descriptor: | CALCIUM ION, GLYCEROL, PUTATIVE ALKALINE AMYLOPULLULANASE, ... | | Authors: | Lammerts van Bueren, A, Ficko-Blean, E, Pluvinage, B, Hehemann, J.H, Higgins, M.A, Deng, L, Ogunniyi, A.D, Stroeher, U.H, Warry, N.E, Burke, R.D, Czjzek, M, Paton, J.C, Vocadlo, D.J, Boraston, A.B. | | Deposit date: | 2011-02-17 | | Release date: | 2011-04-20 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | The Conformation and Function of a Multimodular Glycogen-Degrading Pneumococcal Virulence Factor.
Structure, 19, 2011
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2YLA
 | | INHIBITION OF THE PNEUMOCOCCAL VIRULENCE FACTOR STRH AND MOLECULAR INSIGHTS INTO N-GLYCAN RECOGNITION AND HYDROLYSIS | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Pluvinage, B, Higgins, M.A, Abbott, D.W, Robb, C, Dalia, A.B, Deng, L, Weiser, J.N, Parsons, T.B, Fairbanks, A.J, Vocadlo, D.J, Boraston, A.B. | | Deposit date: | 2011-06-01 | | Release date: | 2011-09-07 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Inhibition of the Pneumococcal Virulence Factor Strh and Molecular Insights Into N-Glycan Recognition and Hydrolysis.
Structure, 19, 2011
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2YL6
 | | Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis | | Descriptor: | 1,2-ETHANEDIOL, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, BETA-N-ACETYLHEXOSAMINIDASE, ... | | Authors: | Pluvinage, B, Higgins, M.A, Abbott, D.W, Robb, C, Dalia, A.B, Deng, L, Weiser, J.N, Parsons, T.B, Fairbanks, A.J, Vocadlo, D.J, Boraston, A.B. | | Deposit date: | 2011-05-31 | | Release date: | 2011-09-14 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Inhibition of the Pneumococcal Virulence Factor Strh and Molecular Insights Into N-Glycan Recognition and Hydrolysis.
Structure, 19, 2011
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2YA1
 | | Product complex of a multi-modular glycogen-degrading pneumococcal virulence factor SpuA | | Descriptor: | PUTATIVE ALKALINE AMYLOPULLULANASE, SODIUM ION, SULFATE ION, ... | | Authors: | Lammerts van Bueren, A, Ficko-Blean, E, Pluvinage, B, Hehemann, J.H, Higgins, M.A, Deng, L, Ogunniyi, A.D, Stroeher, U.H, Warry, N.E, Burke, R.D, Czjzek, M, Paton, J.C, Vocadlo, D.J, Boraston, A.B. | | Deposit date: | 2011-02-17 | | Release date: | 2011-04-20 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | The Conformation and Function of a Multimodular Glycogen-Degrading Pneumococcal Virulence Factor.
Structure, 19, 2011
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2XD3
 | | The crystal structure of MalX from Streptococcus pneumoniae in complex with maltopentaose. | | Descriptor: | MALTOSE/MALTODEXTRIN-BINDING PROTEIN, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | Authors: | Abbott, D.W, Higgins, M.A, Hyrnuik, S, Pluvinage, B, Lammerts van Bueren, A, Boraston, A.B. | | Deposit date: | 2010-04-28 | | Release date: | 2010-06-09 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The Molecular Basis of Glycogen Breakdown and Transport in Streptococcus Pneumoniae.
Mol.Microbiol., 77, 2010
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2XD2
 | | The crystal structure of MalX from Streptococcus pneumoniae | | Descriptor: | MALTOSE/MALTODEXTRIN-BINDING PROTEIN | | Authors: | Abbott, D.W, Higgins, M.A, Hyrnuik, S, Pluvinage, B, Lammerts van Bueren, A, Boraston, A.B. | | Deposit date: | 2010-04-28 | | Release date: | 2010-06-09 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The Molecular Basis of Glycogen Breakdown and Transport in Streptococcus Pneumoniae.
Mol.Microbiol., 77, 2010
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6SNY
 | | Synthetic mimic of an EPCR-binding PfEMP1 bound to EPCR | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Endothelial protein C receptor, ... | | Authors: | Barber, N.M, Higgins, M.K. | | Deposit date: | 2019-08-27 | | Release date: | 2019-09-04 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.11 Å) | | Cite: | Structure-Guided Design of a Synthetic Mimic of an Endothelial Protein C Receptor-Binding PfEMP1 Protein.
Msphere, 6, 2021
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6RCO
 | | PfRH5-binding monoclonal antibody R5.004 | | Descriptor: | ACETATE ION, GLYCEROL, R5.004 heavy chain, ... | | Authors: | Alanine, D.G.W, Draper, S.J, Higgins, M.K. | | Deposit date: | 2019-04-11 | | Release date: | 2019-06-26 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.
Cell, 178, 2019
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