5A69

GH20C, Beta-hexosaminidase from Streptococcus pneumoniae in complex with Gal-PUGNAc

Summary for 5A69

Entry DOI	10.2210/pdb5a69/pdb
Related	5A6A 5A6B 5A6J 5A6K
Descriptor	N-ACETYL-BETA-D-GLUCOSAMINIDASE, [(Z)-[(3R,4R,5R,6R)-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-ylidene]amino] N-phenylcarbamate (3 entities in total)
Functional Keywords	hydrolase, beta-hexosaminidase, carbohydrate conformation, catalytic domain, enzyme inhibitors, host-pathogen interactions, hydrogen bonding, hydrolysis, polysaccharides, protein binding, virulence factors
Biological source	STREPTOCOCCUS PNEUMONIAE
Total number of polymer chains	1
Total formula weight	74534.84
Authors	Cid, M.,Robb, C.S.,Higgins, M.A.,Boraston, A.B. (deposition date: 2015-06-24, release date: 2015-09-23, Last modification date: 2024-01-10)
Primary citation	Robb, M.,Robb, C.S.,Higgins, M.A.,Hobbs, J.K.,Paton, J.C.,Boraston, A.B. A Second beta-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans. J. Biol. Chem., 290:30888-30900, 2015 Cited by PubMed: 26491009 DOI: 10.1074/jbc.M115.688630 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation