1FSG
| TOXOPLASMA GONDII HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH 9-DEAZAGUANINE, ALPHA-D-5-PHOSPHORIBOSYL-1-PYROPHOSPHATE (PRPP) AND TWO MG2+ IONS | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 9-DEAZAGUANINE, HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, ... | Authors: | Heroux, A, White, E.L, Ross, L.J, Kuzin, A.P, Borhani, D.W. | Deposit date: | 2000-09-08 | Release date: | 2000-12-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Substrate deformation in a hypoxanthine-guanine phosphoribosyltransferase ternary complex: the structural basis for catalysis. Structure Fold.Des., 8, 2000
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1QK5
| TOXOPLASMA GONDII HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE WITH XMP, PYROPHOSPHATE AND TWO MG2+ IONS | Descriptor: | HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION, PYROPHOSPHATE 2-, ... | Authors: | Heroux, A, White, E.L, Ross, L.J, Davis, R.L, Borhani, D.W. | Deposit date: | 1999-07-09 | Release date: | 1999-10-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal Structure of Toxoplasma Gondii Hypoxanthine-Guanine Phosphoribosyltransferase with Xmp, Pyrophosphate and Two Mg2+ Ions Bound: Insights Into the Catalytic Mechanism Biochemistry, 38, 1999
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1QK4
| TOXOPLASMA GONDII HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE IMP COMPLEX | Descriptor: | HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE, INOSINIC ACID | Authors: | Heroux, A, White, E.L, Ross, L.J, Borhani, D.W. | Deposit date: | 1999-07-09 | Release date: | 1999-10-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structures of the Toxoplasma Gondii Hypoxanthine-Guanine Phosphoribosyltransferase Gmp and -Imp Complexes: Comparison of Purine Binding Interactions with the Xmp Complex Biochemistry, 38, 1999
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1QK3
| TOXOPLASMA GONDII HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE GMP COMPLEX | Descriptor: | GUANOSINE-5'-MONOPHOSPHATE, HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE | Authors: | Heroux, A, White, E.L, Ross, L.J, Borhani, D.W. | Deposit date: | 1999-07-09 | Release date: | 1999-10-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal Structures of the Toxoplasma Gondii Hypoxanthine-Guanine Phosphoribosyltransferase Gmp and -Imp Complexes: Comparison of Purine Binding Interactions with the Xmp Complex Biochemistry, 38, 1999
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3D9E
| Nitroalkane oxidase: active site mutant D402N crystallized with 1-nitrooctane | Descriptor: | 1-nitrooctane, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Heroux, A, Bozinovski, D.M, Valley, M.P, Fitzpatrick, P.F, Orville, A.M. | Deposit date: | 2008-05-27 | Release date: | 2009-04-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of intermediates in the nitroalkane oxidase reaction. Biochemistry, 48, 2009
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3D9D
| Nitroalkane oxidase: mutant D402N crystallized with 1-nitrohexane | Descriptor: | 1-nitrohexane, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Heroux, A, Bozinovski, D.M, Valley, M.P, Fitzpatrick, P.F, Orville, A.M. | Deposit date: | 2008-05-27 | Release date: | 2009-04-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of intermediates in the nitroalkane oxidase reaction. Biochemistry, 48, 2009
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3D9G
| Nitroalkane oxidase: wild type crystallized in a trapped state forming a cyanoadduct with FAD | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Nitroalkane oxidase, ... | Authors: | Heroux, A, Bozinovski, D.M, Valley, M.P, Fitzpatrick, P.F, Orville, A.M. | Deposit date: | 2008-05-27 | Release date: | 2009-04-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal structures of intermediates in the nitroalkane oxidase reaction. Biochemistry, 48, 2009
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3D9F
| Nitroalkane oxidase: active site mutant S276A crystallized with 1-nitrohexane | Descriptor: | 1-nitrohexane, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Heroux, A, Bozinovski, D.M, Valley, M.P, Fitzpatrick, P.F, Orville, A.M. | Deposit date: | 2008-05-27 | Release date: | 2009-04-07 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of intermediates in the nitroalkane oxidase reaction. Biochemistry, 48, 2009
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5E8B
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3LX0
| Crystal structure of Staphylococcal nuclease variant Delta+PHS D21N at cryogenic temperature | Descriptor: | PHOSPHATE ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | Authors: | Doctrow, B.M, Schlessman, J.L, Garcia-Moreno, E.B, Heroux, A. | Deposit date: | 2010-02-24 | Release date: | 2011-02-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Cooperative Proton Binding in a Cluster of Carboxylic Residues To be Published
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3D0U
| Crystal Structure of Lysine Riboswitch Bound to Lysine | Descriptor: | IRIDIUM HEXAMMINE ION, LYSINE, Lysine Riboswitch RNA | Authors: | Garst, A.D, Heroux, A, Rambo, R.P, Batey, R.T. | Deposit date: | 2008-05-02 | Release date: | 2008-07-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the lysine riboswitch regulatory mRNA element. J.Biol.Chem., 283, 2008
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3D7J
| SCO6650, a 6-pyruvoyltetrahydropterin synthase homolog from Streptomyces coelicolor | Descriptor: | CHLORIDE ION, SODIUM ION, Uncharacterized protein SCO6650 | Authors: | Spoonamore, J.E, Roberts, S.A, Heroux, A, Bandarian, V. | Deposit date: | 2008-05-21 | Release date: | 2008-10-21 | Last modified: | 2012-03-28 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structure of a 6-pyruvoyltetrahydropterin synthase homolog from Streptomyces coelicolor. Acta Crystallogr.,Sect.F, 64, 2008
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2REH
| Mechanistic and Structural Analyses of the Roles of Arg409 and Asp402 in the Reaction of the Flavoprotein Nitroalkane Oxidase | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Nitroalkane oxidase | Authors: | Fitzpatrick, P.F, Bozinovski, D.M, Heroux, A, Shaw, P.G, Valley, M.P, Orville, A.M. | Deposit date: | 2007-09-26 | Release date: | 2008-06-03 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Mechanistic and structural analyses of the roles of Arg409 and Asp402 in the reaction of the flavoprotein nitroalkane oxidase. Biochemistry, 46, 2007
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2R0S
| Crystal Structure of the Rsc4 tandem bromodomain | Descriptor: | Chromatin structure-remodeling complex protein RSC4 | Authors: | VanDemark, A.P, Kasten, M.M, Ferris, E, Heroux, A, Hill, C.P, Cairns, B.R. | Deposit date: | 2007-08-21 | Release date: | 2007-10-30 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation. Mol.Cell, 27, 2007
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2R3C
| Structure of the gp41 N-peptide in complex with the HIV entry inhibitor PIE1 | Descriptor: | CHLORIDE ION, HIV entry inhibitor PIE1, YTTRIUM (III) ION, ... | Authors: | VanDemark, A.P, Welch, B, Heroux, A, Hill, C.P, Kay, M.S. | Deposit date: | 2007-08-29 | Release date: | 2007-10-02 | Last modified: | 2018-08-08 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Potent D-peptide inhibitors of HIV-1 entry Proc.Natl.Acad.Sci.Usa, 104, 2007
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2R5B
| Structure of the gp41 N-trimer in complex with the HIV entry inhibitor PIE7 | Descriptor: | HIV entry inhibitor PIE7, SULFATE ION, gp41 N-peptide | Authors: | VanDemark, A.P, Welch, B, Heroux, A, Hill, C.P, Kay, M.S. | Deposit date: | 2007-09-03 | Release date: | 2007-10-02 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Potent D-peptide inhibitors of HIV-1 entry Proc.Natl.Acad.Sci.Usa, 104, 2007
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2R5D
| Structure of the gp41 N-trimer in complex with the HIV entry inhibitor PIE7 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, HIV entry inhibitor PIE7, ... | Authors: | VanDemark, A.P, Welch, B, Heroux, A, Hill, C.P, Kay, M.S. | Deposit date: | 2007-09-03 | Release date: | 2007-10-02 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Potent D-peptide inhibitors of HIV-1 entry Proc.Natl.Acad.Sci.Usa, 104, 2007
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2RF3
| Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles | Descriptor: | 5'-d(CGCG(TCY)ATTCGCG)-3', SPERMINE, ZINC ION | Authors: | Pallan, P.S, Ittig, D, Heroux, A, Wawrzak, Z, Leumann, C.J, Egli, M. | Deposit date: | 2007-09-27 | Release date: | 2008-02-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles. Chem.Commun.(Camb.), 2008, 2008
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8ASH
| Crystal structure of d(CCGGGGTACCCCGG) with XRB | Descriptor: | 4-[(~{E})-(3,6-dimethyl-1,3-benzothiazol-2-yl)iminomethyl]-~{N},~{N}-dimethyl-aniline, DNA (5'-D(*CP*CP*GP*GP*GP*GP*TP*AP*CP*CP*CP*CP*GP*G)-3') | Authors: | Sbirkova-Dimitrova, H.I, Shivachev, B.L, Rusev, R, Kuvandjiev, N, Heroux, A, Doukov, T. | Deposit date: | 2022-08-19 | Release date: | 2023-01-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.837 Å) | Cite: | Structural Characterization of Alzheimer DNA Promoter Sequences from the Amyloid Precursor Gene in the Presence of Thioflavin T and Analogs Crystals, 12, 2022
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8ASK
| Crystal structure of d(GCCCACCACGGC) | Descriptor: | DNA (5'-D(P*GP*CP*CP*CP*AP*CP*CP*AP*CP*GP*GP*C)-3'), DNA (5'-D(P*GP*CP*CP*GP*TP*GP*GP*TP*GP*GP*GP*C)-3') | Authors: | Sbirkova-Dimitrova, H.I, Shivachev, B.L, Rusev, R, Heroux, A, Doukov, T, Kuvandjiev, N. | Deposit date: | 2022-08-19 | Release date: | 2023-01-18 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.955 Å) | Cite: | Structural Characterization of Alzheimer DNA Promoter Sequences from the Amyloid Precursor Gene in the Presence of Thioflavin T and Analogs Crystals, 12, 2022
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5KEE
| Crystal structure of Staphylococcal nuclease variant Delta+PHS L25K/I92F at cryogenic temperature | Descriptor: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | Authors: | Skerritt, L.A, Caro, J.A, Heroux, A, Schlessman, J.L, Garcia-Moreno E, B. | Deposit date: | 2016-06-09 | Release date: | 2016-06-22 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of Staphylococcal nuclease variant Delta+PHS L25K/I92F at cryogenic temperature To be Published
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5JOB
| Crystal structure of Staphylococcal nuclease variant Delta+PHS L25K/I92A at cryogenic temperature | Descriptor: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | Authors: | Skerritt, L.A, Caro, J.A, Heroux, A, Schlessman, J.L, Garcia-Moreno E, B. | Deposit date: | 2016-05-02 | Release date: | 2016-05-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Crystal structure of Staphylococcal nuclease variant Delta+PHS L25K/I92A at cryogenic temperature To be Published
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1KMS
| HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-([5-QUINOLYLAMINO]METHYL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9439), A LIPOPHILIC ANTIFOLATE | Descriptor: | 6-([5-QUINOLYLAMINO]METHYL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE, DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Klon, A.E, Heroux, A, Ross, L.J, Pathak, V, Johnson, C.A, Piper, J.R, Borhani, D.W. | Deposit date: | 2001-12-17 | Release date: | 2002-07-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution. J.Mol.Biol., 320, 2002
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1KMV
| HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9662), A LIPOPHILIC ANTIFOLATE | Descriptor: | (Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE, DIHYDROFOLATE REDUCTASE, DIMETHYL SULFOXIDE, ... | Authors: | Klon, A.E, Heroux, A, Ross, L.J, Pathak, V, Johnson, C.A, Piper, J.R, Borhani, D.W. | Deposit date: | 2001-12-17 | Release date: | 2002-07-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution. J.Mol.Biol., 320, 2002
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2FJT
| Adenylyl cyclase class iv from Yersinia pestis | Descriptor: | Adenylyl cyclase class IV, SULFATE ION | Authors: | Gallagher, D.T, Smith, N.N, Kim, S.-K, Reddy, P.T, Robinson, H, Heroux, A. | Deposit date: | 2006-01-03 | Release date: | 2006-11-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | Structure of the class IV adenylyl cyclase reveals a novel fold J.Mol.Biol., 362, 2006
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