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PDB: 89 件
4GSA
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CRYSTAL STRUCTURE OF GLUTAMATE-1-SEMIALDEHYDE AMINOMUTASE (AMINOTRANSFERASE) REDUCED WITH CYANOBOROHYDRATE
分子名称: GLUTAMATE SEMIALDEHYDE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
著者Hennig, M, Jansonius, J.N.
登録日1997-02-26
公開日1998-03-04
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active site reactivity.
Proc.Natl.Acad.Sci.USA, 94, 1997
2GSA
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BU of 2gsa by Molmil
CRYSTAL STRUCTURE OF GLUTAMATE-1-SEMIALDEHYDE AMINOMUTASE (AMINOTRANSFERASE, WILD-TYPE FORM)
分子名称: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, GLUTAMATE SEMIALDEHYDE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
著者Hennig, M, Jansonius, J.N.
登録日1997-02-26
公開日1998-03-04
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active site reactivity.
Proc.Natl.Acad.Sci.USA, 94, 1997
1CBK
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BU of 1cbk by Molmil
7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE FROM HAEMOPHILUS INFLUENZAE
分子名称: 7,8-DIHYDRO-7,7-DIMETHYL-6-HYDROXYPTERIN, PROTEIN (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE), SULFATE ION
著者Hennig, M, D'Arcy, A, Dale, G, Oefner, C.
登録日1999-02-26
公開日2000-03-01
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae.
J.Mol.Biol., 287, 1999
1IGS
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BU of 1igs by Molmil
INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS AT 2.0 A RESOLUTION
分子名称: INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE, PHOSPHATE ION
著者Hennig, M, Darimont, B, Kirschner, K, Jansonius, J.N.
登録日1995-08-11
公開日1996-07-11
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献2.0 A structure of indole-3-glycerol phosphate synthase from the hyperthermophile Sulfolobus solfataricus: possible determinants of protein stability.
Structure, 3, 1995
1A53
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COMPLEX OF INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS WITH INDOLE-3-GLYCEROLPHOSPHATE AT 2.0 A RESOLUTION
分子名称: INDOLE-3-GLYCEROL PHOSPHATE, INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE
著者Hennig, M, Darimont, B, Kirschner, K, Jansonius, J.N.
登録日1998-02-19
公開日1999-03-23
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The catalytic mechanism of indole-3-glycerol phosphate synthase: crystal structures of complexes of the enzyme from Sulfolobus solfataricus with substrate analogue, substrate, and product.
J.Mol.Biol., 319, 2002
3GSB
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CRYSTAL STRUCTURE OF GLUTAMATE-1-SEMIALDEHYDE AMINOMUTASE IN COMPLEX WITH GABACULINE
分子名称: 3-AMINOBENZOIC ACID, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, PROTEIN (GLUTAMATE SEMIALDEHYDE AMINOTRANSFERASE)
著者Hennig, M, Jansonius, J.N.
登録日1998-06-26
公開日1999-08-17
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active site reactivity.
Proc.Natl.Acad.Sci.USA, 94, 1997
1NSJ
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BU of 1nsj by Molmil
CRYSTAL STRUCTURE OF PHOSPHORIBOSYL ANTHRANILATE ISOMERASE FROM THERMOTOGA MARITIMA
分子名称: PHOSPHATE ION, PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
著者Hennig, M, Jansonius, J.N.J.
登録日1996-09-13
公開日1997-03-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure at 2.0 A resolution of phosphoribosyl anthranilate isomerase from the hyperthermophile Thermotoga maritima: possible determinants of protein stability.
Biochemistry, 36, 1997
1CNV
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CRYSTAL STRUCTURE OF CONCANAVALIN B AT 1.65 A RESOLUTION
分子名称: CONCANAVALIN B
著者Hennig, M.
登録日1995-02-20
公開日1996-03-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of concanavalin B at 1.65 A resolution. An "inactivated" chitinase from seeds of Canavalia ensiformis.
J.Mol.Biol., 254, 1995
3OC0
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BU of 3oc0 by Molmil
Structure of human DPP-IV with HTS hit (2S,3S,11bS)-3-butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ylamine
分子名称: (2S,3R,11bR)-3-butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4
著者Hennig, M, Stihle, M, Thoma, R.
登録日2010-08-09
公開日2010-08-25
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Discovery of carmegliptin: A potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Bioorg.Med.Chem.Lett., 20, 2010
1NAR
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BU of 1nar by Molmil
CRYSTAL STRUCTURE OF NARBONIN REFINED AT 1.8 ANGSTROMS RESOLUTION
分子名称: NARBONIN
著者Hennig, M, Schlesier, B, Wilson, K.S.
登録日1993-09-10
公開日1994-01-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of narbonin at 1.8 A resolution.
Acta Crystallogr.,Sect.D, 51, 1995
1RWQ
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Human Dipeptidyl peptidase IV in complex with 5-aminomethyl-6-(2,4-dichloro-phenyl)-2-(3,5-dimethoxy-phenyl)-pyrimidin-4-ylamine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(AMINOMETHYL)-6-(2,4-DICHLOROPHENYL)-2-(3,5-DIMETHOXYPHENYL)PYRIMIDIN-4-AMINE, Dipeptidyl peptidase IV
著者Hennig, M, Thoma, R, Stihle, M.
登録日2003-12-17
公開日2004-12-17
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Aminomethylpyrimidines as novel DPP-IV inhibitors: a 10(5)-fold activity increase by optimization of aromatic substituents
Bioorg.Med.Chem.Lett., 14, 2004
1DHN
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1.65 ANGSTROM RESOLUTION STRUCTURE OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS
分子名称: 7,8-DIHYDRONEOPTERIN ALDOLASE
著者Hennig, M, D'Arcy, A, Hampele, I.C, Page, M.G.P, Oefner, C.H, Dale, G.
登録日1998-03-31
公開日1999-04-20
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus.
Nat.Struct.Biol., 5, 1998
2BIT
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BU of 2bit by Molmil
Crystal structure of human cyclophilin D at 1.7 A resolution
分子名称: PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
著者Hennig, M, Thoma, R, Stihle, M, Schlatter, D.
登録日2005-01-26
公開日2005-01-26
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Crystal Engineering Yields Crystals of Cyclophilin D Diffracting to 1.7 A Resolution
Acta Crystallogr.,Sect.D, 61, 2005
3KWJ
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Structure of human DPP-IV with (2S,3S,11bS)-3-(3-Fluoromethyl-phenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ylamine
分子名称: (2S,3S,11bS)-3-[3-(fluoromethyl)phenyl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4 soluble form
著者Hennig, M, Stihle, M, Thoma, R.
登録日2009-12-01
公開日2010-09-15
最終更新日2020-09-09
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3KWF
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human DPP-IV with carmegliptin (S)-1-((2S,3S,11bS)-2-Amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one
分子名称: (4S)-1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-4-(fluoromethyl)pyrrolidin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4
著者Hennig, M, Stihle, M, Thoma, R.
登録日2009-12-01
公開日2010-01-12
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery of carmegliptin: A potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Bioorg.Med.Chem.Lett., 20, 2010
2BIU
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BU of 2biu by Molmil
Crystal structure of human cyclophilin D at 1.7 A resolution, DMSO complex
分子名称: DIMETHYL SULFOXIDE, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
著者Hennig, M, Thoma, R, Stihle, M, Schlatter, D.
登録日2005-01-26
公開日2005-01-26
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Crystal Engineering Yields Crystals of Cyclophilin D Diffracting to 1.7 A Resolution
Acta Crystallogr.,Sect.D, 61, 2005
2JID
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Human Dipeptidyl peptidase IV in complex with 1-(3,4-Dimethoxy-phenyl) -3-m-tolyl-piperidine-4-ylamine
分子名称: (3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIPEPTIDYL PEPTIDASE 4
著者Hennig, M, Stihle, M, Luebbers, T, Thoma, R.
登録日2007-02-28
公開日2008-05-27
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献1,3-Disubstituted 4-Aminopiperidines as Useful Tools in the Optimization of the 2-Aminobenzo[A]Quinolizine Dipeptidyl Peptidase Iv Inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
1NU6
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Crystal structure of human Dipeptidyl Peptidase IV (DPP-IV)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase IV, MERCURY (II) ION
著者Hennig, M, Stihle, M, Thoma, R, Ruf, A.
登録日2003-01-31
公開日2003-08-26
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Basis of Proline-Specific Exopeptidase Activity as Observed in Human Dipeptidyl Peptidase-IV.
Structure, 11, 2003
2DHN
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COMPLEX OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS WITH 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 2.2 A RESOLUTION
分子名称: 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE, 7,8-DIHYDRONEOPTERIN ALDOLASE
著者Hennig, M, D'Arcy, A, Hampele, I.C, Page, M.G.P, Oefner, C.H, Dale, G.
登録日1998-03-31
公開日1999-04-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus.
Nat.Struct.Biol., 5, 1998
1LBM
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CRYSTAL STRUCTURE OF PHOSPHORIBOSYL ANTHRANILATE ISOMERASE (PRAI) IN COMPLEX WITH REDUCED 1-(O-CARBOXYPHENYLAMINO)-1-DEOXYRIBULOSE 5-PHOSPHATE (RCDRP)
分子名称: 1-(O-CARBOXY-PHENYLAMINO)-1-DEOXY-D-RIBULOSE-5-PHOSPHATE, PHOSPHORIBOSYL ANTHRANILATE ISOMERASE
著者Hennig, M, Sterner, R, Kirschner, K.
登録日2002-04-04
公開日2002-12-18
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Two (betaalpha)(8)-barrel enzymes of histidine and tryptophan biosynthesis have similar reaction mechanisms and common strategies for protecting their labile substrates
Biochemistry, 41, 2002
1LBL
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BU of 1lbl by Molmil
Crystal structure of indole-3-glycerol phosphate synthase (IGPS) in complex with 1-(o-carboxyphenylamino)-1-deoxyribulose 5'-phosphate (CdRP)
分子名称: 1-(O-CARBOXY-PHENYLAMINO)-1-DEOXY-D-RIBULOSE-5-PHOSPHATE, indole-3-glycerol phosphate synthase
著者Hennig, M, Darimont, B.D, Kirschner, K, Jansonius, J.N.
登録日2002-04-04
公開日2002-09-18
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The catalytic mechanism of indole-3-glycerol phosphate synthase: Crystal structures of complexes of the enzyme from Sulfolobus solfataricus with the substrate analogue, substrate, and product
J.Mol.Biol., 319, 2002
1LBF
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BU of 1lbf by Molmil
CRYSTAL STRUCTURE OF INDOLE-3-GLYCEROL PHOSPHATE SYNTASE (IGPS)WITH REDUCED 1-(O-CABOXYPHENYLAMINO)-1-DEOXYRIBULOSE 5-PHOSPHATE (RCDRP)
分子名称: 1-(O-CARBOXY-PHENYLAMINO)-1-DEOXY-D-RIBULOSE-5-PHOSPHATE, INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE
著者Hennig, M, Darimont, B, Kirschner, K, Jansonius, J.N.
登録日2002-04-03
公開日2002-06-12
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献The catalytic mechanism of indole-3-glycerol phosphate synthase: crystal structures of complexes of the enzyme from Sulfolobus solfataricus with substrate analogue, substrate, and product.
J.Mol.Biol., 319, 2002
2VB9
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beta-ketoacyl-ACP synthase I (KAS) from E. coli, apo structure
分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, CHLORIDE ION
著者Pappenberger, G, Schulz-Gasch, T, Bailly, J, Hennig, M.
登録日2007-09-06
公開日2007-12-25
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure-Assisted Discovery of an Aminothiazole Derivative as a Lead Molecule for Inhibition of Bacterial Fatty-Acid Synthesis.
Acta Crystallogr.,Sect.D, 63, 2007
2HVM
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HEVAMINE A AT 1.8 ANGSTROM RESOLUTION
分子名称: HEVAMINE
著者Terwisscha Van Scheltinga, A.C, Hennig, M, Dijkstra, B.W.
登録日1996-07-02
公開日1997-01-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The 1.8 A resolution structure of hevamine, a plant chitinase/lysozyme, and analysis of the conserved sequence and structure motifs of glycosyl hydrolase family 18.
J.Mol.Biol., 262, 1996
1F97
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SOLUBLE PART OF THE JUNCTION ADHESION MOLECULE FROM MOUSE
分子名称: JUNCTION ADHESION MOLECULE, MAGNESIUM ION
著者Kostrewa, D, Brockhaus, M, D'Arcy, A, Dale, G, Bazzoni, G, Dejana, E, Winkler, F, Hennig, M.
登録日2000-07-07
公開日2001-01-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献X-ray structure of junctional adhesion molecule: structural basis for homophilic adhesion via a novel dimerization motif.
EMBO J., 20, 2001

 

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