3I7Z
 
 | | Protein Tyrosine Phosphatase 1B - Transition state analog for the first catalytic step | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, EGFR receptor fragment, GLYCEROL, ... | | 著者 | Brandao, T.A.S, Johnson, S.J, Hengge, A.C. | | 登録日 | 2009-07-09 | | 公開日 | 2010-03-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps.
J.Biol.Chem., 285, 2010
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3I80
 | | Protein Tyrosine Phosphatase 1B - Transition state analog for the second catalytic step | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ... | | 著者 | Brandao, T.A.S, Johnson, S.J, Hengge, A.C. | | 登録日 | 2009-07-09 | | 公開日 | 2010-03-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps.
J.Biol.Chem., 285, 2010
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4ZI4
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7MPD
 | | Structure of SsoPTP bound to 2-chloroethylsulfonate | | 分子名称: | 2-chloroethane-1-sulfonic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SsoPTP | | 著者 | Pinkston, J.A, Olsen, K.J, Hengge, A.C, Johnson, S.J. | | 登録日 | 2021-05-04 | | 公開日 | 2021-09-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | Significant Loop Motions in the SsoPTP Protein Tyrosine Phosphatase Allow for Dual General Acid Functionality.
Biochemistry, 60, 2021
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7MPC
 | | Structure of SsoPTP bound to vanadate | | 分子名称: | SsoPTP, VANADATE ION | | 著者 | Pinkston, J.A, Olsen, K.J, Hengge, A.C, Johnson, S.J. | | 登録日 | 2021-05-04 | | 公開日 | 2021-09-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Significant Loop Motions in the SsoPTP Protein Tyrosine Phosphatase Allow for Dual General Acid Functionality.
Biochemistry, 60, 2021
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7S4F
 | | Protein Tyrosine Phosphatase 1B - F182Q mutant bound with Hepes | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Brandao, T.A.S, Hengge, A.C, Johnson, S.J. | | 登録日 | 2021-09-08 | | 公開日 | 2022-09-21 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases.
Chem Sci, 13, 2022
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4Z6B
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4ZN5
 | | YopH W354Y Yersinia enterocolitica PTPase bond with Divanadate glycerol ester in the active site | | 分子名称: | ACETATE ION, Divanadate Glycerol ester, GLYCEROL, ... | | 著者 | Moise, G.E, Johnson, S.J, Hengge, A.C. | | 登録日 | 2015-05-04 | | 公開日 | 2015-10-28 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | | 主引用文献 | Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites.
Biochemistry, 54, 2015
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4YAA
 | | YopH W354Y Yersinia enterocolitica PTPase apo form | | 分子名称: | ACETATE ION, SULFATE ION, Tyrosine-protein phosphatase YopH | | 著者 | Moise, G.E, Johnson, S.J, Hengge, A.C. | | 登録日 | 2015-02-17 | | 公開日 | 2015-10-28 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites.
Biochemistry, 54, 2015
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3QKQ
 | | Protein Tyrosine Phosphatase 1B - W179F mutant bound with vanadate | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ... | | 著者 | Brandao, T.A.S, Johnson, S.J, Hengge, A.C. | | 登録日 | 2011-02-01 | | 公開日 | 2012-08-08 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B.
Arch.Biochem.Biophys., 525, 2012
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3QKP
 | | Protein Tyrosine Phosphatase 1B - Apo W179F mutant with open WPD-loop | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1 | | 著者 | Brandao, T.A.S, Johnson, S.J, Hengge, A.C. | | 登録日 | 2011-02-01 | | 公開日 | 2012-08-08 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B.
Arch.Biochem.Biophys., 525, 2012
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6XEA
 | | Crystal Structure of the PTP1B YopH WPD loop Chimera 3 bound to vanadate | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | | 登録日 | 2020-06-12 | | 公開日 | 2021-12-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.549 Å) | | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases.
Chem Sci, 13, 2022
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6XEE
 | | Crystal Structure of the PTP1B YopH WPD loop Chimera 4 apo form | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | | 登録日 | 2020-06-12 | | 公開日 | 2021-12-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases.
Chem Sci, 13, 2022
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6XE8
 | | Crystal Structure of the PTP1B YopH WPD loop Chimera 3 apo form | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | | 登録日 | 2020-06-12 | | 公開日 | 2021-12-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.952 Å) | | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases.
Chem Sci, 13, 2022
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6XED
 | | Crystal Structure of the PTP1B YopH WPD loop Chimera 3 bound to tungstate | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | | 登録日 | 2020-06-12 | | 公開日 | 2021-12-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.795 Å) | | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases.
Chem Sci, 13, 2022
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6XEF
 | | Crystal structure of the PTP1B YopH WPD loop Chimera 4 bound to vanadate | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | | 登録日 | 2020-06-12 | | 公開日 | 2021-12-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.048 Å) | | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases.
Chem Sci, 13, 2022
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6XEG
 | | Crystal structure of the PTP1B YopH WPD loop Chimera 4 bound to tungstate | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | | 登録日 | 2020-06-12 | | 公開日 | 2021-12-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.549 Å) | | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases.
Chem Sci, 13, 2022
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4H43
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4HAH
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7L0C
 | | Ligand-free PTP1B T177G | | 分子名称: | Tyrosine-protein phosphatase non-receptor type 1 | | 著者 | Shen, R.D, Hengge, A.C, Johnson, S.J. | | 登録日 | 2020-12-11 | | 公開日 | 2021-05-12 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases.
Jacs Au, 1, 2021
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7L0M
 | | Vanadate-bound YopH G352T | | 分子名称: | Protein-tyrosine-phosphatase, VANADATE ION | | 著者 | Shen, R.D, Hengge, A.C, Johnson, S.J. | | 登録日 | 2020-12-11 | | 公開日 | 2021-05-12 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases.
Jacs Au, 1, 2021
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7L0H
 | | Vanadate-bound PTP1B T177G | | 分子名称: | Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION | | 著者 | Shen, R.D, Hengge, A.C, Johnson, S.J. | | 登録日 | 2020-12-11 | | 公開日 | 2021-05-12 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases.
Jacs Au, 1, 2021
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7L0I
 | | Ligand-free YopH G352T | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Protein-tyrosine-phosphatase | | 著者 | Shen, R.D, Hengge, A.C, Johnson, S.J. | | 登録日 | 2020-12-11 | | 公開日 | 2021-05-12 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases.
Jacs Au, 1, 2021
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3F99
 | | W354F Yersinia enterocolitica PTPase apo form | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase yopH | | 著者 | Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C. | | 登録日 | 2008-11-13 | | 公開日 | 2009-01-20 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures.
J.Am.Chem.Soc., 131, 2009
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3D03
 | | 1.9A structure of Glycerophoshphodiesterase (GpdQ) from Enterobacter aerogenes | | 分子名称: | COBALT (II) ION, Phosphohydrolase | | 著者 | Hadler, K.S, Tanifum, E, Yip, S.H.-C, Miti, N, Guddat, L.W, Jackson, C.J, Gahan, L.R, Carr, P.D, Nguyen, K, Ollis, D.L, Hengge, A.C, Larrabee, J.A, Schenk, G. | | 登録日 | 2008-04-30 | | 公開日 | 2008-10-14 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes.
J.Am.Chem.Soc., 130, 2008
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