8D0B
| Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template | Descriptor: | CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... | Authors: | He, Q, Lin, X, Chavez, B.L, Agrawal, S, Lusk, B.L, Lim, C. | Deposit date: | 2022-05-26 | Release date: | 2022-06-22 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Structures of the human CST-Pol alpha-primase complex bound to telomere templates. Nature, 608, 2022
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8D0K
| Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template - PRIM2C advanced PIC | Descriptor: | CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... | Authors: | He, Q, Lin, X, Chavez, B.L, Agrawal, S, Lusk, B.L, Lim, C. | Deposit date: | 2022-05-26 | Release date: | 2022-06-22 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (4.27 Å) | Cite: | Structures of the human CST-Pol alpha-primase complex bound to telomere templates. Nature, 608, 2022
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8D96
| Human DNA polymerase alpha/primase elongation complex I bound to primer/template | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*AP*AP*TP*GP*GP*TP*CP*GP*TP*GP*CP*CP*GP*CP*CP*AP*AP*TP*AP*A)-3'), DNA polymerase alpha catalytic subunit, ... | Authors: | He, Q, Baranovskiy, A, Lim, C, Tahirov, T. | Deposit date: | 2022-06-09 | Release date: | 2023-04-19 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structures of human primosome elongation complexes. Nat.Struct.Mol.Biol., 30, 2023
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8D9D
| Human DNA polymerase-alpha/primase elongation complex II bound to primer/template | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*GP*GP*TP*CP*GP*TP*GP*CP*CP*GP*CP*CP*AP*AP*TP*AP*A)-3'), DNA polymerase alpha catalytic subunit, ... | Authors: | He, Q, Baranovskiy, A, Lim, C, Tahirov, T. | Deposit date: | 2022-06-09 | Release date: | 2023-04-19 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structures of human primosome elongation complexes. Nat.Struct.Mol.Biol., 30, 2023
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6IUY
| Structure of DsGPDH of Dunaliella salina | Descriptor: | 1,3-DIHYDROXYACETONEPHOSPHATE, GLYCEROL, Glycerol-3-phosphate dehydrogenase [NAD(+)], ... | Authors: | He, Q, Toh, J.D, Ero, R, Qiao, Z, Kumar, V, Gao, Y.G. | Deposit date: | 2018-12-01 | Release date: | 2019-12-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The unusual di-domain structure of Dunaliella salina glycerol-3-phosphate dehydrogenase enables direct conversion of dihydroxyacetone phosphate to glycerol. Plant J., 102, 2020
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8HWS
| The complex structure of Omicron BA.4 RBD with BD604, S309, and S304 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BD-604 Fab Heavy chain, BD-604 Fab Light chain, ... | Authors: | He, Q.W, Xu, Z.P, Xie, Y.F. | Deposit date: | 2023-01-02 | Release date: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (2.36 Å) | Cite: | An updated atlas of antibody evasion by SARS-CoV-2 Omicron sub-variants including BQ.1.1 and XBB. Cell Rep Med, 4, 2023
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8HWT
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7WUQ
| Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4 | Descriptor: | Adhesion G-protein coupled receptor G2,mCherry, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | He, Q.T, Guo, S.C, Xiao, P, Sun, J.P, Yu, X, Gou, L, Kong, L.L, Zhang, L. | Deposit date: | 2022-02-09 | Release date: | 2022-04-27 | Last modified: | 2022-05-11 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4. Nature, 604, 2022
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1DTG
| HUMAN TRANSFERRIN N-LOBE MUTANT H249E | Descriptor: | CARBONATE ION, FE (III) ION, TRANSFERRIN | Authors: | MacGillivray, R.T, Bewley, M.C, Smith, C.A, He, Q.Y, Mason, A.B. | Deposit date: | 2000-01-12 | Release date: | 2000-01-21 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Mutation of the iron ligand His 249 to Glu in the N-lobe of human transferrin abolishes the dilysine "trigger" but does not significantly affect iron release. Biochemistry, 39, 2000
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8UMY
| Atomic model of the human CTF18-RFC-PCNA-DNA ternary complex with narrow PCNA opening state II (state 6) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, DNA (20-MER), ... | Authors: | Wang, F, He, Q, Li, H. | Deposit date: | 2023-10-18 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UMW
| Atomic model of the human CTF18-RFC-PCNA-DNA ternary complex in the five-subunit binding state (state 4) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, DNA (20-MER), ... | Authors: | Wang, F, He, Q, Li, H. | Deposit date: | 2023-10-18 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UMV
| Atomic model of the human CTF18-RFC-PCNA-DNA ternary complex with narrow PCNA opening state I (state 5) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, DNA (20-MER), ... | Authors: | Wang, F, He, Q, Li, H. | Deposit date: | 2023-10-18 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UN0
| Atomic model of the human CTF18-RFC-PCNA-DNA ternary complex with cracked and closed PCNA (state 7) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, DNA (20-MER), ... | Authors: | Wang, F, He, Q, Li, H. | Deposit date: | 2023-10-18 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
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8G59
| Cryo-EM structure of the TUG891 bound GPR120-Giq complex | Descriptor: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | Deposit date: | 2023-02-12 | Release date: | 2023-03-08 | Last modified: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (2.64 Å) | Cite: | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8UNJ
| Atomic model of the human CTF18-RFC alone in the apo state (State 1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, MAGNESIUM ION, ... | Authors: | Wang, F, He, Q, Li, H. | Deposit date: | 2023-10-19 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UMT
| Atomic model of the human CTF18-RFC-PCNA binary complex in the three-subunit binding state (state 2) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, MAGNESIUM ION, ... | Authors: | Wang, F, He, Q, Li, H. | Deposit date: | 2023-10-18 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UMU
| Atomic model of the human CTF18-RFC-PCNA binary complex in the four-subunit binding state (state 3) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chromosome transmission fidelity protein 18 homolog, MAGNESIUM ION, ... | Authors: | Wang, F, He, Q, Li, H. | Deposit date: | 2023-10-18 | Release date: | 2024-05-08 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC. Proc.Natl.Acad.Sci.USA, 121, 2024
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1OQH
| Crystal Structure of the R124A mutant of the N-lobe human transferrin | Descriptor: | CARBONATE ION, FE (III) ION, POTASSIUM ION, ... | Authors: | Baker, H.M, He, Q.-Y, Brigg, S.K, Mason, A.B, N Baker, E. | Deposit date: | 2003-03-10 | Release date: | 2003-03-18 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and functional consequences of binding site mutations in transferrin: crystal structures of the Asp63Glu and Arg124Ala mutants of the N-lobe of human transferrin Biochemistry, 42, 2003
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6PQP
| Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist BITC | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-benzylthioformamide, ... | Authors: | Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y. | Deposit date: | 2019-07-09 | Release date: | 2020-01-08 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 105, 2020
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6PQQ
| Cryo-EM structure of human TRPA1 C621S mutant in the apo state | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily A member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y. | Deposit date: | 2019-07-09 | Release date: | 2020-01-08 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 105, 2020
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6PQO
| Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist JT010 | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-N-(3-methoxypropyl)acetamide, ... | Authors: | Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y. | Deposit date: | 2019-07-09 | Release date: | 2020-01-08 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 105, 2020
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1JQF
| Human Transferrin N-Lobe Mutant H249Q | Descriptor: | CARBONATE ION, FE (III) ION, POTASSIUM ION, ... | Authors: | Baker, H.M, Mason, A.B, He, Q.-Y, MacGillivray, R.T.A, Baker, E.N. | Deposit date: | 2001-08-06 | Release date: | 2001-10-17 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Ligand variation in the transferrin family: the crystal structure of the H249Q mutant of the human transferrin N-lobe as a model for iron binding in insect transferrins. Biochemistry, 40, 2001
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1OQG
| Crystal structure of the D63E mutant of the N-lobe human transferrin | Descriptor: | CARBONATE ION, FE (III) ION, Serotransferrin | Authors: | Baker, H.M, He, Q.-Y, Brigg, S.K, Mason, A.B, Baker, E.N. | Deposit date: | 2003-03-09 | Release date: | 2003-03-18 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and functional consequences of binding site mutations in transferrin: crystal structures of the Asp63Glu and Arg124Ala mutants of the N-lobe of human transferrin Biochemistry, 42, 2003
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8T2I
| Negative stain EM assembly of MYC, JAZ, and NINJA complex | Descriptor: | AFP homolog 2, Maltose/maltodextrin-binding periplasmic protein, Protein TIFY 10A, ... | Authors: | Zhou, X.E, Zhang, Y, Zhou, Y, He, Q, Cao, X, Kariapper, L, Suino-Powell, K, Zhu, Y, Zhang, F, Karsten, M. | Deposit date: | 2023-06-06 | Release date: | 2023-06-28 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (10.4 Å) | Cite: | Assembly of JAZ-JAZ and JAZ-NINJA complexes in jasmonate signaling. Plant Commun., 4, 2023
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1N7X
| HUMAN SERUM TRANSFERRIN, N-LOBE Y45E MUTANT | Descriptor: | CARBONATE ION, FE (III) ION, Serotransferrin | Authors: | Adams, T.E, Mason, A.B, He, Q.Y, Halbrooks, P.J, Briggs, S.K, Smith, V.C, Macgillivray, R.T, Everse, S.J. | Deposit date: | 2002-11-18 | Release date: | 2003-03-18 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | THE POSITION OF ARGININE 124 CONTROLS THE RATE OF IRON RELEASE FROM THE N-LOBE OF HUMAN SERUM TRANSFERRIN. A STRUCTURAL STUDY J.Biol.Chem., 278, 2003
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