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1DTG

HUMAN TRANSFERRIN N-LOBE MUTANT H249E

Summary for 1DTG
Entry DOI10.2210/pdb1dtg/pdb
DescriptorTRANSFERRIN, FE (III) ION, CARBONATE ION, ... (4 entities in total)
Functional Keywordsiron transport, glycoprotein, metal-binding, polymorphism, 3d- structure, metal transport
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P02787
Total number of polymer chains1
Total formula weight36994.76
Authors
MacGillivray, R.T.,Bewley, M.C.,Smith, C.A.,He, Q.Y.,Mason, A.B. (deposition date: 2000-01-12, release date: 2000-01-21, Last modification date: 2021-11-03)
Primary citationMacGillivray, R.T.,Bewley, M.C.,Smith, C.A.,He, Q.Y.,Mason, A.B.
Mutation of the iron ligand His 249 to Glu in the N-lobe of human transferrin abolishes the dilysine "trigger" but does not significantly affect iron release.
Biochemistry, 39:1211-1216, 2000
Cited by
PubMed: 10684598
DOI: 10.1021/bi991522y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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