8A9L
| Cryo-EM structure of alpha-synuclein filaments from Parkinson's disease and dementia with Lewy bodies | 分子名称: | Alpha-synuclein, Unknown fragment | 著者 | Yang, Y, Shi, Y, Schweighauser, M, Zhang, X.J, Kotecha, A, Murzin, A.G, Garringer, H.J, Cullinane, P, Saito, Y, Foroud, T, Warner, T.T, Hasegawa, K, Vidal, R, Murayama, S, Revesz, T, Ghetti, B, Hasegawa, M, Lashley, T, Scheres, H.W.S, Goedert, M. | 登録日 | 2022-06-28 | 公開日 | 2022-08-31 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Structures of alpha-synuclein filaments from human brains with Lewy pathology. Nature, 610, 2022
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6LKN
| Crystal structure of ATP11C-CDC50A in PtdSer-bound E2P state | 分子名称: | 1-deoxy-alpha-D-mannopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50A, ... | 著者 | Abe, K, Irie, K, Nakanishi, H, Hasegawa, K. | 登録日 | 2019-12-19 | 公開日 | 2020-06-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Crystal structure of a human plasma membrane phospholipid flippase. J.Biol.Chem., 295, 2020
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2PJZ
| The crystal structure of putative Cobalt transport ATP-binding protein (cbiO-2), ST1066 | 分子名称: | Hypothetical protein ST1066, SULFATE ION | 著者 | Hirata, K, Hasegawa, K, Ebihara, A, Yamamoto, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2007-04-17 | 公開日 | 2008-04-22 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The crystal structure of putative Cobalt transport ATP-binding protein (cbiO-2), ST1066 To be Published
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1QPK
| MUTANT (D193G) MALTOTETRAOSE-FORMING EXO-AMYLASE IN COMPLEX WITH MALTOTETRAOSE | 分子名称: | CALCIUM ION, PROTEIN (MALTOTETRAOSE-FORMING AMYLASE), alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Yoshioka, Y, Hasegawa, K, Matsuura, Y, Katsube, Y, Kubota, M. | 登録日 | 1999-05-26 | 公開日 | 1999-11-17 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Roles of catalytic residues in alpha-amylases as evidenced by the structures of the product-complexed mutants of a maltotetraose-forming amylase. Protein Eng., 12, 1999
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5B2H
| Crystal structure of HA33 from Clostridium botulinum serotype C strain Yoichi | 分子名称: | HA-33, TRIETHYLENE GLYCOL | 著者 | Akiyama, T, Hayashi, S, Matsumoto, T, Hasegawa, K, Yamano, A, Suzuki, T, Niwa, K, Watanabe, T, Sagane, Y, Yajima, S. | 登録日 | 2016-01-15 | 公開日 | 2016-06-15 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Conformational divergence in the HA-33/HA-17 trimer of serotype C and D botulinum toxin complex Biochem.Biophys.Res.Commun., 476, 2016
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9ARS
| Crystal structure of SARS-CoV-2 main protease E166V mutant in complex with an inhibitor TKB-245 | 分子名称: | (1R,2S,5S)-N-{(1S,2S)-1-(4-fluoro-1,3-benzothiazol-2-yl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Bulut, H, Hattori, S, Hayashi, H, Hasegawa, K, Li, M, Wlodawer, A, Misumi, S, Tamamura, H, Mitsuya, H. | 登録日 | 2024-02-23 | 公開日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and virologic mechanism of emergence of main protease inhibitor-resistance in SARS-CoV-2 as selected with main protease inhibitors To Be Published
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9ART
| Crystal structure of SARS-CoV-2 main protease A191T mutant in complex with an inhibitor 5h | 分子名称: | 3C-like proteinase nsp5, N-[(2S)-1-({(1S,2S)-1-(1,3-benzothiazol-2-yl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide | 著者 | Bulut, H, Hattori, S, Hayashi, H, Hasegawa, K, Li, M, Wlodawer, A, Tamamura, H, Mitsuya, H. | 登録日 | 2024-02-23 | 公開日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Structural and virologic mechanism of emergence of main protease inhibitor-resistance in SARS-CoV-2 as selected with main protease inhibitors To Be Published
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9AVQ
| Crystal structure of SARS-CoV-2 main protease A191T mutant in complex with an inhibitor Nirmatrelvir | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5, DI(HYDROXYETHYL)ETHER | 著者 | Bulut, H, Hattori, S, Hayashi, H, Hasegawa, K, Li, M, Wlodawer, A, Tamamura, H, Mitsuya, H. | 登録日 | 2024-03-04 | 公開日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Structural and virologic mechanism of emergence of main protease inhibitor-resistance in SARS-CoV-2 as selected with main protease inhibitors To Be Published
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9ARQ
| Crystal structure of SARS-CoV-2 main protease (authentic protein) in complex with an inhibitor TKB-245 | 分子名称: | (1R,2S,5S)-N-{(1S,2S)-1-(4-fluoro-1,3-benzothiazol-2-yl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Bulut, H, Hattori, S, Hayashi, H, Hasegawa, K, Li, M, Wlodawer, A, Tamamura, H, Mitsuya, H. | 登録日 | 2024-02-23 | 公開日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and virologic mechanism of emergence of main protease inhibitor-resistance in SARS-CoV-2 as selected with main protease inhibitors To Be Published
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6J8M
| Low-dose structure of bovine heart cytochrome c oxidase in the fully oxidized state determined using 30 keV X-ray | 分子名称: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ... | 著者 | Ueno, G, Shimada, A, Yamashita, E, Hasegawa, K, Kumasaka, T, Shinzawa-Itoh, K, Yoshikawa, S, Tsukihara, T, Yamamoto, M. | 登録日 | 2019-01-20 | 公開日 | 2019-06-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Low-dose X-ray structure analysis of cytochrome c oxidase utilizing high-energy X-rays. J.Synchrotron Radiat., 26, 2019
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7UE1
| HIV-1 Integrase Catalytic Core Domain Mutant (KGD) in Complex with Inhibitor GRL-142 | 分子名称: | (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate, Integrase, SULFATE ION | 著者 | Aoki, M, Aoki-Ogata, H, Bulut, H, Hayashi, H, Davis, D, Hasegawa, K, Yarchoan, R, Ghosh, A.K, Pau, A.K, Mitsuya, H. | 登録日 | 2022-03-21 | 公開日 | 2023-03-22 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants. Sci Adv, 9, 2023
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8K9N
| Subatomic resolution structure of Pseudoazurin from Alcaligenes faecalis | 分子名称: | COPPER (II) ION, Pseudoazurin, SULFATE ION | 著者 | Fukuda, Y, Lintuluoto, M, Kurihara, K, Hasegawa, K, Inoue, T, Tamada, T. | 登録日 | 2023-08-01 | 公開日 | 2024-02-14 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (0.86 Å) | 主引用文献 | Overlooked Hydrogen Bond in a Blue Copper Protein Uncovered by Neutron and Sub- angstrom ngstrom Resolution X-ray Crystallography. Biochemistry, 63, 2024
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1JDA
| MALTOTETRAOSE-FORMING EXO-AMYLASE | 分子名称: | 1,4-ALPHA MALTOTETRAHYDROLASE, CALCIUM ION | 著者 | Yoshioka, Y, Hasegawa, K, Matsuura, Y, Katsube, Y, Kubota, M. | 登録日 | 1997-06-16 | 公開日 | 1997-10-15 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of a mutant maltotetraose-forming exo-amylase cocrystallized with maltopentaose. J.Mol.Biol., 271, 1997
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1JDC
| MUTANT (E219Q) MALTOTETRAOSE-FORMING EXO-AMYLASE COCRYSTALLIZED WITH MALTOTETRAOSE (CRYSTAL TYPE 1) | 分子名称: | 1,4-ALPHA MALTOTETRAHYDROLASE, CALCIUM ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Yoshioka, Y, Hasegawa, K, Matsuura, Y, Katsube, Y, Kubota, M. | 登録日 | 1997-06-16 | 公開日 | 1997-10-15 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structures of a mutant maltotetraose-forming exo-amylase cocrystallized with maltopentaose. J.Mol.Biol., 271, 1997
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1JDD
| MUTANT (E219Q) MALTOTETRAOSE-FORMING EXO-AMYLASE COCRYSTALLIZED WITH MALTOTETRAOSE (CRYSTAL TYPE 2) | 分子名称: | 1,4-ALPHA MALTOTETRAHYDROLASE, CALCIUM ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Yoshioka, Y, Hasegawa, K, Matsuura, Y, Katsube, Y, Kubota, M. | 登録日 | 1997-06-16 | 公開日 | 1997-10-15 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structures of a mutant maltotetraose-forming exo-amylase cocrystallized with maltopentaose. J.Mol.Biol., 271, 1997
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5XAA
| Complete structure factors and an atomic model of the calcium pump (SERCA1A) and associated phospholipids in the E2-ALF-(TG) crystals of P21212 symmetry | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | 著者 | Norimatsu, Y, Hasegawa, K, Shimizu, N, Toyoshima, C. | 登録日 | 2017-03-11 | 公開日 | 2017-05-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Protein-phospholipid interplay revealed with crystals of a calcium pump. Nature, 545, 2017
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5XA8
| Complete structure factors and an atomic model of the calcium pump (SERCA1A) and associated phospholipids in the E1-ALF4-ADP-2CA2+ crystals | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | 著者 | Norimatsu, Y, Hasegawa, K, Shimizu, N, Toyoshima, C. | 登録日 | 2017-03-11 | 公開日 | 2017-05-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Protein-phospholipid interplay revealed with crystals of a calcium pump. Nature, 545, 2017
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5XA9
| Complete structure factors and an atomic model of the calcium pump (SERCA1A) and associated phospholipids in the E2-ALF-(TG) crystals of C2 symmetry | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | 著者 | Norimatsu, Y, Hasegawa, K, Shimizu, N, Toyoshima, C. | 登録日 | 2017-03-11 | 公開日 | 2017-06-14 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Protein-phospholipid interplay revealed with crystals of a calcium pump. Nature, 545, 2017
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5XA7
| Complete structure factors and an atomic model of the calcium pump (SERCA1A) and associated phospholipids in the E1-2CA2+ crystals | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, SODIUM ION, ... | 著者 | Norimatsu, Y, Hasegawa, K, Shimizu, N, Toyoshima, C. | 登録日 | 2017-03-11 | 公開日 | 2017-05-17 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Protein-phospholipid interplay revealed with crystals of a calcium pump. Nature, 545, 2017
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5XAB
| Complete structure factors and an atomic model of the calcium pump (SERCA1A) and associated phospholipids in the E2(TG) crystals | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, ... | 著者 | Norimatsu, Y, Hasegawa, K, Shimizu, N, Toyoshima, C. | 登録日 | 2017-03-11 | 公開日 | 2017-06-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Protein-phospholipid interplay revealed with crystals of a calcium pump. Nature, 545, 2017
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3VUO
| Crystal structure of nontoxic nonhemagglutinin subcomponent (NTNHA) from clostridium botulinum serotype D strain 4947 | 分子名称: | NTNHA | 著者 | Sagane, Y, Miyashita, S.-I, Miyata, K, Matsumoto, T, Inui, K, Hayashi, S, Suzuki, T, Hasegawa, K, Yajima, S, Yamano, A, Niwa, K, Watanabe, T. | 登録日 | 2012-07-03 | 公開日 | 2012-09-19 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Small-angle X-ray scattering reveals structural dynamics of the botulinum neurotoxin associating protein, nontoxic nonhemagglutinin Biochem.Biophys.Res.Commun., 425, 2012
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7VP0
| Crystal structure of P domain from norovirus GI.9 capsid protein. | 分子名称: | MAGNESIUM ION, VP1 | 著者 | Katsura, K, Sakai, N, Hasegawa, K, Kimura-Someya, T, Shirouzu, M. | 登録日 | 2021-10-15 | 公開日 | 2022-08-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Lewis fucose is a key moiety for the recognition of histo-blood group antigens by GI.9 norovirus, as revealed by structural analysis. Febs Open Bio, 12, 2022
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8J5B
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3AJN
| Structural basis of glycine amide on suppression of protein aggregation by high resolution X-ray analysis | 分子名称: | AMINOMETHYLAMIDE, CHLORIDE ION, Lysozyme C, ... | 著者 | Ito, L, Shiraki, K, Hasegawa, K, Kumasaka, T. | 登録日 | 2010-06-09 | 公開日 | 2011-02-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Glycine amide shielding on the aromatic surfaces of lysozyme: Implication for suppression of protein aggregation Febs Lett., 585, 2011
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3AGG
| X-ray analysis of lysozyme in the absence of Arg | 分子名称: | ACETATE ION, CHLORIDE ION, Lysozyme C, ... | 著者 | Ito, L, Shiraki, K, Hasegawa, K, Baba, S, Kumasaka, T. | 登録日 | 2010-03-31 | 公開日 | 2011-03-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | High-resolution X-ray analysis reveals binding of arginine to aromatic residues of lysozyme surface: implication of suppression of protein aggregation by arginine Protein Eng.Des.Sel., 24, 2011
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