6GL1
 
 | | HLA-E*01:03 in complex with the HIV epitope, RL9HIV | | 分子名称: | ARG-MET-TYR-SER-PRO-THR-SER-ILE-LEU, Beta-2-microglobulin, MHC class I antigen, ... | | 著者 | Walters, L.C, Gillespie, G.M, McMichael, A.J, Rozbesky, D, Jones, E.Y, Harlos, K. | | 登録日 | 2018-05-22 | | 公開日 | 2018-08-08 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.623 Å) | | 主引用文献 | Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.
Nat Commun, 9, 2018
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5J69
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1VCA
 | | CRYSTAL STRUCTURE OF AN INTEGRIN-BINDING FRAGMENT OF VASCULAR CELL ADHESION MOLECULE-1 AT 1.8 ANGSTROMS RESOLUTION | | 分子名称: | HUMAN VASCULAR CELL ADHESION MOLECULE-1 | | 著者 | Jones, E.Y, Harlos, K, Bottomley, M.J, Robinson, R.C, Driscoll, P.C, Edwards, R.M, Clements, J.M, Dudgeon, T.J, Stuart, D.I. | | 登録日 | 1995-03-21 | | 公開日 | 1995-09-15 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution.
Nature, 373, 1995
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4ZEL
 | | Human dopamine beta-hydroxylase | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, ... | | 著者 | Vendelboe, T.V, Harris, P, Christensen, H.E.M, Harlos, K, Walter, T, Zhao, Y, Omari, K. | | 登録日 | 2015-04-20 | | 公開日 | 2016-04-20 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | The crystal structure of human dopamine beta-hydroxylase at 2.9 angstrom resolution.
Sci Adv, 2, 2016
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1QFT
 | | HISTAMINE BINDING PROTEIN FROM FEMALE BROWN EAR RHIPICEPHALUS APPENDICULATUS | | 分子名称: | HISTAMINE, PROTEIN (FEMALE-SPECIFIC HISTAMINE BINDING PROTEIN 2) | | 著者 | Paesen, G.C, Adams, P.L, Harlos, K, Nuttal, P.A, Stuart, D.I. | | 登録日 | 1999-04-14 | | 公開日 | 2000-04-19 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Tick histamine-binding proteins: isolation, cloning, and three-dimensional structure.
Mol.Cell, 3, 1999
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5OPG
 | | Structure of the Hantaan virus Gn glycoprotein ectodomain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SULFATE ION, ... | | 著者 | Rissanen, I, Stass, R, Zeltina, A, Li, S, Hepojoki, J, Harlos, K, Gilbert, R.J.C, Huiskonen, J.T, Bowden, T.A. | | 登録日 | 2017-08-09 | | 公開日 | 2017-08-23 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structural Transitions of the Conserved and Metastable Hantaviral Glycoprotein Envelope.
J. Virol., 91, 2017
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5OSN
 | | Crystal Structure of Bovine Enterovirus 2 determined with Serial Femtosecond X-ray Crystallography | | 分子名称: | Capsid protein, GLUTAMIC ACID, POTASSIUM ION, ... | | 著者 | Roedig, P, Ginn, H.M, Pakendorf, T, Sutton, G, Harlos, K, Walter, T.S, Meyer, J, Fischer, P, Duman, R, Vartiainen, I, Reime, B, Warmer, M, Brewster, A.S, Young, I.D, Michels-Clark, T, Sauter, N.K, Kotecha, A, Kelly, J, Rowlands, D.J, Sikorsky, M, Nelson, S, Damiani, D.S, Alonso-Mori, R, Ren, J, Fry, E.E, David, C, Stuart, D.I, Wagner, A, Meents, A. | | 登録日 | 2017-08-17 | | 公開日 | 2017-08-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | High-speed fixed-target serial virus crystallography.
Nat. Methods, 14, 2017
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2JJU
 | | Structure of human signal regulatory protein (sirp) beta | | 分子名称: | CHLORIDE ION, SIGNAL REGULATORY PROTEIN BETA-1, SULFATE ION | | 著者 | Hatherley, D, Graham, S.C, Turner, J, Harlos, K, Stuart, D.I, Barclay, A.N. | | 登録日 | 2008-04-22 | | 公開日 | 2008-08-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | | 主引用文献 | Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with Cd47.
Mol.Cell, 31, 2008
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2JJW
 | | Structure of human signal regulatory protein (sirp) gamma | | 分子名称: | SIGNAL REGULATORY PROTEIN GAMMA | | 著者 | Hatherley, D, Graham, S.C, Turner, J, Harlos, K, Stuart, D.I, Barclay, A.N. | | 登録日 | 2008-04-22 | | 公開日 | 2008-08-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with Cd47.
Mol.Cell, 31, 2008
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1OLZ
 | | The ligand-binding face of the semaphorins revealed by the high resolution crystal structure of SEMA4D | | 分子名称: | SEMAPHORIN 4D | | 著者 | Love, C.A, Harlos, K, Mavaddat, N, Davis, S.J, Stuart, D.I, Jones, E.Y, Esnouf, R.M. | | 登録日 | 2003-08-19 | | 公開日 | 2003-09-11 | | 最終更新日 | 2018-02-28 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Ligand-Binding Face of the Semaphorins Revealed by the High-Resolution Crystal Structure of Sema4D
Nat.Struct.Biol., 10, 2003
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5NUZ
 | | Junin virus GP1 glycoprotein in complex with an antibody Fab fragment | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ISOPROPYL ALCOHOL, ... | | 著者 | Zeltina, A, Krumm, S.A, Sahin, M, Struwe, W.B, Harlos, K, Nunberg, J.H, Crispin, M, Pinschewer, D.D, Doores, K.J, Bowden, T.A. | | 登録日 | 2017-05-03 | | 公開日 | 2017-06-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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2JJT
 | | Structure of human CD47 in complex with human signal regulatory protein (SIRP) alpha | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LEUKOCYTE SURFACE ANTIGEN CD47, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1 | | 著者 | Hatherley, D, Graham, S.C, Turner, J, Harlos, K, Stuart, D.I, Barclay, A.N. | | 登録日 | 2008-04-22 | | 公開日 | 2008-08-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.
Mol. Cell, 31, 2008
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2JJV
 | | Structure of human signal regulatory protein (sirp) beta(2) | | 分子名称: | CHLORIDE ION, SIGNAL-REGULATORY PROTEIN BETA 1., SULFATE ION | | 著者 | Hatherley, D, Graham, S.C, Turner, J, Harlos, K, Stuart, D.I, Barclay, A.N. | | 登録日 | 2008-04-22 | | 公開日 | 2008-08-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with Cd47.
Mol.Cell, 31, 2008
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2JJS
 | | Structure of human CD47 in complex with human signal regulatory protein (SIRP) alpha | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IODIDE ION, LEUKOCYTE SURFACE ANTIGEN CD47, ... | | 著者 | Hatherley, D, Graham, S.C, Turner, J, Harlos, K, Stuart, D.I, Barclay, A.N. | | 登録日 | 2008-04-22 | | 公開日 | 2008-08-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.
Mol. Cell, 31, 2008
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1QFV
 | | HISTAMINE BINDING PROTEIN FROM FEMALE BROWN EAR RHIPICEPHALUS APPENDICULATUS | | 分子名称: | HISTAMINE, PROTEIN (FEMALE-SPECIFIC HISTAMINE BINDING PROTEIN 2) | | 著者 | Paesen, G.C, Adams, P.L, Harlos, K, Nuttal, P.A, Stuart, D.I. | | 登録日 | 1999-04-14 | | 公開日 | 2000-04-19 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Tick histamine-binding proteins: isolation, cloning, and three-dimensional structure.
Mol.Cell, 3, 1999
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5ZH3
 | | CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-6 | | 分子名称: | (3S)-6,8-dihydroxy-3-{[(2R,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, LYSINE, Lysine-tRNA ligase | | 著者 | Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A. | | 登録日 | 2018-03-11 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | | 主引用文献 | Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
J. Med. Chem., 61, 2018
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6FKM
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5ZH5
 | | CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-2 | | 分子名称: | (3S)-6,8-dihydroxy-3-{[(2R,6S)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, CHLORIDE ION, LYSINE, ... | | 著者 | Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A. | | 登録日 | 2018-03-11 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.08 Å) | | 主引用文献 | Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
J. Med. Chem., 61, 2018
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6F8P
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5ZH4
 | | CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-7 | | 分子名称: | (3R)-6,8-dihydroxy-3-{[(2S,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, CHLORIDE ION, LYSINE, ... | | 著者 | Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A. | | 登録日 | 2018-03-11 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
J. Med. Chem., 61, 2018
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6FKK
 | | Drosophila Semaphorin 1b, extracellular domains 1-2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MIP07328p, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Rozbesky, D, Harlos, K, Jones, E.Y. | | 登録日 | 2018-01-24 | | 公開日 | 2019-02-06 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | | 主引用文献 | Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning.
Nat Commun, 10, 2019
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6FKN
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2UUX
 | | Structure of the tryptase inhibitor TdPI from a tick | | 分子名称: | SULFATE ION, TRYPTASE INHIBITOR | | 著者 | Siebold, C, Paesen, G.C, Harlos, K, Peacey, M.F, Nuttall, P.A, Stuart, D.I. | | 登録日 | 2007-03-08 | | 公開日 | 2007-04-03 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | A Tick Protein with a Modified Kunitz Fold Inhibits Human Tryptase.
J.Mol.Biol., 368, 2007
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2UUY
 | | Structure of a tick tryptase inhibitor in complex with bovine trypsin | | 分子名称: | CALCIUM ION, CATIONIC TRYPSIN, CHLORIDE ION, ... | | 著者 | Siebold, C, Paesen, G.C, Harlos, K, Peacey, M.F, Nuttall, P.A, Stuart, D.I. | | 登録日 | 2007-03-08 | | 公開日 | 2007-04-10 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | A Tick Protein with a Modified Kunitz Fold Inhibits Human Tryptase.
J.Mol.Biol., 368, 2007
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5ZH2
 | | CRYSTAL STRUCTURE OF PfKRS WITH INHIBITOR CLADO-5 | | 分子名称: | (3R)-6,8-dihydroxy-3-{[(2R,6R)-6-methyloxan-2-yl]methyl}-3,4-dihydro-1H-2-benzopyran-1-one, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... | | 著者 | Babbar, P, Malhotra, N, Sharma, M, Harlos, K, Reddy, D.S, Manickam, Y, Sharma, A. | | 登録日 | 2018-03-11 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | | 主引用文献 | Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
J. Med. Chem., 61, 2018
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