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PDB: 24 件
1SHJ
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Caspase-7 in complex with DICA allosteric inhibitor
分子名称: 2-(2,4-DICHLORO-PHENOXY)-N-(2-MERCAPTO-ETHYL)-ACETAMIDE, Caspase-7, SULFATE ION
著者Hardy, J.A, Lam, J, Nguyen, J.T, O'Brien, T, Wells, J.A.
登録日2004-02-25
公開日2004-08-17
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of an allosteric site in the caspases
Proc.Natl.Acad.Sci.USA, 101, 2004
1SHL
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CASPASE-7 IN COMPLEX WITH FICA ALLOSTERIC INHIBITOR
分子名称: 5-FLUORO-1H-INDOLE-2-CARBOXYLIC ACID-(2-MERCAPTO-ETHYL)-AMIDE, Caspase-7
著者Hardy, J.A, Lam, J, Nguyen, J.T, O'Brien, T, Wells, J.A.
登録日2004-02-25
公開日2004-08-17
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Discovery of an allosteric site in the caspases
Proc.Natl.Acad.Sci.USA, 101, 2004
4ZVT
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Caspase-7 Variant 1 (V1) with reprogrammed substrate specificity due to Y230A/W232M/S234N substitutions, bound to VEID inhibitor.
分子名称: Caspase-7, VEID inhibitor
著者Hardy, J.A, MacPherson, D.J, Hill, M.E.
登録日2015-05-18
公開日2016-04-20
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.
Acs Chem.Biol., 11, 2016
4ZVU
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Caspase-7 wild-type bound to the caspase-6 cognate tetrapeptide inhibitor Ac-VEID-cho
分子名称: Caspase-7, Tetrapeptide Inhibitor Ac-VEID-CHO
著者Hardy, J.A, MacPherson, D.J, Hill, M.E.
登録日2015-05-18
公開日2016-04-20
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.601 Å)
主引用文献Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.
Acs Chem.Biol., 11, 2016
1FBU
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HEAT SHOCK TRANSCRIPTION FACTOR DNA BINDING DOMAIN
分子名称: HEAT SHOCK FACTOR PROTEIN
著者Hardy, J.A, Nelson, H.C.M.
登録日2000-07-16
公開日2001-01-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Proline in alpha-helical kink is required for folding kinetics but not for kinked structure, function, or stability of heat shock transcription factor.
Protein Sci., 9, 2000
1FBQ
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HEAT SHOCK TRANSCRIPTION FACTOR DNA BINDING DOMAIN CONTAINING THE P237K MUTATION
分子名称: HEAT SHOCK FACTOR PROTEIN
著者Hardy, J.A, Nelson, H.C.M.
登録日2000-07-16
公開日2001-01-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Proline in alpha-helical kink is required for folding kinetics but not for kinked structure, function, or stability of heat shock transcription factor.
Protein Sci., 9, 2000
1FBS
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HEAT SHOCK TRANSCRIPTION FACTOR DNA BINDING DOMAIN CONTAINING THE P237A MUTATION
分子名称: HEAT SHOCK FACTOR PROTEIN
著者Hardy, J.A, Nelson, H.C.M.
登録日2000-07-16
公開日2001-01-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Proline in alpha-helical kink is required for folding kinetics but not for kinked structure, function, or stability of heat shock transcription factor.
Protein Sci., 9, 2000
3NKF
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Crystal structure of human ligand-free mature caspase-6 with intersubunit linker attached
分子名称: Caspase-6
著者Vaidya, S, Hardy, J.A.
登録日2010-06-18
公開日2010-12-08
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6.
J.Mol.Biol., 406, 2011
3R5K
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A designed redox-controlled caspase-7
分子名称: Caspase-7, FORMIC ACID
著者Witkowski, W.A, Hardy, J.A.
登録日2011-03-18
公開日2011-06-29
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献A designed redox-controlled caspase.
Protein Sci., 20, 2011
3S8E
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Phosphorylation regulates assembly of the caspase-6 substrate-binding groove
分子名称: Caspase-6
著者Velazquez-Delgado, E.M, Hardy, J.A.
登録日2011-05-27
公開日2012-04-11
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Phosphorylation regulates assembly of the caspase-6 substrate-binding groove.
Structure, 20, 2012
5K20
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Caspase-7 S239E Phosphomimetic
分子名称: Caspase-7 large subunit, Caspase-7 small subunit, FORMIC ACID
著者Eron, S.J, Hardy, J.A.
登録日2016-05-18
公開日2017-01-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献PAK2 Phosphorylation Inhibits Caspase-7 by Two Divergent Mechanisms: Slowing Activation and Blocking Substrate Binding
To Be Published
3H1P
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Mature Caspase-7 I213A with DEVD-CHO inhibitor bound to active site
分子名称: Caspase-7, N-ACETYL-L-ALPHA-ASPARTYL-L-ALPHA-GLUTAMYL-N-[(2S)-1-CARBOXY-3-HYDROXYPROPAN-2-YL]-L-VALINAMIDE
著者Witkowski, W.A, Hardy, J.A.
登録日2009-04-13
公開日2009-06-30
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献L2' loop is critical for caspase-7 active site formation.
Protein Sci., 18, 2009
3K7E
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Crystal structure of human ligand-free mature caspase-6
分子名称: Caspase-6
著者Vaidya, S, Hardy, J.A.
登録日2009-10-13
公開日2010-10-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure-function analysis of caspase-6
To be Published
4FXO
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Zinc-mediated allosteric inhibiton of caspase-6
分子名称: Caspase-6, ZINC ION
著者Velazquez-Delgado, E.M, Hardy, J.A.
登録日2012-07-03
公開日2012-08-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Zinc-mediated Allosteric Inhibition of Caspase-6.
J.Biol.Chem., 287, 2012
4M9I
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A125C NS2B-NS3 protease from dengue virus at pH 5.5
分子名称: NS2B-NS3 protease
著者Yildiz, M, Hardy, J.A.
登録日2013-08-14
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus.
Acs Chem.Biol., 8, 2013
4M9F
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Dengue virus NS2B-NS3 protease A125C variant at pH 8.5
分子名称: NS2B-NS3 protease
著者Yildiz, M, Ghosh, S, Bell, J.A, Sherman, W, Hardy, J.A.
登録日2013-08-14
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus.
Acs Chem.Biol., 8, 2013
4M9K
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NS2B-NS3 protease from dengue virus at pH 5.5
分子名称: NS2B-NS3 protease
著者Yildiz, M, Hardy, J.A.
登録日2013-08-14
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus.
Acs Chem.Biol., 8, 2013
4M9T
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NS2B-NS3 protease from dengue virus in the presence of DTNB, a covalent allosteric inhibitor
分子名称: CHLORIDE ION, NS2B-NS3 protease
著者Bell, J.A, Yildiz, M, Hardy, J.A.
登録日2013-08-15
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus.
Acs Chem.Biol., 8, 2013
4M9M
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BU of 4m9m by Molmil
NS2B-NS3 protease from dengue virus at pH 8.5
分子名称: NS2B-NS3 protease
著者Yildiz, M, Hardy, J.A.
登録日2013-08-14
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus.
Acs Chem.Biol., 8, 2013
4ZVR
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BU of 4zvr by Molmil
Caspase-7 Variant 4 (V4) with reprogrammed substrate specificity due to Y230V/W232Y/S234V/Q276D substitutions bound to DEVD inhibitor.
分子名称: Caspase-7, Peptide ACE-ASP-GLU-VAL-ASJ
著者Hill, M.E, MacPherson, D.J, Hardy, J.A.
登録日2015-05-18
公開日2016-04-20
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.
Acs Chem.Biol., 11, 2016
4ZVS
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BU of 4zvs by Molmil
Caspase-7 Variant 1 (V1) with reprogrammed substrate specificity due to Y230A/W232M/S234N substitutions, bound to DEVD inhibitor.
分子名称: Caspase-7, DEVD inhibitor
著者MacPherson, D.J, Hill, M.E, Hardy, J.A.
登録日2015-05-18
公開日2016-04-20
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.
Acs Chem.Biol., 11, 2016
4ZVP
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Caspase-7 Variant 2 (V2) with reprogrammed substrate specificity due to Y230V/W232M/Q276C substitutions bound to DEVD inhibitor.
分子名称: Caspase-7, Peptide ACE-ASP-GLU-VAL-ASA
著者Hill, M.E, MacPherson, D.J, Hardy, J.A.
登録日2015-05-18
公開日2016-04-20
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.
Acs Chem.Biol., 11, 2016
4ZVO
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Caspase-7 Variant 4 (V4) with reprogrammed substrate specificity due to Y230V/W232Y/S234V/Q276D substitutions bound to VEID inhibitor.
分子名称: Caspase-7, Peptide ACE-VAL-GLU-ILE-ASJ
著者Hill, M.E, MacPherson, D.J, Hardy, J.A.
登録日2015-05-18
公開日2016-04-20
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.
Acs Chem.Biol., 11, 2016
4ZVQ
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BU of 4zvq by Molmil
Caspase-7 Variant 2 (V2) with reprogrammed substrate specificity due to Y230V/W232M/Q276C substitutions bound to VEID inhibitor.
分子名称: Caspase-7, Peptide ACE-VAL-GLU-ILE-ASA
著者Hill, M.E, MacPherson, D.J, Hardy, J.A.
登録日2015-05-18
公開日2016-04-20
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.
Acs Chem.Biol., 11, 2016

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